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Biostatistician - Centre for Lymphoid Cancer

Application Deadline

Role Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient and employee safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Reporting to the Clinical and Research Directors of the Centre for Lymphoid Cancer, BC Cancer Agency, the Biostatistician provides support in the areas of study design, analysis, and consulting for biological and clinical cancer research. This role oversees survival analysis and statistical modeling of clinico-biologic factors associated with patient outcomes and maintains information collected in the provincial clinical lymphoma database. The Biostatistician also provides the monitoring of lymphoid cancer interventions and lymphoid cancer health service performance indicators for use in the planning, implementation and evaluation of lymphoid cancer care in the province. The Biostatistician is responsible for tracking trends and detecting emerging issues and associations between a wide range of lymphoid cancer risk factors, health determinants, and health outcomes. The Biostatistician manages the preparation of annual, quarterly, period, and ad hoc reports and is responsible for ensuring high quality and accuracy of these reports. The Biostatistician is responsible for providing statistical support and maintains the integrity of the data to a renowned lymphoma cancer research group which consists of Clinicians, Researchers, Biologists, and Bioinformaticians on lymphoma cancer research and related projects.

Key Accountabilities

  • Develops novel statistical models to discover untapped potential in  clinical data, biological phenomena, and novel associations of clinic-biologic factors with patient outcomes.
  • Monitors and assesses existing provincial clinical database of lymphoma patients to provide accurate and timely information. Provides regular reports and presentation of statistical analyses and results to the group
  • Provides support for the development and collaboration of experimental design of research projects to ensure statistical rigor. Evaluates existing and emerging data analysis tools, provides recommendations regarding new tool adoption and performs risk/impact analyses in support of the planning of system development, enhancement and maintenance.
  • Performs quantitative data analyses using advanced statistical methodologies and statistical software.
  • Identifies and provides advice about data limitations and ensures adequate data quality for analytic purposes.
  • Links data sources from the provincial clinical lymphoma database with other major health information systems such as the Ministry of Health (Vital Statistics, hospital discharge database, Pharmanet, Medical Services Plan). Maintains relationships with senior managers in these organizations; takes measures to protect all data and information being used to comply with protection of confidentiality and privacy policies.
  • Develops and produces analytical outputs (e.g. reports, presentations, posters) that support the Centre for Lymphoid Cancer Agency and BCCRC Committees in the monitoring, planning and evaluation of population trends, health services utilization, and health outcomes for lymphoid cancer interventions, including health care system quality trends and variations.
  • Develops and produces reports that monitor and benchmark cost, utilization, quality and other performance indicators and communicates findings to the BCCRC and PHSA Executives, PHSA Board, Ministry of Health and external stakeholders at the local, regional, provincial and national levels. Formulates recommendations based on findings, including strategic interventions, program and costing recommendations. Represents the Centre for Lymphoid Cancer in various meetings as a speaker or contributor.
  • Plans, develops and delivers training programs, initiatives and materials related to lymphoid cancer research and data analyses in collaboration with BCCRC staff and other organizations throughout the province.
  • Identifies learning needs that contribute to skill enhancement and career progression for self and fosters a working environment that stimulates learning and inquiry for self and others. Takes responsibility for keeping self-up-to-date regarding new initiatives, developments and trends in statistical analysis, renal utilization and health services issues through literature review, contact with peers at other organizations, professional associations and attendance at conferences, seminars, workshop and education programs. Communicates information and makes recommendations to the Clinical & Research Directors for evaluation and approval.

Qualifications

A level of education, training, and experience equivalent to a Master’s Degree in Biostatistics, Statistics, Epidemiology, Health Information Science, or Computer Science and five (5) years of experience in a health analytics, health research or health information field. Understanding of molecular biology and cancer genomics is an asset.

Advanced knowledge of frequentist statistics, probability distributions, statistical inference and modeling, particularly Bayesian statistics and machine learning. Knowledge of database management principles. Exceptional knowledge of survival analysis, including cox regression, Kaplan-Meier estimation, statistical language R and experience using ‘Rmarkdown’ or an alternative statistical language. Experience in database graphical, presentation, communication and software applications, such as Linux, MS Access and SQL. Strong analytical, problem-solving and system analysis skills including the ability to comprehend complex issues and related data/information and present information in concise meaningful ways. Ability to develop complex and customized queries and reports. Ability to function in a self-directed manner. Excellent ability to communicate effectively both verbally and in writing. Demonstrated interpersonal skills with a variety of people. Excellent time management skills. Demonstrated ability to respond to the needs of stakeholders supported by an acute awareness of the impact of actions. Ability to handle multiple concurrent tasks. Physical ability to perform the duties of the job.

Research Project Manager

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values — science, timeliness, respect — to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: RPC-R00022-2021-05-28

Do you have a background in science research — from its processes and practices to proposals & peer-review? Can you develop an award winning grant application, facilitate efficient and productive meetings, gather the right information and engage the right people at the right ti​me? We're looking for a Research Project Manager to help GSC faculty and leaders continue to deliver world-leading genomics, bioinformatics, cancer and precision medicine research.

Reporting to the Head, Project Management or Projects Team Leader and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and monitor and facilitate progress against these objectives and milestones. Projects will involve personalized oncogenomics, collaborative services management, or other cancer genomics research.

Duties/Accountabilities

  • Establishing budgets for research projects, grants, collaborations and core activities
  • Assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
  • Monitoring budgets and expenditures
  • Establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives, which may include, meeting coordination and follow-up, coordination of case reviews
  • Maintaining accurate information on sample status, including sample and associated metadata acquisition, processing, stakeholder reporting
  • recommending strategies for improving projects management methods and processes
  • Liaising with grant/core funding agencies
  • Interacting directly with research collaborators or clinical study teams as required

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research, clinical trials research, biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

Successful candidate(s) will be offered positions through Provincial Health Services Authority at level Research Project Coordinator, which is equivalent to that described above

Core Skills and Abilities

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Project Manager in the subject line of your email.

This posting will remain online until filled.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis. This restriction would be re-evaluated upon re-contracting

Research Programmer - Data Scientist

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: RP_R00008_ 2021_05_19

Dr. Aly Karsan and the Karsan lab team at Genome Sciences Centre (GSC) are seeking a Research Programmer to join a Marathon of Hope Cancer Centre research project. The team will be working with other research programmers at the Karsan lab for developing data analysis pipelines for various next-generation sequencing (NGS) data such as but not limited to scRNA-Seq, targeted sequencing, ATAC-Seq, and BS-Seq, for the study of cancer evolution. We seek candidates with strong analytical and programming skills to research, develop, and improve our research pipelines.

The role is ideally suited for detail-oriented individuals with a strong interest in data analysis, research, and scientific programming within a high throughput academic setting.  The Karsan lab has a history of strong publications and can offer great experience in research with full access to the GSC’s world-class compute cluster.  Additionally, the Karsan Lab has a diverse computational biology core for knowledge sharing, collaboration, and support. 

Duties/Accountabilities

  • Design and implement bioinformatic data pipelines to meet objectives of the project
  • Work with other project team members to develop and test code, and implement analysis
  • Evaluate and incorporate third-party software into pipelines
  • Produce thorough but concise written documentation of experiments, algorithms, validations, and other procedures as required.

 Qualifications

  • Graduation from a recognized Bachelor of Science Program in Computer Science or relevant program. A Master’s degree in a relevant field would be a strong asset. 
  • Two (2) years of recent related experience or an equivalent combination of education, training, and experience.

Core Skills and Abilities

  • Expertise with scientific programming and able to provide links to code samples via GitHub
  • Familiarity with molecular and cellular biology
  • Excellent verbal and written communication skills
  • Demonstrated ability to interpret results
  • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
  • Established ability to efficiently organize work assignments and establish priorities
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.

Additional Assets

  • Familiarity in statistical analysis using modern computational tools (experience with any relevant tools will be considered, but R and Python are preferred)
  • Familiarity in next-generation sequencing datasets
  • Understanding of cancer biology
  • Functional knowledge of distributed version control systems, such as SVN or GIT

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Research Programmer – Data Scientist, Karsan Lab in the subject line of your email.

This posting will remain online until filled.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis. This will be re-evaluated once plans to return to the office are made.

Assistant Bioinformatics Coordinator

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Summary

Job Reference No:  ABC_HSA# 108912_P00183_2021_05_18

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Assistant Bioinformatics Coordinator provides supervisory and technical support to the Bioinformatics group of the Genome Sequence Centre (GSC).  Ensures that the day-to-day activities of a large scale, high throughput facility meet research, data analysis throughput and software development objectives. 

Duties

  • Assists the Bioinformatics Coordinator in the day to day activities of the Bioinformatics group by performing duties such as providing input on quantity and quality of work, making recommendations for improvements, workflow and procedures.
  • Coordinates projects of the Bioinformatics group by performing duties such as chairing project-specific meetings and provides project status reports to the Bioinformatics Coordinator, with suggestions towards any required improvement of project management, task allocation and overall process.
  • Develops and implements assays to monitor project progress and measure project accomplishments to ensure that appropriate project focus is maintained and to provide feedback to staff.
  • Provides supervisory support to the Bioinformatics group by performing duties such as:
    • Orientating new staff.
    • Providing input to the Bioinformatics Coordinator on training requirements.
    • Providing input to the Production Coordinator on the establishment of clear definitions of responsibility for employees.
    • Assigning workload assignments and establishing work schedules.
    • Reviewing and establishing work priorities and adjusting work schedules to ensure priorities are met.
    • Completing performance reviews and addressing performance issues in conjunction with the Production Coordinator.
  • Participates in the recruitment of staff through methods such as interviewing internal and external applicants and forwards hiring recommendations.
  • Participates in the development and implementation of quality improvement programs to ensure services are provided in the most efficient and effective way by performing duties such as:
    • Monitoring quality and quantity of service and information provided by the bioinformatics group and identifying areas for change and/or improvement.
    • Generating test metrics to evaluate progress of research programs.
  • Assesses practical needs for identified research direction of the GSC in conjunction with the Bioinformatics Coordinator and Analysis Group Leader.
  • Participates in a variety of meetings by performing duties such as providing and/or receiving information and contributing to decision making.
  • Participates, in conjunction with the Bioinformatics Coordinator, in determining the computer infrastructure necessary for successful completion of projects and ensured viability of research programs by performing duties such as providing input and recommendations regarding purchasing decisions related to hardware, software and related items for the Bioinformatics platform.
  • Interprets statistical analyses and makes recommendations for review including preparing reports on statistical findings for publication and presentation in HTML format or as advised.
  • Conducts feasibility studies for computerization by performing duties such as determining user requirements, examining and identifying problems with existing systems and recommending modifications to and/or new systems; provides details of estimated implementation costs including associated staffing requirements.
  • Performs technical functions related to the bioinformatic functions of the GSC.
  • Performs other related duties as required.

Qualifications

Education, Training and Experience

  • Graduation from a recognized Bachelor’s program in a related discipline such as Biochemistry, Genetics, Computer Science, Electrical Engineering or Physics.  A minimum of four (4) years of recent related experience including experience in computer programming and quantitative data analysis, handling biological sequence and/or mapping data, database development and data storage schemas or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

  • Experience with computer operating systems such as Linux, UNIX.
  • Demonstrated ability to work with software such as C, C++, Perl , Matlab, MySQL.
  • Demonstrated ability to accept responsibility and work independently.
  • Demonstrated ability to work effectively with others in a team environment.
  • Demonstrated ability to supervise staff and schedule work.
  • Excellent organizational, leadership interpersonal and communication skills.
  • Physical ability to perform the duties of the job.

Apply

Please submit a cover letter, curriculum vitae and the names of three referees willing to provide letters of reference. The cover letter should include a brief description of your previous research experience and long-term career goals. Please email your application to bcgscjobs@bcgsc.ca.

Important!

*We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

*All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely on a temporary basis. This restriction would be re-evaluated upon re-contracting.

Research Associate - Scientific Program Lead

Position Description

The post holder will support and work closely with Dr Aparicio, leader of Molecular Oncology, UBC Nan and Lorraine Robertson Chair of Breast Cancer, in developing scientific proposals, assisting in manuscript development and review, coordinating international multi-PI research studies and interacting with funders and advocates in reporting the activities of the program. A PhD with demonstrated experience in authoring manuscripts, preparing funding applications and reports, is a requirement for the role. Preference will be given to candidates with experience in biosciences and cancer research. Ability to articulate science clearly in a written form and a high degree of independence and self organization are core skills for this post.

Major responsibilities include

  • Provide input into writing research proposals and writes significant portions of grant applications.
  • Develops and recommends project budgets, monitors expenditure of funds relative to budget, ensures appropriate, transparent justifications for expenditures. Participates in the development and implementation of new projects, by developing new material, researching and sourcing equipment and recommending staffing and resource requirements.
  • Manages and develops necessary agreements for the Aparicio program in conjunction with the BC Cancer Technology Development Office and UBC Office of Research Services/University-Industry Liaison Office.
  • Responds to ongoing requests for regular reports by maintaining and updating information to ensure compliance with granting agencies and other external organizations.
  • Serves as a primary point of liaison between researchers, administrators, and funding agencies REBs, national and international health organizations, educational institutions, government and private agencies.
  • Identifies opportunities for developing new initiatives, grants and projects that enhance funding of research in the Aparicio program. This may include, but is not limited to funding from external organizations such as MSFHR, CIHR, Genome Canada, CFI, NSERC, NCIC, LRF, NIH, the provincial government and industry.
  • Assists with Research Ethics Board applications and amendments as required, and ensures compliance with Research Ethics Board guidelines.
  • Develops and maintains a clear engagement and communication plan for both internal and external audiences.  This includes promotion and representation of Aparicio program research through websites and social media platforms, and the development and facilitation of workshops, conferences, guest lecturers, etc.
  • Identifies new translational pathways, such as commercial partnerships, licencing etc. for new technologies and encourage entrepreneurial activities as appropriate.
  • Conducts regular literature reviews relating to research areas.  Contributes intellectual and scientific input to manuscripts for publications, provides scientific proofreading. 

Eligibility requirement

Interested individuals with a PhD or MD/PhD, a strong publication record and excellent academic credentials are encouraged to apply. Experience in grant preparation and scientific manuscript preparation is required.

  • Strong interpersonal skills and the ability to work effectively with internal and external stakeholders who possess a wide range of education and expertise. 
  • Ability to use independent judgment and to manage and impart information to a diverse range of internal and external stakeholders.
  • Ability to exercise appropriate tact, discretion, confidentiality, and good judgment in all matters.
  • Knowledge of and/or experience in project management principles, accounting and fiscal management is preferable.

This is a one year appointment and depending on funding and successful progress of the research it may be renewed for additional years.

UBC hires on the basis of merit and is committed to employment equity. All qualified persons are encouraged to apply. UBC is strongly committed to diversity within its community and especially welcomes applications from visible minority group members, women, Aboriginal persons, persons with disabilities, persons of any sexual orientation or gender identity, and others who may contribute to the further diversification of ideas. However, Canadians and permanent residents of Canada will be given priority.

We thank all interested applicants for their interest, however, only those applicants short-listed will be contacted for an interview.

Research Asst/Tech 4 – Molecular Biologist

We are seeking a highly-motivated and highly skilled individual with expertise or experience in cloning, sub-cloning, CRISPR-Cas9, next-generation sequencing and a strong background in molecular biology. The successful applicant will work full-time under the direction and supervision of both Dr. Samuel Aparicio, Principal Investigator, and the Laboratory Research and Operations manager. The position will provide the candidate with a high level of exposure to all current on-going project within Aparicio Lab, such as areas of single cell genomics and translational research, CRISPR-cas9 and patient derived xenograft drug screening, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally; position start date is flexible.

JOB SUMMARY

The Aparicio lab uses the latest technologies to rapidly identify genes that are involved in the development of breast cancer. Through the use of single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patient tissues, we hope to gain a better understanding of tumor microenvironment. In addition, we explore the effect drugs on tumor evolution through the use of patient derived xenograft and CRISPR-Cas9. This position involves providing high level, senior technical support in the main areas of molecular biology, biochemistry and cell biology for researchers on current on-going research projects. Individual should possess a strong molecular biology background, with experience in DNA/RNA extraction and handling, subcloning, cloning and tissue culture. Recent hands on experience with cloning, sub-cloning and CRISPR-Cas9 work will be considered an asset. Furthermore, experience, understanding and familiarity with handling of genomics DNA for next-generation sequencing and preparation of next-generation sequencing library will be an advantage.

ORGANIZATIONAL STATUS

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Institute in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, or Laboratory and Research Operation Manager, in addition, the applicant may assist in overseeing technical work of students and trainees.

WORK PERFORMED

  • Plans and performs advance procedures, complex experiments and/or techniques of molecular biology, biochemistry and cell biology for current on-going research projects
  • Oversee progression of projects assigned, in addition,  participate, and provide suggestion or expertise for other research activities on-going.
  • Generation, preparation and submission of next-generation sequencing libraries.
  • Track samples, record data and work a LMIS systems
  • Provide senior level technical expertise and support in molecular biology, protein biochemistry, tissue culture and virology
  • Developing and implementing standard operating protocols (SOPs).
  • Maintains laboratory records and experimental data; when require summarize results in research reports and lab presentations.
  • Assist in general lab maintenance, reagent preparation, receiving and inventory of lab supplies.
  • Assist, develop and/or update Standard Operating Procedures (SOPs) to ensure compliance with regulatory bodies.
  • Presents data at scientific meetings, writes reports and contributes to writing ethics and grant applications when required.
  • Assist in general maintenance of the lab and receiving and inventory of lab supplies.
  • Provide training and instruction for specialized techniques and equipment.
  • Provide expertise in the area of Molecular Biology, Biochemistry and Cell Biology to help troubleshoot complex experimental methods and procedure for staff, junior staff, trainees and students.
  • Assist lab manager with oversight of trainee students.
  • Carries out any other related duties as assigned or required in keeping with the qualifications and requirements of this level of technician.
  • Optimizing existing protocols, as well as, developing new protocol to improve throughput, quality control, efficiency, and/or robustness in collaboration with teammates and other research staff.

CONSEQUENCE OF ERROR

The work is of a complex nature and required high level of training, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Errors may result in the permanent loss of irreplaceable tissue samples, loss of thousands of dollars of material and/or damage to equipment.  Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly. Noncompliance with biosafety and chemical safety regulations may also result in closure of facility or loss of grant funding.

SUPERVISION RECEIVED

The successful applicant will work under minimum supervision. From time to time, Principal Investigator or Laboratory Research and Operations Manager may provide specific instructions on unusual problems, or new project outlines. This position will report to the Principal Investigator or Laboratory Research and Operations Manager.   

SUPERVISION GIVEN

Depending on experience and expertise, the successful applicant is expected to assist in training and supervision of graduate students/trainees or junior staff, including providing instruction on use of lab equipment and procedures, and will help troubleshoot experiments in their area of expertise.

QUALIFICATIONS

  • A MSc in Biological Sciences (Molecular Biology or other relevant field) or BSc with 3-5 years of related experience in academic research or biotech industry settings, preference will be given to applicants with work experience in single cell genomics biology or molecular biology.
  • A working knowledge and understanding of advance molecular biology and biochemistry techniques such as next-generation sequencing, PCR, DNA/RNA purification and cloning techniques is essential; prior working experience in next-generation sequencing and library construction is considered a great asset.
  • Experience with cell culture and aseptic technique.
  • Working hands-on experience in tissue handling and tissue dissociation methods would be an asset.
  • Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNA / DNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation, and western blotting.
  • Preference will be given to applicants with, molecular cloning and subcloning, single cell genomics, next-generation sequencing, and 10x Genomics experience.
  • Demonstrated understanding of experimental design and assay optimization.
  • Strong interpersonal skills, communication skills (orally and written) and the ability to interact positively and productively with other team members are essential.
  • Excellent documentation and organizational skills.
  • The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

Client Support Analyst

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Summary

Job Reference No: CSA_HEU# 107599_F00420_2021_04_27

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Provides computer technical support services at the Genome Sequence Centre (GSC).  Duties include investigating and resolving hardware and software problems, installing, configuring and testing hardware and software, providing training to users and participating in GSC bioinformatic projects.

Duties

  • Maintains the computer system and network for the GSC by performing duties such as responding to system, communications and user problems, investigating problems and taking corrective action as per established procedures. Resolves user issues on the technical infrastructure. Refers problems as required Installs, configures, modifies and tests all computer hardware within the GSC network.
  • Installs, configures and upgrades server software as directed.
  • Installs and provides technical support for GSC operating systems and including UNIX-based scientific applications such as Apache, AceDB, CONSED, MySQL, Perl Modules, and other bioinformatic software.
  • Provides training to users in the use of hardware and software and prepares instructional material.
  • Works with others in the implementation of the GSC network infrastructure (servers, network, workstations, website) by installing network components and testing.
  • Installs, configures, modifies and tests all computer hardware within the GSC network.
  • Maintains printers, barcode readers and associated hardware.
  • Modifies website content as required.  Maintains hardware and runs web server software.
  • Carries out and monitors GSC wide backup and recovery procedures.
  • Provides input into the development of the GSC’s information technology infrastructure strategy which includes data, voice and video technology.
  • Under direction, monitors and maintains security profiles for computer systems by adding and deleting user names and reviewing security logs.
  • Codes, modifies, tests and maintains programs from specifications to complement systems implementation and meet technical and client support requirements.
  • Maintains an inventory of software and their version for all computers within the GSC network.
  • Writes basic computer programs to automate frequently performed tasks.
  • Performing other related duties as required.

Qualifications

Education, Training and Experience

Completion of Grade 12 plus graduation from a recognized two (2) year systems technology diploma, plus two (2) years of recent related experience or an equivalent combination of education, training and experience.

Skills and Abilities

  • Ability to type.
  • Ability to communicate and deal effectively both verbally and in writing.
  • Ability to work with other effectively.
  • Physical ability to carry out the duties of the position.
  • Ability to organize work.
  • Ability to operate related equipment.

Apply

Please submit a cover letter, curriculum vitae and the names of three referees willing to provide letters of reference. The cover letter should include a brief description of your previous experience and long-term career goals. Please email your application to bcgscjobs@bcgsc.ca.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis. This restriction would be re-evaluated upon re-contracting.

Computational Biologist, Variant Databases

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: CBVD_HSA Req # 107052_P01069_2021_04_16

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority, patient safety is a priority and a responsibility shared by everyone at PHSA. As such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Computational Biologist will participate in the ongoing design, implementation and maintenance of the full stack (database backend as well as API, web visualization and frontend) of the database applications, housing genomic and clinical research data. The Computational Biologist will also participate in several high-profile national data sharing efforts in which the databases play a central role.

Duties

  • Participates in maintaining, designing and developing the GSC analysis and variant databases, including:
    • Checking data integrity and loading new data into existing tables;
    • Working with external data sources for genomic and sample metadata;
    • Design and implementation of new schemas and tables to house new data types;
  • API and front-end web application development.
  • Works with upstream bioinformatics and lab teams generating data to be housed in the database and responding to internal requests for query and API support.
  • Collaborates with other sequencing sites in Canada and internationally to share data and define best practices for data sharing.
  • Works closely with GSC Systems team and Quality Assurance team to establish and carry out best practices for data security, and ensure compliance with ISO 27001 certification, CAP/DAP clinical accreditation requirements and other data use agreements.
  • Works with clinical and research teams to develop web interfaces and patient reports for use in the clinic and within the research community.
  • Performs literature searches, testing and validation of new data analysis software, prepares presentations at scientific conferences.
  • Participates in code walk-throughs and reviews of solutions.
  • Participates in the design and build of database and software solutions taking performance into consideration.
  • Coordinates production problem resolution for assigned applications, including working with other technical teams.
  • Evaluates third-party software and incorporates new systems into legacy systems.
  • Produces thorough but concise written documentation of software, validations, SOPs, and other processes and procedures as required.

Qualifications

Education, Training and Experience

  • Graduation from a recognized Bachelor of Science Program in Computer Science or equivalent with significant computer science components. 
  • Two (2) years of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders. 

Skills and Abilities

  • Demonstrated expertise in database programming and database design.
  • Demonstrated ability in Python and/or Javascript (NodeJS).
  • Experience designing and/or maintaining a relational database including knowledge of SQL or PostgreSQL, and with ORMs.
  • Familiarity with non-relational databases such as Hadoop or graph databases.
  • Experience with REST API development.
  • Experience with front-end web development (React, AngularJS).
  • Functional knowledge of distributed version control systems, such as GIT.
  • Experience developing software as part of a team, familiarity with Agile development and ticketing systems.
  • Comfortable working in a UNIX environment, including experience with shell scripting and common command-line tools.
  • Excellent verbal and written communication skills.
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
  • Demonstrated ability to efficiently organize work assignments and establish priorities.

Apply

Please submit a cover letter, curriculum vitae and the names of three referees willing to provide letters of reference. The cover letter should include a brief description of your previous research experience and long-term career goals. Please email your application to bcgscjobs@bcgsc.ca.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis.

Research Assistant 2, Proteomics

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: RA 2_R00004_2021_04_14

Working as part of the proteomics core facility, the individual will assist in the day-to-day operation of the core. This individual will operate and maintain the hardware and software present in the core facility. In addition, this individual will work together with the Facility Manager and users to plan, coordinate, conduct and report on assigned research projects. Key responsibilities of the individual will include communication with colleagues and collaborators for project planning and results dissemination, preparation of samples for proteomic and/or metabolomic analysis, as well as basic mass spectrometry data analysis.

Key accountabilities include:

  • Performs a variety of established technical procedures according to written protocols.
  • Performs experiments by following established laboratory procedures according to written protocols.
  • Records results, including computer data entry.
  • Provides input regarding modification of procedures as requested by the Department Head, Principal Investigator, or designate.
  • Maintains and stores cell lines and primary cultures.
  • Maintains and stores test materials and products.
  • Maintains inventory of laboratory supplies and equipment.
  • May demonstrate work methods or procedures to less experienced assistants as designated.

Additional responsibilities include:

  • Liaising with collaborators to coordinate sample submission
  • Preparing samples for proteomic analysis
  • Analyzing the samples on facility instrumentation
  • Operating and maintaining facility instrumentation
  • Performing initial mass spectrometry data analysis
  • Maintaining logs of samples analyzed and instrument use
  • Communicating results to lab members as well as collaborators

Eligibility

The successful candidate is expected to have a level of education, training, and experience equivalent to graduation from a recognized technical program in an appropriate discipline or similar; plus two (2) years of recent related experience in a research laboratory.

Apply

Please submit a cover letter, curriculum vitae and the names of three referees willing to provide letters of reference. The cover letter should include a brief description of your previous research experience and long-term career goals. Please email your application to bcgscjobs@bcgsc.ca.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis.

Knowledge Translation Coordinator

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Are you an excellent communicator with passion for science and technology?

Do you have a knack for creative writing and design, with an eye for detail?

Can you translate technical language and jargon for non-scientific audiences?

The GSC is looking to add a Knowledge Translation Coordinator to its Knowledge Translation team. Reporting to the Head of Knowledge Translation, this position will support the development of materials, activities and events that help communicate the GSC’s research projects, collaborations and innovations to a variety of audiences, both scientifically literate and not.

Main Responsibilities

  • Coordinate the development of digital and print materials as well as activities and events in collaboration with the Knowledge Translation team, scientists, trainees, project managers and other staff members.
  • Write, edit, design and proofread scientific and technical publications, as well as copy for non-scientific audiences including research summaries, web and social media content, multimedia, etc. 
  • Recommend strategies and develop plans, tools and practices for reaching new audiences in collaboration with the Head of KT and other project and program leaders.
  • Monitor status and progress for KT activities to ensure quality and timeliness; provides relevant information and project progress reports.
  • Propose and create compelling content (including design materials using Adobe Suite) for the web and social media related to the GSC’s research projects and programs, and technology platforms and services.
  • Identify and evaluate objectives and project milestones; flag discrepancies for the attention for the Head of KT.
  • Work with client relationship management software (Salesforce) to ensure timely and professional communications with stakeholders about research projects and scientific collaborations.

Qualifications

A level of education, training and experience equivalent to completion of a Bachelor’s of Science (a Master’s or PhD is an asset) in biology, genetics or a related field from a recognized university plus a minimum of five (5) years of recent related experience in an academic or industry research setting (experience in the biotechnology sector is an asset).

Skills and Knowledge

  • Demonstrated experience and expertise in science communication, including the development of plans and strategies, print and digital materials, and event organization, for research, education, business, marketing, promotion and/or knowledge translation/transfer/mobilization/exchange purposes.
  • Excellent command of the English language, and exceptional communications skills including in speech and writing; fluency with other languages is an asset.
  • Experience and confidence in editing, proofreading and/or providing review and critique on the written work of both junior and senior staff members, including scientists and principal investigators.
  • Understanding of Canadian scientific and research processes, including ethics, funding and peer-reviewed publication best practices.
  • Fundamental computer literacy is mandatory, including familiarity with the Microsoft suite of products (Word, Excel, PowerPoint, Outlook); experience with the Adobe Suite of products (Photoshop, Illustrator, InDesign) and/or with Client Relationship Management software (Salesforce) for business development purposes are very strong assets.
  • Demonstrated organizational, analytical and critical thinking skills, including the ability to manage multiple projects and activities within a fast-paced environment under pressure and to do so independently or cooperatively, optimistically and respectfully in a diverse and inclusive team environment.

Apply

Please submit a cover letter and resume to bcgscjobs@bcgsc.ca

The position will remain open until filled.

We thank all applicants; however, only those selected for the next step will be contacted.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority. 

Due to COVID-19 restrictions, the position will require working remotely on a temporary basis.

Post-doctoral Fellow (PDF) Single Cell Genomics, Molecular Biology

We are seeking a highly-motivated post-doctoral fellow (PDF) with strong leadership ability and expertise in single cell genomics and transcriptomics, and a strong background in molecular biology. The successful applicant will work full-time under the supervision of Dr. Samuel Aparicio. The position start date is flexible.

JOB SUMMARY:

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patient tissues and patient-derived xenografts (PDX). A PDF position is available in the Aparicio lab based at the BC Cancer Research Center in Vancouver, Canada, collaborating on an exciting project mapping clonal dynamics in human cancers with new single cell methods. The post holder will have the opportunity to interact as part of the international CRUK Grand Challenge IMAXT project, bringing new measurement methods and computational techniques to the 3D reconstruction of tumours, and mapping drug sensitivity and drug combinations using sgRNA/CRISPR methods in vivo. The program works closely with the Shah computational biology program, based at Memorial Sloan Kettering Cancer Centre, on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage.

ORGANIZATIONAL STATUS:

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Center in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, and will play a senior leadership role in the laboratory.

WORK PERFORMED:

  • Provide leadership, strategic direction, and translational research pertaining to single cell genomics and transcriptomics, and CRISPR methods.
  • Design and implement research plan to investigate the clonal dynamics in human cancer through single cell methods.
  • Design and conduct animal experiments.
  • Conduct in vivo testing or characterization of drugs, small molecules, knockouts or antibodies in relevant PDX animal models.
  • Foster research collaborations and work jointly with academic, clinical, industry, and other partners.
  • Scientifically document lab experiments, data analysis, interpretations.
  • Write manuscripts, present results at internal and external meetings.
  • Identify funding opportunities and if required write or assist with grant proposals
  • Lead and mentor junior trainees/students in the laboratory

CONSEQUENCE OF ERROR:

This is a senior research position that plays a critical role in the development of this novel field. PDF is accountable for the quality and integrity of the research and data, including analyses and interpretation, as well as the effective and efficient management of research projects and deliverables. This position requires innovation, strategic planning, and adaptability. Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly.

SUPERVISION RECEIVED:

The PDF will work with a high degree of independence and set priorities under broad directives from Dr. Aparicio. The PDF will be expected to provide direction and mentoring in the laboratory under the supervision of Dr. Aparicio. This position will also provide the candidate with a high level of exposure to single cell genomics and translational research, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally.

SUPERVISION GIVEN:

The PDF will be expected to provide mentorship and guidance to undergraduate, graduate students and other research members as required.

QUALIFICATION:

  • Ph.D. in biology, cell biology, molecular biology, biochemistry, genetics, genomics, or similar discipline.
  • The candidate should have a solid scientific and technical background with excellent written/oral communication, interpersonal and organizational skills.
  • Preference will be given to candidates with a proven track record with a minimum of 2-3 first author publications in reputable journals.
  • Proficiency in cell biology, molecular biology, histology, genetics, genomics, next-generation sequencing and biochemistry techniques.
  • Demonstrate the ability to work in a highly interdisciplinary environment.
  • Experience with cancer research.
  • Expertise and hands-on experience in animal studies, including all aspects of design, handling, breeding, tissue collection, histology, and analyses are essential.
  • Familiarity with testing/characterization of small molecule or drug in vivo is preferred.
  • Previous biochemical/cell biology and molecular biology experience with single cell genomics / transcriptomics, next generation sequencing, drugs screen and PDX modeling is an asset.
  • Experience with statistical analyses and scientific writing. Previous experience with grant writing is an asset.
  • Experience with bioinformatics approaches to biological data and familiarity with handling of genomics data is an asset.
  • Applicants with experience and a strong track record with large drug target screening, single cell methods, and PDX mouse models are especially encouraged to apply.

To apply: Please send your Cover Letter, CV, Transcript and Work Sample to careersmolonc@bccrc.ca

Please put your full name and job title “Post-doctoral Fellow (PDF) Single Cell Genomics, Molecular Biology" in the subject line.

Research Administration Coordinator

Job Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Reporting to the Department Head or designate, the Research Administrative Coordinator, BC Cancer Research Centre is responsible for providing support in areas of human resources, payroll, grant and research administration. This role, on behalf of Principal Investigators (PI’s) and leaders, monitors payroll and financial cost centres through to resolution of payroll issues. The Research Administrative Coordinator also provides administrative support including managing the grant application process and providing work direction to junior administrative staff in the team.

Duties/Accountablilties

  • In collaboration with the Principal Investigator(s) (PIs) coordinates the preparation and submission of grant proposals by identifying submission guidelines, collating information required and ensuring submission deadlines are met. Follows up with the granting agency on the submission of proposals, monitors post award financial accounts to ensure accuracy. Provides progress reports, highlights discrepancies and provides recommendations to resolve discrepancies and budget concerns to the PI(s) as appropriate.
  • Interacts with a variety of individuals and agencies such as universities and granting agencies both national and international.  Ensures flow of information with internal and external stakeholders regarding grant related matters and makes arrangements for visiting speakers and guests.
  • Human resources responsibilities include recruitment of staff by posting/advertising internally and externally (UBC), coordinating interviews and screening applications for review by hiring supervisors. Manages new hires orientation process in the department and ensures all safety and personnel documentations are in place according to policies, guidelines and legislations.
  • Ensures all hiring, appointment and payroll processes such as new hire letters and timekeeping are complete for employees. Liaises with various PHSA units such as Payroll and Human Resources and in some cases, UBC to ensure a seamless process and minimize errors. Brings issues and recommendations of remedies to department head or designate for approval. 
  • Acts as the main contact for ordering supplies for the department and approves lab and office supplies by performing duties such as submitting purchase requisitions and obtaining authorizing signature as necessary. Manages and processes various requisitions such as travel, expense reimbursements, cheque requests, and honorariums for the Department Head and PIs. Acts as liaison with various departments of BCCA/PHSA including purchasing, stores, and finance to obtain information and follow-up on the status of outstanding issues and requests.
  • Coordinates registration and travel arrangements for staff attendance at seminars and meetings. This includes completing registration (on-line or phone), abstract submission, making travel and lodging reservations, culminating expense reimbursements to the attendee and/or cost recovery from the conference organizers as appropriate.
  • Provides work direction to junior and contract administrative staff including orientating new staff and assigning and reviewing work, coordinating work assignments to ensure completion, answering questions and providing support, ensuring policies and procedures are followed and providing input to performance evaluations as required.

Qualifications

A level of education, training, and experience equivalent to a Diploma in a relevant area such as business administration or finance from a recognized college plus three (3) years’ recent related experience a research environment and in project management.
Strong interpersonal and communication skills and the ability to demonstrate good judgment, tact and discretion. Detail oriented and able to complete accurate work in a timely matter. Demonstrated time management skills and ability to assist others in meeting deadlines.  Knowledge of and experience with grant applications.  Knowledge and experience in budget preparation, tracking expenditures and identifying sources of variance. Proficient in scientific and medical terminology.  Ability to work both independently and as team leader to organize work and manage multiple priorities in a fast paced environment. Demonstrated ability to make sound decisions and resolve administrative issues/problems. Fully proficient in the use of a variety of software packages including word processing, spreadsheets and databases and related equipment. Demonstrated ability to evaluate personal work and existing systems and identify areas for improvement. Physical ability to perform the duties of the position.

To apply: please send your Resume and cover letter to careersmolonc@bccrc.ca

Please put “Research Administrative Coordinator” and your full name in the subject line.

Research Assistant 2

Application Deadline

What you’ll do 

  • Performs a variety of established technical procedures according to written protocols, including revising and updating all Standard Operating Procedures (SOPs) in compliance with internal IDP change control procedures, all safety standards as mandated by WCB, UBC, BCCA/BCCRC and cGMP and GLP regulations.
  • Provides assistance in various quality management activities to ensure all IDP processes and systems  operate in compliance with GxP regulations which includes but not limited to: (1) maintaining equipment qualification, validation and preventive  maintenance program including all records, (2) maintaining vendor and contractor surveillance program including all documentation (3) maintaining IDP training records and documentation  system, and (4) overseeing maintenance of environmental monitoring systems: validation status, system preventative maintenance and records as required.
  • Provides backup support for quality assurance with inspection of IDP manufacturing activities and review of Batch Record documentation as required.
  • Provides support in hosting and handling of external client and regulatory audits of the IDP as required.
  • Maintains inventory of laboratory supplies and equipment including assigning and tracking usage of laboratory notebooks and archiving of completed notebooks.
  • Provides support in IDP shipping functions as required.
  • Provides support in quality control functions including searching for vendors, sampling of raw materials and supplies, performing monitoring data trend analysis as required.
  • Provides overall  backup quality control/archivist/quality assurance function to the IDP QMU as required.
  • Maintaining documentation and reviewing department lab equipment inventory, cytotoxic and radionucleotide inventory.
  • Facilitates quality assurance retain samples inventory system.
  • Performs other document control and management related duties as assigned.
  • May demonstrate work methods or procedures to less experienced assistants as designated.

What you bring  

  • A level of education, training, and experience equivalent to graduation from a recognized Bachelor’s program in an appropriate discipline (e.g. Bachelor of Science)
  • Two (2) years of recent related experience in a research laboratory.
  • Experience working in GMP or GLP environment is an asset.

How to Apply

Please submit your cover letter and resume to etadmin@bccrc.ca

Postdoctoral Fellow, Gastrointestinal Cancers

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely on a temporary basis.


Role Summary

A Post-doctoral position is available immediately for a highly motivated recent PhD or MD/PhD graduate to join a dynamic translational research group, headed by Dr. Isabella Tai, Associate Professor in the Division of Gastroenterology, University of British Columbia and Senior Scientist at Canada's Michael Smith Genome Sciences Centre at BC Cancer.

Current projects in the laboratory revolve around improving our understanding of the mechanisms involved in the development of chemotherapy resistance and metastasis in gastrointestinal cancers (colorectal, gastric, liver and biliary cancers). The goal is to develop either novel therapeutic targets for GI cancer treatment or novel screening tools for diagnosis. We continue to use the latest genomics (including single cell sequencing), proteomics and bioinformatic approaches to identify potential targets or markers for this purpose. Learn more about research projects in the Tai lab here.

Eligibility

Interested individuals with a recent PhD or MD/PhD and strong publication records and excellent academic credentials are encouraged to apply.  Experience in molecular biology, cell biology, tissue culture and animal tumor models, is preferable.  Experience in bioinformatics is an asset.

Duration

Three years (possibility of extension).

To Apply

Please submit a cover letter, curriculum vitae, and the names of three referees willing to provide letters of reference. The cover letter should include a brief description of your previous research experience, long-term career goals and an indication of the desired length of postdoctoral position.

Please email your application to bcgscjobs@bcgsc.ca

Research Programmer

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely on a temporary basis.


Role Summary

The Karsan lab team at Canada’s Michael Smith Genome Sciences Centre (GSC) is seeking a research programmer to join a Genome British Columbia software automation project. The team will be working with the Karsan lab, which is responsible for developing high-throughput, clinically accredited pipelines to analyse sequenced data from genomic assays for individualized patient management of cancer. We seek candidates with strong Python software and programming skills to automate and improve existing pipelines and potentially incorporate third-party software into the system.

The role is ideally suited for a creative individual with a strong interest in software development and testing, data analysis, and automation within a high throughput academic setting.

Key responsibilities

  • Design, plan, and implement automated bioinformatics pipelines to meet the objectives of the project
  • Work with other project team members to develop and test code, and implement software
  • Evaluate third-party software and incorporate new systems into legacy systems
  • Produce thorough but concise written documentation of algorithms, validations, SOPs, and other processes and procedures as required

Qualifications

Education, training and experience

  • Graduation from a recognized Bachelor of Science Program in Computer Science. A Master’s degree in a relevant field would be a strong asset. 
  • Two (2) years of recent related experience or an equivalent combination of education, training, and experience acceptable to the project lead.

Core Skills and Abilities 

  • Expertise with Python 3.X and able to provide links to code samples via GitHub or another open repository
  • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
  • Familiarity with molecular and cellular biology
  • Excellent verbal and written communication skills.
  • Demonstrated ability to efficiently organize work assignments and establish priorities.
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.

Additional Assets

  • Familiarity in statistical analysis using modern computational tools.  Experience with any relevant tools will be considered, but R and Python are preferred
  • Familiarity with the development, testing, and maintenance of relational databases
  • Familiarity in next-generation sequencing
  • Experience with software testing
  • Experience with Agile software practices
  • Functional knowledge of distributed version control systems, such as SVN or GIT

To Apply

Please email your cover letter and resume to bcgscjobs@bcgsc.ca

Please note that this position will remain posted until filled.

Postdoctoral fellow, Bioinformatics

Job Summary

The candidate would work within a dynamic and vibrant lab with a proven track record of outstanding achievements and contributions in breast oncology research. This position allows the candidate to contribute bold and innovative research that can be translated to new understanding in the evolutionary processes that drive cancers.

This position's primary focus in the lab will be to lead and to participate in projects involving the investigation of functional genomics using sequencing and expression data for breast oncology and cancer evolution. Using the wide network of connections and collaborations of the principal investigator, and extensive biomedical resources at the institution, candidates will be able to build on the existing research of the lab to quickly start up their own research projects.

The position will provide a unique opportunity for mentoring trainees, supervising analysts and interacting with industry. This is an excellent platform to receive outstanding training to gain the important skills for a successful medical research career in academia or industry.

This funded position with the University of British Columbia, at the BC Cancer Research Centre allows the candidate to flourish under the guidance of an experienced mentor

Organizational Status

The Postdoctoral Fellow will play a leadership role in the Aparicio lab, and will be reporting directly to Dr. Samuel Aparicio who is the primary investigator of the laboratory.

Work Performed

  • Management and supervision of trainees;
  • May be involved in recruitment and training of trainees;
  • Performing regular reviews of the relevant literature;
  • Planning and designing of experiments;
  • Analyzing, interpreting and compiling data in study reports, presenting results, and participating in the preparation of scientific manuscripts and grant application packages;
  • Updating Dr. Aparicio and the group on the status of projects during lab meetings, in email correspondence and phone conferences;
  • Managing projects with key academic and industry partners.

Minimum Qualifications

  • PhD degree in the computer science, bioinformatics or equivalent
  • At least 4 years experience in bioinformatics research
  • Experience in genomics and next-generation sequencing
  • Extensive knowledge of cellular and molecular biology, biochemistry and genetics
  • Experience with cancer research a plus
  • Proven ability to multi-task in a deadline oriented environment with minimal supervision
  • Effective oral and written communication, analytical, and interpersonal skills
  • Excellent organizational skill and ability to learn new skills quickly
  • Ability to work independently and within a team environment.
  • Accuracy and attention to detail required
  • Candidates should demonstrate the ability to work in a highly interdisciplinary environment.

Supervision Received 

  • Works independently under direction of PI, Dr. Samuel Aparicio
  • Opportunities to work collaboratively with Industry partners and other researchers at UBC and globally

Supervision Given

  • Assists and oversees research assistants and students as required
  • Assists and provides guidelines to other research members, as required

How to Apply

Exceptional candidates should submit a cover letter outlining your research interests and fit with the laboratory's research, curriculum vitae, and the names of three referees willing to provide letters of reference.

Due to the number of resumes we receive, we are unable to confirm receipt of submissions over the phone, or provide the status of the competition. Only shortlisted candidates will be contacted.

Equity and diversity are essential to academic excellence.  An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged.  We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

Email to apply: careersmolonc@bccrc.ca

Please put Bioinformatics PDF in the subject line.

Research Administration Coordinator

Application Deadline

What you’ll do 

  • In collaboration with the Principal Investigator(s) (PIs) coordinate the preparation and submission of grant proposals by identifying submission guidelines, collating information required and ensuring submission deadlines are met. Follow up with the granting agency on the submission of proposals, monitors post award financial accounts to ensure accuracy. Provide progress reports, highlight discrepancies and provide recommendations to resolve discrepancies and budget concerns to the PI(s) as appropriate. 
  • Interact with a variety of individuals and agencies such as universities and granting agencies both national and international. Ensure flow of information with internal and external stakeholders regarding grant related matters and make arrangements for visiting speakers and guests.
  • Human resources responsibilities include recruitment of staff by posting/advertising internally and externally (UBC), coordinating interviews and screening applications for review by hiring supervisors. Manage new hires orientation process in the department and ensures all safety and personnel documentations are in place according to policies, guidelines and legislations.
  • Ensure all hiring, appointment and payroll processes such as new hire letters and timekeeping are complete for employees. Liaise with various PHSA units such as Payroll and Human Resources and in some cases, UBC to ensure a seamless process and minimize errors. Bring issues and recommendations of remedies to department head or designate for approval. 
  • Act as the main contact for ordering supplies for the department and approves lab and office supplies by performing duties such as submitting purchase requisitions and obtaining authorizing signature as necessary. Manage and process various requisitions such as travel, expense reimbursements, cheque requests, and honorariums for the Department Head and PIs. Act as liaison with various departments of BCCA/PHSA including purchasing, stores, and finance to obtain information and follow-up on the status of outstanding issues and requests. 
  • Coordinate registration and travel arrangements for staff attendance at seminars and meetings. This includes completing registration (on-line or phone), abstract submission, making travel and lodging reservations, culminating expense reimbursements to the attendee and/or cost recovery from the conference organizers as appropriate.
  • Provide work direction to junior and contract administrative staff including orientating new staff and assigning and reviewing work, coordinating work assignments to ensure completion, answering questions and providing support, ensuring policies and procedures are followed and providing input to performance evaluations as required.

 

What you bring  

  • A level of education, training, and experience equivalent to a Diploma in a relevant area such as business administration or finance from a recognized college
  • Three (3) years’ recent related experience a research environment and in project management. 
  • Strong interpersonal and communication skills and the ability to demonstrate good judgment, tact and discretion.
  • Detail oriented and able to complete accurate work in a timely matter.
  • Demonstrated time management skills and ability to assist others in meeting deadlines.
  • Knowledge of and experience with grant applications.
  • Knowledge and experience in budget preparation, tracking expenditures and identifying sources of variance.
  • Proficient in scientific and medical terminology.
  • Ability to work both independently and as team leader to organize work and manage multiple priorities in a fast paced environment.
  • Demonstrated ability to make sound decisions and resolve administrative issues/problems.
  • Fully proficient in the use of a variety of software packages including word processing, spreadsheets and databases and related equipment.
  • Demonstrated ability to evaluate personal work and existing systems and identify areas for improvement.
  • Physical ability to perform the duties of the position.

MD or PhD Postdoctoral Fellow and MSc or PhD Graduate Students for translational research

We are looking for outstanding, motivated graduate students as well as postdoctoral fellows to join the Kuchenbauer Lab, who can share our passion for medicine/science and want to make a difference for patients´ lives.

Our research is mainly translational and focuses on immunotherapies such as allogenic stem cell transplantation for acute myeloid leukemia. We are driven to improve patients’ lives by addressing clinical “every day” challenges with state of the art research including preclinical animal models. Our goal is to translate our research into clinically applicable therapies. Scientific focuses are hematopoietic stem cell transplantation, hematopoietic stem cells physiology and pathophysiology as well as innovative treatment for Multiple Myeloma.

Multiple positions are available, starting as soon as possible. Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to Dr. Arefeh Rouhi (arouhi@bccrc.ca).

Seeking talented students, postdoctoral fellows and lab staff

We are looking for outstanding, motivated graduate students as well as postdoctoral fellows (full time or part time) who share our passion for medicine/science and want to make a difference for patients´ lives.

Our research is mainly translational and focuses on immunotherapies such as allogenic stem cell transplantation for acute myeloid leukemia. We are driven to improve patients' lives by addressing clinical “every day” challenges with state of the art research including preclinical animal models. Our goal is to translate our research into clinically applicable therapies. Scientific focuses are hematopoietic stem cell transplantation, hematopoietic stem cells physiology and pathophysiology as well as innovative treatment for Multiple Myeloma.

Multiple positions are available, including research students or technicians.  Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to Dr. Arefeh Rouhi (arouhi[@]bccrc.ca).

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