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Research Associate

Application Deadline

The candidate will provide operational and administrative leadership and technical guidance to all staff and student/trainees in the laboratory. The candidate will be directly accountable to the Principal Investigator for all operational and scientific issues in the lab.  Responsibilities include developing and ensuring compliance with lab policies and standardized protocols where applicable, monitoring levels of reagent and equipment usage, and assisting lab members with logistical aspects of experimental design and execution.

Key Accountabilities

•            Monitors level of equipment usage in the laboratory, orders reagents and consumables, oversees general management of laboratory space and operation.

•            Supervises students and trainees within the laboratory and ensures proper adherence to Standard Operating Procedures (SOPs) for all users of the laboratory space. 

•            Provides training to all staff, students and other users of the laboratory space to ensure compliance with safety standards as mandated by PHSA/BCCA/BCCRC. Ensures incident reports and complaints are filed, reviewed and followed up and ensures required certifications (Ethics, Radiation, Biohazard etc) and renewals are applied for and received in a timely fashion as required.

•            May conduct research experiments independently and contribute to the writing of manuscripts, publications and grant proposals to support PI’s research program as required.

Qualifications

PhD in a related discipline plus 2-5 years experience in a research or laboratory environment.

Demonstrated strong interpersonal skills, coupled with excellent organization and project management skills.  Ability to supervise. Excellent written and verbal communication skills. Strong time management and the ability to multi-task with multiple priorities. Strong attention to detail.  Ability to work under pressure and independently with minimal supervision and/or direction as part of the management team.  Demonstrated analytical, negotiation and problem solving skills. Advanced knowledge of laboratory products and equipment and an in-depth knowledge of WHMIS, WCB and Occupational Health and Safety standards.

Please send cover letter and CV to Shannon Valdez svaldez@bccrc.ca 

Knowledge Translation Coordinator

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Are you an excellent communicator with passion for science and technology?

Do you have a knack for creative writing and design, with an eye on detail?

Can you translate technical language and jargon for non-scientific audiences?

The GSC is looking to add a Knowledge Translation Coordinator to its Knowledge Translation team. Reporting to the Head of Knowledge Translation, this position will support the development of materials, activities and events that help communicate the GSC’s research projects, collaborations and innovations to a variety of audiences, both scientifically literate and not.

Main Responsibilities

  • Coordinate the development of digital and print materials as well as activities and events in collaboration with the Knowledge Translation team, scientists, trainees, project managers and other staff members.
  • Write, edit, design and proofread scientific and technical publications, as well as copy for non-scientific audiences including research summaries, web and social media content, multimedia, etc. 
  • Recommend strategies and develop plans, tools and practices for reaching new audiences in collaboration with the Head of KT and other project and program leaders.
  • Monitor status and progress for KT activities to ensure quality and timeliness; provides relevant information and project progress reports.
  • Propose and create compelling content (including design materials using Adobe Suite) for the web and social media related to the GSC’s research projects and programs, and technology platforms and services.
  • Identify and evaluate objectives and project milestones; flag discrepancies for the attention for the Head of KT.
  • Work with client relationship management software (Salesforce) to ensure timely and professional communications with stakeholders about research projects and scientific collaborations.
  • Other duties as required. 

Qualifications

A level of education, training and experience equivalent to completion of a Bachelor’s of Science (a Master’s or PhD is an asset) in biology, genetics or a related field from a recognized university plus a minimum of five (5) years of recent related experience in an academic or industry research setting (experience in the biotechnology sector is an asset).

Skills and Knowledge

  • Demonstrated experience and expertise in science communication, including the development of plans and strategies, print and digital materials, and event organization, for research, education, business, marketing, promotion and/or knowledge translation/transfer/mobilization/exchange purposes.
  • Excellent command of the English language, and exceptional communications skills including in speech and writing; fluency with other languages is an asset.
  • Experience and confidence in editing, proofreading and/or providing review and critique on the written work of both junior and senior staff members, including scientists and principal investigators.
  • Understanding of Canadian scientific and research processes, including ethics, funding and peer-reviewed publication processes, policies and procedures.
  • Fundamental computer literacy is mandatory, including familiarity with the Microsoft suite of products (Word, Excel, PowerPoint, Outlook); experience with the Adobe Suite of products (Photoshop, Illustrator, InDesign) and/or with Client Relationship Management software (Salesforce) for business development purposes are very strong assets.
  • Demonstrated organizational, analytical and critical thinking skills, including the ability to manage multiple projects and activities within a fast-paced environment under pressure and to do so independently or cooperatively, optimistically and respectfully in a diverse and inclusive team environment.

Apply

Please submit a cover letter and resume to bcgscjobs@bcgsc.ca

The position will remain open until filled.

We thank all applicants; however, only those selected for the next step will be contacted.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority. 

Due to COVID-19 restrictions, the position would require working remotely on a part-time temporary basis. This restriction would be re-evaluated upon re-contracting.

Cloud Engineer, Programmer, Architect (Microsoft Azure)

JOB SUMMARY

A position is open immediately for a cloud engineer to work with our interdisciplinary team of researchers and software developers at the BC Cancer Research, a non-profit research centre under the Provincial Health Services Authority and University of British Columbia. We are seeking a passionate individual to join a team of programmers and data scientists currently developing cloud-based software solutions and services to help accelerate academic research for the Molecular Oncology Department at BC Cancer.  Our group currently handles petabytes of digital patient data from thousands of individuals and samples, and face exciting challenges in performance, scalability, security, user experience and optimization. The successful candidate will work closely with researchers and programmers to design and implement best solutions utilizing cloud infrastructure and services for existing and novel problems.  Ideal candidates will demonstrate experience in designing and deploying effective cloud solutions to existing and novel computational, networking and storage challenges.

ORGANIZATIONAL STATUS

Working on software tasks, both independently and reporting to the project lead in Molecular Oncology or designate, and in conjunction with investigators within BC Cancer, UBC and internationally.

WORK PERFORMED

  • Development and maintenance of cloud applications and services
  • Migration of on-premise applications and services to cloud
  • Designing and implementing networking and security groups in Azure
  • Cost-optimization and security monitoring of Azure activities
  • Documentation and training of cloud environment usage
  • Governance and administration of cloud environment
  • Exploring and prototyping applications on other cloud providers

CONSEQUENCE OF ERROR

Accountable for the infrastructure and platform for major production research systems that have significant research progress implications.

SUPERVISION RECEIVED

Supervision from Principal Investigator or designate. Results reviewed for achievement of overall objectives.

SUPERVISION GIVEN

May help to supervise undergraduate trainees and/or junior software technicians.

QUALIFICATIONS

Essential

  • Minimum of 2 years of relevant work experience in Azure cloud engineering
  • Minimum of 4 years of relevant work experience in software design and programming
  • Experience designing and implement cloud-based solutions
  • Experience with large-scale data management
  • Experience with large-scale data processing
  • Programming in Python or a combination of relevant languages
  • Strong verbal/written communication skills and willingness to work in a team

Preferred

  • Undergraduate degree in engineering or computer science
  • Experience with scientific high performance computing environments and solutions
  • Experience working in an academic research environment
  • Azure Fundamentals and Expert Certification

To apply: Please send your Cover Letter, CV, Transcript and Work Sample to careersmolonc@bccrc.ca

Please put your full name and job title “Cloud Engineer, Programmer, Architect (Microsoft Azure)" in the subject line.

Research Programmer

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: RP POG_R00008_2021_03_16

Canada’s Michael Smith Genome Science Centre of BC Cancer is looking for an enthusiastic and self-motivated Research Programmer to work on a federated genome data sharing project based on the Global Alliance for Genomics and Health framework. The position is within Dr. Steven Jones’ group, therefore the successful candidate will have the opportunity to get insights on Personalized OncoGenomics (POG) program and other precision medicine initiatives. This requires a combination of interest in DNA technology and a strong background in software development.

Eligibility

The successful candidate will have the following qualifications:

  • Undergraduate degree in computer science, software engineering or any quantitative science field related to genomics or cancer biology.
  • Experience in front and/or back end development as well as solid programming skills in Python is a must.
  • Experience with Flask and Javascript or other web framework would be particularly useful.
  • Basic understanding of DNA technology or previous work experience with genetic data is a plus, but not required for the position.
  • The position requires working with a wide variety of researchers, software developers and clinicians, thus excellent communication skills are essential.

Apply

Please submit a cover letter, curriculum vitae and the names of three referees willing to provide letters of reference. The cover letter should include a brief description of your previous research experience and long-term career goals. Please email your application to bcgscjobs@bcgsc.ca.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a part-time temporary basis. This restriction would be re-evaluated upon re-contracting.

Research Assistant 2

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference Number: RA2-R0004-2021-03-10

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Incumbents have directly related laboratory experience and familiarity with specific research programs and methodologies of the hiring laboratory.  They work under supervision and perform experiments by following established laboratory procedures.  They report to the Department Head, Principal Investigator, or designate, with duties including: 

  • Performs a variety of established technical procedures according to written protocols.
  • Performs experiments by following established laboratory procedures according to written protocols.
  • Records results, including computer data entry.
  • Provides input regarding modification of procedures as requested by the Department Head, Principal Investigator, or designate.
  • Maintains and stores cell lines and primary cultures.
  • Maintains and stores test materials and products.
  • Maintains inventory of laboratory supplies and equipment.
  • May demonstrate work methods or procedures to less experienced assistants as designated.

Eligibility

A level of education, training, and experience equivalent to graduation from a recognized Bachelor’s program in an appropriate discipline (e.g., Bachelor of Science) plus two (2) years of recent related experience in a research laboratory. A familiarity with mammalian cell culture techniques, flow cytometry/FACS and library construction for DNA sequencing will be considered essential assets.

Apply

Please submit a cover letter, curriculum vitae and the names of three referees willing to provide letters of reference. The cover letter should include a brief description of your previous research experience and long-term career goals. Please email your application to bcgscjobs@bcgsc.ca.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a part-time temporary basis. This restriction would be re-evaluated upon re-contracting.

Post-Doctoral Fellow, Immunogenomics

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference Number: PDF-01553-2021-03-08

The GSC is seeking a Post-Doctoral Fellow to conduct scientific research in the areas of immunogenomics, T cell biology, and genetically engineered cell therapy, with a special focus on discovery and characterization of therapeutic T cell receptors using novel high-throughput screening approaches.

Experience in recombinant DNA and gene editing technologies, gene therapy vectors, mammalian cell culture (including primary T cell culture), flow cytometry/FACS, and cell-based assays (such as ELISPOT) is desired. Familiarity with 2nd and 3rd generation DNA sequencing platforms (including single-cell sequencing platforms) will be an asset.

Reporting to Dr. Robert Holt, Distinguished Scientist & Co-Director of the BC Cancer Immunotherapy Program, your typical duties will include the following:
•    Contributing to the design and construction of cell libraries for high-throughput screening experiments.
•    Performing high-throughput T cell receptor profiling screens.
•    Characterization and validation of novel discoveries stemming from high-throughput screening studies. 
•    Reporting research methods and results in meetings, seminars and conferences.
•    Contributing to and/or leading scientific publications and funding proposals

Eligibility

The ideal candidate should possess a PhD degree and recent experience in immunology, genomics, cancer biology, cell biology or a related discipline. A strong publication record and track record of successful funding applications are highly desirable. This position is funded by the Michael Smith Foundation for Health Research Innovation to Commercialization program and, as such, an interest or aptitude for technology development and/or industrial applications would be a valuable asset.  

Apply

Please submit a cover letter, curriculum vitae and the names of three referees willing to provide letters of reference. The cover letter should include a brief description of your previous research experience and long-term career goals. Please email your application to bcgscjobs@bcgsc.ca.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a part-time temporary basis. This restriction would be re-evaluated upon re-contracting.

Post-doctoral Fellow (PDF) Single Cell Genomics, Molecular Biology

We are seeking a highly-motivated post-doctoral fellow (PDF) with strong leadership ability and expertise in single cell genomics and transcriptomics, and a strong background in molecular biology. The successful applicant will work full-time under the supervision of Dr. Samuel Aparicio. The position start date is flexible.

JOB SUMMARY:

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patient tissues and patient-derived xenografts (PDX). A PDF position is available in the Aparicio lab based at the BC Cancer Research Center in Vancouver, Canada, collaborating on an exciting project mapping clonal dynamics in human cancers with new single cell methods. The post holder will have the opportunity to interact as part of the international CRUK Grand Challenge IMAXT project, bringing new measurement methods and computational techniques to the 3D reconstruction of tumours, and mapping drug sensitivity and drug combinations using sgRNA/CRISPR methods in vivo. The program works closely with the Shah computational biology program, based at Memorial Sloan Kettering Cancer Centre, on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage.

ORGANIZATIONAL STATUS:

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Center in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, and will play a senior leadership role in the laboratory.

WORK PERFORMED:

  • Provide leadership, strategic direction, and translational research pertaining to single cell genomics and transcriptomics, and CRISPR methods.
  • Design and implement research plan to investigate the clonal dynamics in human cancer through single cell methods.
  • Design and conduct animal experiments.
  • Conduct in vivo testing or characterization of drugs, small molecules, knockouts or antibodies in relevant PDX animal models.
  • Foster research collaborations and work jointly with academic, clinical, industry, and other partners.
  • Scientifically document lab experiments, data analysis, interpretations.
  • Write manuscripts, present results at internal and external meetings.
  • Identify funding opportunities and if required write or assist with grant proposals
  • Lead and mentor junior trainees/students in the laboratory

CONSEQUENCE OF ERROR:

This is a senior research position that plays a critical role in the development of this novel field. PDF is accountable for the quality and integrity of the research and data, including analyses and interpretation, as well as the effective and efficient management of research projects and deliverables. This position requires innovation, strategic planning, and adaptability. Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly.

SUPERVISION RECEIVED:

The PDF will work with a high degree of independence and set priorities under broad directives from Dr. Aparicio. The PDF will be expected to provide direction and mentoring in the laboratory under the supervision of Dr. Aparicio. This position will also provide the candidate with a high level of exposure to single cell genomics and translational research, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally.

SUPERVISION GIVEN:

The PDF will be expected to provide mentorship and guidance to undergraduate, graduate students and other research members as required.

QUALIFICATION:

  • Ph.D. in biology, cell biology, molecular biology, biochemistry, genetics, genomics, or similar discipline.
  • The candidate should have a solid scientific and technical background with excellent written/oral communication, interpersonal and organizational skills.
  • Preference will be given to candidates with a proven track record with a minimum of 2-3 first author publications in reputable journals.
  • Proficiency in cell biology, molecular biology, histology, genetics, genomics, next-generation sequencing and biochemistry techniques.
  • Demonstrate the ability to work in a highly interdisciplinary environment.
  • Experience with cancer research.
  • Expertise and hands-on experience in animal studies, including all aspects of design, handling, breeding, tissue collection, histology, and analyses are essential.
  • Familiarity with testing/characterization of small molecule or drug in vivo is preferred.
  • Previous biochemical/cell biology and molecular biology experience with single cell genomics / transcriptomics, next generation sequencing, drugs screen and PDX modeling is an asset.
  • Experience with statistical analyses and scientific writing. Previous experience with grant writing is an asset.
  • Experience with bioinformatics approaches to biological data and familiarity with handling of genomics data is an asset.
  • Applicants with experience and a strong track record with large drug target screening, single cell methods, and PDX mouse models are especially encouraged to apply.

To apply: Please send your Cover Letter, CV, Transcript and Work Sample to careersmolonc@bccrc.ca

Please put your full name and job title “Post-doctoral Fellow (PDF) Single Cell Genomics, Molecular Biology" in the subject line.

Research Associate

Job Reference Number: RA-R00006-2021-02-22

About us

Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC

As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely on part-time temporary basis.  This restriction would be re-evaluated upon re-contracting*


Role Summary

Canada’s Michael Smith Genome Sciences (GSC) at BC Cancer is looking for a Research Associate to work within the Technology Development Group (Biochemistry), to assess or develop new technologies that will continue to propel the GSC forward at the leading edge of science. Such work may, for example, include  the evaluation of leading technologies that emerge in the marketplace, and the development of novel genomic technologies, such as those that support large-scale provincial and national projects, including BC Cancer’s Personalized OncoGenomics program, the Terry Fox Research Institute (TFRI) PROFYLE project and the TFRI-led Marathon of Hope Cancer Centres Network—a major federal initiative co-developed with GSC involvement to accelerate the adoption of cancer precision medicine in Canada.

Working in the Technology Development Group (Biochemistry), under the direction of the Director of the GSC and directly reporting to the Group Leader, the successful applicant will help test, devise, develop and implement ‘omic technologies in the laboratory, as well as analyze, propose and present innovative workflows to increase the efficiency of genomics activities. We seek an engaged, enthusiastic team player with excellent bench and computational skills, a demonstrated ability to design and conduct well-controlled experiments, and a passion for genome science.

Main Responsibilities

  • Test and/or develop novel and efficient methods to enable the scale and throughput the GSC requires to operate at the leading edge of its fields.
  • Perform pilot or “custom” experiments, which may require e.g. following protocols published in the literature, or modifying an existing production protocol to meet specific project needs.
  • Provide support to production groups, such as drafting Standard Operating Procedures, training production staff, and troubleshooting exercises.
  • Summarize and analyze data and results, and formally present findings in meetings and discussions, including at local, national and international meetings Interact closely and in support of group leaders and their teams to address priorities and project timelines          
  • Co-author scientific manuscripts related to research and technology findings.
  • Co-develop research grant applications.
  • Contribute to quarterly and annual reports for research projects.
  • Perform other related duties as required.

Qualifications

Education and experience

  • PhD in a life sciences-related discipline, or MSc with 3 years demonstrated experience in genomics, or molecular biology. Knowledge or experience in e.g. high-throughput, large-scale DNA sequencing and genomic library production would be a plus.

Skills and abilities

  • Molecular Biology.
  • Knowledge and experience in laboratory automation.
  • Knowledge of science and technologies pertaining to cancer genomics.
  • Knowledge and experience in operating a laboratory information management system (LIMS) is advantageous.
  • Experience with formal quality assurance systems is advantageous.
  • Experience with high-throughput sequencing is desirable.
  • Experience in a supervisory role is an asset.  

To Apply

Please send a copy of your resume and a detailed cover letter to bcgscjobs@bcgsc.ca with the subject title, Research Associate Position RA-R00006-2021-02-22.

While we are looking to fill this position as soon as possible, please note that this position will remain open until filled.

We thank all applicants; however, only those selected for the next step will be contacted

Computer Systems Specialist

Job Code: CSS HEU Req # 104022

About us

Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC

As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely on part-time temporary basis.  This restriction would be re-evaluated upon re-contracting*


Role Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Computer Systems Specialist provides high-end technical support for the GSC information technology infrastructure.  This infrastructure includes the data servers, data network, and client workstations, as well as the website.  Duties include establishing technical standards, designing infrastructure architecture, installing, configuring and upgrading infrastructure components, monitoring infrastructure security and performance, and proactively planning infrastructure enhancements.

This position is unionized and falls under the HEU collective agreement
http://www.heabc.bc.ca/public/CAs/FBA/FBA_CA_2019-2022.pdf

Duties

  • Maintains the enterprise class storage systems.
  • Manages the data backup and recovery procedures.
  • Installs, configures, modifies and tests computer hardware used as servers on the GSC network.
  • Installs, configures, and upgrades server software.
  • Designs and implements the GSC network infrastructure, including the design of network topology and the selection and installation of network components.
  • Monitors the security of the information technology infrastructure and its components, including firewalls.
  • Prepares and communicates policies and procedures on security.
  • Develops configuration standards and implementation procedures for network peripherals such as client workstations and network printers.
  • Maintains website hardware and runs webserver software.
  • Creates and maintains mailing groups.
  • Codes, modifies, tests and maintains programs to meet user requirements.
  • Develops GSC wide backup and recovery procedures.
  • Monitors and reports on the performance of all infrastructure components, and responds to and resolves any issues regarding performance.
  • Prepares plans for proactive infrastructure upgrades, including evidence-based reporting on the rationale for such upgrades.
  • Resolves user issues on the technical infrastructure.
  • Provides expert advice on technical issues.
  • Assists with strategic planning on GSC information technology infrastructure, including data, voice and video.
  • Consults with external contacts, including vendors and external partners, on issues regarding technical infrastructure.
  • Performs related duties as required.

Qualifications

Education, Training and Experience

  • Completion of Grade 12, plus graduation from a recognized two-year systems technology diploma plus three (3) years of recent related experience, which includes experience in:
    1. Enterprise class storage systems
    2. Backup and recovery procedures to disk and tape
    3. Client/server architecture.
    4. Multi-user networked environment.
    5. Personal computers.

            Or an equivalent combination of education, training and experience.

Skills and Abilities

  • Ability to type.
  • Ability to communicate and deal effectively with all levels of staff both verbally and in writing.
  • Physical ability to carry out the duties of the position.
  • Ability to organize work.
  • Ability to operate related equipment.

To Apply

Use the subject title:  CSS HEU Req # 104022 Computer Systems Specialist

For internal applicants please visit internaljobs.phsa.ca to apply online.  

For external applicants, please send a copy of your resume and a detailed cover letter to bcgscjobs@bcgsc.ca

Lab Operations Safety Coordinator

Job Reference No.:  SC-R00022-2021-02-05

About us

Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC

As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely on part-time temporary basis.  This restriction would be re-evaluated upon re-contracting*


Role Summary

The activities required in this role are conducted in accordance with the strategic directions of the Provincial Health Services Authority (PHSA), BC Cancer (BCC), the BC Cancer Research Centre (BCCRC), and the Genome Sciences Centre (GSC). Reporting to the Lab Operations Team Leader, the Safety Coordinator is the GSC’s primary safety liaison to the BCCRC’s Safety Office and its constituent departments, and is responsible for coordinating various safety aspects of the GSC’s Production and clinical DNA sequencing operations. This includes both dry and wet lab personnel in multiple buildings. To accomplish this, the Safety Coordinator interacts with virtually all department personnel to ensure that legal, accreditation, and functional safety requirements are met, and that a participatory culture of safety engagement is maintained.

Key Responsibilities

  • Ensures compliance with existing CAP (College of American Pathologist), ISO27001 (International Organization for Standardization), and DAP (Diagnostic Accreditation Program) safety regulations; implements policies and procedures to ensure successful compliance; communicates pertinent information to stakeholders; participates in regular audits by accreditation agencies; assists in developing policies and procedures for prospective accreditations.
  • Works with the Quality Systems group to regularly review and update the departmental safety manual; communicates changes in safety policies to relevant personnel.
  • Engages in regular safety education activities to re-enforce policies and procedures to department personnel; works with Knowledge Translation and Communication team to maintain regular content in the GSC newsletter; conducts regular safety education on relevant topics; coordinates regular seminars by external groups to provide professional education.
  • Chairs the Echelon Joint Occupational Health & Safety Committee (EJOHSC), and represents the GSC at the CRC JOHSC meeting; carries out action items and activities prescribed by the JOHS committees; is the primary safety liaison to various operational meetings.
  • High degree of familiarity with WorkSafeBC and WHMIS regulations and knowledgeably applies them to both dry and wet lab space; regularly audits compliance; educates personnel on changes to regulations; provides tools and guidance to personnel to facilitate compliance.
  • Participates in and documents both casual and formal safety inspections at all GSC sites; documents safety concerns, consults with stakeholders and implements corrective actions.
  • Works with department personnel to address ergonomic issues; guides personnel through a complex ergonomics process; works with PHSA Ergonomists to devise, implement and monitor corrective actions.
  • Manages all safety-related training requirements; oversees compliance in maintaining certification; ensures that all safety training is documented promptly and accurately; communicates with personnel who are delinquent with safety training.
  • Oversees hazardous waste disposal at all GSC sites; works with wet lab staff to determine safe disposal procedures; manages administrative aspects of invoicing and collection; maintains records of service; ensures compliance with accreditation and legal requirements.
  • Conducts incident and near-miss investigations; guides personnel through the reporting process, and implements corrective actions; consults with stakeholders and JOHS committees regarding incidents.
  • Monitors wet labs for chemical inventories and compatibilities; performs regular analyses and chemical risk assessments; maintains SDS database and ensures availability of SDS to wet lab staff.
  • Works collaboratively with the Lab Operations and Quality Systems teams to create, implement, and document safety procedures and SOPs.
  • Keeps apprised of proposed and actual changes to laws, regulations, and policies put forward by the Public Health Agency of Canada (PHAC), WorkSafeBC, BCCRC, CAP, and DAP; engages GSC stakeholders on these changes; works to implement changes as required.
  • Attends external conferences, working groups, and meetings to represent the GSC; leads team participation in safety-related competitions; maintains professional relationships in order to guide best practices and share information.
  • Provides and documents safety orientations for incoming staff members.
  • Oversees the First Aid program.
  • Participates in emergency on-call rotations.
  • Manages the departmental Incident Management Team (IMT); organizes meetings; maintains emergency response documentation; conducts practice drills.
  • Performs other related duties as assigned.

Qualifications

  • A level of education, training, and experience equivalent to completion of a Bachelor of Science from a recognized college, plus a minimum of 3 (three) years of recent related experience in a research role.
  • Experience in laboratory safety management is required, with demonstrated familiarity with PHAC and WorkSafeBC regulations. Applicants should have strong capabilities in Microsoft Access and Excel, with a high aptitude for self-learning of new technical skills.  Excellent organizational and communication skills are required.
  • Relevant experience in a clinically- or ISO-accredited environment is desirable, but not required.

To Apply

Please send a copy of your resume and a detailed cover letter to bcgscjobs@bcgsc.ca with the subject title:   Lab Operations Safety Coordinator SC-R00022-2021-02-05

Research Administration Coordinator

Job Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Reporting to the Department Head or designate, the Research Administrative Coordinator, BC Cancer Research Centre is responsible for providing support in areas of human resources, payroll, grant and research administration. This role, on behalf of Principal Investigators (PI’s) and leaders, monitors payroll and financial cost centres through to resolution of payroll issues. The Research Administrative Coordinator also provides administrative support including managing the grant application process and providing work direction to junior administrative staff in the team.

Duties/Accountablilties

  • In collaboration with the Principal Investigator(s) (PIs) coordinates the preparation and submission of grant proposals by identifying submission guidelines, collating information required and ensuring submission deadlines are met. Follows up with the granting agency on the submission of proposals, monitors post award financial accounts to ensure accuracy. Provides progress reports, highlights discrepancies and provides recommendations to resolve discrepancies and budget concerns to the PI(s) as appropriate.
  • Interacts with a variety of individuals and agencies such as universities and granting agencies both national and international.  Ensures flow of information with internal and external stakeholders regarding grant related matters and makes arrangements for visiting speakers and guests.
  • Human resources responsibilities include recruitment of staff by posting/advertising internally and externally (UBC), coordinating interviews and screening applications for review by hiring supervisors. Manages new hires orientation process in the department and ensures all safety and personnel documentations are in place according to policies, guidelines and legislations.
  • Ensures all hiring, appointment and payroll processes such as new hire letters and timekeeping are complete for employees. Liaises with various PHSA units such as Payroll and Human Resources and in some cases, UBC to ensure a seamless process and minimize errors. Brings issues and recommendations of remedies to department head or designate for approval. 
  • Acts as the main contact for ordering supplies for the department and approves lab and office supplies by performing duties such as submitting purchase requisitions and obtaining authorizing signature as necessary. Manages and processes various requisitions such as travel, expense reimbursements, cheque requests, and honorariums for the Department Head and PIs. Acts as liaison with various departments of BCCA/PHSA including purchasing, stores, and finance to obtain information and follow-up on the status of outstanding issues and requests.
  • Coordinates registration and travel arrangements for staff attendance at seminars and meetings. This includes completing registration (on-line or phone), abstract submission, making travel and lodging reservations, culminating expense reimbursements to the attendee and/or cost recovery from the conference organizers as appropriate.
  • Provides work direction to junior and contract administrative staff including orientating new staff and assigning and reviewing work, coordinating work assignments to ensure completion, answering questions and providing support, ensuring policies and procedures are followed and providing input to performance evaluations as required.

Qualifications

A level of education, training, and experience equivalent to a Diploma in a relevant area such as business administration or finance from a recognized college plus three (3) years’ recent related experience a research environment and in project management.
Strong interpersonal and communication skills and the ability to demonstrate good judgment, tact and discretion. Detail oriented and able to complete accurate work in a timely matter. Demonstrated time management skills and ability to assist others in meeting deadlines.  Knowledge of and experience with grant applications.  Knowledge and experience in budget preparation, tracking expenditures and identifying sources of variance. Proficient in scientific and medical terminology.  Ability to work both independently and as team leader to organize work and manage multiple priorities in a fast paced environment. Demonstrated ability to make sound decisions and resolve administrative issues/problems. Fully proficient in the use of a variety of software packages including word processing, spreadsheets and databases and related equipment. Demonstrated ability to evaluate personal work and existing systems and identify areas for improvement. Physical ability to perform the duties of the position.

To apply: please send your Resume and cover letter to careersmolonc@bccrc.ca

Please put “Research Administrative Coordinator” and your full name in the subject line.

Project Manager

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely.  This restriction would be re-evaluated upon re-contracting*


Role Summary

The Genome Sciences Centre is seeking a Projects Manager. This role is for a Manager of research projects, grants and platforms in a research environment.

Reporting to the Head, Project Management or Projects Team Leader and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and monitor and facilitate progress against these objectives and milestones. Projects will involve personalized oncogenomics, collaborative services management, or other cancer genomics research.

Key Responsibilities

  • establishing budgets for research projects, grants, collaborations and core activities
  • assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
  • monitoring budgets and expenditures
  • establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives, which may include, meeting coordination and follow-up, coordination of case reviews
  • maintain accurate information on sample status, including sample and associated metadata acquisition, processing, stakeholder reporting
  • recommending strategies for improving projects management methods and processes
  • liaising with grant/core funding agencies
  • interacting directly with research collaborators or clinical study teamsas required

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged.

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research, clinical trials research, the biotech or software industries. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

Successful candidate(s) will be offered positions through Provincial Health Services Authority at level Research Project Coordinator, which is equivalent to that described above.

To Apply

Please send a copy of your resume and a detailed cover letter to bcgscjobs@bcgsc.ca

Please note that this position will remain open until filled.

We thank all applicants; however, only those selected for the next step will be contacted.

Assistant Bioinformatics Coordinator

Job Code: ABC HSA Req # 103782

About us

Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC

As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely on part-time temporary basis.  This restriction would be re-evaluated upon re-contracting*


Job Summary

This position is unionized and falls under the HSA collective agreement

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Assistant Bioinformatics Coordinator provides supervisory and technical support to the Bioinformatics group of the GSC, ensuring that the day-to-day activities of a large scale, high throughput facility meet research, data analysis throughput and software development objectives. 

Duties

  • Assists the Bioinformatics Coordinator in the day to day activities of the Bioinformatics group by performing duties such as providing input on quantity and quality of work, making recommendations for improvements, workflow and procedures.
  • Coordinates projects of the Bioinformatics group by performing duties such as chairing project-specific meetings and provides project status reports to the Bioinformatics Coordinator, with suggestions towards any required improvement of project management, task allocation and overall process.
  • Develops and implements assays to monitor project progress and measure project accomplishments to ensure that appropriate project focus is maintained and to provide feedback to staff.
  • Provides supervisory support to the Bioinformatics group by performing duties such as:
    • Orientating new staff.
    • Providing input to the Bioinformatics Coordinator on training requirements.
    • Providing input to the Production Coordinator on the establishment of clear definitions of responsibility for employees.
    • Assigning workload assignments and establishing work schedules.
    • Reviewing and establishing work priorities and adjusting work schedules to ensure priorities are met.
    • Completing performance reviews and addressing performance issues in conjunction with the Production Coordinator.
  • Participates in the recruitment of staff through methods such as interviewing internal and external applicants and forwards hiring recommendations.
  • Participates in the development and implementation of quality improvement programs to ensure services are provided in the most efficient and effective way by performing duties such as:
    • Monitoring quality and quantity of service and information provided by the bioinformatics group and identifying areas for change and/or improvement.
    • Generating test metrics to evaluate progress of research programs.
  • Assesses practical needs for identified research direction of the GSC in conjunction with the Bioinformatics Coordinator and Analysis Group Leader.
  • Participates in a variety of meetings by performing duties such as providing and/or receiving information and contributing to decision making.
  • Participates, in conjunction with the Bioinformatics Coordinator, in determining the computer infrastructure necessary for successful completion of projects and ensured viability of research programs by performing duties such as providing input and recommendations regarding purchasing decisions related to hardware, software and related items for the Bioinformatics platform.
  • Interprets statistical analyses and makes recommendations for review including preparing reports on statistical findings for publication and presentation in HTML format or as advised.
  • Conducts feasibility studies for computerization by performing duties such as determining user requirements, examining and identifying problems with existing systems and recommending modifications to and/or new systems; provides details of estimated implementation costs including associated staffing requirements.
  • Performs technical functions related to the bioinformatic functions of the GSC.
  • Performs other related duties as required.

Qualifications

Education, Training and Experience

Graduation from a recognized Bachelor’s program in a related discipline such as Biochemistry, Genetics, Computer Science, Electrical Engineering or Physics.  A minimum of four (4) years of recent related experience including experience in computer programming and quantitative data analysis, handling biological sequence and/or mapping data, database development and data storage schemas or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

  • Experience with computer operating systems such as Linux, UNIX.
  • Demonstrated ability to work with software such as C, C++, Perl , Matlab, MySQL.
  • Demonstrated ability to accept responsibility and work independently.
  • Demonstrated ability to work effectively with others in a team environment.
  • Demonstrated ability to supervise staff and schedule work.
  • Excellent organizational, leadership interpersonal and communication skills.
  • Physical ability to perform the duties of the job.

To Apply

Please send a copy of your resume and a detailed cover letter to bcgscjobs@bcgsc.ca

Programmer, Computer Vision Developer, Microscopy

JOB SUMMARY

A position is open immediately for a research programmer to work with our interdisciplinary team of researchers and software developers at the British Columbia Cancer Agency (BCCA). We are seeking a passionate individual to join a team of biologists, engineers and data scientists currently developing state of the art methods for spatial imaging of RNA species in human cancers at single cell resolution. Studying tumours at the single cell level can reveal biological differences that may not be resolved when studying the tumour as a whole. The imaging methods being developed include the use of molecularly encoded super-resolution microscopy to detect single molecules of RNA in tissue specimens. The successful candidate will develop and support a microscopy imaging software suite integrating super-resolution microscopy, fluidics and camera functions to facilitate sequential imaging of human cancers. The candidate will also work with biologists and data scientists to analyze images and identify RNA species.

ORGANIZATIONAL STATUS

Working in a research project, both independently and reporting to the project lead in Molecular Oncology or designate, and in conjunction with investigators within the BCCA, UBC and internationally.

WORK PERFORMED

  • Development and maintenance of image analysis software suite
  • Support or development existing microscopy system
  • Assisting in generation of research results from microscopy system
  • Assisting in the computational analysis of digital image files from the system
  • Documentation and training of microscope system to other users
  • Machine learning techniques and platforms
  • Working with open source computer vision libraries

CONSEQUENCE OF ERROR

Accountable for the operation of the microscopy system and downstream image analysis that will have significant research progress implications.

SUPERVISION RECEIVED

Supervision from Principal Investigator or designate. Results reviewed for achievement of overall objectives.

SUPERVISION GIVEN

May help to supervise undergraduate trainees and/or junior software technicians.

QUALIFICATIONS

Essential

  • Minimum of 2 years of relevant work/research experience
  • Microscopy image processing experience
  • Microscopy engineering experience
  • Programming in Python or a combination of relevant languages
  • Strong verbal/written communication skills and willingness to work in a team

Preferred

  • Undergraduate degree in engineering or computer science
  • Machining and design experience
  • Expertise in cellular biology and expression analysis
  • Experience in software engineering and design
  • Experience with scientific high performance computing environments and solutions
  • Experience working in an academic research environment
  • Special consideration will be given to those in research areas that involve computer vision or machine learning.

To apply: Please send your CV and cover letter to careersmolonc@bccrc.ca

Please put your full name and job title “Programmer, Computer vision developer, Microscopy" in the subject line.

Research Assistant 2

Application Deadline

What you’ll do 

  • Performs a variety of established technical procedures according to written protocols, including revising and updating all Standard Operating Procedures (SOPs) in compliance with internal IDP change control procedures, all safety standards as mandated by WCB, UBC, BCCA/BCCRC and cGMP and GLP regulations.
  • Provides assistance in various quality management activities to ensure all IDP processes and systems  operate in compliance with GxP regulations which includes but not limited to: (1) maintaining equipment qualification, validation and preventive  maintenance program including all records, (2) maintaining vendor and contractor surveillance program including all documentation (3) maintaining IDP training records and documentation  system, and (4) overseeing maintenance of environmental monitoring systems: validation status, system preventative maintenance and records as required.
  • Provides backup support for quality assurance with inspection of IDP manufacturing activities and review of Batch Record documentation as required.
  • Provides support in hosting and handling of external client and regulatory audits of the IDP as required.
  • Maintains inventory of laboratory supplies and equipment including assigning and tracking usage of laboratory notebooks and archiving of completed notebooks.
  • Provides support in IDP shipping functions as required.
  • Provides support in quality control functions including searching for vendors, sampling of raw materials and supplies, performing monitoring data trend analysis as required.
  • Provides overall  backup quality control/archivist/quality assurance function to the IDP QMU as required.
  • Maintaining documentation and reviewing department lab equipment inventory, cytotoxic and radionucleotide inventory.
  • Facilitates quality assurance retain samples inventory system.
  • Performs other document control and management related duties as assigned.
  • May demonstrate work methods or procedures to less experienced assistants as designated.

What you bring  

  • A level of education, training, and experience equivalent to graduation from a recognized Bachelor’s program in an appropriate discipline (e.g. Bachelor of Science)
  • Two (2) years of recent related experience in a research laboratory.
  • Experience working in GMP or GLP environment is an asset.

How to Apply

Please submit your cover letter and resume to etadmin@bccrc.ca

Research Asst/Tech 3

Job Summary
Researchers in the Department of Molecular Oncology at the BC Cancer Research Institute uses the latest technologies to rapidly identify genes that are involved in the development of cancer. This position will be involved in providing technical support in molecular biology, biochemistry, microscopy and robotics for current on-going research projects in the lab.

Organizational Status
The successful applicant will report to the Principal Investigator or his/her delegate and may assist in overseeing technical work of students and trainees.

Work Performed

  • Plans and performs experiments utilizing complex procedures and/or techniques
  • Processes primary tissue samples
  • Maintain cell cultures using aseptic techniques
  • Provide molecular biology support – DNA and RNA, cloning, extraction/isolation, PCR
  • Provide basic protein biochemistry support – western blotting
  • Experience with antibody labelling is preferred
  • Ability to record data and work with informatics systems that stores and display data is essential
  • Carries out laboratory techniques following standard operating protocols
  • Maintains laboratory records and experimental data; when require summarize results in research reports and lab presentations
  • Performs other related duties as assigned


Consequence of Error/Judgement
The work is of a complex nature, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Non compliance with biosafety and chemical safety regulations may result in closure of facility or loss of grant funding.

Supervision Received
The successful applicant will report to the Principal Investigator or designate.

Supervision Given
Depending on experience and expertise, the successful applicant maybe be required to assist in training of graduate students/trainees including instruction in use of lab equipment and procedures and will troubleshoot experiments in their area of expertise.

Minimum Qualifications
Completion of a relevant technical program or a university degree in a relevant discipline and a minimum three years of related experience or an equivalent combination of education and experience.

 

Preferred Qualifications

  • Working knowledge and understanding of molecular biology and biochemistry techniques is essential, with prior working experience in molecular biology in laboratory setting is considered an asset.
  • Experience with cell culture and aseptic technique preferred.
  • Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNA / DNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation, and western blotting.
  • Preference will be given to applicants with antibody labeling experience.
  • Experience in immunocytochemistry and basic data analysis in R or similar statistics package would be an asset
  • Demonstrated understanding of experimental design and assay optimization.
  • Strong interpersonal skills and the ability to interact positively and productively with other team members are essential.
  • Ability to communicate effectively both orally and in writing.
  • The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

To apply: Please send cover letter and resume to careersmolonc@bccrc.ca  – Please put your full name and the job title in the subject line.

Research Asst/Tech 4

Job Summary
Researchers in the Department of Molecular Oncology at the BC Cancer Research Institute uses the latest technologies to rapidly identify genes that are involved in the development of cancer. This senior position will be involved with working on the Single Cell genomics project, in addition, providing general technical support in molecular biology, biochemistry, microscopy and robotics for other current on-going research projects in the lab.

Organizational Status
The successful applicant will report to the Principal Investigator or his/her delegate and may assist in overseeing technical work of students and trainees.

Work Performed

  • Plans and performs experiments utilizing complex procedures and/or techniques.
  • Using of liquid handling robotics and 10x genomics platforms to investigate single cell genomics
  • Visualize and analyse cells using microscopy and flowcytometry.
  • Generation, preparation and submission of Next Generation Sequencing Libraries.
  • Track samples, record data and work with informatics systems that stores and displays data
  • Liaise with collaborators and vendors.
  • Provide technical expertise in molecular biology, protein biochemistry, virology, support and guidance to collaborators and researchers.
  • Data analysis using R script or other basic statistic analysis program
  • Provide molecular biology support – DNA and RNA, cloning, extraction/isolation, PCR
  • Provide basic protein biochemistry support – western blotting
  • Carries out laboratory techniques following standard operating protocols.
  • Maintains laboratory records and experimental data; when require summarize results in research reports and lab presentations.
  • Assist, develop or update Standard Operating Procedures (SOPs) to ensure compliance with regulatory bodies
  • Assist in general maintenance of the lab and receiving and inventory of lab supplies
  • Researches and determines the applicability of new technology and systems related to work
  • Conducts complex analysis and interpretation of data resulting from high throughput experiments.
  • Presents data at scientific meetings, writes reports and contributes to writing ethics and grant applications.
  • Carries out any other related duties as assigned or required in keeping with the qualifications and requirements of this level of technician.

Consequence of Error/Judgement
The work is of a complex nature and required high level of training, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Errors may result in the permanent loss of irreplaceable tissue samples, loss of thousands of dollars of material and/or damage to equipment.  Loss of research results could result in the failure of a funded project and put in jeopardy any future funding and the international reputation of the Laboratory. Non compliance with biosafety and chemical safety regulations may also result in closure of facility or loss of grant funding.

Supervision Received
Works under minimum supervision, receiving specific instructions only on unusual problems or when receiving new project outlines from the principal investigator. The successful applicant will report to the Principal Investigator or designate.

Supervision Given
Depending on experience and expertise, the successful applicant maybe be required to assist in training and supervision of graduate students/trainees or junior staff, including providing instruction in use of lab equipment and procedures, and will help troubleshoot experiments in their area of expertise.

Qualifications

  • Undergraduate degree in a relevant discipline or Graduation from a technical college or institute.
  • A postgraduate degree in Science is preferred but not required. Minimum of 5 years related experience or the equivalent combination of education and experience in a research lab setting.
  • A working knowledge and understanding of molecular biology and biochemistry techniques is essential, with prior working experience in molecular biology in laboratory setting is considered an asset.
  • Experience with cell culture and aseptic technique.
  • Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNA / DNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation, and western blotting.
  • Preference will be given to applicants with liquid handling robotics, single cell genomics, Next Generation Sequencing, 10x Genomics experience.
  • Experience in immunocytochemistry and basic data analysis in R or similar statistics package would be an asset
  • Demonstrated understanding of experimental design and assay optimization.
  • Strong interpersonal skills and the ability to interact positively and productively with other team members are essential.
  • Ability to communicate effectively both orally and in writing.
  • The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively

To apply: Please send cover letter and resume to careersmolonc@bccrc.ca  – Please put your full name and the job title in the subject line.

Manager, Systems

About us

Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC

As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely on part-time temporary basis.  This restriction would be re-evaluated upon re-contracting*


Role Summary

Canada’s Michael Smith Genome Science (the “GSC”) at BC Cancer is looking for a Manager, Systems, responsible for developing, maintaining, and supporting the IT infrastructure of the GSC.

Under the direction of the Head of Bioinformatics, the Manager, Systems develops a vision for the IT infrastructure capable of supporting the future research direction and production requirements of the GSC.

The Manager, Systems ensures the confidentiality, integrity and availability of data within the department and organization.

 If you have experience leading teams, managing multiple projects at the same time, and you enjoy solving problems and working with multiple stakeholders, please read on.

 Key accountabilities

  • Liaise with members of senior management to solicit requirements and report progress of IT
  • Manage high-level planning for informatics research and laboratory production requirements
  • Manage the design and development of IT systems and projects
  • Provide leadership, coaching and direction to the Systems team including coop students
  • Coordinate and prioritize project plans and tasks
  • Address and resolve reported project roadblocks, and develop procedures to reduce these
  • Manage support issues from all staff and maintain systems to ensure that support issues are handled and prioritized accordingly
  • Develop service level agreements within the organization
  • Develop and manage process for new releases and changes to the production environment
  • Manage software license compliance, and participate in regular audits
  • Responsible for data security, storage and archiving as per business requirements
  • Develop and enforce technical information system standards
  • Design and develop implementation of information systems policies and training material

Qualifications

  • Undergraduate degree from a recognized institution in Computer Science, Electrical Engineering and/or Life Sciences or related field or a combination of relevant education and work  experience
  • A minimum of 7 years of relevant experience working in an IT department or similar environment
  • A minimum of 2 years’ experience managing and directing a systems team
  • Knowledge of softwares such as Slurm, Atlassian, Linux (Centos, Ubuntu), Windows10,  Macintosh, Office, LDAP, AD, Exchange an asset
  • Experience working with network such as Brocade and Barracuda an asset
  • Knowledge of audit process, including ISO an asset
  • Demonstrated ability to work independently and collaboratively as appropriate
  • Excellent organizational and leadership skills. Ability to coach and motivate staff
  • Excellent oral, written and interpersonal communication skills
  • Ability to use audience appropriate communication and language to present information and convey concepts
  • Ability to achieve results in a fast-paced research environment

To Apply

Please send a copy of your resume and a detailed cover letter to bcgscjobs@bcgsc.ca

While we are looking to fill this position as soon as possible, please note that this position will remain open until filled.

We thank all applicants; however, only those selected for the next step will be contacted.

Postdoctoral Fellow, Gastrointestinal Cancers

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position may require working remotely.  This restriction would be re-evaluated upon re-contracting*


Role Summary

A Post-doctoral position is available immediately for a highly motivated recent PhD or MD/PhD graduate to join a dynamic translational research group, headed by Dr. Isabella Tai, Associate Professor in the Division of Gastroenterology, University of British Columbia and Senior Scientist at Canada's Michael Smith Genome Sciences Centre at BC Cancer.

Current projects in the laboratory revolve around improving our understanding of the mechanisms involved in the development of chemotherapy resistance and metastasis in gastrointestinal cancers (colorectal, gastric, liver and biliary cancers). The goal is to develop either novel therapeutic targets for GI cancer treatment or novel screening tools for diagnosis. We continue to use the latest genomics (including single cell sequencing), proteomics and bioinformatic approaches to identify potential targets or markers for this purpose. Learn more about research projects in the Tai lab here.

Eligibility

Interested individuals with a recent PhD or MD/PhD and strong publication records and excellent academic credentials are encouraged to apply.  Experience in molecular biology, cell biology, tissue culture and animal tumor models, is preferable.  Experience in bioinformatics is an asset.

Duration

Three years (possibility of extension).

To Apply

Please submit a cover letter, curriculum vitae, and the names of three referees willing to provide letters of reference. The cover letter should include a brief description of your previous research experience, long-term career goals and an indication of the desired length of postdoctoral position.

Please email your application to bcgscjobs@bcgsc.ca

Research Programmer

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely.  This restriction would be re-evaluated upon re-contracting*


Role Summary

The Karsan lab team at Canada’s Michael Smith Genome Sciences Centre (GSC) is seeking a research programmer to join a Genome British Columbia software automation project. The team will be working with the Karsan lab, which is responsible for developing high-throughput, clinically accredited pipelines to analyse sequenced data from genomic assays for individualized patient management of cancer. We seek candidates with strong Python software and programming skills to automate and improve existing pipelines and potentially incorporate third-party software into the system.

The role is ideally suited for a creative individual with a strong interest in software development and testing, data analysis, and automation within a high throughput academic setting.

Key responsibilities

  • Design, plan, and implement automated bioinformatics pipelines to meet the objectives of the project
  • Work with other project team members to develop and test code, and implement software
  • Evaluate third-party software and incorporate new systems into legacy systems
  • Produce thorough but concise written documentation of algorithms, validations, SOPs, and other processes and procedures as required

Qualifications

Education, training and experience

  • Graduation from a recognized Bachelor of Science Program in Computer Science. A Master’s degree in a relevant field would be a strong asset. 
  • Two (2) years of recent related experience or an equivalent combination of education, training, and experience acceptable to the project lead.

Core Skills and Abilities 

  • Expertise with Python 3.X and able to provide links to code samples via GitHub or another open repository
  • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
  • Familiarity with molecular and cellular biology
  • Excellent verbal and written communication skills.
  • Demonstrated ability to efficiently organize work assignments and establish priorities.
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.

Additional Assets

  • Familiarity in statistical analysis using modern computational tools.  Experience with any relevant tools will be considered, but R and Python are preferred
  • Familiarity with the development, testing, and maintenance of relational databases
  • Familiarity in next-generation sequencing
  • Experience with software testing
  • Experience with Agile software practices
  • Functional knowledge of distributed version control systems, such as SVN or GIT

To Apply

Please email your cover letter and resume to bcgscjobs@bcgsc.ca

Please note that this position will remain posted until filled.

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