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Post-doctoral Fellow in the proteomic discovery of immunotherapy

Job Code: PdFP 09-26-2019

The Genome Sciences Centre within the BC Cancer Research Centre, in Vancouver, British Columbia, Canada has an opening for a post-doctoral fellow in the laboratory of Dr. Gregg Morin to work on a project involving the discovery and development of pediatric cancer surfaceome immunotherapeutic targets.

The scientist will join an ongoing collaboration with Drs. John Maris (CHOP) and Poul Sorensen (Molecular Oncology, BC Cancer) to study surface protein expression in high-risk pediatric cancers by analyzing patient derived xenograft (PDX) samples. The fellow will perform laboratory research to design and interpret experiments using proteomic, molecular, biochemical, and genomic tools to thoroughly and robustly quantify changes in surface protein expression. Specifically, the candidate will develop and perform global proteomic techniques in conjunction with a variety of surface enrichment techniques to identify and evaluate specific molecular vulnerabilities in childhood cancers that would be useful for immunotherapeutic targeting. The desirable candidate should have experience in protein biochemistry, proteomic sample preparation, liquid chromatography, and/or mass spectrometry. Experience with mammalian tissue culture, enzymatic assays, recombinant protein purification, molecular biology, and mass-spectrometry based proteomics will be beneficial to the candidate.

The successful scientist will join the laboratory of Dr. Gregg Morin in Canada’s Michael Smith Genome Sciences Centre at BC Cancer. In collaboration with the laboratories of Dr. John Maris and Dr. Poul Sorensen, and the Genome Sciences Centre, the team has access to exceptional tools for next generation sequencing, bioinformatics, and advanced proteomics.

The Genome Sciences Centre provides a stimulating working environment and is located at the British Columbia Cancer Research Centre in Vancouver, one of the world’s most livable and attractive cities. 

Additional information can be obtained at Careers, www.bcgsc.ca

To Apply

Applicants should send a cover letter, curriculum vitae, and names of three referees by email to bcgscjobs@bcgsc.ca, and reference “Post-doctoral Fellow, Immunotherapy – G Morin Lab” and your family name in the subject line.

Graduate Student Position

One graduate student position is available at the Department of Molecular Oncology, BC Cancer Research Centre for the development of novel radiopharmaceuticals for detection and radiotherapy of cancer. The graduate student candidate will register through the Interdisciplinary Oncology Program (www.iop.ca), University of British Columbia, and pursue either a MS or PhD degree.

The student candidate will conduct research on the design and synthesis of imaging probes and radiotherapeutic agents targeting biomarkers overexpressed in cancers. Research activities will involve the production and isolation of radioisotopes, peptide and multi-step organic synthesis, and radiolabeling small molecules, peptides and antibodies with imaging or radiotherapeutic isotopes.

Qualified candidates should have a bachelor degree preferably in chemistry with interests in organic or medicinal chemistry. The ability to conduct research in a collaborative environment is required including good oral and written communication skills in English. For more information regarding application for the Interdisciplinary Oncology Program at the University of British Columbia, please check the following website: www.iop.ca

Before applying, interested student candidates should first contact:

Kuo-Shyan Lin, PhD

Senior Scientist, BC Cancer Research Centre

Associate Professor, University of British Columbia

E-mail: klin@bccrc.ca

Post-Doc Fellowship in PET Imaging

Position: The University of British Columbia (UBC) and the BC Cancer, part of the Provincial Health Services Authority in the Province of British Columbia, Canada, are seeking a post-doctoral fellow. The research will take place in the laboratories of Dr. Rahmim (Quantitative Tomography; rahmimlab.com)  and Dr. Benard (http://molonc.bccrc.ca/benard-lab), in close collaboration with other clinical research and imaging experts at UBC and BC Cancer Research Center. The efforts will include development and assessment of innovative image enhancement and quantification methods that seek to improve the clinical value of PET images. More specifically, the post-doctoral fellow will apply advanced image processing methods to oncological PET images, and derive and validate effective therapeutic biomarkers in cancer patients.

Requirements: Qualified candidates will have a Ph.D. in medical physics, biomedical engineering, electrical engineering, applied mathematics, or a related field. Prior experience in image processing, machine learning or radiomics methods is a requirement. The candidate should have a strong interest and commitment to research. Creativity with an aim towards independent research as well as good communication skills are also emphasized. The initial appointment is for one year, which may be renewed based on performance.

Application: Interested candidates should send a CV, complete list of past research topics and publications, and the names of three references to Jayne Hunter (JHunter@bccancer.bc.ca). Review of applications will begin immediately and continue until the position is filled.

Research Programmer

Job Information

Classification Title: Information Systems & Technology (A)

Business Title: Research Programmer

Department: Pathology

Job Summary

A position with the Department of Pathology and Laboratory Medicine of the University of British Columbia is open immediately for a research programmer to work with our interdisciplinary team of researchers and software developers within the Department of Molecular Oncology at BC Cancer, part of the Provincial Health Services Authority. We are seeking a creative, experienced, and dedicated individual to play a key role in the bioinformatics analysis of computational genomic research data.

The research programmer will work with other team members and researchers in the department to conduct computational analysis, ranging from routine runs to novel discovery tasks.  With detailed instructions, you will be finding and applying bioinformatics algorithms to computational genomics problems.  When appropriate, your solutions will be deployed in full production processes, and you will work closely with other programmers to ensure the successful implementation and  deployment of automated workflows and analyses.

You will be on-site in the Department of Molecular Oncology at BC Cancer, working closely with software developers, students and researchers operating at the leading edge of the field of cancer genomics.  Our department has recently made meaningful advances in the understanding of tumour evolution and the software platforms developed in the lab will be used by world-leading scientists at BC Cancer and international collaborators to gain insight into how cancers initiate, develop and acquire resistance to treatment. More information on the department and research we conduct can be found here http://molonc.bccrc.ca/

Organizational Status

We are a small team of software developers and scientists embedded within a larger cancer research department.  You will be working with students and researchers to tackle genomics problems, and collaborating with developers and bioinformaticians on the team to develop high-throughput and automated analysis solutions.  You will be reporting to the bioinformatics team lead or designate.

Work Performed

Research and implement bioinformatics solution as requested

Perform simple to complex bioinformatics analysis and requests with supervision

As a team member, develop, test and automate bioinformatics solutions

Handle bioinformatics data retrieval, processing and dissemination requests

Assist researchers in computational, statistical and visualization tasks for publication

Consequences of Error

You will be receiving instructions from researchers, students and collaborators and will be responsible for the correctness of your work.  Failure to perform may result in setbacks to research and operational activity.

Supervision Received

You will be supervised by the bioinformatics team lead or designate.

Supervision Given

You will help advise and recommend best course of actions to other members of the lab on subjects pertaining to bioinformatics analysis and your field of expertise.

Education / Work Experience

Essential

BSc in bioinformatics, computer science, or equivalent

Minimum 2 year of additional relevant work/educational experience in genomics

Proven bioinformatics research experience

Experience with data analysis in R and Python

Experience with command-line interfaces and scripting in UNIX operating systems

Experience designing and creating analysis workflows and pipelines

Experience with next-generation sequencing (NGS) data

Preferred

MSc in bioinformatics, computer science or equivalent

Experience with scientific high performance computing environments

Experience with bioinformatics data management solutions

Post-Doctoral Fellow (Bioinformatics)

Exciting postdoctoral training opportunity with the OVCARE Program at the University of British Columbia and the Department of Molecular Oncology at BC Cancer, studying the cellular origins of ovarian and other gynecological cancers through single cell sequencing technologies. The Department of Pathology at the University of British Columbia invites applications for a Postdoctoral Fellow. The successful applicant will work with Dr. Andrew Roth and Dr. David Huntsman as a part of the multidisciplinary OVCARE team (BC's Gynecological Cancer Research Program, ovcare.ca) and bioinformatics team of the BC Cancer’s Department of Molecular Oncology (http://molonc.bccrc.ca). 

We are studying the early events in ovarian cancer initiation by genetically manipulating organoids derived from normal tissues and transgenic mice. Our interest lies in dissecting the relative contributions of and interactions between cell of origin, mutation and microenvironment on the development of the common cancers of the uterus , ovary and fallopian tube. For this particular project, ARID1A (a member of the SWI/SNF chromatin remodeling complex) is knocked out and mutant PIK3CA (a kinase involved in intracellular signaling) is introduced into the cells. Organoids are grown out from cells containing these genetic manipulations and single cell RNAseq, DNAseq and ATACseq will be performed. The successful candidate will integrate these datasets, as well as co-supervise students assigned to analyze other single cell sequencing datasets. We are looking for someone who has strong communication and leadership skills and who will work well in a group setting.

Qualifications

- PhD in Bioinformatics, Computer Science, Statistics or related fields.

- Experience working with large genomic datasets.

- Experience managing data from multiple sources and running bioinformatics pipelines.

- Experience working with single cell RNA-Seq and/or single cell DNA-Seq.

- Strong background in data science, machine learning preferred.

- Programming skills in R and/or Python required.

The position will commence as soon as possible. The initial appointment will be for a one-year term, with potential for annual renewal. Salary will be commensurate with qualifications and experience.

Research Animal Technician 2

Role Summary 

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

These positions supervise designated staff by scheduling and assigning work, and assist in daily animal care operations by leading various health monitoring and colony management programs, trouble-shooting minor issues and performing other administrative tasks. These positions also maintain the daily care of laboratory mice and perform various surgical procedures and laboratory techniques.

Key Accountabilities

• Develops, implements, reviews and updates animal care standard operating procedures for assigned area.
• Leads various animal care programs such as health monitoring and colony management.
• Maintains current knowledge of, and ensures compliance with, animal care regulations.
• Supervises designated staff by scheduling and assigning work, providing orientation and training and monitoring performance.
• Maintains daily care of laboratory mice including maintaining adequate food and water levels and observing mice for general health conditions.
• Performs surgeries and techniques including blood collection, surgical implantations, tumour implantation, injection of solutions, collection of tissues and organs and embryo manipulations, and cryopreservation.
• Performs laboratory techniques such as media preparation, cell culture and hormone preparation, and polymerase chain reaction analysis as required.
• Leads training programs, prepares and gives presentations and orients and trains staff and animal users on proper animal care theory, protocols, techniques and procedures.
• Changes and cleans animal cages, bottles and racks.
• Performs general cleaning of animal facilities including disinfecting equipment, walls, floors, rooms, etc.
• Performs census duties such as counting cages and reporting cage numbers.
• Receives and processes laboratory animal care supplies.

Qualifications

A level of education, training, and experience equivalent to graduation from a recognized program in Animal Health or Veterinary Technology, or a Bachelor’s program in an appropriate discipline (e.g. Animal Science); plus five (5) years of recent related experience in a research laboratory, including two (2) years in a supervisory capacity.

To apply: Please send cover letter and resume to careersmolonc@bccrc.ca – Please put “Research Assistant Tech 2_full name” in the subject line.

Assistant Bioinformatics Coordinator, Software Development

The Assistant Bioinformatics Coordinator provides supervisory and technical support to the Bioinformatics group of the Genome Sequence Centre (GSC). Ensures that the day-to-day activities of a large scale, high throughput facility meet research, data analysis throughput and software development objectives.

Job Code: ABCSD HSA Req 86652

Key Accountabilities

  • Assists the Bioinformatics Coordinator in the day to day activities of the Bioinformatics group by performing duties such as providing input on quantity and quality of work, making recommendations for improvements, workflow and procedures. 
  • Coordinates projects of the Bioinformatics group by performing duties such as chairing project-specific meetings and provides project status reports to the Bioinformatics Coordinator, with suggestions towards any required improvement of project management, task allocation and overall process.
  • Develops and implements assays to monitor project progress and measure project accomplishments to ensure that appropriate project focus is maintained and to provide feedback to staff. 
  • Provides supervisory support to the Bioinformatics group by performing duties such as:
    • Orientating new staff.
    • Providing input to the Bioinformatics Coordinator on training requirements and performing group specific training.
    • Providing input to the Bioinformatics Coordinator on the establishment of clear definitions of responsibility for employees. 
    • Assigning workload assignments and establishing work schedules.
    • Reviewing and establishing work priorities and adjusting work schedules to ensure priorities are met.
    • Completing performance reviews and addressing performance issues in conjunction with the Bioinformatics Coordinator.
  • Participates in the recruitment of staff through methods such as interviewing internal and external applicants and forwards hiring recommendations.
  • Participates in the development and implementation of quality improvement programs to ensure services are provided in the most efficient and effective way by performing duties such as:
    • Monitoring quality and quantity of service and information provided by the bioinformatics group and identifying areas for change and/or improvement.
    • Generating test metrics to evaluate progress of research programs.
    • Writing and updating Standard operating procedures pertaining to tasks and pipelines run by the group.
    • Coordinating and writing technical validation documents for new and improved pipelines and processes.
  • Assesses practical needs for identified research direction of the GSC in conjunction with the Bioinformatics Coordinator and Bioinformatics Group Leader.
  • Participates in a variety of meetings by performing duties such as providing and/or receiving information and contributing to decision making.
  • Participates, in conjunction with the Bioinformatics Coordinator, in determining the computer infrastructure necessary for successful completion of projects and ensured viability of research programs by performing duties such as providing input and recommendations regarding purchasing decisions related to hardware, software and related items for the Bioinformatics platform.
  • Interprets statistical analyses and makes recommendations for review including preparing reports on statistical findings for publication and presentation in HTML format or as advised.
  • Conducts feasibility studies for computerization by performing duties such as determining user requirements, examining and identifying problems with existing systems and recommending modifications to and/or new systems; provides details of estimated implementation costs including associated staffing requirements.
  • Performs technical functions related to the bioinformatic  department of the GSC.
  • Performs other related duties as required.

Qualifications 

Education, Training and Experience 

Graduation from a recognized Bachelor’s program in a related discipline such as Biochemistry, Genetics, Computer Science, Electrical Engineering or Physics.  A minimum of four (4) years of recent related experience including experience in computer programming and quantitative data analysis, handling biological sequence and/or mapping data, database development and data storage schemas or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders. 

Skills and Abilities 

  • Experience with computer operating systems such as Linux, MacOS.

  • Demonstrated ability to work with software languages, frameworks and databases such as Python, C, C++, Javascript, React.js, Perl , R, Postgres, MySQL, Hadoop.

  • Demonstrated ability to accept responsibility and work independently.

  • Demonstrated ability to work effectively with others in a team environment.

  • Demonstrated ability to supervise staff and schedule work.

  • Excellent organizational, leadership interpersonal and communication skills.

  • Physical ability to perform the duties of the job.

To Apply

External Applicants 

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

Internal Applicants 

Internal (HEU and HSA union members) applicants please visit internaljobs.phsa.ca to apply online for internal job postings.

Research Engineer

The BC Cancer Michael Smith Genome Sciences Centre is looking for a talented engineer with interdisciplinary skills and interests for a variety of automation and clinical device projects. This includes designing and building novel instrumentation for high throughput biological analysis as well as programming commercial liquid handlers.

Skills therefore include electromechanical design and machine shop work as well as robot-level software development. Projects require building strong partnerships with interdisciplinary groups of life scientists, and clinicians so strong communication skills are key. Knowledge of biology is valuable but not critical. Reporting to a Professional Engineer, this position enables considerable scope to learn and develop further engineering skills.

Job Code: RE 08-01-2019

Key Accountabilities 

  • Design, prototype manufacture and program electro-mechanical assemblies for novel life science instrumentation.

  • Maintain, program, and operate commercial liquid handling instrumentation

  • Communicate and work closely with a variety of groups and disciplines to troubleshoot and improve efficiency and performance of various automated pipelines

  • Develop software for novel instrumentation and data analysis 

Qualifications 

  • A bachelor’s degree in an engineering discipline, with 1-3 years of experience working in a multi-disciplinary environment

  • Exceptional communication, documentation and analysis skills

  • Experienced with C,C++/CLI, C#, MATLAB, Visual Studio

  • Hands-on experience designing, troubleshooting, and making software, mechanical and electrical systems

  • Familiarity with machining and prototyping

  • Able to work well independently with little supervision but also adept at working in groups/teams

  • Able to efficiently manage a multitude of different tasks

  • Experience with fluidics and molecular biology would be an asset

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RE 08-01-2019") in the subject line of your emailed application.

Research Programmer

The Genome Sciences Centre is seeking a temporary full time Research Programmer to work on cancer genomics projects to develop clinical assays for (1) Lymphoid cancers and (2) cancer monitoring and detection using blood samples (aka liquid biopsy). The successful applicant will work in a team to develop high-throughput, clinically accredited pipelines to aid in identifying pathogenic alterations in cancer. This project involves the development of new assays for cancer patients with the goal of individualized patient management.

Job Code: RP 07-31-2019

Key Accountabilities 

  • Design, documentation, and analysis of experiments to test new assays and new methods
  • Summary and presentation of experimental findings to stakeholders
  • Modification and development of bioinformatic pipelines to analyze genomic data yielding clinical grade variant and expression data
  • Assist in choosing and modifying targets for assay development
  • Analysis of NGS data to investigate clonality, somatic hypermutation, microsattelite instability and intergenic translocations
  • Development and assessment of bioinformatic tools for RNA-Seq expression analysis and variant calling
  • Development and assessment of bioinformatic tools for determining the clinical significance of detected variants
  • Statistical analysis to determine analytical sensitivity and specificity of obtained results
  • Development of software pipelines for analyzing next-generation sequencing data
  • Support of research staff by providing analysis and software tools
  • Contributions to the writing of research publications

Qualifications

  • Graduation from a recognized Bachelor of Science Program in Bioinformatics, Biological Sciences, Statistics, Engineering, or Computer Science.   A Master’s or Doctoral degree in a relevant field would be a strong asset. 
  • Two (2) years of recent related experience or an equivalent combination of education, training and relevant experience.

Skills and Abilities 

  • Knowledge of RNA-Seq and other genomic data analysis, including expression analysis, structural variant detection, and variant-calling.
  • Experience working in a Unix environment, including experience with shell scripting and common command-line tools
  • Expertise in one or more scripting language(s) (e.g. Python)
  • Experience working with next-generation sequencing data and tools (i.e. tools for alignment and variant-calling)
  • Expertise in statistical analysis using modern computational tools.  Experience with any relevant tools will be considered, but R and Python are preferred
  • Experience writing reports of results in accurate and concise language; expertise in scientific/technical writing is required
  • Experience with methods in high-dimensional data analysis for bioinformatics such as clustering, machine learning and data mining would be assets
  • Experience with software testing and cluster computing would be assets
  • Familiarity with cancer genetics would be an asset, as would a history of publications in relevant fields.

The successful candidate will also have:

  • Excellent verbal and written communication skills
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
  • Demonstrated ability to efficiently organize work assignments and establish priorities.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RP 07-31-2019") in the subject line of your emailed application.

Projects Coordinator

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position. Reporting to the Leader, Projects Management Team and working within the context of a research culture and in accordance with established policies and procedures, vision and values of the Genome Sciences Centre (GSC), the Projects Coordinator works with the Projects Managers in the management of various projects and grants at the GSC. A major focus of this position involves monitoring the budgets for various projects and grants as well as progress/milestones, and compilation and analysis of project management data to support project proposals and reports. The Projects Coordinator also coordinates communication from the project team to stakeholders, providing an important liaison role in the project team.

Job Code: PC 07-10-2019

Key Accountabilities 

Scope and Complexity 

The Projects Coordinator works closely with the Projects Managers, as well as with specific project scientists and Principal Investigators (PIs) to monitor project progress and compile data for reporting both internal and external to the organization.  This position requires analytical thinking and superior organization skills to accurately acquire, compile and communicate project information. 

The Projects Coordinator works with, and can impact, several levels of the Centre, across projects and teams, providing a link for staff on project management activities and progress, and the use of templates and tools to assist in project activities.  The Projects Coordinator requires the ability to exercise independent judgment in facilitating communication and compilation of appropriate project data.  Flexibility is required in order to respond to stakeholder’s needs, contractual requirements and strategic priorities. 

The Projects Coordinator works with the Projects Managers and Leader, Projects Management Team to monitor budgets and milestones for various projects and grants at the GSC.  The Projects Coordinator liaises with others in the Centre and in other organizations as required to gather project data related to budgets, costs, spending, milestones, activity status, communications, and other areas as determined by the Leader, Projects Management Team and Projects Manager.  The Projects Coordinator also develops tools and techniques to gather and monitor routine data on progress and status to help ensure that the project objectives/milestones, as well as reporting requirements, are met.  These strategies may include developing reporting templates, forms and other tools with Microsoft Word, Excel, and PowerPoint. 

Communications

Internally, the Projects Coordinator communicates with the Projects Managers and Projects Team Leader to provide specific data and information on project progress and status.  This position is a key member of the Projects team and works through the Projects Manager with the department heads and senior scientists to ensure that accurate data on projects is collected, compiled and reported.  The Projects Coordinator consults the Centre’s staff as required, demonstrating political sensitivity and discretion when working across all levels of the organization, among all groups and departments. 

Externally, the Projects Coordinator liaises with agencies on communication and reporting matters.  The position interacts with project staff at other institutions to facilitate and maintain collaborative relationships. 

Duties 

  • Participates on multiple projects and programs throughout the project lifespan; participates in initiatives in project management research, methodology, design, planning, implementation, integration, evaluation and ongoing monitoring. 
  • Contributes to the monitoring of budgets and progress for research projects, grants and core activities in collaboration with the Leader, Projects Management Team and Projects Managers, to ensure that funds are spent as planned and within budget and that project objectives are achieved. 
  • Compiles, analyzes, summarizes and communicates data to describe project progress and status.  Evaluates whether project objectives/milestones are met in consultation with the Leader, Projects Management Team and Projects Managers.  Identifies discrepancies between project progress and anticipated status for the attention of the Projects Team Leader. 
  • Recommends strategies and develops plans in collaboration with Projects Manager to resolve project efficiency issues where required. 
  • Liaises with agencies and collaborators on communication and reporting discrepancies and refers strategic issues to the Leader, Projects Management Team. 
  • Assists the Leader, Projects Management Team and Projects Managers in preparation of written progress reports for projects, grants and collaborations by providing updated budget summary/milestone information. 
  • Contributes to the preparation, assembly, presentation and distribution of project proposals and reports by compiling information, preparing reporting information including charts, tables and figures. 
  • Performs other related duties as assigned.

Qualifications 

A level of education, training, and experience equivalent to completion of a diploma/certificate from a recognized college (preferably in Science or Business), plus a minimum of 3 (three) years of recent related experience in project management and/or a research development management role. 

Knowledge of project management methodologies and principles, project evaluation and monitoring, and multiple project interaction and integration. Demonstrated ability to manage multiple tasks and assignments within a fast paced environment.  Demonstrated organizational, analytical and decision-making skills.  Excellent ability to organize work and communicate effectively.  Excellent communication skills both verbal and written.  Demonstrated computer literacy (Microsoft Word, Excel, PowerPoint, Project).  Ability to work under pressure of deadlines.  Ability to accept responsibility and work independently.  Must be physically able to perform the job duties.

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "PC 07-10-2019") in the subject line of your emailed application.

Research Assistant 2, Proteomics

The position is in a mass spectrometry-based proteomics group in the Genome Sciences Centre at BC Cancer. The candidate will work as part of a team performing cutting-edge translational research using a broad range of proteomics techniques. The Research Assistant 2 – Proteomics works under supervision and performs experiments by following established laboratory procedures.

Job Code: RA2 07-04-2019

Key Accountabilities 

  • Prepare samples for proteomic analysis
  • Operating facility instrumentation including off-line HPLC fractionation systems, mass spectrometers, and speed vacs
  • Perform initial data analysis
  • Assist in the development of cutting edge protocols for clinical proteomics
  • Maintain logs of samples analyzed and instrument use
  • Liaise with collaborators to coordinate sample submission and communicating results
  • Collaborate with client lab personnel
  • Maintain a details lab notebook

Qualifications 

  • A laboratory technician degree in chemical and biotechnical science with direct work experience in proteomics. 
  • Theoretical knowledge and practical experience with tandem mass spectrometry
  • Experience with state-of-the-art mass spectrometry instrumentation including Orbitraps
  • Experience with clinical sample preparation for proteomics and nucleic acid analysis
  • Experience with processing cells and tissues for global and targeted proteomics
  • Practical experience with analytical reversed phase chromatography (HPLC and nanoLC), specifically for peptide separation
  • Two (2) years recent related experience in a research laboratory

In accordance with Canadian Immigration requirements, this advertisement is first directed to Canadian citizens and permanent residents but international candidates are invited to apply. We encourage applications from all qualified individuals, including Aboriginal peoples, persons with disabilities and members of visible minorities. English is the official language used at PHSA.

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RA2 07-04-2019") in the subject line of your emailed application.

Computational Biologist, Software Developer

The Genome Sciences Centre is seeking a full-time Computational Biologist to join our software development team in a state of the art, high throughput genomics facility. The successful applicant will participate in developing, improving and maintaining bioinformatics tools for a high-throughput processing pipeline. We seek candidates with strong programming experience in python, or other high-level objects-oriented languages (e.g. C#, Ruby, etc.). Experience with Agile and DevOps best practices are also desirable. The role is ideally suited for a creative individual with a strong interest in software development and data analysis within an academic setting. Packaging and distribution of developed tools and analysis results to the scientific community and contribution to preparation of scientific publications are expected.

Job Code: CBSD HSA Req# 85480

Key Accountabilities

  • Expertise with Python and ability to specify, implement, test, and, maintain back end applications and systems as assigned.
  • Devises or modifies systems to solve complex problems associated with high throughput pipelines, considering computer equipment capacity and limitations, operating time and form of desired results.
  • Participates in code walk-throughs and reviews of solutions.
  • Designs & builds solution taking performance into consideration.
  • Coordinates production problem resolution for assigned applications, including working with other technical teams.
  • Evaluate third-party software and incorporate new systems into legacy systems
  • Produce thorough but concise written documentation of algorithms, validations, SOPs, and other processes and procedures as required.
  • Presenting results of software testing internally and externally
  • Literature searches, testing and validation of new data analysis software.
  • Performing other related duties as required.

Qualifications

Education, Training and Experience 

  • Graduation from a recognized Bachelor of Science Program in either Biological Sciences or Computer Science.
  • Two (2) year’s of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities 

  • Proven expertise with Python and or other similar high level languages
  • Functional Knowledge of distributed version control systems, such as GIT
  • Excellent verbal and written communication skills.
  • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
  • Demonstrated ability to efficiently organize work assignments and establish priorities.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

To Apply

External Applicants 

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

Internal Applicants

Internal (HEU and HSA union members) applicants please visit internaljobs.phsa.ca to apply online for internal job postings.

Quality Control Specialist

BC Cancer has an opening for a temporary full time Quality Control Specialist. The Quality Control Specialist will support the manufacturing, quality control and quality assurance activities for BC Cancer's Cancer Immunotherapy Program, at BC Cancer's Deeley Research Centre (DRC) in Victoria. These systems include, but are not limited to, performing and validating quality control assays, instrument calibration/preventive maintenance, monitoring and trending quality control data, and other activities as appropriate to maintain GMP compliance for the DRC’s T-cell manufacturing facility. The Quality Control Specialist receives guidance from and reports to, BC Cancer's Cancer Immunotherapy Program's QA Manager.

Job Code: QCS 03-08-2019

 

Key Accountabilities 

  • Assisting laboratory production staff in identifying quality control (QC) issues in manufacturing processes

  • Assisting in SOP and specification development by identifying and contributing QC-related material to production SOPs

  • Working with the QA Manager and the DRC T-cell manufacturing team to draft QC-related SOPs

  • Performing daily QC tasks and duties including the following:

    • Carrying out established QC assays according to Standard Operating Procedures (SOPs)
    • Maintaining formal documentation of laboratory processes
    • Maintaining validation and QC programs for instrumentation and procedures
    • Scheduling and prioritizing repair and preventative maintenance of laboratory equipment
    • Monitoring, trending and analyzing QC data and generating analysis reports
    • Communicating QC policies, metrics and trends to program staff
    • Assisting the QA Manager in conducting QA/QC training of program staff and maintaining training records
    • Assisting the QA Manager, QA team, and T-Cell manufacturing team with external audits and associated written reports
    • Assisting the QA Manager during investigations associated with QC assay failures, identifying root causes, summarizing findings and following up with corrective/preventative actions.
    • Performing other related duties as assigned

 

Qualifications 

Education, Training and Experience

  • A Bachelor's degree from a recognized university in Biology, Chemistry, Molecular Biology or a related discipline
  • Four (4) years of recent experience applying QA/QC in an academic, biotechnology or pharmaceutical GMP manufacturing/laboratory environment
  • Prior hands-on experience with equipment qualification, QC test methods and other processes related to GMP/GLP practices
  • Hands-on experience with cell culturing techniques would be an asset
  • Knowledge of the clinical trials regulatory environment in Canada, cell therapy, immunology and/or immunotherapy would be an asset

Skills and Abilities 

  • Demonstrated ability to accept responsibility and work independently
  • Demonstrated ability to work effectively with others in a team environment
  • Demonstrated ability to organize work and establish priorities
  • Demonstrated ability to communicate effectively both orally and in writing

To Apply 

Please send your resume with cover letter to bcgscjobs@bcgsc.ca

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "QCS 03-08-2019") in the subject line of your emailed application.

Breast Pathology Fellowship

Application Deadline

Breast Pathology Fellowship
Providence Health Care, Department of Pathology and Laboratory Medicine

One Year Term (with potential extension)

This unique fellowship is comprised of both clinical and research components in equal parts and provides an opportunity to gain research experience as a fellow. Fellows will divide their time between BC Cancer Agency, Mount Saint Joseph and St. Paul’s Hospitals and rotate through the clinical pathology laboratory and the research laboratory at BC Cancer. Fellows work closely with the breast multidisciplinary team, actively participating in rounds and providing service and consultation to clinicians in matter relating to breast diseases. It is expected that the fellow participates in collaborative research, with an option to conduct individual research, all under the guidance of a faculty member and/or pathologist]. This includes research proposals, submitting abstracts to scientific meetings and preparing manuscripts for publication in peer-reviewed journals.

Candidates with the following qualifications/experience are preferred:

  • Canadian citizenship or permanent residency.
  • MSc or PhD.
  • Research experience, especially molecular biology.

Salary will be commensurate with qualifications and experience.

To apply for this rewarding career development opportunity, please forward (1) a letter of application outlining your areas of interest, (2) a copy of your current CV, and (3) names and contact information of three references, to:

PHSA Talent Acquisition
careers@phsa.ca

Post-doctoral Fellow Single Cell Genomics, Molecular Biology

A postdoctoral fellowship position is available in the Aparicio lab based at the BC Cancer Research Centre in Vancouver, Canada, collaborating on an exciting project mapping clonal dynamics in human cancers with new single cell methods. 

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patients and patient-derived xenografts. The post holder will have the opportunity to interact as part of the international CRUK Grand Challenge IMAXT project, bringing new measurement methods and computational techniques to the 3D reconstruction of tumour and mapping drug sensitivity and drug combinations using sgRNA/CRISPR methods in vivo. The program works closely with the Shah lab computational biology program on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage.

How to Apply: Please send the following documents to careersmolonc@bccrc.ca and put “Single Cell Genomics, Aparicio Lab – PDF Position” and your family name in the subject line.

  • Cover Letter
  • Resume
  • Transcript
  • Work Sample

Post-doctoral Fellow – SWI/SNF Chromatic Remodeling Complexes and Cancer Progression

Postdoctoral Research Fellow – SWI/SNF Chromatic Remodeling Complexes and Cancer Progression

BC’s Gynecological Cancer Research Program (OVCARE)
Department of Pathology, Faculty of Medicine
University of British Columbia, Vancouver, Canada

Exciting postdoctoral training opportunity studying targeted therapies for ovarian and other gynecological cancers with the OVCARE Program at the University of British Columbia and BC Cancer.

The Department of Pathology at the University of British Columbia invites applications for a Postdoctoral Fellow. The successful applicant will work with the multidisciplinary OVCARE team (BC’s Gynecological Cancer Research Program) directed by Dr. David Huntsman. This position will be translational and interdisciplinary in nature aimed at deciphering the role of cancer-associated mutations, especially those related to the SWI/SNF chromatin remodeling complexes, in tumourigenesis and their potential as druggable targets.

Applicants should have a PhD or MD/PhD with a strong background and publication record in a relevant field (e.g. genetics, cellular and molecular biology). The position will rely heavily on in vitro and in vivo models of cancer so demonstrated expertise in this area is required. In addition, either experience in bioinformatics would be an asset. The position will commence as soon as possible. Excellent verbal and written communication skills are required. The initial appointment will be for a one-year term, with potential for annual renewal. Salary will be commensurate with qualifications and experience.

Qualified candidates should send (by email) a statement of research interest, curriculum vitae and contact details for 3 referees to:

Yemin Wang, PhD
BC’s Gynecological Cancer Research Program
University of British Columbia and BC Cancer

675 West 10th Avenue
Vancouver, BC V5Z 1L3
Email: yewang@bccrc.ca

Big Data Genome Studies

Application Deadline

A graduate student position is available for students interested in pursuing MSc or Phd studies in Bioinformatics at the University of British Columbia. The project is aimed at characterizing the function of every mammalian gene through thorough analysis of every known and predicted gene in the mouse genome via “Big Data” analysis. To address this critical gap in biomedical research, the International Mouse Phenotyping Consortium was created to generate a null mutation for every gene in the mouse genome, to collect phenotypic data for each mutation, and to disseminate the data to the broader scientific community. Immunophenotyping by flow cytometry (FCM), is one of the 30 core phenotyping assays of this global effort. However, the full quantitative potential of the IMPC FCM effort can only be realized with mechanisms to effectively share, analyze and interpret the data.


The selected candidate will develop and use state-of-the-art computational methodologies for supervised and unsupervised clustering and classification to systematically analyze tens of thousands of high-dimensional samples to help understand the function of each gene. The candidate will also be supported to attend bioinformatics workshops and conferences to advance and disseminate their research.


Qualifications: The ideal candidate will have a strong background in Computational Biology, Bioinformatics, or equivalent with strong experience in handling high-throughput data sets as well as statistics and programming skills (we love R here). The individual will have strong verbal and written skills and the ability to work efficiently in a team environment.
In addition to the outstanding research opportunities available in this setting, students also enjoy the many cultural and sporting amenities provided in Vancouver.


Please contact Dr. Brinkman directly at rbrinkman@bccrc.ca and provide the following information:


– Short cover letter explaining your interest in the lab
– Resume
– Scanned copy of transcript or listing of course grades
– Names and contact information for two individuals who will be willing to provide letters of reference
 

Seeking talented students, postdoctoral fellows and lab staff

Application Deadline

We are looking for outstanding, motivated graduate students as well as postdoctoral fellows (full time or part time) who share our passion for medicine/science and want to make a difference for patients´ lives.

Our research is mainly translational and focuses on immunotherapies such as allogenic stem cell transplantation for acute myeloid leukemia. We are driven to improve patients' lives by addressing clinical “every day” challenges with state of the art research including preclinical animal models. Our goal is to translate our research into clinically applicable therapies. Scientific focuses are hematopoietic stem cell transplantation, hematopoietic stem cells physiology and pathophysiology as well as innovative treatment for Multiple Myeloma.

Multiple positions are available, including research students or technicians.  Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to Dr. Arefeh Rouhi (arouhi[@]bccrc.ca).
 

Co-op Postion - Postdoctoral or Graduate Student

Application Deadline

1 positions available Jan 2020 – Aug 2020 (8 months)


Investigating the inter/intra-tumor heterogeneity in follicular lymphoma and diffuse large B-cell lymphoma and their accompanying reactive immune components. This project utilizes state-of-the-art single cell analysis (mass cytometry (CyTOF), single cell RNA sequencing), and variety of bioinformatics tools (high dimensional data analysis, machine learning, Bayesian statistics and some deep learning method such as variational auto encoder) . This work is of direct clinical relevance in providing detailed phenotypic characterizations that are required in order to define biomarkers for lymphoma classification and prognosis, and monitoring of patient-specific responses to therapy. In this position you will have opportunities to learn and practice on: 1) handling and processing clinical samples; 2) maintaining and operating the CyTOF and multi-parameter flow cytometry; 3) Multi-dimensional data analysis. We prefer applicants who are detail-oriented and have a strong interest in bioinformatics/programming as such skills will allow for more involvement in data analysis.  Applicants may apply via their school's co-op program.


The candidate will work on pathogenetic mechanisms in T-ALL and/or analysis of tumor ecosystem in human lymphoma by mass cytometry (CyTOF).

Please contact your university Co-op program to apply.  
 

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