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Research Assistant/ Tech 3 – Drug Screen/ Assay development

Application Deadline

JOB SUMMARY

The Aparicio lab uses the latest technologies to rapidly identify genes that are involved in the development of breast cancer. Through the use of high-throughput screening methods, we will be screening cancers of diverse genotypes for sensitivity and mechanism of response to G-Quadruplex stabilizers CX5461, Pyridostatin and other related compounds. 

We are seeking a highly-motivated and highly skilled individual with expertise or experience in tissue culture, handling and working with hazardous drugs/compounds, and functional assay development/drug screening. The successful applicant will work full-time under the direction and supervision of both Dr. Samuel Aparicio, Principal Investigator, and the Laboratory Research and Operations manager. The position will provide the candidate with a high level of exposure to all current on-going project within Aparicio Lab, such as areas of single cell genomics and translational research, CRISPR-cas9 and patient derived xenograft, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally; position start date is flexible.

ORGANIZATIONAL STATUS

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Institute in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, or Laboratory and Research Operation Manager. More information on the lab, please visit https://aparicio.molonc.ca

WORK PERFORMED

  • Plans, designs and performs high throughput drug/compound screening assay.
  • Handle, aliquot and preparation of hazardous (possibly cytotoxic) drug compounds for use in screening assay.
  • Using aseptic technique to grow and maintain various types of cell-line and primary cell cultures.
  • Using a LMIS system to track and record sample data
  • Developing and implementing standard operating protocols (SOPs).
  • Maintains laboratory records and experimental data.
  • Assist in general lab maintenance such as reagent preparation, receiving and inventory of lab supplies.
  • Presents data and updates at scientific meetings, writes reports when required.
  • Provide training and instruction for specialized techniques and equipment.
  • Carries out any other related duties as assigned or required in keeping with the qualifications and requirements of this technician level.

CONSEQUENCE OF ERROR

The work is of a complex nature and required high level of training, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Errors may result in the permanent loss of irreplaceable tissue samples, loss of thousands of dollars of material and/or damage to equipment.  Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly. Noncompliance with biosafety and chemical safety regulations may also result in closure of facility or loss of grant funding.

SUPERVISION RECEIVED

The successful applicant will work under minimum supervision. From time to time, Principal Investigator, Research Associates or Laboratory Research and Operations Manager may provide specific instructions on unusual problems, or new project outlines. This position will report to the Principal Investigator or Laboratory Research and Operations Manager.   

SUPERVISION GIVEN

Depending on experience and expertise, the successful applicant might be assisting in training and supervision of student trainees or junior staff, including providing instruction on use of lab equipment and procedures, and will help troubleshoot experiments in their area of expertise.

QUALIFICATIONS

  • A MSc in Biological Sciences (Molecular Biology or other relevant field) or BSc with 1-2 years of related experience in academic research or biotech industry settings, preference will be given to applicants with work experience in drug screen / assay development.
  • A working knowledge and understanding of molecular biology and biochemistry techniques is essential; prior hands-on working experience in tissue culture, aseptic techniques, handling of hazardous drug/compound, assay development, and high-throughput screening will be considered an asset.
  • Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques.
  • Demonstrated understanding of experimental design, high-throughput screening methods and assay design, and optimization.
  • Strong interpersonal skills, communication skills (orally and written) and the ability to interact positively and productively with other team members are essential.
  • Excellent documentation and organizational skills.
  • The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

To apply: please include your resume and cover letter.

Genome Sciences Technologist—Library Core

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No. GST_P00634_HSA118077_LibCore_2011_11_15

Job Summary

The Genome Sciences Technologist performs various molecular biology techniques and procedures including library construction which are involved in the operation of a large scale, high throughput DNA mapping and DNA sequencing production facility. 

Duties

  1. Following established laboratory procedures, performs tasks such as colony purification of plasmid/BAC clones, RNA and DNA purification, DNA sequencing, analysis of DNA fingerprints for physical map construction, Polymerase Chain Reaction (PCR) experiments, DNA restriction analysis, agarose gel electrophoresis, southern blot analysis and library construction.
     
  2. Prepares solutions following standard operating procedures.
     
  3. Maintains general lab and equipment cleanliness.  Recognizes and reports malfunctions in equipment.
     
  4. Processes patient samples according to established procedures for clinical sequencing diagnostic tests.
     
  5. Performs other related duties as required.

Qualifications

Education, Training and Experience

Graduation from a recognized diploma program in Biotechnology, Microbiology or Biochemistry and two (2) years’ of recent related experience in a research laboratory or an equivalent combination of education, training and experience acceptable to the Genome Sciences Centre Group Leaders and Production Coordinators.

Skills and Abilities

  • Knowledge of molecular biology techniques particularly DNA and RNA preparation and manipulation.
  • Demonstrated ability to perform detailed procedures reproducibly and accurately.
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
  • Demonstrated ability to efficiently organize work assignments and establish priorities.
  • Basic knowledge of and ability to operate personal computers.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: GST_P00634_HSA118077_LibCore_2011_11_15 in the subject line of your email.

This posting will remain online until filled.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Process Development Coordinator—CCGI

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No: PDC_E00375_CCGI_2021_11_15

Summary

The role of the CCGI at the GSC is to contribute to patient care by developing, validating, and running clinical bioinformatics pipelines and generating clinical patient reports. Reporting to the Group Leader of the Sequencing Team, the Process Development Coordinator will take the lead role in pipeline validation. 

Duties/Accountabilities

  • Oversees the validation and implementation of pipelines into the CCGI team.
  • Takes the lead on validation design, content, and quality assurance documentation.
  • Analyze and assess sequencing data including alignments and variant calling.
  • Perform critical concordance, LoD, sensitivity and specificity analysis and data assessment.

Qualifications

  • Graduation from a recognized Bachelor’s program in an appropriate discipline such as Computer Science, Bioinformatics, Genetics, Molecular Biology or Biochemistry (PhD) preferred);
  • Five (5) years of recent related experience in a research and or clinical laboratory including supervisory experience
     
    OR
     
    An equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Eligibility

  • Experience analyzing and assessing the quality of NGS data, including:
    • short-read alignment and
    • variant-calling (small variants, copy-number variants, fusions),
  • Strong  skills in statistical analysis and data visualization (e.g. with R),
  • Sufficient molecular biology background to take part in designing validations and drawing conclusions from the results,
  • Ability to work independently with minimal oversight,
  • Ability to collaborate with other CCGI members to complete pipeline validations in a timely manner,
  • Strong analytical and written communication skills,
  • High attention to detail, and
  • Experience in experimental design.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: PDC_E00375_CCGI_2021_11_15 in the subject line of your email.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans. As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Research Programmer, Ryan Morin Lab

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No: RP_R00008_RDMorin Lab_2011_11_05

Job Summary

The Genome Sciences Centre at BC Cancer is looking for a highly motivated programmer with bioinformatics expertise to work in a fast-paced and highly rewarding research environment with a group of scientists and students who are at the bleeding edge of lymphoid cancer research. The successful candidate will work closely with all laboratories in the Centre for Lymphoid Cancer, namely Drs. David Scott, Christian Steidl, Leandro Venterutti and Ryan Morin. We are seeking a highly organized and motivated individual who will take a leadership role in conceptualizing, designing and implementing pipelines for standardizing and automating high-throughput analyses of cancer genome data. The position will support a growing diverse team including trainees and clinical researchers with expertise in bioinformatics, biostatistics and molecular biology. As a member of this group, you will be tasked with ongoing implementation, documentation, improvement, and testing of analytical tools and pipelines and will be required to follow best practices in software engineering. This will include ensuring proper handling, quality assurance and versioning of experimental data and metadata. You will also actively participate in routine code review and maintain robust version control of analytical pipelines using GitHub and continuous integration. As these pipelines typically begin with terabyte-scale inputs and require hundreds to thousands of concurrent processes, part of your job will involve ensuring efficient parallelization using a high-performance cluster with an emphasis on compatibility, reproducibility, ease of installation, and interoperability with various cloud-like computing environments. 

Organizational Status

Reports to Dr. Ryan Morin, Senior Scientist, Genome Sciences Centre and Bioinformatics Lead, Centre for Lymphoid Cancer. 

Specific Duties

As a scientific programmer you will work with our team members to:

  • Design, implement, and maintain pipelines for cancer genomic analyses based on the needs of the team, mostly using Snakemake, Python, and R
  • Suggest, and implement, improvements within our existing code base to increase efficiency and reduce the burden of large temporary files 
  • Design and implement testing suite to ensure robustness, scalability, and reproducibility of existing and new bioinformatic pipelines
  • Review pull requests and ensure internal and external contributors adhere to best practices and ensure compatibility with existing features
  • Assist trainees and staff with converting non-production code (R and Python) into reusable, documented, modular code 
  • Implement a testing framework using continuous integration to ensure the functionality of existing and new code is consistently maintained
  • Evaluate third-party software for new applications and integrate into new or existing pipelines
  • Build on existing databases and expand on existing application programming interfaces

Qualifications

  • Bachelor’s Degree in Computer Science completed

Required Skills:

  • 1+ years of Python programming experience and demonstrated track record in contributing to open-source software
  • Demonstrated proficiency in R (including tidyverse)
  • Excellent problem solving and troubleshooting skills
  • Organization and ability to produce results while maintaining multiple tasks
  • Experience developing software in a Linux or UNIX-like environment including shell scripting and common command-line tools
  • Experienced using Git for source control and willingness to assist a diverse team with its proper use
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment

Preferred Skills:

  • Experience with basic Linux systems administration
  • Effective use of high-performance computing environment using the Slurm workload manager
  • Expertise with automated software testing
  • Package/dependency management expertise (e.g. conda) and/or experience with Docker, Singularity, or Kubernetes
  • Experience with mySQL or similar databases
  • Working knowledge of a combination of Awk and Perl and experience with databases would be beneficial

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: RP_R00008_RDMorin Lab_2011_11_05 in the subject line of your email.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans. As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Research Assistant 2

Application Deadline

JOB SUMMARY

The Aparicio lab uses the latest technologies to rapidly identify genes that are involved in the development of breast cancer. Through the use of single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patient tissues, we hope to gain a better understanding of tumor microenvironment. In addition, we explore the effect drugs on tumor evolution through the use of patient derived xenograft and CRISPR-Cas9. This position involves providing high level, senior technical support in the main areas of molecular biology, biochemistry and cell biology for researchers on current on-going research projects.

We are seeking a highly-motivated and highly skilled individual with expertise or experience in cloning, sub-cloning, CRISPR-Cas9, next-generation sequencing and a strong background in molecular biology; with recent hands-on experience in DNA/RNA extraction and handling, subcloning, cloning and tissue culture. Furthermore, experience, understanding and familiarity with handling of genomics DNA for next-generation sequencing and preparation of next-generation sequencing library will be an advantage.

The successful applicant will work full-time under the direction and supervision of both Dr. Samuel Aparicio, Principal Investigator, and the Laboratory Research and Operations manager. The position will provide the candidate with a high level of exposure to all current on-going project within Aparicio Lab, such as areas of single cell genomics and translational research, CRISPR-cas9 and patient derived xenograft drug screening, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally; position start date is flexible.

ORGANIZATIONAL STATUS

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Institute in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, or Laboratory and Research Operation Manager, in addition, the applicant may assist in overseeing technical work of students and trainees. More information on the lab, please visit https://aparicio.molonc.ca

WORK PERFORMED

  • Plans and performs advance procedures, complex experiments and/or techniques of molecular biology, biochemistry and cell biology for current on-going research projects
  • Oversee progression of projects assigned, in addition, participate, and provide suggestion or expertise for other research activities on-going.
  • Generation, preparation and submission of next-generation sequencing libraries.
  • Using a LMIS system to track and record sample data
  • Provide senior level technical expertise and support in molecular biology, protein biochemistry, tissue culture and virology
  • Developing and implementing standard operating protocols (SOPs).
  • Maintains laboratory records and experimental data.
  • Assist in general lab maintenance such as reagent preparation, receiving and inventory of lab supplies.
  • Assist, develop and/or update Standard Operating Procedures (SOPs) to ensure compliance with regulatory bodies.
  • Presents data at scientific meetings, writes reports and contributes to writing ethics and grant applications when required.
  • Assist in general maintenance of the lab and receiving and inventory of lab supplies.
  • Provide training and instruction for specialized techniques and equipment.
  • Provide expertise in the area of Molecular Biology, Biochemistry and Cell Biology to help troubleshoot complex experimental methods and procedure for staff, junior staff, trainees and students.
  • Assist lab manager with oversight of trainee students.
  • Optimizing existing protocols, as well as, developing new protocol to improve throughput, quality control, efficiency, and/or robustness in collaboration with teammates and other research staff.
  • Carries out any other related duties as assigned or required in keeping with the qualifications and requirements of this technician level.

CONSEQUENCE OF ERROR

The work is of a complex nature and required high level of training, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Errors may result in the permanent loss of irreplaceable tissue samples, loss of thousands of dollars of material and/or damage to equipment.  Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly. Noncompliance with biosafety and chemical safety regulations may also result in closure of facility or loss of grant funding.

SUPERVISION RECEIVED

The successful applicant will work under minimum supervision. From time to time, Principal Investigator or Laboratory Research and Operations Manager may provide specific instructions on unusual problems, or new project outlines. This position will report to the Principal Investigator or Laboratory Research and Operations Manager.   

SUPERVISION GIVEN

Depending on experience and expertise, the successful applicant is expected to assist in training and supervision of graduate students/trainees or junior staff, including providing instruction on use of lab equipment and procedures, and will help troubleshoot experiments in their area of expertise.

QUALIFICATIONS

  • A MSc in Biological Sciences (Molecular Biology or other relevant field) or BSc with 3-5 years of related experience in academic research or biotech industry settings, preference will be given to applicants with work experience in single cell genomics biology or molecular biology.
  • A working knowledge and understanding of advance molecular biology and biochemistry techniques such as next-generation sequencing, PCR, DNA/RNA purification and cloning techniques is essential; prior working experience in next-generation sequencing and library construction is considered a great asset.
  • Experience with cell culture and aseptic technique.
  • Working hands-on experience in tissue handling and tissue dissociation methods would be an asset.
  • Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNA / DNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation, and western blotting.
  • Preference will be given to applicants with, molecular cloning and subcloning, single cell genomics, next-generation sequencing, and 10x Genomics experience.
  • Demonstrated understanding of experimental design and assay optimization.
  • Strong interpersonal skills, communication skills (orally and written) and the ability to interact positively and productively with other team members are essential.
  • Excellent documentation and organizational skills.
  • The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

Please include the following documents when applying:

  • Cover Letter
  • CV
  • Contact information for two or three references

Research Assistant/ Tech 4 - Single Cell Genomics

Application Deadline

Job Summary

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patient tissues and to gain a better understanding of tumor microenvironment. Researchers uses the latest Single Cell Genomics technologies to rapidly identify genes that are involved in the development of cancer. This position will be working on the Single Cell Genomic research projects currently on-going in the research lab, providing technical guidance, expertise, and support to other internal/external researchers on Single Cell Genomics, in addition, helping with continual development and on-going production at 2 separate research facilities located in Vancouver, B.C. 

We are seeking a highly-motivated and highly skilled individual with expertise or experience in single cell genomics, robotics, next-generation sequencing and a strong background in molecular biology. The successful applicant will work full-time under the direction and supervision of both Dr. Samuel Aparicio, Principal Investigator, and the Laboratory Research and Operations manager. Individual should possess a strong molecular biology background; experience with liquid handling robotics is considered an asset. Experience with bioinformatics approaches to biological data and familiarity with handling of genomics and next-generation sequencing data will be an advantage. This position will provide the candidate with a high level of exposure to single cell genomics and translational research, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally; position start date is flexible.


Organizational Status
Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Institute in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, or Laboratory Research and Operations Manager, in addition, the applicant may assist in overseeing technical work of students and trainees. More information on the lab, please visit https://aparicio.molonc.ca



Work Performed

Consequence of Error/Judgement
The work is of a complex nature and required high level of training, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Errors may result in the permanent loss of irreplaceable tissue samples, loss of thousands of dollars of material and/or damage to equipment.  Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly. Noncompliance with biosafety and chemical safety regulations may also result in closure of facility or loss of grant funding.

Supervision Received
The successful applicant will work under minimum supervision. From time to time, Principal Investigator or Laboratory Research and Operations Manager may provide specific instructions on unusual problems, or new project outlines. This position will report to the Principal Investigator or Laboratory Research and Operations Manager.   

Supervision Given
Depending on experience and expertise, the successful applicant maybe be required to assist in training and supervision of graduate students/trainees, junior staff, or external collaborators; including providing instruction on use of lab equipment and procedures, and will help troubleshoot experiments in their area of expertise.

Minimum Qualifications
Completion of a university degree in a relevant discipline or technical program and a minimum four years of related experience or an equivalent combination of education and experience. Some positions may require a graduate degree.

A MSc in Biological Sciences (Molecular Biology or other relevant field) or BSc with 4-5 years of related experience in academic research or biotech industry settings, preference will be given to applicants with work experience in single cell genomics biology or molecular biology.

Preferred Qualifications

  • Plans and performs experiments utilizing established complex procedures and/or techniques for investigating single cell genomics, involving the use of liquid handling robotics and 10x genomics platforms
  • Visualize and analyze cells using microscopy and flowcytometry.
  • Generation, preparation and submission of next-generation sequencing libraries.
  • Using a LMIS system to track and record sample data
  • Provide technical expertise and support in molecular biology, protein biochemistry, tissue culture and virology
  • Develop and implement standard operating protocols (SOPs).
  • Maintains laboratory records and experimental data.
  • Assist in general lab maintenance such as reagent preparation, receiving and inventory of lab supplies.
  • Conducts complex data analysis and interpretation of data resulting from high throughput experiments.
  • Presents data at scientific meetings, writes reports and contributes to writing ethics and grant applications.
  • Carries out any other related duties as assigned or required in keeping with the qualifications and requirements of this technician level.
  • A working knowledge and understanding of molecular biology and biochemistry techniques such as next-generation sequencing, PCR, DNA/RNA purification and cloning techniques is essential; prior working experience in next-generation sequencing and library construction is considered a great asset.
  • Experience with cell culture and aseptic technique.
  • Working hands-on experience in tissue handling and tissue dissociation methods would be an asset.
  • Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNA / DNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation, and western blotting.
  • Preference will be given to applicants with liquid handling robotics, single cell genomics, next-generation sequencing, and 10x Genomics experience.
  • Experience in immunocytochemistry and basic data analysis in R or similar statistics package would be an asset.
  • Demonstrated understanding of experimental design and assay optimization.
  • Strong interpersonal skills, communication skills (orally and written) and the ability to interact positively and productively with other team members are essential.
  • Excellent documentation and organizational skills.
  • Able to multi-task, prioritize and handle multi-project assignments concurrently.
  • The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

Please include the following documents when applying:

  • Cover Letter
  • CV
  • Contact information for two or three references

Project Manager–Personalized OncoGenomics

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: RPC_R00022_POG_2021_10_27

Reporting to the Head Project Management or Projects Team Leader and working closely with the Principal Investigators and Project Leaders, the POG Project Manager will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and monitor and facilitate progress against these objectives and milestones. Projects will involve personalized oncogenomics, immunotherapy, collaborative services management, or other cancer genomics research.

Key Responsibilities

  • Actively manage sample acquisition process, ensuring communication amongst the various parties and troubleshooting any deviations
  • Ad hoc sample process development for atypical samples
  • Point person for questions regarding sample acquisition and responsible for leading acquisition team meetings
  • Assist with site administration set up as needed
  • Maintain accurate tracking on sample status, including sample and associated metadata acquisition, processing, stakeholder reporting
  • Coordinate with clinical team for case presentation at tumour board
  • Coordinate and assist the pathology team as needed, including invoice preparation and assistance with sample retrieval
  • Recommend, develop and implement strategies for improving processes
  • Process development as needed, including design, implementation and documentation
  • Assist with clinical data capture
  • Other duties as required

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged.

Qualifications

While equivalencies will be considered, a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus 5 years' recent related experience in project management and/or research development management would be ideal.

Certification as a Project Management professional and experience in academic scientific research or the biotech or software industry will be helpful. Proficiency with MS Word, Excel and Project, excellent organizational, analytical and verbal and written communication skills are essential.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: RPC_R00022_POG_2021_10_27 in the subject line of your email.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans. As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Quality Assurance Technologist

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: QAT_P00427_HSA116744_QAQC_2021_10_26

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Quality Assurance Technologist assists in the maintenance of Quality Assurance (QA) systems for the Genome Sciences Centre (GSC) production laboratories.  These systems include, but are not limited to, document control, validation, auditing, corrective/preventative actions, and instrument calibration/preventive maintenance.  The Quality Assurance Technologist receives guidance from the Quality Assurance Associate in prioritization and performance of these tasks.

Duties

  1. Assists in establishing QA functions modeled on ISO 9000:2000 standards and Good Laboratory Practices (GLP’s).
  2. Performs daily QA tasks and duties such as:
    • Maintaining formal documentation of laboratory processes (SOPs).
    • Conducting internal and external audits on a regular basis and reporting audit findings in an accurate and timely manner. 
    • Maintaining a comprehensive corrective and preventive action program.
    • Maintaining a validation program for instrumentation and procedures.
    • Scheduling and prioritizing repair and preventative maintenance of laboratory equipment.
  3. Communicates quality policy, metrics and trends to GSC staff.
  4. Participates in the design and development of LIMS and other laboratory software.
  5. Assists in conducting training sessions for production staff.  Maintains training records.
  6. Assists in the provision of input to the technology development staff regarding the development of improved laboratory workflow and procedures.
  7. Performs other related duties as assigned.

Qualifications

Education, Training and Experience

Graduation from a recognized Diploma program in Biotechnology and one (1) years of recent related experience in a research laboratory including experience in a  biotechnology/pharmaceutical Quality Assurance/Quality Control (QA/QC) environment and familiarity with both standard molecular biology techniques and laboratory automation or an equivalent combination of education training and experience.

Skills and Abilities

  • Ability to work effectively, independently, and as a member of a team.
  • Demonstrated ability to organize work and establish priorities.
  • Demonstrated ability to communicate effectively both orally and in writing.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: QAT_P00427_HSA116744_QAQC_2021_10_26 in the subject line of your email.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans. As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Data Manager

Application Deadline

Job Summary

A position with the Department of Pathology and Laboratory Medicine of the University of British Columbia is open immediately for a data manager to work with our interdisciplinary team of researchers and software developers within the Department of Molecular Oncology at BC Cancer Research, part of the Provincial Health Services Authority. We are seeking a creative, experienced, and dedicated individual to play a key role in managing large amounts of experimental and computational genomic research data.

The data manager will become the point person for data needs for both dry and wet lab researchers, students, and managers.  They will be responsible for the accurate organization and curation of thousands of patient’s worth of genomic, administrative, experiment, and sequencing data.  They will work closely with developers to develop computational solutions for storing, organizing, and distributing all the aforementioned data.  They will enact, educate and enforce data storage policies to ensure the organization of the database.  They will be responsible for the resolution of errors existing in database and optimizing costs for existing repositories.

You will be on-site in the Department of Molecular Oncology at BC Cancer, working closely with software developers, students and researchers operating at the leading edge of the field of cancer genomics.  Our department has recently made meaningful advances in understanding of tumour evolution and the software platforms developed in the lab will be used by world-leading scientists at BC Cancer and international collaborators to gain insight into how cancers initiate, develop and acquire resistance to treatment. More information on the lab, please visit https://aparicio.molonc.ca

Organizational Status

We are a small team of software developers and scientists embedded within a larger cancer research lab.  You will be working closely with researchers and developers to ensure the smooth daily operations of the team and the department in their data input and query needs.  You will be reporting to the principle investigator or designate.

Work Performed

  • Research and design data storage policy and best practices pertaining to items such as organization, privacy, security and ethics
  • Implement and enforce data storage best practices on research data
  • Collaborate with developers and researchers to design and create data storage solutions for data from various sources including: administrative, medical, experimental, genomic
  • Ensure the valid and correct entry of data into storage solutions
  • Assist researchers and developers with their data query needs
  • Assist researchers and manager in creating and reviewing data sharing agreements with other researchers and collaborators outside the group

Consequence of Error/Judgement

You will be independently responsible for the smooth daily data operations of the lab as required by the users or the system.  You will be deciding and carrying the best course of action for unforeseen issues and problems involving data input, validation, query and delivery.  Failure to perform may cause minor operational setbacks to reputational and financial impact in the publication and research process.

Supervision Received

You will be supervised by the principle investigator or designate.

Supervision Given

You will help advise and recommend best course of actions to other members of the lab on subjects pertaining to data access and your field of expertise.

Qualifications

Undergraduate or certified degree in information technology, programming or relevant discipline as determined by employer. Minimum of one year of related experience, or the equivalent combination of education and experience.

  • Excellent documentation and organization skills
  • Excellent professionalism and persistence 
  • Friendly and personable with excellent communication skills
  • Experience managing large volumes of complex data
  • Experience in basic scripting
  • Familiarity with scripting and automation
  • Background in biology and/or computational biology preferred

Team Leader, Finance

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job reference number: RPM2_R00024_2021_10_18_Finance

Are you proactive, an expert at multi-tasking, and have outstanding attention to details? Do you have experience working with research grant management? Are you interested in contributing to enabling and supporting world-leading cancer research in a dynamic and inclusive team environment? If so, keep on reading as the GSC has an amazing opportunity for a seasoned leader in finance!

The GSC is looking for a new leader for its Finance team.

The GSC has a complex portfolio of projects, funders and partners, with more than 100 accounts and several dozen funders. As Team Leader for Finance, you will lead a team of five finance coordinators in the accounting team for all project accounts for the department, including reconciliation, reporting, accounts payable and receivable, expense authorizations and audit response. You will also be a key member of the Management and Administration Group, working closely with the leaders of project management, people systems, sourcing and procurement and operations. Team leadership includes performance management and ongoing supervision and mentorship of team members, as well as recruitment of new team members as needed. You may also be included in recruitment for other teams, and have opportunities to contribute to and participate in professional development.

Qualifications

Eligibility

  • Communicates with the various departments and levels of management within PHSA, UBC and SFU to ensure we have the most up to date policies and information for the various accounts, cost centres, financial analysis and reports.
  • Monitors expenditures on a regular basis. Reviews all financial information for GSC core operating and grant funds to ensure transactions are eligible and in compliance with funding agencies, BC Cancer, UBC, and SFU etc.
  • Ensures that monthly reconciliation of accounts and records are maintained and summarized for senior management to review.
  • Ensures core and grant-funded budgets remain within allowable spending limits. Manages the follow-up of accounts over budget by initiating remedial action, including withholding allocation to cost centres and communicating potential risks to scientists and senior staff.
  • Provides input into financial policies regarding the appropriate use of funds, approval process, records and reports to ensure the data integrity.
  • Participates in the creation and maintenance of internal controls.
  • Liaises with other groups within the GSC and the Management team to improve processes and procedures.
  • Supervises staff by providing clear responsibilities. Ensures team is provided with excellent training and mentoring opportunities. Monitors workload and ensures work levels meet operational requirements.
  • Provides period and year-end schedule to help coordinate tasks to ensure information is accurate and completed by reporting deadlines. 
  • Works with BC Cancer Research Finance to provide appropriate information required for internal and external audits.

Skills & Abilities

  • Baccalaureate degree from a recognized University in Business Administration and a Professional Accounting designation (CPA), plus 5 to 7 years of recent related experience in grant fund management; or a combination of skills and experience.
  • Experience managing a team of finance professionals.
  • Strong knowledge and working experience with generally accepted accounting principles and finances.
  • Demonstrated analytical and problem solving skills; strong oral and written communication skills.
  • Ability to be flexible to meet and adapt to changes in organizational priorities in a fast paced environment.
  • Excellent Microsoft Office skills, particularly Excel.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca using Job Reference No: RPM2_R00024_2021_10_18_Finance in the subject line of your email.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans. As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Postdoctoral Fellow

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

The Holt Laboratory at BC Cancer is looking for a qualified candidate to aid in the preclinical and clinical development of novel cancer vaccines and cellular immunotherapies. The candidate will work with local, national and international partners, collaborators and service providers in academia, industry, government and not-for-profit organizations.

Qualifications

  • A recent PhD, and competency with standard methods and approaches in microbiology and immunology, or a closely related field.
  • Familiarity with cancer immunology and immunotherapy 
  • Bioinformatics skills and the ability to analyse large genomics and  proteomics data sets
  • Familiarity with regulatory aspects of preclinical and clinical research methodology
  • Excellent verbal and written communication skills
  • Ability to work in a team environment. 

This position will begin ASAP.  This is a one-year term appointment subject to annual renewal.  Salary will be commensurate with qualifications and experience.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using PDF_01553_2021_10_04_Holt Lab in the subject line of your email.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Postdoctoral Fellow–Bioinformatics

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: PDF_01553_Jones Lab_2021_10_01

The GSC is currently looking for a Post-Doctoral Fellow to work on the Genome Canada funded LSARP, “Canada’s Earth BioGenome project”. 

The successful incumbent will work with the project team to lead the activities on the development, application and validation of novel approaches and workflows in the area of integrated de novo genome assembly over multiple sequencing technologies. They will develop automated bioinformatics workflow as well as assembly submission. They will also work closely together with Earth BioGenome Project (EBP) consortium on the sequencing and assembly standards. The successful incumbent will work with project leaders to ensure all scientific milestones are achieved and contribute to progress reporting as required. There will be expectations to represent the project within the global EBP consortium and the development of outreach materials and website information. Opportunities will exist for further research on the genomic information developed and for scholarly publication.​

Duties

  • Work with multidisciplinary scientists at the GSC and collaborators to analyze whole genome and transcriptome sequence data, and set up collaborative working plans.
  • Develop and maintain bioinformatics pipelines for genome assembly and data analysis.
  • Produce written documentation of algorithms, validations, SOPs, and other processes related to pipeline updates and procedures as required.
  • Present results of bioinformatics software testing internally and externally.
  • Perform literature searches, testing and validation of new data analysis software related to bioinformatics pipelines.
  • Perform other related duties as required.

Eligibility

Skills and Abilities

  • Knowledge of genomics, genome assembly, and genome analysis software.
  • Fluency in one or more programming languages, such as Python, Javascript and SQL.
  • Experience working in a UNIX/Linus environment and writing shell scripts.
  • Previous API development projects using Open API or Rest API is a plus.
  • Excellent communication and organization skills and ability to efficiently manage time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities.
  • Ability for critical thinking and independent learning.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using PDF_01553_Jones Lab_2021_10_01 in the subject line of your email.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Research Associate–Bioinformatics

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values — science, timeliness, respect — to join us on our mission to use genome science for the betterment of health and society.

Job Reference No.; RA_R00006_Jones Lab_2021_09_28

Summary

The GSC is currently looking for a Research Associate to work on the Genome Canada funded LSARP, “Canada’s Earth BioGenome project”. 

The successful incumbent will work with the project team to lead the activities on the development, application and validation of novel approaches and workflows in the area of integrated de novo genome assembly over multiple sequencing technologies. They will develop automated bioinformatics workflow as well as assembly submission. They will also work closely together with Earth BioGenome Project (EBP) consortium on the sequencing and assembly standards. They will work with Project Leaders to ensure all scientific milestones are achieved and contribute to progress reporting as required. There will be expectations to represent the project within the global EBP consortium and the development of outreach materials and website information. Opportunities will exist for further research on the genomic information developed and for scholarly publication.​

Duties

  • Work with multidisciplinary scientists at the GSC and collaborators to analyze whole genome and transcriptome sequence data, and set up collaborative working plans.
  • Develop and maintain bioinformatic pipelines for genome assembly and data analysis.
  • Produces written documentation of algorithms, validations, SOPs, and other processes related to pipeline updates and procedures as required.
  • Presents results of bioinformatics software testing internally and externally.
  • Performs literature searches, testing and validation of new data analysis software related to bioinformatics pipelines.
  • Performs other related duties as required.

Skills and Abilities

  • Expertise in bioinformatics, emphasizing genome sequence analysis and gene annotation.
  • Knowledge and experience using scientific tools, technologies and online resources as pertaining to de novo genome assembly.
  • Fluency in multiple programming languages, including Python, Javascript and SQL.
  • Expertise developing and operating in a UNIX/Linus environment and writing shell scripts.
  • Experience developing custom scripts and pipelines using high performance computing and other available tools. Pipelines may include de novo assembly, annotation, database query, pan-genome construction and visualization tools, RNA-seq, phylogenetic tree reconstruction.
  • Previous API development projects using Open API or Rest API is a plus.
  • Excellent communication and organization skills, and ability to efficiently manage time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities.
  • Ability for critical thinking and independent learning.
  • Experience in a supervisory role is an asset.  

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using RA_R00006_Jones Lab_2021_09_28 in the subject line of your email.

This position will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Process Development Coordinator–Clinical

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values — science, timeliness, respect — to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: PCD_E00375_Clinical_2021_08_11

Reporting to the Bioinformatics Group Leader the Process Development Coordinator (PDC) will support the development, testing and validation of clinical bioinformatics processes at the Genome Sciences Centre (GSC)—a large scale, high throughput biologics facility. The PDC will develop new Clinical procedures and bioinformatic workflows, monitor and review performance within the clinical production process, and where applicable, improve existing analyses.

Scope and complexity

The PDC monitors existing processes and recommends and/or develops new processes in support of the clinical sequencing objectives at the GSC. The PDC designs and performs informatic experiments to validate either existing methods or novel methods providing new functionality. The successful candidate will strive to streamline existing functionality, and maximize output quality and efficiency while balancing costs. Monitoring of results and comparison to outlined standards will be performed.

The PDC collaborates closely with key stakeholders for the clinical process including the clinical director, bioinformatics groups and quality assurance group.

Duties/Accountabilities

Oversees the development and testing of clinical bioinformatics production processes by:

  1. Designing and performing experiments pertaining to the generation of clinically relevant results.  This includes, but is not limited to, the development and testing of new analyses, protocol optimization, Quality Assurance and Quality Control, testing of prototypes and related activities. The PDC continually monitors performance of protocols within the production process and identifies areas for improvement. All activities will yield documented recommendations and implementation plans.
  2. Troubleshooting existing clinical computational processes where necessary. Makes recommendations and adjustments and reports problems.
  3. Training designated members of the clinical bioinformatics group in new or optimized analysis workflows. Writes or revises protocols accordingly.
  4. Performing technical functions related to the Bioinformatics groups of the GSC.
  5. Other related duties as necessary.
     

Qualifications

  • Graduation from a recognized Bachelor’s program in an appropriate discipline such as Computer Science, Bioinformatics, Genetics, Molecular Biology or Biochemistry (PhD) preferred).
  • Five (5) years of recent related experience in a research and or clinical laboratory including supervisory experience

OR

An equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and knowledge

  • Proven expertise with Python and/or other similar high level languages.
  • Demonstrated ability in R or other similar statistical programming languages and in statistical analysis.
  • Functional knowledge of distributed version control systems, such as Git.
  • Demonstrated experience with next generation/ third generation sequencing technology with an in-depth understanding of standards and guidelines for validating clinical bioinformatics analysis pipelines using these technologies.
  • Excellent verbal and written communication skills.
  • Comfortable working in a Linux environment, including experience with shell scripting and common command-line tools.
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
  • Experience liaising with multiple stakeholders to support consensus goals.
  • Demonstrated ability to efficiently organize work assignments and establish priorities to meet set milestones.
  • Demonstrated ability to write technical documents including validations and procedure manuals
  • Excellent analytical skills
  • Demonstrated ability to accept responsibility and work independently.
  • Experience with bioinformatic workflow managers eg Nextflow would be considered an asset.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using the Job Reference No. PCD_E00375_Clinical_2021_08_11 in the subject line of your email.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Postdoctoral Fellow, Immune-oncology

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values — science, timeliness, respect — to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: PCD_E00375_Evgin Lab_2021_08_11

Role Summary

A postdoctoral position is immediately available in the Genome Sciences Centre at the BC Cancer Research Institute in the group of Dr. Laura Evgin to participate in research investigating cell therapy and viro-immunotherapy for lymphoma. The research will focus primarily on the development of novel combinatorial strategies using oncolytic viruses and vaccines to leverage CAR T cell efficacy.

The ideal candidate should possess a PhD degree and recent experience in immunology, virology, genomics, cancer biology, cell biology or a related discipline. A strong background in immunology and record of accomplishment (first-author publications) is required. Proficiency in classical immunologic and molecular biology techniques including primary cell culture, rodent (mouse) handling and injections, cloning, virus infections, and multi-parameter flow cytometry are needed for success in this position. A background in bioinformatics is also an asset. In addition, the successful candidate should demonstrate creativity, a strong work ethic, and the ability to handle multiple projects. Excellent verbal and written communication skills are important, as well as the ability to work in a team environment. 

This is a one-year term appointment subject to annual renewal. 

Apply

Applicants should submit a CV, a one-page cover letter highlighting research interests and goals, and the name and contact details of 3 references. Please email your application to bcgscjobs@bcgsc.ca with "Job Reference No: PCD_E00375_Evgin Lab_2021_08_11" in the subject line.

While we appreciate all applications, please note that only selected candidates will be contacted.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Research Project Manager (temporary leave replacement)

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values — science, timeliness, respect — to join us on our mission to use genome science for the betterment of health and society.

Summary

This position is for a temporary 18-month leave replacement.

Job Reference No: RPC-R00022-2021-08-11

Do you have a background in science research — from its processes and practices to proposals & peer-review? Can you develop an award winning grant application, facilitate efficient and productive meetings, gather the right information and engage the right people at the right ti​me? We're looking for a Research Project Manager to help GSC faculty and leaders continue to deliver world-leading genomics, bioinformatics, cancer and precision medicine research.

Reporting to the Head, Project Management or Projects Team Leader and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and monitor and facilitate progress against these objectives and milestones. Projects will involve personalized oncogenomics, collaborative services management, or other cancer genomics research.

Duties/Accountabilities

  • Establishing budgets for research projects, grants, collaborations and core activities
  • Assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
  • Monitoring budgets and expenditures
  • Establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives, which may include, meeting coordination and follow-up, coordination of case reviews
  • Maintaining accurate information on sample status, including sample and associated metadata acquisition, processing, stakeholder reporting
  • recommending strategies for improving projects management methods and processes
  • Liaising with grant/core funding agencies
  • Interacting directly with research collaborators or clinical study teams as required

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research, clinical trials research, biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

Successful candidate(s) will be offered positions through Provincial Health Services Authority at level Research Project Coordinator, which is equivalent to that described above

Core Skills and Abilities

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Project Manager in the subject line of your email.

This posting will remain online until filled.

Important!

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Research Programmer - Jones Lab

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: RP_R00008_Jones Lab_2021_07_30

The GSC is looking for an enthusiastic and self-motivated Research Programmer to work on the next generation of federated genome and health data sharing platform, CanDIG—a Canadian data-sharing platform contributing to the development of an international effort to facilitate information exchange as part of the Global Alliance for Genomics & Health (GA4GH). CanDIG also supports large-scale provincial and national data sharing projects, including BC Cancer’s Personalized OncoGenomics program, the Terry Fox Research Institute's (TFRI) PROFYLE project and the TFRI-led Marathon of Hope Cancer Centres Network—a major federal initiative to accelerate the adoption of precision medicine for cancer in Canada. This role requires a combination of interest in DNA technology and a strong background in software development.

Key Responsibilities

  • Designs, plans and implements computer modeling of research data.
  • Works with other project team members to develop and test code, and implements software.
  • Develops graphical user interfaces.
  • Prepares programming documentation in accordance with prescribed standards.
  • Conducts literature reviews and provides input and recommendations to the Department Head or Principal Investigator regarding new computer applications or statistical techniques.
  • Participates in the lab meetings and presents work for review by others.
  • May provide day to day work direction to others.
  • Provides contributions to the preparation and/or presentation of research papers.

Qualifications

The successful candidate will have an undergraduate degree in computer science, bioinformatics or a related subject.

Abilities

  • 2+ years of experience in Python programming.
  • Previous experience or exposure in the bioinformatics settings.
  • Full stack web development experience with web frameworks such as Flask or Django.
  • Previous experience in designing, implementing and testing REST APIs.
  • General understanding or previous experience in microservice architecture and development.
  • General knowledge in Unix environment, Version Control (Git), and Agile methodologies. 
  • The position requires working with a wide variety of researchers, software developers and clinicians, thus excellent communication skills are essential.

Assets

  • Experience or knowledge in handling genomics data files.
  • Prior experience in developing front-end applications using React.js.
  • Experience building rich queries using GraphQL or other data query language.
  • Experience working with distributed systems.
  • Basic understanding of DNA technology or previous work experience with genetic data is a plus, but not required for the position.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: RP_R00008_Jones Lab_2021_07_30 in the subject line of your email.

This posting will remain online until filled.

Important

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Business Analyst and Project Support

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: RPC2_R00026_2021_07_06

Reporting to the Manager, QA/QC, the Business Analyst and Project Support (BA) leads the analysis and documentation of business requirements to support projects for designated programs/services. This position works in close collaboration with other stakeholders to develop business systems enhancements, business solutions, or business processes including GSC’s bioinformatics processes. The BA functions as a Subject Matter Expert (SME) to the project team through performing gap analysis of systems and business process mapping including the identification of linkages to other business systems.  

The BA will:

  • Provide key contributions to the development of solutions to ensure that business processes and/or project deliverables are consistent, accurate, and timely.  
  • Participate in and contributes to strategic planning. 
  • Develop project plans for the design, development, and implementation of new business processes, and supports the transition from current systems, practices and processes to an integrated system, common practices, and standardized processes with current or improved functionality.  

Responsibilities

  • Ensures key results are achieved in accordance with the project plan by analyzing current business systems and processes, generating ideas and formulating recommendations/options, and supporting members of the project in prioritizing tasks and reaching decisions that are within project scope and timelines. 
  • Implements or contributes to the implementation of effective processes to assess project risks, identifies risk mitigation strategies and monitors risk throughout the project lifecycle. Supports the Managers/Team Leads by providing regular updates on the progress as well as any areas of risk associated with the completion of the project both within the project scope and the timeline. Provides professional expertise to staff, departments, stakeholders, and guidance regarding standard process for project management.
  • Coordinates and participates in the analysis, acceptance criteria definition, development, testing, training, implementation, and maintenance phases of assigned bioinformatics projects. Carries out post-implementation reviews of systems and makes recommendations for improvements.
  • Utilizes formal data gathering techniques and analysis tools such as flowcharts, diagrams, dashboards, roles and responsibility matrix (RACI), and work effort estimates. Provides details of estimated implementation costs including associated staffing requirements.
  • Reviews, analyzes and defines current/future state processes, determines user and/or department requirements and contributes to the development of specifications and testing for all identified development, system modifications, and installations. Performs impact analyses. 
  • Provides user support, advice and guidance, and orientation in situations that require interpretation and judgement Develops content, as required, for training modules, delivers training, and provides and guidance to system users and department staff. Develops and maintains various business processes, policies and procedures, as well as reference documentation such as user instructions, manuals, and reference materials.  
  • Provides support to colleagues and users during the development, maintenance and operation of various computer systems by performing duties such as troubleshooting system software problems and testing alternative solutions. 
  • Participates in the formal data collection and analysis to help identify system deficiencies and/or operational inefficiencies in order to report and develop new ways of improving business efficiencies including the data analysis related to business case developments, project proposals, and other key strategic and transformative initiatives. 
  • Assembles, creates and maintains information systems technical and operational documentation according to departmental standards.
  • Assists with preparation of Requests for Information/Proposal, development of evaluation processes and tools, and evaluation of vendor responses by serving on working groups, documenting detailed requirements, and coordinating project team and vendor communications.

Education and skills

  • A level of education, training, and experience equivalent to a Bachelor's degree in Health Information Science, Computer Science, or a related discipline, plus five (5) years recent related experience which includes software/system project planning, analysis and implementation.  
  • Demonstrated ability to carry out business process mapping and fit gap analysis.  
  • Excellent interpersonal, oral, and written communication skills with the ability manage multiple interactions with multiple groups while working on multiple issues at the same time.  
  • Superior analytical, problem-solving and system analysis skills.  
  • Proven ability to plan and execute projects with stringent timelines.  
  • Ability to work effectively as part of a team.  
  • Demonstrated ability to provide professional expertise to staff, departments and GSC stakeholders, and guidance regarding standard processes for software/computer system related project management.  
  • Demonstrated ability to provide user support, advice and training, and other user liaison services.
  • Public Service and Health Sector experience and knowledge are an asset.  

How to apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Business Analyst and Project Support in the subject line of your email. 

This posting will remain open until filled.

Important!

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. 

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Biostatistician - Centre for Lymphoid Cancer

Application Deadline

Role Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient and employee safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Reporting to the Clinical and Research Directors of the Centre for Lymphoid Cancer, BC Cancer Agency, the Biostatistician provides support in the areas of study design, analysis, and consulting for biological and clinical cancer research. This role oversees survival analysis and statistical modeling of clinico-biologic factors associated with patient outcomes and maintains information collected in the provincial clinical lymphoma database. The Biostatistician also provides the monitoring of lymphoid cancer interventions and lymphoid cancer health service performance indicators for use in the planning, implementation and evaluation of lymphoid cancer care in the province. The Biostatistician is responsible for tracking trends and detecting emerging issues and associations between a wide range of lymphoid cancer risk factors, health determinants, and health outcomes. The Biostatistician manages the preparation of annual, quarterly, period, and ad hoc reports and is responsible for ensuring high quality and accuracy of these reports. The Biostatistician is responsible for providing statistical support and maintains the integrity of the data to a renowned lymphoma cancer research group which consists of Clinicians, Researchers, Biologists, and Bioinformaticians on lymphoma cancer research and related projects.

Key Accountabilities

  • Develops novel statistical models to discover untapped potential in  clinical data, biological phenomena, and novel associations of clinic-biologic factors with patient outcomes.
  • Monitors and assesses existing provincial clinical database of lymphoma patients to provide accurate and timely information. Provides regular reports and presentation of statistical analyses and results to the group
  • Provides support for the development and collaboration of experimental design of research projects to ensure statistical rigor. Evaluates existing and emerging data analysis tools, provides recommendations regarding new tool adoption and performs risk/impact analyses in support of the planning of system development, enhancement and maintenance.
  • Performs quantitative data analyses using advanced statistical methodologies and statistical software.
  • Identifies and provides advice about data limitations and ensures adequate data quality for analytic purposes.
  • Links data sources from the provincial clinical lymphoma database with other major health information systems such as the Ministry of Health (Vital Statistics, hospital discharge database, Pharmanet, Medical Services Plan). Maintains relationships with senior managers in these organizations; takes measures to protect all data and information being used to comply with protection of confidentiality and privacy policies.
  • Develops and produces analytical outputs (e.g. reports, presentations, posters) that support the Centre for Lymphoid Cancer Agency and BCCRC Committees in the monitoring, planning and evaluation of population trends, health services utilization, and health outcomes for lymphoid cancer interventions, including health care system quality trends and variations.
  • Develops and produces reports that monitor and benchmark cost, utilization, quality and other performance indicators and communicates findings to the BCCRC and PHSA Executives, PHSA Board, Ministry of Health and external stakeholders at the local, regional, provincial and national levels. Formulates recommendations based on findings, including strategic interventions, program and costing recommendations. Represents the Centre for Lymphoid Cancer in various meetings as a speaker or contributor.
  • Plans, develops and delivers training programs, initiatives and materials related to lymphoid cancer research and data analyses in collaboration with BCCRC staff and other organizations throughout the province.
  • Identifies learning needs that contribute to skill enhancement and career progression for self and fosters a working environment that stimulates learning and inquiry for self and others. Takes responsibility for keeping self-up-to-date regarding new initiatives, developments and trends in statistical analysis, renal utilization and health services issues through literature review, contact with peers at other organizations, professional associations and attendance at conferences, seminars, workshop and education programs. Communicates information and makes recommendations to the Clinical & Research Directors for evaluation and approval.

Qualifications

A level of education, training, and experience equivalent to a Master’s Degree in Biostatistics, Statistics, Epidemiology, Health Information Science, or Computer Science and five (5) years of experience in a health analytics, health research or health information field. Understanding of molecular biology and cancer genomics is an asset.

Advanced knowledge of frequentist statistics, probability distributions, statistical inference and modeling, particularly Bayesian statistics and machine learning. Knowledge of database management principles. Exceptional knowledge of survival analysis, including cox regression, Kaplan-Meier estimation, statistical language R and experience using ‘Rmarkdown’ or an alternative statistical language. Experience in database graphical, presentation, communication and software applications, such as Linux, MS Access and SQL. Strong analytical, problem-solving and system analysis skills including the ability to comprehend complex issues and related data/information and present information in concise meaningful ways. Ability to develop complex and customized queries and reports. Ability to function in a self-directed manner. Excellent ability to communicate effectively both verbally and in writing. Demonstrated interpersonal skills with a variety of people. Excellent time management skills. Demonstrated ability to respond to the needs of stakeholders supported by an acute awareness of the impact of actions. Ability to handle multiple concurrent tasks. Physical ability to perform the duties of the job.

Research Project Manager

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values — science, timeliness, respect — to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: RPC-R00022-2021-05-28

Do you have a background in science research — from its processes and practices to proposals & peer-review? Can you develop an award winning grant application, facilitate efficient and productive meetings, gather the right information and engage the right people at the right ti​me? We're looking for a Research Project Manager to help GSC faculty and leaders continue to deliver world-leading genomics, bioinformatics, cancer and precision medicine research.

Reporting to the Head, Project Management or Projects Team Leader and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and monitor and facilitate progress against these objectives and milestones. Projects will involve personalized oncogenomics, collaborative services management, or other cancer genomics research.

Duties/Accountabilities

  • Establishing budgets for research projects, grants, collaborations and core activities
  • Assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
  • Monitoring budgets and expenditures
  • Establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives, which may include, meeting coordination and follow-up, coordination of case reviews
  • Maintaining accurate information on sample status, including sample and associated metadata acquisition, processing, stakeholder reporting
  • recommending strategies for improving projects management methods and processes
  • Liaising with grant/core funding agencies
  • Interacting directly with research collaborators or clinical study teams as required

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research, clinical trials research, biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

Successful candidate(s) will be offered positions through Provincial Health Services Authority at level Research Project Coordinator, which is equivalent to that described above

Core Skills and Abilities

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Project Manager in the subject line of your email.

This posting will remain online until filled.

Important!

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

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