We have opportunities for professionals across the spectrum - from corporate to clinical. Take a look through our current opportunities - maybe you'll find the opportunity you've been waiting for.

http://www.phsa.ca/careers

Computational Biologist, Database Developer HSA Req# 095325

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.


Job Title

Computational Biologist, Database Developer
HSA Req# 095325

Role Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority, patient safety is a priority and a responsibility shared by everyone at PHSA. As such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Computational Biologist will participate in the analysis of sequencing data by developing, refining and adapting bioinformatics tools for a high-throughput processing pipeline. They will also participate in the development and maintenance of our production databases, which provide tracking of all of the laboratory and bioinformatics analysis pipelines at the GSC. Packaging and distribution of developed tools and analysis results to the scientific community and contribution to preparation of scientific publications are expected. 

Key Responsibilities

  • Develops and maintains the core sequence analysis pipelines at the GSC, including but not limited to:
    • QC of sequencing data
    • Alignment of sequenced reads
    • Formatting and manipulation of alignment files for use by downstream pipelines (e.g., merging, reheadering)
    • Dissemination of data to collaborators
    • New analyses pipelines as required
  • Develops and maintains GSC laboratory, quality and analysis databases, including:
    • Routine database integrity checks and database maintenance
    • Development of views and interfaces for data entry
    • Development of reports for internal users and collaborators
    • Investigation of new frameworks and designing new schemas and tables
  • Communicates with stakeholders in the lab, on analysis teams, and with external collaborators to understand and document requirements for development and to respond to questions about collaborator data and data quality
  • Works with upstream and lab teams generating data to be housed in the database, with downstream users of the databases to meet requirements and responds to internal requests for query and API support
  • Maintains and develops ETL pipelines between GSC production databases
  • Manages the storage and compression of over 5 Pb of internally generated sequencing data as well as the download and storage of external data
  • Works closely with the GSC Systems team and Quality Assurance team to establish and carry out best practices for data security and ensure compliance with IS27001 certification and other data use agreements
  • Tests and validates new data analysis software for analyses such as alignment, duplicate marking and merging
  • Participates in code walk-throughs and reviews of solutions
  • Designs and builds database solutions taking performance into consideration
  • Coordinates production problem resolution for assigned applications, including working with other technical teams
  • Evaluates third-party software and incorporate new systems into legacy systems
  • Produces thorough but concise written documentation of database tables, applications, validations, SOPs, and other processes and procedures as required
  • Performs other related duties as required

Qualifications

Education, training and experience:

  • Graduation from a recognized Bachelor of Science Program in Computer Science or equivalent with significant computer science components 
  • Two (2) years of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders

Skills and abilities:

  • Demonstrated expertise in database programming and database design
  • Demonstrated ability in Python
  • Experience designing and/or maintaining a relational database including knowledge of SQL or PostgreSQL, and with ORMs
  • Experience with REST API development
  • Experience with front-end web development (AngularJS, React)
  • Functional knowledge of distributed version control systems, such as GIT
  • Experience developing software as part of a team, familiarity with Agile development and ticketing systems
  • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
  • Excellent verbal and written communication skills
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment
  • Demonstrated ability to efficiently organize work assignments and establish priorities
  • Previous experience in a bioinformatic setting, though not required, would be considered an asset

To Apply

HSA union position
Internal applicants please visit internaljobs.phsa.ca to apply online for internal job postings.
External applicants please email a cover letter and resume to bcgscjobs@bcgsc.ca.

Biospecimen Technician Tumour Tissue Repository

Application Deadline

Job Summary:

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.Reporting to the Director, Tumour Tissue Repository (TTR), the Biospecimen Technician carries out or delegates the tasks necessary for the day-to-day operations of the TTR. These include collecting and receiving tissue biospecimens, processing tissue and blood biospecimens, performing biospecimen inventory management, preparing biospecimens for shipping and related duties.

Duties/Accountabilities:

  • Ensures all tissue and blood biospecimens are collected promptly and are processed according to existing standard operating procedures.
  • Responsible for the preparation and release of biospecimen cohorts from the TTR in conjunction with members of the TTR team. The Biospecimen Technician is responsible for processing the biospecimens as per the researcher’s requirements, updating the TTR inventory records, and shipping the biospecimens to the researcher.
  • Uses a database tool to extract data to assist in the identification of cohorts for researchers, in conjunction with members of the TTR team.
  • Works in an interdisciplinary setting and communicates with BC Cancer Agency and the Vancouver Island Health Authority care and research staff including physicians, nurses, clerical and support staff.
  • Demonstrates lab methods or procedures to less experienced lab staff working in the TTR and affiliated projects.
  • Responsible for daily or weekly maintenance of lab equipment, including -80 freezers, LN2 vapour freezers, centrifuge, transporters, and cryostat.
  • Is one member of a response team responsible for 24 hr monitoring and emergency response of lab freezers.
  • Provides back-up for the TTR Consent Nurse, including communication with TTR patient-donors for the purpose of obtaining TTR program consent and responding to the TTR pager and office calls/faxes.


Qualifications:

A level of education, training, and experience equivalent to Bachelor of Science degree in a related discipline such as Biology, Biochemistry, or Physiology and two years’ recent related experience in a research laboratory, including at least one year experience with histological preparations. Working knowledge of standard molecular biology techniques. Strong interpersonal skills and demonstrated ability to communicate effectively with all levels of staff, orally and in writing. Demonstrated ability to prioritize work with a constantly changing schedule. Ability to use histological equipment.

Gascoyne Lymphoma Research Fellowship

Application Deadline

Invitation for Applications

On June 30th, 2016, Dr. Randy D. Gascoyne retired from his distinguished career as hematopathologist and Medical Director of the Provincial Lymphoma Pathology Program at BC Cancer passing the baton to the next generation of clinicians and scientists that he helped train and mentor. Dr. Gascoyne was the inaugural Research Director of BC Cancer’s Centre for Lymphoid Cancer (CLC). He also was a Distinguished Scientist and the Department Head of Lymphoid Cancer Research at the BC Cancer Research Centre. The legacy of Dr. Gascoyne’s work will be felt at BC Cancer for a very long time.

Combining this legacy with Dr. Gascoyne’s generous philanthropic contributions over the years, he recently worked with the BC Cancer Foundation to create the Gascoyne Lymphoma Research Fellowship to bring the best talent in hematopathology research to British Columbia and the Centre for Lymphoid Cancer.

Request for Applications:

BC Cancer Research is proud to announce the first competition for the prestigious Gascoyne Lymphoma Research Fellowship. Dr. Christian Steidl, Research Director and Dr. David Scott, Clinical Director of the Centre for Lymphoid Cancer invite submissions of applications from pathologists, hematopathologists, cancer researchers, clinician scientists, clinical hematologists and clinical oncologists who have a strong interest in accelerating their career in experimental hematopathology. The fellowship position will reside in the Department of Lymphoid Cancer Research of the BC Cancer Research Institute, a part of with the Provincial Health Services Authorities (PHSA) and the University of British Columbia (UBC). Candidates must show potential to work with patient samples and/or disease model systems in a wet lab environment. Familiarity with clinical pathology procedures, lymphoid cancer classification, pathogenesis and an understanding of modern treatment modalities is desired.

The successful candidate will have synergies and a natural integration with the Centre for Lymphoid Cancer (CLC) and possess a unique skill set that will enrich the activities of the CLC. The successful candidate should be knowledgeable of novel technologies and treatments and be willing to contribute to the BC Cancer Research translational research agenda. This fellowship presents the opportunity for an individual to experience realistic hands-on training and all applicants should consider if this aligns with career goals. The ideal candidate will have long term plans for a career in clinical service, academia or industry and be prepared during this fellowship to work towards those next career steps.

Candidates should prepare their application package using the following guidelines:

1. CV or biosketch with focus on previous achievements in the fields of experimental cancer research, laboratory medicine, clinical pathology / hematopathology, clinical hematology, clinical oncology (as applicable).

2. Cover letter addressed to the BC Cancer Clinical and Research Directors of the Centre for Lymphoid Cancer stating your interest in joining the Centre (maximum of 1-page, singlespaced, minimum of 11 pt. font).

3. Summary of training expectation and career plans highlighting, 1) Continuity of training; 2) Synergy with CLC research priorities; 3) Career opportunities associated with the Gascoyne fellowship; and 4) Long term career plans (maximum 1-page, single-spaced, minimum of 11 pt. font).

Submission of application package:

Please send your application as pdf files or any questions to mshemko@bccrc.ca with a deadline of June 30, 2020.

Research Associate - Bioinformatics

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.


Role Summary

The GSC is currently looking for a senior bioinformatician to develop approaches to analyzing and sharing “big data”. This role is instrumental in the development of the CFI-funded cyberinfrastructure project, CanDIG—a state-of-the-art data sharing platform contributing to the development of an international effort to facilitate information exchange as part of the Global Alliance for Genomics & Health (GA4GH). CanDIG also supports large-scale provincial and national data sharing projects, including BC Cancer’s Personalized OncoGenomics program, the Terry Fox Research Institute (TFRI) PROFYLE project and the TFRI-led Marathon of Hope Cancer Centres Network—a major federal initiative to accelerate the adoption of precision medicine for cancer in Canada.

Based at the BC Cancer Research Institute in Vancouver, the successful incumbent will help to devise, develop and implement data sharing methods between our partner sites for cancer genome and transcriptome data. They will also research how these data can be used within Canada to improve precision medicine as it applies to the delivery of healthcare for cancer, ultimately generating a "big data" analytics platform from which further insights into the biology of cancer will be realized.  

Key Responsibilities

  • Conduct research and supervise projects 
  • Develop and use new and novel methods for the analysis of cancer genome sequence
  • Interact closely with principal investigators and clinicians about the biology and clinical history of research subjects
  • Evaluate sequence variants using software prediction tools, and apply guidelines for the interpretation of sequence variants in the context of precision medicine
  • Manage and track of next generation DNA and RNA sequence data
  • Develop innovative ways to annotate and discover relationships between cancer genes and clinical outcomes
  • Present findings at local, national and international scientific meetings
  • Write scientific manuscripts related to research findings
  • Develop research grant applications
  • Contribute to required quarterly and annual reports for research projects
  • Work with principal investigators to ensure that all scientific milestones are achieved
  • Develop computer code according to professional and industry standards
  • Perform other related duties as required

Qualifications

Education and Experience:

  • PhD in a life sciences or quantitative discipline
  • A minimum of 2 years demonstrated experience in bioinformatics, focused on genome sequence data processing and analysis

Skills and Abilities:

  • Expertise in bioinformatics, emphasizing genome sequence analysis and gene annotation
  • Knowledge of scientific tools, technologies and online resources as pertaining to cancer genomics
  • Python, Javascript and SQL programming experience
  • Previous API development projects using Open API or Rest API is a plus
  • Experience with high-performance computing
  • Experience in a supervisory role is an asset

To Apply

email cover letter and resume to: bcgscjobs@bcgsc.ca

Projects Manager

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.


Role Summary

The Genome Sciences Centre is seeking a Projects Manager. This role is for a Manager of research projects, grants and platforms in a research environment.

Reporting to the Head Project Management or Projects Team Leader and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and monitor and facilitate progress against these objectives and milestones. Projects will involve personalized oncogenomics, immunotherapy, collaborative services management, or other cancer genomics research.

Key Responsibilities

  • establishing budgets for research projects, grants, collaborations and core activities
  • assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
  • monitoring budgets and expenditures
  • establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives, which may include, meeting coordination and follow-up, coordination of case reviews
  • maintain accurate information on sample status, including sample and associated metadata acquisition, processing, stakeholder reporting
  • recommending strategies for improving projects management methods
  • liaising with grant/core funding agencies
  • interacting directly with research collaborators or clinical study teamsas required

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged.

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research or the biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

 Successful candidate(s) will be offered positions through Provincial Health Services Authority at level Research Project Coordinator, which is equivalent to that described above.

To Apply

email: bcgscjobs@bcgsc.ca

Research Assistant/Tech 3

JOB SUMMARY

Researchers in the Department of Molecular Oncology at the BC Cancer Research Centre use the latest technologies to rapidly identify genes that are involved in the development of cancer. This position will be involved in performing research in drug pharmacology directed at human tumours, with assays in immunodeficient mice (xenotransplants).

ORGANIZATIONAL STATUS

The successful applicant will report to the Principal Investigator or his/her delegate and may assist in overseeing technical work of students and trainees.

WORK PERFORMED

- Plans and performs experiments utilizing complex procedures and/or techniques.

- Processes tissue samples and carries out primary cell isolation as instructed.

- Carries out laboratory techniques following standard operating protocols.

- Maintains laboratory records of both animal data and experimental data; when require summarize results in research reports and lab presentations.

- Assists senior level staff with writing and updating Standard Operating Procedures (SOPs) and Animal Ethics Certificates.

– Assists in the daily care of transgenic animals and maintains colonies of human tumour bearing immunodeficient animals.

- Carries out and oversees procedures involving immunization, oral gavage, injections, tumour inoculation, tumour volume measurements, blood and tissue collection, surgical procedures, necropsy, and post-operative care.

- Daily health monitoring and care of laboratory animals.

- Be able to recognize and resolve behavioral and/or housing issues; may provide technical instruction and training for other staff and/or trainees for those activities.

- Performs other related duties as assigned.

– On a rotation basis, must be available for emergency calls 24/7 and respond appropriately.

CONSEQUENCE OF ERROR

The work is of a complex nature, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Non compliance with ARC regulations may result in closure of facility. Non compliance with animal protocols may result in loss of grant funding.

SUPERVISION RECEIVED

The successful applicant will report to the Principal Investigator or designate.

SUPERVISION GIVEN

The successful applicant will assist in training graduate students/trainees including instruction in use of lab equipment and procedures and will troubleshoot experiments in their area of expertise.

QUALIFICATIONS

Undergraduate degree in a relevant discipline or Graduation from a technical college or institute. A postgraduate degree in Science is preferred. CALAS certification (e.g. RLAT) is an asset. Minimum of 3 years related experience or the equivalent combination of education and experience. Experience in the monitoring and management of human tumour bearing animals is essential and central to the role. A working knowledge of the CCAC guidelines and compassion and sensitivity for animals required. Experience with cell culture and aseptic technique preferred, involving both isolation and maintenance of rodent primary cultures and cell lines. Experience in the use and handling of hazardous materials such as biological agents, radioactive substances and/or cytotoxic drugs is essential. Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNNDNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation and western blotting. Demonstrated understanding of experimental design and assay optimization. Strong interpersonal skills and the ability to interact positively and productively with other team members are essential. Ability to communicate effectively both orally and in writing. The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively

APPLICATION INSTRUCTIONS

To apply please send your CV and cover letter to careersmolonc@bccrc.ca with subject line: RA/Tech 3.

Postdoctoral Fellow – Integrative Genomic Analysis of Lymphoid Cancers

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.


Postdoctoral Fellow
Job code: LYMPHOMA-PDF
Lab/group: Ryan Morin Lab  

Role Summary
The Morin and Scott laboratories are seeking a Postdoctoral Fellow to take a leadership role in an ongoing effort to resolve the molecular aetiology of aggressive lymphoid cancers using genomic techniques. This individual will work closely with a team of bioinformaticians, biostatisticians and clinician-scientists in a highly productive and stimulating research environment at a world-class research facility in Vancouver, Canada.

The successful applicant will apply cutting-edge bioinformatic techniques to analyze hundreds of terabytes of high-throughput sequencing data produced from clinical cancer samples, namely RNA-seq (bulk/single cell), whole exome, whole genome, and circulating tumour DNA sequencing data. This position demands a strong background in bioinformatics, computational biology or data science. Detailed knowledge of cancer biology (particularly non-Hodgkin lymphomas) would be an asset.

Familiarity with algorithms for inferring clonal structure of tumours and network/pathway deregulation from sequence data is also desirable. Experience with machine learning, statistical modelling, survival analysis, and data visualization are all desirable. Characteristics of the ideal candidate include strong verbal and written communication skills, attention to detail, creativity, and the ability to remain organized in a fast-paced and dynamic environment. The successful candidate will thrive in our highly collaborative setting while also being able to drive projects independently.

Diversity is an integral part of Canadian history, culture, and identity. In the Morin laboratory, we strive to maintain an equitable and inclusive culture where all forms of diversity are seen as added value in the unifying goal of reducing the impact of cancer.

The successful candidate will report to Drs. ​Ryan Morin​ and David Scott and will be affiliated with Canada’s Michael Smith Genome Sciences Centre at BC Cancer.

Key Responsibilities :
Duties will include some combination of the following:

  • Deploy pipelines to detect somatic alterations such as CNAs, SNVs, indels and structural alterations/fusion transcripts
  • Perform clustering analyses on mutational and/or gene expression features to identify novel subgroupings
  • Develop machine learning models for the accurate identification of somatic mutations in heterogeneous and/or noisy tumour samples (e.g. FFPE, unpaired, ctDNA)
  • Identify cis-regulatory mutations using copy number, SV, and non-coding mutations
  • Quantify mutational signatures de novo or using reference signatures for simple somatic mutations and SVs
  • Model the effect of coding and non-coding mutations, respectively, on protein and RNA structure and function
  • Resolve clonal substructure and track tumour evolution using tissue biopsies and ctDNA
  • Identify gene expression or splicing features associated with clinical or genetic variables
  • Create bespoke visualizations of high-dimensional genomic datasets
  • Design and execute experiments and disseminate results through conference presentations and publications
  • Contribute to the writing of grant applications and training of junior lab members

Qualifications
Suitable candidates should possess a PhD degree in bioinformatics, computer science, or molecular biology and must be competent in at least one programming language such as Python or R.

To apply
Applicants are requested to send a cover letter and CV to rdmorin@sfu.ca with LYMPHOMA-PDF in the subject line

Administrative Coordinator

Application Deadline

Reporting to the Department Head or designate, the Administrative Coordinator, BC Cancer Research Centre is responsible for providing support in areas of human resources, payroll, grant and research administration. This role, on behalf of Principal Investigators (PI’s) and leaders, monitors payroll and financial cost centres through to resolution of payroll issues. The Administrative Coordinator also provides administrative support including managing the grant application process and providing work direction to junior administrative staff in the team.

Key Accountabilities

  • In collaboration with the Principal Investigator(s) (PIs) coordinates the preparation and submission of grant proposals by identifying submission guidelines, collating information required and ensuring submission deadlines are met. Follows up with the granting agency on the submission of proposals, monitors post award financial accounts to ensure accuracy. Provides progress reports, highlights discrepancies and provides recommendations to resolve discrepancies and budget concerns to the PI(s) as appropriate.
  • Interacts with a variety of individuals and agencies such as universities and granting agencies both national and international. Ensures flow of information with internal and external stakeholders regarding grant related matters and makes arrangements for visiting speakers and guests.
  • Human resources responsibilities include recruitment of staff by posting/advertising internally and externally (UBC), coordinating interviews and screening applications for review by hiring supervisors. Manages new hires orientation process in the department and ensures all safety and personnel documentations are in place according to policies, guidelines and legislations.
  • Ensures all hiring, appointment and payroll processes such as new hire letters and timekeeping are complete for employees. Liaises with various PHSA units such as Payroll and Human Resources and in some cases, UBC to ensure a seamless process and minimize errors. Brings issues and recommendations of remedies to department head or designate for approval.
  • Acts as the main contact for ordering supplies for the department and approves lab and office supplies by performing duties such as submitting purchase requisitions and obtaining authorizing signature as necessary. Manages and processes various requisitions such as travel, expense reimbursements, cheque requests, and honorariums for the Department Head and PIs. Acts as liaison with various departments of BCCA/PHSA including purchasing, stores, and finance to obtain information and follow-up on the status of outstanding issues and requests.
  • Coordinates registration and travel arrangements for staff attendance at seminars and meetings. This includes completing registration (on-line or phone), abstract submission, making travel and lodging reservations, culminating expense reimbursements to the attendee and/or cost recovery from the conference organizers as appropriate.
  • Provides work direction to junior and contract administrative staff including orientating new staff and assigning and reviewing work, coordinating work assignments to ensure completion, answering questions and providing support, ensuring policies and procedures are followed and providing input to performance evaluations as required.


Qualifications

A level of education, training, and experience equivalent to a Diploma in a relevant area such as business administration or finance from a recognized college plus three (3) years’ recent related experience a research environment and in project management.

Strong interpersonal and communication skills and the ability to demonstrate good judgment, tact and discretion. Detail oriented and able to complete accurate work in a timely matter. Demonstrated time management skills and ability to assist others in meeting deadlines.  Knowledge of and experience with grant applications.  Knowledge and experience in budget preparation, tracking expenditures and identifying sources of variance. Proficient in scientific and medical terminology.  Ability to work both independently and as team leader to organize work and manage multiple priorities in a fast paced environment. Demonstrated ability to make sound decisions and resolve administrative issues/problems. Fully proficient in the use of a variety of software packages including word processing, spreadsheets and databases and related equipment. Demonstrated ability to evaluate personal work and existing systems and identify areas for improvement. Physical ability to perform the duties of the position.

To apply: Please send cover letter and resume to careersmolonc@bccrc.ca  – Please put “Admin Coordinator” and your full name and Job title in the subject line.

Research Assistant 2

Application Deadline

Role Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

These are fully qualified working level positions.  Incumbents have directly related laboratory experience and familiarity with specific research programs and methodologies of the hiring laboratory.  They work under supervision and perform experiments by following established laboratory procedures.  They report to the Department Head, Principal Investigator, or designate.

Key Accountabilities

  • Performs a variety of established technical procedures according to written protocols.
  • Performs experiments by following established laboratory procedures according to written protocols.
  • Records results, including computer data entry.
  • Provides input regarding modification of procedures as requested by the Department Head, Principal Investigator, or designate.
  • Maintains and stores cell lines and primary cultures.
  • Maintains and stores test materials and products.
  • Maintains inventory of laboratory supplies and equipment.
  • May demonstrate work methods or procedures to less experienced assistants as designated.

Qualifications

A level of education, training, and experience equivalent to graduation from a recognized Bachelor’s program in an appropriate discipline (e.g. Bachelor of Science); plus two (2) years of recent related experience in a research laboratory.

MD or PhD Postdoctoral Fellow and MSc or PhD Graduate Students for translational research

We are looking for outstanding, motivated graduate students as well as postdoctoral fellows to join the Kuchenbauer Lab, who can share our passion for medicine/science and want to make a difference for patients´ lives.

Our research is mainly translational and focuses on immunotherapies such as allogenic stem cell transplantation for acute myeloid leukemia. We are driven to improve patients’ lives by addressing clinical “every day” challenges with state of the art research including preclinical animal models. Our goal is to translate our research into clinically applicable therapies. Scientific focuses are hematopoietic stem cell transplantation, hematopoietic stem cells physiology and pathophysiology as well as innovative treatment for Multiple Myeloma.

Multiple positions are available, starting as earlier as September 2018. Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to Dr. Arefeh Rouhi (arouhi@bccrc.ca).

Seeking talented students, postdoctoral fellows and lab staff

We are looking for outstanding, motivated graduate students as well as postdoctoral fellows (full time or part time) who share our passion for medicine/science and want to make a difference for patients´ lives.

Our research is mainly translational and focuses on immunotherapies such as allogenic stem cell transplantation for acute myeloid leukemia. We are driven to improve patients' lives by addressing clinical “every day” challenges with state of the art research including preclinical animal models. Our goal is to translate our research into clinically applicable therapies. Scientific focuses are hematopoietic stem cell transplantation, hematopoietic stem cells physiology and pathophysiology as well as innovative treatment for Multiple Myeloma.

Multiple positions are available, including research students or technicians.  Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to Dr. Arefeh Rouhi (arouhi[@]bccrc.ca).

Research Assistant 2, Proteomics

The position is in a mass spectrometry-based proteomics group in the Genome Sciences Centre at BC Cancer. The candidate will work as part of a team performing cutting-edge translational research using a broad range of proteomics techniques. The Research Assistant 2 – Proteomics works under supervision and performs experiments by following established laboratory procedures.

Job Code: RA2 07-04-2019

Key Accountabilities 

  • Prepare samples for proteomic analysis
  • Operating facility instrumentation including off-line HPLC fractionation systems, mass spectrometers, and speed vacs
  • Perform initial data analysis
  • Assist in the development of cutting edge protocols for clinical proteomics
  • Maintain logs of samples analyzed and instrument use
  • Liaise with collaborators to coordinate sample submission and communicating results
  • Collaborate with client lab personnel
  • Maintain a details lab notebook

Qualifications 

  • A laboratory technician degree in chemical and biotechnical science with direct work experience in proteomics. 
  • Theoretical knowledge and practical experience with tandem mass spectrometry
  • Experience with state-of-the-art mass spectrometry instrumentation including Orbitraps
  • Experience with clinical sample preparation for proteomics and nucleic acid analysis
  • Experience with processing cells and tissues for global and targeted proteomics
  • Practical experience with analytical reversed phase chromatography (HPLC and nanoLC), specifically for peptide separation
  • Two (2) years recent related experience in a research laboratory

In accordance with Canadian Immigration requirements, this advertisement is first directed to Canadian citizens and permanent residents but international candidates are invited to apply. We encourage applications from all qualified individuals, including Aboriginal peoples, persons with disabilities and members of visible minorities. English is the official language used at PHSA.

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RA2 07-04-2019") in the subject line of your emailed application.

Post-doctoral Fellow Single Cell Genomics, Molecular Biology

A postdoctoral fellowship position is available in the Aparicio lab based at the BC Cancer Research Centre in Vancouver, Canada, collaborating on an exciting project mapping clonal dynamics in human cancers with new single cell methods. 

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patients and patient-derived xenografts. The post holder will have the opportunity to interact as part of the international CRUK Grand Challenge IMAXT project, bringing new measurement methods and computational techniques to the 3D reconstruction of tumour and mapping drug sensitivity and drug combinations using sgRNA/CRISPR methods in vivo. The program works closely with the Shah lab computational biology program on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage.

How to Apply: Please send the following documents to careersmolonc@bccrc.ca and put “Single Cell Genomics, Aparicio Lab – PDF Position” and your family name in the subject line.

  • Cover Letter
  • Resume
  • Transcript
  • Work Sample

Big Data Genome Studies

Application Deadline

A graduate student position is available for students interested in pursuing MSc or Phd studies in Bioinformatics at the University of British Columbia. The project is aimed at characterizing the function of every mammalian gene through thorough analysis of every known and predicted gene in the mouse genome via “Big Data” analysis. To address this critical gap in biomedical research, the International Mouse Phenotyping Consortium was created to generate a null mutation for every gene in the mouse genome, to collect phenotypic data for each mutation, and to disseminate the data to the broader scientific community. Immunophenotyping by flow cytometry (FCM), is one of the 30 core phenotyping assays of this global effort. However, the full quantitative potential of the IMPC FCM effort can only be realized with mechanisms to effectively share, analyze and interpret the data.


The selected candidate will develop and use state-of-the-art computational methodologies for supervised and unsupervised clustering and classification to systematically analyze tens of thousands of high-dimensional samples to help understand the function of each gene. The candidate will also be supported to attend bioinformatics workshops and conferences to advance and disseminate their research.


Qualifications: The ideal candidate will have a strong background in Computational Biology, Bioinformatics, or equivalent with strong experience in handling high-throughput data sets as well as statistics and programming skills (we love R here). The individual will have strong verbal and written skills and the ability to work efficiently in a team environment.
In addition to the outstanding research opportunities available in this setting, students also enjoy the many cultural and sporting amenities provided in Vancouver.


Please contact Dr. Brinkman directly at rbrinkman@bccrc.ca and provide the following information:


– Short cover letter explaining your interest in the lab
– Resume
– Scanned copy of transcript or listing of course grades
– Names and contact information for two individuals who will be willing to provide letters of reference
 

Co-op Positions

Application Deadline

2 positions available May 2020 – Dec 2020 (8 months)

Co-op position 1 - Our lab has developed in house a synthetic model of T cell acute lymphoblastic leukemia by lentiviral transduction of hematopoietic stem progenitor cells from human umbilical cord blood. One co-op student will be working on investigating how various conditions contribute to this leukemic transformation. In this position, you will learn aseptic technique for culturing human primary cells, how to produce lentivirus and transduce cells, flow cytometry techniques and analysis, mouse necropsies and cell cryopreservation. We would prefer someone with wet lab experience and is organized and detail-oriented.

Co-op position 2 - Investigating the tumour ecosystem in human non-Hodgkin’s lymphoma. Using state-of-the-art single cell analysis (mass cytometry (CyTOF), single cell RNA sequencing and high-parameter flow cytometry), this project will investigate the heterogeneity of tumour cells and their surrounding non-malignant immune and stromal cells. This work is of direct clinical relevance in providing detailed phenotypic characterizations that are required in order to define biomarkers for lymphoma classification and prognosis. In this position, you will have opportunities to learn: 1) handling and processing clinical samples, including tissue digestion and culture of human primary cells; 2) maintaining and operating the CyTOF and multi-parameter flow cytometry; 3) Multi-dimensional data analysis. We prefer applicants who are detail-oriented and have a strong interest in bioinformatics/programming as such skills will allow for more involvement in data analysis. 

Applicants may apply via their school's co-op program.
 

Back to top