Making novel discoveries in the biology underlying normal development and cancer progression.

Our Focus

Ongoing research across a wide spectrum of biomedicine and the life sciences; including biochemistry, stem cell biology, immunology, molecular genetics, molecular medicine and gene therapy.

The Terry Fox Laboratory (TFL) has expertise in diverse research areas, including mammalian systems, normal and malignant mammary tissues, lineage specification in the gut, and yeast genetics. Experimental approaches employed at TFL include genetically engineered models, patient xenograft models, in vitro cell based assays, highly dimension single cell phenotyping, molecular biology and biochemistry, DNA regulation, transcriptomics, epigenetics, and DNA repair. In recent years, TFL has placed emphasis on the development of new technologies and their use to address fundamental questions in the control of cell growth and differentiation, aging, and gene regulation.

Blood Cancer

Working with innovative model systems and patients our research addresses the root causes of leukemias and myeloma and is developing new tools for their diagnosis, characterization and treatment.

Genome Dynamics

Genes influence every aspect of human biology and disease. We are studying how our genes and genomes are faithfully maintained as we age and the complex ways in which they are regulated to control development or are dysregulated during cancer formation.

Stem Cells

Stem cells are critical components on healthy aging and tumour suppression since they enable the development and maintenance of adult tissues. We are working to understand how stem cell properties enable blood, breast and liver development and how these properties are co-opted in cancers.

Research Labs & Principal Investigators

News & Events

Apr 21, 2020

Sherrie X Wang (Brinkman Lab) defends her MSc thesis entitled “Flow cytometry data analysis pipeline – data quality control tool development and biomarker discovery”

Congratulations to Sherrie X Wang from the Brinkman Lab, who successfully defended her MSc thesis entitled “Flow cytometry data analysis pipeline – data quality control tool development and biomarker discovery” on April 8, 2020.

Apr 21, 2020

Carl-Adam Mattsson (Lansdorp Lab) defends his MSc thesis entitled “A bioinformatic workflow to analyze single cell template strand sequencing data"

Congratulations to Carl-Adam Mattsson from the Lansdorp Lab, who successfully defended his MSc thesis entitled “A bioinformatic workflow to analyze single cell template strand sequencing data" on April 6, 2020.

Apr 21, 2020

Annie Sui-On Tam (Stirling Lab) defends her PhD thesis entitled “The conserved role of RNA splicing factors in genome maintenance”

Congratulations to Annie Sui-On Tam from the Stirling Lab, who successfully defended her PhD thesis entitled “The conserved role of RNA splicing factors in genome maintenance” on March 18, 2020.

Recent Publications

Ultrasensitive Detection of NOTCH1 c.7544_7545delCT Mutations in Chronic Lymphocytic Leukemia by Droplet Digital PCR Reveals High Frequency of Subclonal Mutations and Predicts Clinical Outcome in Cases with Trisomy 12.

The Journal of molecular diagnostics : JMD, 2020
Hoofd, Catherine, Huang, Steven J, Gusscott, Samuel, Lam, Sonya, Wong, Rachel, Johnston, Alexa, Ben-Neriah, Susana, Steidl, Christian, Scott, David W, Bruyere, Helene, Gillan, Tanya L, Toze, Cynthia L, Gerrie, Alina S, Weng, Andrew P

TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma.

Nature medicine, 2020
Ennishi, Daisuke, Healy, Shannon, Bashashati, Ali, Saberi, Saeed, Hother, Christoffer, Mottok, Anja, Chan, Fong Chun, Chong, Lauren, Abraham, Libin, Kridel, Robert, Boyle, Merrill, Meissner, Barbara, Aoki, Tomohiro, Takata, Katsuyoshi, Woolcock, Bruce W, Viganò, Elena, Gold, Michael, Molday, Laurie L, Molday, Robert S, Telenius, Adele, Li, Michael Y, Wretham, Nicole, Dos Santos, Nancy, Wong, Mark, Viller, Natasja N, Uger, Robert A, Duns, Gerben, Baticados, Abigail, Madero, Angel, Bristow, Brianna N, Farinha, Pedro, Slack, Graham W, Ben-Neriah, Susana, Lai, Daniel, Zhang, Allen W, Salehi, Sohrab, Shulha, Hennady P, Chiu, Derek S, Mostafavi, Sara, Gerrie, Alina S, Huang, Da Wei, Rushton, Christopher, Villa, Diego, Sehn, Laurie H, Savage, Kerry J, Mungall, Andrew J, Weng, Andrew P, Bally, Marcel B, Morin, Ryan D, Cohen Freue, Gabriela V, Staudt, Louis M, Connors, Joseph M, Marra, Marco A, Shah, Sohrab P, Gascoyne, Randy D, Scott, David W, Steidl, Christian
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