Careers

Start Date:

June 1, 2020

Duration of Position:

June 1 – September 3^rd  2020

Job Title:

Co-op Student

Hourly rate:

$15/hr

Supervisor’s Name:

Francois Bénard

Administrative and Research Manager:  Heather Saprunoff – Functional Imaging

Supervisor’s email:

hsaprunoff@bccancer.bc.ca

Role Summary:
Co op Student Clinical Study Data Entry and Office Assistant

Key tasks include:

Student will use a variety of computerized database and query tools, spreadsheets, and word processing software to perform data updating, data retrieval, and performing basic analysis for database completion. Maintains study related documentation and performs data management functions to ensure accuracy and quality of information management systems including clarifying discrepancies and editing/correcting/inputting data.

Performs follow up phone calls to study participants and completes study forms for upload to the required databases. Performs follow up phone and email requests to physicians’ offices for required study documentation.  Will complete training on policies required before undertaking research involving humans; provided in house. Performs clerical duties such as photocopying, filing, and maintaining and/or creating electronic folders.

Qualifications:

A level of education, training, and experience equivalent to completion of Grade 12, supplemented by recognized university level science courses. Strong knowledge of Excel and word processing software. Detail orientated with the ability to work quickly and accurately. Ability to communicate effectively verbally and in writing and respond professionally to internal and external inquiries. Ability to demonstrate tact and discretion in preparing, disclosing and handling information of a confidential nature

To apply:

To apply please send your CV and cover letter to careersmolonc@bccrc.ca with subject line: Co-op Bénard lab.

JOB SUMMARY

Researchers in the Department of Molecular Oncology at the BC Cancer Research Centre use the latest technologies to rapidly identify genes that are involved in the development of cancer. This position will be involved in performing research in drug pharmacology directed at human tumours, with assays in immunodeficient mice (xenotransplants).

ORGANIZATIONAL STATUS

The successful applicant will report to the Principal Investigator or his/her delegate and may assist in overseeing technical work of students and trainees.

WORK PERFORMED

- Plans and performs experiments utilizing complex procedures and/or techniques.

- Processes tissue samples and carries out primary cell isolation as instructed.

- Carries out laboratory techniques following standard operating protocols.

- Maintains laboratory records of both animal data and experimental data; when require summarize results in research reports and lab presentations.

- Assists senior level staff with writing and updating Standard Operating Procedures (SOPs) and Animal Ethics Certificates.

– Assists in the daily care of transgenic animals and maintains colonies of human tumour bearing immunodeficient animals.

- Carries out and oversees procedures involving immunization, oral gavage, injections, tumour inoculation, tumour volume measurements, blood and tissue collection, surgical procedures, necropsy, and post-operative care.

- Daily health monitoring and care of laboratory animals.

- Be able to recognize and resolve behavioral and/or housing issues; may provide technical instruction and training for other staff and/or trainees for those activities.

- Performs other related duties as assigned.

– On a rotation basis, must be available for emergency calls 24/7 and respond appropriately.

CONSEQUENCE OF ERROR

The work is of a complex nature, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Non compliance with ARC regulations may result in closure of facility. Non compliance with animal protocols may result in loss of grant funding.

SUPERVISION RECEIVED

The successful applicant will report to the Principal Investigator or designate.

SUPERVISION GIVEN

The successful applicant will assist in training graduate students/trainees including instruction in use of lab equipment and procedures and will troubleshoot experiments in their area of expertise.

QUALIFICATIONS

Undergraduate degree in a relevant discipline or Graduation from a technical college or institute. A postgraduate degree in Science is preferred. CALAS certification (e.g. RLAT) is an asset. Minimum of 3 years related experience or the equivalent combination of education and experience. Experience in the monitoring and management of human tumour bearing animals is essential and central to the role. A working knowledge of the CCAC guidelines and compassion and sensitivity for animals required. Experience with cell culture and aseptic technique preferred, involving both isolation and maintenance of rodent primary cultures and cell lines. Experience in the use and handling of hazardous materials such as biological agents, radioactive substances and/or cytotoxic drugs is essential. Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNNDNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation and western blotting. Demonstrated understanding of experimental design and assay optimization. Strong interpersonal skills and the ability to interact positively and productively with other team members are essential. Ability to communicate effectively both orally and in writing. The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively

APPLICATION INSTRUCTIONS

To apply please send your CV and cover letter to careersmolonc@bccrc.ca with subject line: RA/Tech 3.

Postdoctoral Fellow
Job code: LYMPHOMA-PDF
Lab/group: Ryan Morin Lab  

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

Role Summary
The Morin and Scott laboratories are seeking a Postdoctoral Fellow to take a leadership role in an ongoing effort to resolve the molecular aetiology of aggressive lymphoid cancers using genomic techniques. This individual will work closely with a team of bioinformaticians, biostatisticians and clinician-scientists in a highly productive and stimulating research environment at a world-class research facility in Vancouver, Canada.

The successful applicant will apply cutting-edge bioinformatic techniques to analyze hundreds of terabytes of high-throughput sequencing data produced from clinical cancer samples, namely RNA-seq (bulk/single cell), whole exome, whole genome, and circulating tumour DNA sequencing data. This position demands a strong background in bioinformatics, computational biology or data science. Detailed knowledge of cancer biology (particularly non-Hodgkin lymphomas) would be an asset.

Familiarity with algorithms for inferring clonal structure of tumours and network/pathway deregulation from sequence data is also desirable. Experience with machine learning, statistical modelling, survival analysis, and data visualization are all desirable. Characteristics of the ideal candidate include strong verbal and written communication skills, attention to detail, creativity, and the ability to remain organized in a fast-paced and dynamic environment. The successful candidate will thrive in our highly collaborative setting while also being able to drive projects independently.

Diversity is an integral part of Canadian history, culture, and identity. In the Morin laboratory, we strive to maintain an equitable and inclusive culture where all forms of diversity are seen as added value in the unifying goal of reducing the impact of cancer.

The successful candidate will report to Drs. ​Ryan Morin​ and David Scott and will be affiliated with Canada’s Michael Smith Genome Sciences Centre at BC Cancer.

Key Responsibilities :
Duties will include some combination of the following:

• Deploy pipelines to detect somatic alterations such as CNAs, SNVs, indels and structural alterations/fusion transcripts
• Perform clustering analyses on mutational and/or gene expression features to identify novel subgroupings
• Develop machine learning models for the accurate identification of somatic mutations in heterogeneous and/or noisy tumour samples (e.g. FFPE, unpaired, ctDNA)
• Identify cis-regulatory mutations using copy number, SV, and non-coding mutations
• Quantify mutational signatures de novo or using reference signatures for simple somatic mutations and SVs
• Model the effect of coding and non-coding mutations, respectively, on protein and RNA structure and function
• Resolve clonal substructure and track tumour evolution using tissue biopsies and ctDNA
• Identify gene expression or splicing features associated with clinical or genetic variables
• Create bespoke visualizations of high-dimensional genomic datasets
• Design and execute experiments and disseminate results through conference presentations and publications
• Contribute to the writing of grant applications and training of junior lab members

Qualifications
Suitable candidates should possess a PhD degree in bioinformatics, computer science, or molecular biology and must be competent in at least one programming language such as Python or R.

To apply
Applicants are requested to send a cover letter and CV to rdmorin@sfu.ca with LYMPHOMA-PDF in the subject line

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, religion, gender, pregnancy, marital status, national origin or ancestry, disability, age, sexual orientation or gender identity.

Reporting to the Department Head or designate, the Administrative Coordinator, BC Cancer Research Centre is responsible for providing support in areas of human resources, payroll, grant and research administration. This role, on behalf of Principal Investigators (PI’s) and leaders, monitors payroll and financial cost centres through to resolution of payroll issues. The Administrative Coordinator also provides administrative support including managing the grant application process and providing work direction to junior administrative staff in the team.

Key Accountabilities

• In collaboration with the Principal Investigator(s) (PIs) coordinates the preparation and submission of grant proposals by identifying submission guidelines, collating information required and ensuring submission deadlines are met. Follows up with the granting agency on the submission of proposals, monitors post award financial accounts to ensure accuracy. Provides progress reports, highlights discrepancies and provides recommendations to resolve discrepancies and budget concerns to the PI(s) as appropriate.
• Interacts with a variety of individuals and agencies such as universities and granting agencies both national and international. Ensures flow of information with internal and external stakeholders regarding grant related matters and makes arrangements for visiting speakers and guests.
• Human resources responsibilities include recruitment of staff by posting/advertising internally and externally (UBC), coordinating interviews and screening applications for review by hiring supervisors. Manages new hires orientation process in the department and ensures all safety and personnel documentations are in place according to policies, guidelines and legislations.
• Ensures all hiring, appointment and payroll processes such as new hire letters and timekeeping are complete for employees. Liaises with various PHSA units such as Payroll and Human Resources and in some cases, UBC to ensure a seamless process and minimize errors. Brings issues and recommendations of remedies to department head or designate for approval.
• Acts as the main contact for ordering supplies for the department and approves lab and office supplies by performing duties such as submitting purchase requisitions and obtaining authorizing signature as necessary. Manages and processes various requisitions such as travel, expense reimbursements, cheque requests, and honorariums for the Department Head and PIs. Acts as liaison with various departments of BCCA/PHSA including purchasing, stores, and finance to obtain information and follow-up on the status of outstanding issues and requests.
• Coordinates registration and travel arrangements for staff attendance at seminars and meetings. This includes completing registration (on-line or phone), abstract submission, making travel and lodging reservations, culminating expense reimbursements to the attendee and/or cost recovery from the conference organizers as appropriate.
• Provides work direction to junior and contract administrative staff including orientating new staff and assigning and reviewing work, coordinating work assignments to ensure completion, answering questions and providing support, ensuring policies and procedures are followed and providing input to performance evaluations as required.

Qualifications

A level of education, training, and experience equivalent to a Diploma in a relevant area such as business administration or finance from a recognized college plus three (3) years’ recent related experience a research environment and in project management.

Strong interpersonal and communication skills and the ability to demonstrate good judgment, tact and discretion. Detail oriented and able to complete accurate work in a timely matter. Demonstrated time management skills and ability to assist others in meeting deadlines.  Knowledge of and experience with grant applications.  Knowledge and experience in budget preparation, tracking expenditures and identifying sources of variance. Proficient in scientific and medical terminology.  Ability to work both independently and as team leader to organize work and manage multiple priorities in a fast paced environment. Demonstrated ability to make sound decisions and resolve administrative issues/problems. Fully proficient in the use of a variety of software packages including word processing, spreadsheets and databases and related equipment. Demonstrated ability to evaluate personal work and existing systems and identify areas for improvement. Physical ability to perform the duties of the position.

To apply: Please send cover letter and resume to careersmolonc@bccrc.ca  – Please put “Admin Coordinator” and your full name and Job title in the subject line.

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position. This is a regular full-time staff position and a non-academic option for Research Associates who have completed their term(s) at PHSA and are transitioning from the academic path to begin conducting scientific research outside the academic research stream.  It is also suitable for individuals who have gained experience at external organizations and who meet the required qualification criteria.  The staff scientist performs the duties of a Research Associate but works with more independence. Role Summary

Working under the supervision of the Principal Investigator, these positions propose experimental hypotheses, design experimental questions and protocols, and plan, coordinate, conduct and report on assigned research projects.  They evaluate research data, revise techniques and develop new methods and approaches to solve scientific problems.

Key Accountabilities

Proposes experimental hypotheses for research and designs experimental questions and protocols in consultation with the Principal Investigator. Applies standard scientific techniques and utilizes technical expertise and experience to plan, coordinate, conduct and report on assigned research projects.  Notifies Principal Investigator of issues related to laboratory protocols and experimental designs and recommends solutions. Prepares Research Ethics Board applications and amendments as required, and ensures compliance with Research Ethics Board guidelines. Develops new laboratory methods and modifies existing procedures to facilitate research projects. Collects, records, analyzes, validates, interprets and organizes experimental and research data and communicates scientific findings to Principal Investigator.  Recommends research direction based on preliminary findings in consultation with the Principal Investigator. Sources funding opportunities and provides input into writing research proposals and developing budget for grant applications. Writes grants to secure funding in support of research projects when permitted by funding agency and supported by the Department Works with department administration to monitor and report on project budget and expenditures to ensure prudent use of financial resources. Conducts regular literature reviews relating to research areas.  Contributes intellectual and scientific input to manuscripts for publications.  Presents research findings at national and/or international conferences. Facilitates constructive and collaborative relationships with both the Principal Investigator and internal and external research partners.

Qualifications

A level of education, training and experience equivalent to a Ph.D. in a related scientific field plus five (5) years of recent, relevant post-doctoral research experience.

Role Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position. These are fully qualified working level positions.  Incumbents have directly related laboratory experience and familiarity with specific research programs and methodologies of the hiring laboratory.  They work under supervision and perform experiments by following established laboratory procedures.  They report to the Department Head, Principal Investigator, or designate.

Key Accountabilities

Performs a variety of established technical procedures according to written protocols. Performs experiments by following established laboratory procedures according to written protocols. Records results, including computer data entry. Provides input regarding modification of procedures as requested by the Department Head, Principal Investigator, or designate. Maintains and stores cell lines and primary cultures. Maintains and stores test materials and products. Maintains inventory of laboratory supplies and equipment. May demonstrate work methods or procedures to less experienced assistants as designated.

Qualifications

A level of education, training, and experience equivalent to graduation from a recognized Bachelor’s program in an appropriate discipline (e.g. Bachelor of Science); plus two (2) years of recent related experience in a research laboratory.

We are looking for outstanding, motivated graduate students as well as postdoctoral fellows to join the Kuchenbauer Lab, who can share our passion for medicine/science and want to make a difference for patients´ lives.

Our research is mainly translational and focuses on immunotherapies such as allogenic stem cell transplantation for acute myeloid leukemia. We are driven to improve patients’ lives by addressing clinical “every day” challenges with state of the art research including preclinical animal models. Our goal is to translate our research into clinically applicable therapies. Scientific focuses are hematopoietic stem cell transplantation, hematopoietic stem cells physiology and pathophysiology as well as innovative treatment for Multiple Myeloma.

Multiple positions are available, starting as earlier as September 2018. Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to Dr. Arefeh Rouhi (arouhi@bccrc.ca).

We are looking for outstanding, motivated graduate students as well as postdoctoral fellows (full time or part time) who share our passion for medicine/science and want to make a difference for patients´ lives.

Our research is mainly translational and focuses on immunotherapies such as allogenic stem cell transplantation for acute myeloid leukemia. We are driven to improve patients' lives by addressing clinical “every day” challenges with state of the art research including preclinical animal models. Our goal is to translate our research into clinically applicable therapies. Scientific focuses are hematopoietic stem cell transplantation, hematopoietic stem cells physiology and pathophysiology as well as innovative treatment for Multiple Myeloma.

Multiple positions are available, including research students or technicians.  Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to Dr. Arefeh Rouhi (arouhi[@]bccrc.ca).

One graduate student position is available at the Department of Molecular Oncology, BC Cancer Research Centre for the development of novel radiopharmaceuticals for detection and radiotherapy of cancer. The graduate student candidate will register through the Interdisciplinary Oncology Program (www.iop.ca), University of British Columbia, and pursue either a MS or PhD degree.

The student candidate will conduct research on the design and synthesis of imaging probes and radiotherapeutic agents targeting biomarkers overexpressed in cancers. Research activities will involve the production and isolation of radioisotopes, peptide and multi-step organic synthesis, and radiolabeling small molecules, peptides and antibodies with imaging or radiotherapeutic isotopes.

Qualified candidates should have a bachelor degree preferably in chemistry with interests in organic or medicinal chemistry. The ability to conduct research in a collaborative environment is required including good oral and written communication skills in English. For more information regarding application for the Interdisciplinary Oncology Program at the University of British Columbia, please check the following website: www.iop.ca

Before applying, interested student candidates should first contact:

Kuo-Shyan Lin, PhD

Senior Scientist, BC Cancer Research Centre

Associate Professor, University of British Columbia

E-mail: klin@bccrc.ca

Ongoing recruitment.

Possible projects: Role of leukemia stem cells in T-ALL, examining the tumor ecosytem in lymphomas, or pathogenetic mechanisms in T-ALL.

Interested applicants may submit letter of interest and CV to aweng@bccrc.ca.

Job Information

Classification Title: Information Systems & Technology (A)

Business Title: Research Programmer

Department: Pathology

Job Summary

A position with the Department of Pathology and Laboratory Medicine of the University of British Columbia is open immediately for a research programmer to work with our interdisciplinary team of researchers and software developers within the Department of Molecular Oncology at BC Cancer, part of the Provincial Health Services Authority. We are seeking a creative, experienced, and dedicated individual to play a key role in the bioinformatics analysis of computational genomic research data.

The research programmer will work with other team members and researchers in the department to conduct computational analysis, ranging from routine runs to novel discovery tasks.  With detailed instructions, you will be finding and applying bioinformatics algorithms to computational genomics problems.  When appropriate, your solutions will be deployed in full production processes, and you will work closely with other programmers to ensure the successful implementation and  deployment of automated workflows and analyses.

You will be on-site in the Department of Molecular Oncology at BC Cancer, working closely with software developers, students and researchers operating at the leading edge of the field of cancer genomics.  Our department has recently made meaningful advances in the understanding of tumour evolution and the software platforms developed in the lab will be used by world-leading scientists at BC Cancer and international collaborators to gain insight into how cancers initiate, develop and acquire resistance to treatment. More information on the department and research we conduct can be found here http://molonc.bccrc.ca/

Organizational Status

We are a small team of software developers and scientists embedded within a larger cancer research department.  You will be working with students and researchers to tackle genomics problems, and collaborating with developers and bioinformaticians on the team to develop high-throughput and automated analysis solutions.  You will be reporting to the bioinformatics team lead or designate.

Work Performed

Research and implement bioinformatics solution as requested

Perform simple to complex bioinformatics analysis and requests with supervision

As a team member, develop, test and automate bioinformatics solutions

Handle bioinformatics data retrieval, processing and dissemination requests

Assist researchers in computational, statistical and visualization tasks for publication

Consequences of Error

You will be receiving instructions from researchers, students and collaborators and will be responsible for the correctness of your work.  Failure to perform may result in setbacks to research and operational activity.

Supervision Received

You will be supervised by the bioinformatics team lead or designate.

Supervision Given

You will help advise and recommend best course of actions to other members of the lab on subjects pertaining to bioinformatics analysis and your field of expertise.

Education / Work Experience

Essential

BSc in bioinformatics, computer science, or equivalent

Minimum 2 year of additional relevant work/educational experience in genomics

Proven bioinformatics research experience

Experience with data analysis in R and Python

Experience with command-line interfaces and scripting in UNIX operating systems

Experience designing and creating analysis workflows and pipelines

Experience with next-generation sequencing (NGS) data

Preferred

MSc in bioinformatics, computer science or equivalent

Experience with scientific high performance computing environments

Experience with bioinformatics data management solutions

Exciting postdoctoral training opportunity with the OVCARE Program at the University of British Columbia and the Department of Molecular Oncology at BC Cancer, studying the cellular origins of ovarian and other gynecological cancers through single cell sequencing technologies. The Department of Pathology at the University of British Columbia invites applications for a Postdoctoral Fellow. The successful applicant will work with Dr. Andrew Roth and Dr. David Huntsman as a part of the multidisciplinary OVCARE team (BC's Gynecological Cancer Research Program, ovcare.ca) and bioinformatics team of the BC Cancer’s Department of Molecular Oncology (http://molonc.bccrc.ca). 

We are studying the early events in ovarian cancer initiation by genetically manipulating organoids derived from normal tissues and transgenic mice. Our interest lies in dissecting the relative contributions of and interactions between cell of origin, mutation and microenvironment on the development of the common cancers of the uterus , ovary and fallopian tube. For this particular project, ARID1A (a member of the SWI/SNF chromatin remodeling complex) is knocked out and mutant PIK3CA (a kinase involved in intracellular signaling) is introduced into the cells. Organoids are grown out from cells containing these genetic manipulations and single cell RNAseq, DNAseq and ATACseq will be performed. The successful candidate will integrate these datasets, as well as co-supervise students assigned to analyze other single cell sequencing datasets. We are looking for someone who has strong communication and leadership skills and who will work well in a group setting.

Qualifications

- PhD in Bioinformatics, Computer Science, Statistics or related fields.

- Experience working with large genomic datasets.

- Experience managing data from multiple sources and running bioinformatics pipelines.

- Experience working with single cell RNA-Seq and/or single cell DNA-Seq.

- Strong background in data science, machine learning preferred.

- Programming skills in R and/or Python required.

The position will commence as soon as possible. The initial appointment will be for a one-year term, with potential for annual renewal. Salary will be commensurate with qualifications and experience.

The position is in a mass spectrometry-based proteomics group in the Genome Sciences Centre at BC Cancer. The candidate will work as part of a team performing cutting-edge translational research using a broad range of proteomics techniques. The Research Assistant 2 – Proteomics works under supervision and performs experiments by following established laboratory procedures.

Job Code: RA2 07-04-2019

Key Accountabilities 

• Prepare samples for proteomic analysis
• Operating facility instrumentation including off-line HPLC fractionation systems, mass spectrometers, and speed vacs
• Perform initial data analysis
• Assist in the development of cutting edge protocols for clinical proteomics
• Maintain logs of samples analyzed and instrument use
• Liaise with collaborators to coordinate sample submission and communicating results
• Collaborate with client lab personnel
• Maintain a details lab notebook

Qualifications 

• A laboratory technician degree in chemical and biotechnical science with direct work experience in proteomics. 
• Theoretical knowledge and practical experience with tandem mass spectrometry
• Experience with state-of-the-art mass spectrometry instrumentation including Orbitraps
• Experience with clinical sample preparation for proteomics and nucleic acid analysis
• Experience with processing cells and tissues for global and targeted proteomics
• Practical experience with analytical reversed phase chromatography (HPLC and nanoLC), specifically for peptide separation
• Two (2) years recent related experience in a research laboratory

In accordance with Canadian Immigration requirements, this advertisement is first directed to Canadian citizens and permanent residents but international candidates are invited to apply. We encourage applications from all qualified individuals, including Aboriginal peoples, persons with disabilities and members of visible minorities. English is the official language used at PHSA.

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RA2 07-04-2019") in the subject line of your emailed application.

Breast Pathology Fellowship
Providence Health Care, Department of Pathology and Laboratory Medicine

One Year Term (with potential extension)

This unique fellowship is comprised of both clinical and research components in equal parts and provides an opportunity to gain research experience as a fellow. Fellows will divide their time between BC Cancer Agency, Mount Saint Joseph and St. Paul’s Hospitals and rotate through the clinical pathology laboratory and the research laboratory at BC Cancer. Fellows work closely with the breast multidisciplinary team, actively participating in rounds and providing service and consultation to clinicians in matter relating to breast diseases. It is expected that the fellow participates in collaborative research, with an option to conduct individual research, all under the guidance of a faculty member and/or pathologist]. This includes research proposals, submitting abstracts to scientific meetings and preparing manuscripts for publication in peer-reviewed journals.

Candidates with the following qualifications/experience are preferred:

• Canadian citizenship or permanent residency.
• MSc or PhD.
• Research experience, especially molecular biology.

Salary will be commensurate with qualifications and experience.

To apply for this rewarding career development opportunity, please forward (1) a letter of application outlining your areas of interest, (2) a copy of your current CV, and (3) names and contact information of three references, to:

PHSA Talent Acquisition
careers@phsa.ca

A postdoctoral fellowship position is available in the Aparicio lab based at the BC Cancer Research Centre in Vancouver, Canada, collaborating on an exciting project mapping clonal dynamics in human cancers with new single cell methods. 

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patients and patient-derived xenografts. The post holder will have the opportunity to interact as part of the international CRUK Grand Challenge IMAXT project, bringing new measurement methods and computational techniques to the 3D reconstruction of tumour and mapping drug sensitivity and drug combinations using sgRNA/CRISPR methods in vivo. The program works closely with the Shah lab computational biology program on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage.

How to Apply: Please send the following documents to careersmolonc@bccrc.ca and put “Single Cell Genomics, Aparicio Lab – PDF Position” and your family name in the subject line.

• Cover Letter
• Resume
• Transcript
• Work Sample

Postdoctoral Research Fellow – SWI/SNF Chromatic Remodeling Complexes and Cancer Progression

BC’s Gynecological Cancer Research Program (OVCARE)
Department of Pathology, Faculty of Medicine
University of British Columbia, Vancouver, Canada

Exciting postdoctoral training opportunity studying targeted therapies for ovarian and other gynecological cancers with the OVCARE Program at the University of British Columbia and BC Cancer.

The Department of Pathology at the University of British Columbia invites applications for a Postdoctoral Fellow. The successful applicant will work with the multidisciplinary OVCARE team (BC’s Gynecological Cancer Research Program) directed by Dr. David Huntsman. This position will be translational and interdisciplinary in nature aimed at deciphering the role of cancer-associated mutations, especially those related to the SWI/SNF chromatin remodeling complexes, in tumourigenesis and their potential as druggable targets.

Applicants should have a PhD or MD/PhD with a strong background and publication record in a relevant field (e.g. genetics, cellular and molecular biology). The position will rely heavily on in vitro and in vivo models of cancer so demonstrated expertise in this area is required. In addition, either experience in bioinformatics would be an asset. The position will commence as soon as possible. Excellent verbal and written communication skills are required. The initial appointment will be for a one-year term, with potential for annual renewal. Salary will be commensurate with qualifications and experience.

Qualified candidates should send (by email) a statement of research interest, curriculum vitae and contact details for 3 referees to:

Yemin Wang, PhD
BC’s Gynecological Cancer Research Program
University of British Columbia and BC Cancer

675 West 10^th Avenue
Vancouver, BC V5Z 1L3
Email: yewang@bccrc.ca

A graduate student position is available for students interested in pursuing MSc or Phd studies in Bioinformatics at the University of British Columbia. The project is aimed at characterizing the function of every mammalian gene through thorough analysis of every known and predicted gene in the mouse genome via “Big Data” analysis. To address this critical gap in biomedical research, the International Mouse Phenotyping Consortium was created to generate a null mutation for every gene in the mouse genome, to collect phenotypic data for each mutation, and to disseminate the data to the broader scientific community. Immunophenotyping by flow cytometry (FCM), is one of the 30 core phenotyping assays of this global effort. However, the full quantitative potential of the IMPC FCM effort can only be realized with mechanisms to effectively share, analyze and interpret the data.

The selected candidate will develop and use state-of-the-art computational methodologies for supervised and unsupervised clustering and classification to systematically analyze tens of thousands of high-dimensional samples to help understand the function of each gene. The candidate will also be supported to attend bioinformatics workshops and conferences to advance and disseminate their research.

Qualifications: The ideal candidate will have a strong background in Computational Biology, Bioinformatics, or equivalent with strong experience in handling high-throughput data sets as well as statistics and programming skills (we love R here). The individual will have strong verbal and written skills and the ability to work efficiently in a team environment.
In addition to the outstanding research opportunities available in this setting, students also enjoy the many cultural and sporting amenities provided in Vancouver.

Please contact Dr. Brinkman directly at rbrinkman@bccrc.ca and provide the following information:

– Short cover letter explaining your interest in the lab
– Resume
– Scanned copy of transcript or listing of course grades
– Names and contact information for two individuals who will be willing to provide letters of reference
 

2 positions available May 2020 – Dec 2020 (8 months)

Co-op position 1 - Our lab has developed in house a synthetic model of T cell acute lymphoblastic leukemia by lentiviral transduction of hematopoietic stem progenitor cells from human umbilical cord blood. One co-op student will be working on investigating how various conditions contribute to this leukemic transformation. In this position, you will learn aseptic technique for culturing human primary cells, how to produce lentivirus and transduce cells, flow cytometry techniques and analysis, mouse necropsies and cell cryopreservation. We would prefer someone with wet lab experience and is organized and detail-oriented.

Co-op position 2 - Investigating the tumour ecosystem in human non-Hodgkin’s lymphoma. Using state-of-the-art single cell analysis (mass cytometry (CyTOF), single cell RNA sequencing and high-parameter flow cytometry), this project will investigate the heterogeneity of tumour cells and their surrounding non-malignant immune and stromal cells. This work is of direct clinical relevance in providing detailed phenotypic characterizations that are required in order to define biomarkers for lymphoma classification and prognosis. In this position, you will have opportunities to learn: 1) handling and processing clinical samples, including tissue digestion and culture of human primary cells; 2) maintaining and operating the CyTOF and multi-parameter flow cytometry; 3) Multi-dimensional data analysis. We prefer applicants who are detail-oriented and have a strong interest in bioinformatics/programming as such skills will allow for more involvement in data analysis. 

Applicants may apply via their school's co-op program.