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Research Asst/Tech 3

Job Summary
Researchers in the Department of Molecular Oncology at the BC Cancer Research Institute uses the latest technologies to rapidly identify genes that are involved in the development of cancer. This position will be involved in providing technical support in molecular biology, biochemistry, microscopy and robotics for current on-going research projects in the lab.

Organizational Status
The successful applicant will report to the Principal Investigator or his/her delegate and may assist in overseeing technical work of students and trainees.

Work Performed

  • Plans and performs experiments utilizing complex procedures and/or techniques
  • Processes primary tissue samples
  • Maintain cell cultures using aseptic techniques
  • Provide molecular biology support – DNA and RNA, cloning, extraction/isolation, PCR
  • Provide basic protein biochemistry support – western blotting
  • Experience with antibody labelling is preferred
  • Ability to record data and work with informatics systems that stores and display data is essential
  • Carries out laboratory techniques following standard operating protocols
  • Maintains laboratory records and experimental data; when require summarize results in research reports and lab presentations
  • Performs other related duties as assigned


Consequence of Error/Judgement
The work is of a complex nature, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Non compliance with biosafety and chemical safety regulations may result in closure of facility or loss of grant funding.

Supervision Received
The successful applicant will report to the Principal Investigator or designate.

Supervision Given
Depending on experience and expertise, the successful applicant maybe be required to assist in training of graduate students/trainees including instruction in use of lab equipment and procedures and will troubleshoot experiments in their area of expertise.

Minimum Qualifications
Completion of a relevant technical program or a university degree in a relevant discipline and a minimum three years of related experience or an equivalent combination of education and experience.

 

Preferred Qualifications

  • Working knowledge and understanding of molecular biology and biochemistry techniques is essential, with prior working experience in molecular biology in laboratory setting is considered an asset.
  • Experience with cell culture and aseptic technique preferred.
  • Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNA / DNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation, and western blotting.
  • Preference will be given to applicants with antibody labeling experience.
  • Experience in immunocytochemistry and basic data analysis in R or similar statistics package would be an asset
  • Demonstrated understanding of experimental design and assay optimization.
  • Strong interpersonal skills and the ability to interact positively and productively with other team members are essential.
  • Ability to communicate effectively both orally and in writing.
  • The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

To apply: Please send cover letter and resume to careersmolonc@bccrc.ca  – Please put your full name and the job title in the subject line.

Research Asst/Tech 4

Job Summary
Researchers in the Department of Molecular Oncology at the BC Cancer Research Institute uses the latest technologies to rapidly identify genes that are involved in the development of cancer. This senior position will be involved with working on the Single Cell genomics project, in addition, providing general technical support in molecular biology, biochemistry, microscopy and robotics for other current on-going research projects in the lab.

Organizational Status
The successful applicant will report to the Principal Investigator or his/her delegate and may assist in overseeing technical work of students and trainees.

Work Performed

 

Consequence of Error/Judgement
The work is of a complex nature and required high level of training, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Errors may result in the permanent loss of irreplaceable tissue samples, loss of thousands of dollars of material and/or damage to equipment.  Loss of research results could result in the failure of a funded project and put in jeopardy any future funding and the international reputation of the Laboratory. Non compliance with biosafety and chemical safety regulations may also result in closure of facility or loss of grant funding.

Supervision Received
Works under minimum supervision, receiving specific instructions only on unusual problems or when receiving new project outlines from the principal investigator. The successful applicant will report to the Principal Investigator or designate.

Supervision Given
Depending on experience and expertise, the successful applicant maybe be required to assist in training and supervision of graduate students/trainees or junior staff, including providing instruction in use of lab equipment and procedures, and will help troubleshoot experiments in their area of expertise.

Minimum Qualifications
Completion of a university degree in a relevant discipline or technical program and a minimum four years of related experience or an equivalent combination of education and experience. Some positions may require a graduate degree.

Preferred Qualifications

  • Plans and performs experiments utilizing complex procedures and/or techniques.
  • Using of liquid handling robotics and 10x genomics platforms to investigate single cell genomics
  • Visualize and analyse cells using microscopy and flowcytometry.
  • Generation, preparation and submission of Next Generation Sequencing Libraries.
  • Track samples, record data and work with informatics systems that stores and displays data
  • Liaise with collaborators and vendors.
  • Provide technical expertise in molecular biology, protein biochemistry, virology, support and guidance to collaborators and researchers.
  • Data analysis using R script or other basic statistic analysis program
  • Provide molecular biology support – DNA and RNA, cloning, extraction/isolation, PCR Provide basic protein biochemistry support – western blotting
  • Carries out laboratory techniques following standard operating protocols. Maintains laboratory records and experimental data; when require summarize results in research reports and lab presentations.
  • Assist, develop or update Standard Operating Procedures (SOPs) to ensure compliance with regulatory bodies
  • Assist in general maintenance of the lab and receiving and inventory of lab supplies
  • Researches and determines the applicability of new technology and systems related to work
  • Conducts complex analysis and interpretation of data resulting from high throughput experiments.
  • Presents data at scientific meetings, writes reports and contributes to writing ethics and grant applications.
  • Carries out any other related duties as assigned or required in keeping with the qualifications and requirements of this level of technician.
  • Working knowledge and understanding of molecular biology and biochemistry techniques is essential, with prior working experience in molecular biology in laboratory setting is considered an asset.
  • Experience with cell culture and aseptic technique.
  • Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNA / DNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation, and western blotting.
  • Preference will be given to applicants with liquid handling robotics, single cell genomics, Next Generation Sequencing, 10x Genomics experience.
  • Experience in immunocytochemistry and basic data analysis in R or similar statistics package would be an asset
  • Demonstrated understanding of experimental design and assay optimization.
  • Strong interpersonal skills and the ability to interact positively and productively with other team members are essential.
  • Ability to communicate effectively both orally and in writing.
  • The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively

To apply: Please send cover letter and resume to careersmolonc@bccrc.ca  – Please put your full name and the job title in the subject line.

Assistant, Employee Relations Team

About us

Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science.

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC

As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak, to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely on a part-time temporary basis.  This restriction would be re-evaluated upon re-contracting.*

Role Summary:

Based in Vancouver, Canada’s Michael Smith Genome Science Centre (GSC) at BC Cancer is looking for an Assistant in the Employee Relations team.

Under the direction of the Manager, Employee Relations, the Assistant requires strong attention to detail to maintain a number of documents and record information in various HR systems. 

The Assistant maintains confidentiality within the department and organization.

If you are an enthusiastic new graduate or are at an early stage in your career, please read on as we’d love to hear from you!

 Key accountabilities:

  • Time and attendance: Uses the established time and attendance system to enter and track staff attendance and verify shift hours. Enters all leave forms into system accurately and efficiently.
  • HRIS: Supports HR and Finance as required by submitting eForms.
  • Employee documentation and reports preparation: Creates, collects, distributes, scans and files a variety of documents and reports for audits or other purposes. Downloads, prepares and maintains reports as needed by the HR team.
  • Employee & Collaborator files: Sets up and maintains online and paper files for current and terminated employees and collaborators using a records information system ensuring compliance with corporate records management standards.
  • Ensures that documentation is filed accordingly and in place for accreditation purposes.
  • Creates Onboarding and Offboarding tickets for collaborator account requests. Monitors updates on tickets and forwards as appropriate.
  • Books meetings for the team and coordinates supplies as appropriate.

Qualifications:

  • A level of education, training and experience equivalent to the completion of a Bachelor’s degree in Business Administration or similar field, plus one-year recent related experience. Possession of a CPHR certification and prior work experience in an HR role in a research environment would be an asset.
  • Excellent organization skills and ability to prioritize and exercise initiative.
  • Excellent verbal and written communication skills including demonstrated ability to communicate with tact and diplomacy.
  • Superior accuracy and outstanding attention to detail.
  • Excellent interpersonal skills and ability to establish and maintain effective working relationships with internal and external contacts.
  • Demonstrated commitment to and experience delivering a high level of customer service.
  • Ability to exercise discretion and deal with highly sensitive and confidential information.
  • Ability to work both independently and as a team member.
  • Strong administrative skills and knowledge of office procedures and filing systems (electronic and paper).
  • Advanced skills using Microsoft Office suite and ability to learn and navigate new systems.

To Apply:

Please send a copy of your resume and a detailed cover letter to bcgscjobs@bcgsc.ca.

Please note that this position will remain open until filled; however, we anticipate to start interviews in mid-January 2021.

We thank all applicants; however, only those selected for the next step will be contacted.

Manager, Systems

About us

Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC

As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely on part-time temporary basis.  This restriction would be re-evaluated upon re-contracting*

Role Summary:

Canada’s Michael Smith Genome Science (the “GSC”) at BC Cancer is looking for a Manager, Systems, responsible for developing, maintaining, and supporting the IT infrastructure of the GSC.

Under the direction of the Head of Bioinformatics, the Manager, Systems develops a vision for the IT infrastructure capable of supporting the future research direction and production requirements of the GSC.

The Manager, Systems ensures the confidentiality, integrity and availability of data within the department and organization.

 If you have experience leading teams, managing multiple projects at the same time, and you enjoy solving problems and working with multiple stakeholders, please read on.

 Key accountabilities:

  • Liaise with members of senior management to solicit requirements and report progress of IT
  • Manage high-level planning for informatics research and laboratory production requirements
  • Manage the design and development of IT systems and projects
  • Provide leadership, coaching and direction to the Systems team including coop students
  • Coordinate and prioritize project plans and tasks
  • Address and resolve reported project roadblocks, and develop procedures to reduce these
  • Manage support issues from all staff and maintain systems to ensure that support issues are handled and prioritized accordingly
  • Develop service level agreements within the organization
  • Develop and manage process for new releases and changes to the production environment
  • Manage software license compliance, and participate in regular audits
  • Responsible for data security, storage and archiving as per business requirements
  • Develop and enforce technical information system standards
  • Design and develop implementation of information systems policies and training material

Qualifications:

  • Undergraduate degree from a recognized institution in Computer Science, Electrical Engineering and/or Life Sciences or related field or a combination of relevant education and work  experience
  • A minimum of 7 years of relevant experience working in an IT department or similar environment
  • A minimum of 2 years’ experience managing and directing a systems team
  • Knowledge of softwares such as Slurm, Atlassian, Linux (Centos, Ubuntu), Windows10,  Macintosh, Office, LDAP, AD, Exchange an asset
  • Experience working with network such as Brocade and Barracuda an asset
  • Knowledge of audit process, including ISO an asset
  • Demonstrated ability to work independently and collaboratively as appropriate
  • Excellent organizational and leadership skills. Ability to coach and motivate staff
  • Excellent oral, written and interpersonal communication skills
  • Ability to use audience appropriate communication and language to present information and convey concepts
  • Ability to achieve results in a fast-paced research environment

To Apply:

Please send a copy of your resume and a detailed cover letter to bcgscjobs@bcgsc.ca

While we are looking to fill this position as soon as possible, please note that this position will remain open until filled.

We thank all applicants; however, only those selected for the next step will be contacted.

Staff Scientist

About us

Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC

As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely on part-time temporary basis as well as in the lab.  This restriction would be re-evaluated upon re-contracting*


Role Summary:

The Evgin Laboratory at Canada’s Michael Smith Genome Science (GSC) at BC Cancer is looking for a qualified candidate to aid in the development of novel oncolytic viruses and cellular immunotherapies. Projects include preclinical studies utilizing in vivo and in vitro models of cancer and infection and seek to develop combinatorial therapeutic approaches. The individual will aid in setting up a new lab space and thus organizational skills and attention to detail are paramount.

The successful candidate will have a PhD or equivalent degree and at least five years of relevant experience.

Knowledge of and research experience with standard methods and approaches in microbiology, immunology, cell biology, molecular biology, virology, genomics and mouse models are assets; and familiarity with the fields of cancer immunology and immunotherapy are highly desirable.

The applicant should also demonstrate the ability to work independently, supervise trainees and technical staff, and conceive, initiate, prioritize, organize and manage multiple concurrent projects.  Excellent verbal and written communication skills are a necessity as well as the ability to work in a team environment. 

This position will begin ASAP.  This is a one-year term appointment subject to annual renewal. 

Salary will be commensurate with qualifications and experience.

Please submit a cover letter, curriculum vitae, and the names of three referees willing to provide letters of reference to bcgscjobs@bcgsc.ca. The cover letter should include a brief description of your previous research experience and long-term career goals, plus supervisory and administrative service. 

Please not that this position will remain open until filled.

Coordinator, Research Funds Services

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Reporting to Administrator, Research Business Operations, the Coordinator, Research Funds Services provides research financial reporting and administration on assigned grant funded programs. The responsibilities include monitoring research projects and research grant budgets, coordinating the development and submission of research financial reports, liaising with PHSA restricted funds finance team to ensure grants financial information is accurately maintained, monitoring and tracking receipts and disbursements and assisting with the management, allocation and coordination of  research funds among Partners and Stakeholders.

    

Duties/Accountablilties:

• Monitors research expenditures and reviews and analyzes research financial information of assigned grant funded programs for the Administrator,  Research Business Operations, and Research Project Managers to assist with planning budgets. This includes pulling appropriate research general ledger accounting information, performing review of research accounts and classifying financial information for reporting, invoicing and budgeting purposes. Ensures research budgets remain within allowable spending limits by tracking and monitoring receipts, disbursements and expenses of general accounts. Investigates and identifies errors/discrepancies and creates journal entries to correct accounting records and maintain research financial information integrity.

• Prepares and reviews research purchase orders and expense claims to ensure applicability and correct expense coding. Verifies appropriate back-up provided and ensures compliance with PHSA policy as well as external funding agency policies. Identifies/determines if expense claim is allowable and makes suggestions on alternative options, if necessary. Follows up with vendors on outstanding credits or erroneous billing as well as cheque payment requests and facilitates payment options by ensuring that required information is obtained (cheque payment, wire transfer, credit card, etc.)

• Performs periodic reconciliation of the research general ledger, research corporate card purchases, research capital expenditures, research payroll reports and receivables to ensure accuracy and timely follow-up.

• Prepares research billing invoices based on the general ledger on a weekly, quarterly and ad-hoc basis to ensure timely collection of revenue from external funding agencies. Ensures research payments are received in full and follows-up on outstanding bad debt accounts.

• Communicates internally with Accounts Payable, Accounts Receivable and PHSA Finance and provides direction on account coding to accurately reflect nature of research financial transaction. Monitors and reconciles research shadow accounts held at UBC and SFU by pulling the general ledger held at these institutions to ensure accurate and complete yearly reporting of funding received. Communicates with the universities regarding accounting discrepancies and generates journal entries and/or invoices to reflect accurate research financial information.

• Monitors research reporting/invoicing due dates and coordinates timelines to ensure that deadlines are met. Compiles and prepares research financial reports/invoices as needed (quarterly, yearly, etc.) and ensures that expenditures reported are in compliance with spending guidelines and GAAP (generally accepted accounting principles). Identifies under/over-expenditures and recommends options to ensure that the research project stays within budget.

• Provides support during annual and interim audits by compiling research general ledger information and ensuring proper documentation is kept on file. Provides analysis to identify/explain journal entries as required by the auditor. Coordinates periodic research financial and annual reports as required by granting agencies, PHSA , partner universities and stakeholders to ensure information is summarized according to guidelines.

    

Qualifications:

A level of education, training and experience equivalent to a Diploma in Accounting/Financial Management or pursuing a professional designation program and preferably three (3) years of recent related experience in a multi government institutional setting, including experience working with national and international granting and funding bodies. 

Knowledge and experience in working with General Accepted Accounting Principles (GAAP) in a university/life science environment. Knowledge of grant management and familiarity with granting agencies and their guidelines and policies. Working knowledge of the university/health care funding process and procurement practices is an asset. Demonstrated ability to conduct oneself in a professional and confidential manner.  Demonstrated administrative and organizational skills.  Demonstrated ability to productively use word processing, excel spreadsheets, financial reporting and project/budget management applications.  Demonstrated ability to communicate effectively both verbally and in writing.  Ability to work independently with minimal direction. Ability to handle workload pressures and demonstrated ability to prioritize.  Ability to supervise junior staff.

To apply: Please send cover letter and resume to careersmolonc@bccrc.ca  – Please put your full name and the job title in the subject line.

Postdoctoral Fellow, Gastrointestinal Cancers

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position may require working remotely.  This restriction would be re-evaluated upon re-contracting*


Role Summary

A Post-doctoral position is available immediately for a highly motivated recent PhD or MD/PhD graduate to join a dynamic translational research group, headed by Dr. Isabella Tai, Associate Professor in the Division of Gastroenterology, University of British Columbia and Senior Scientist at Canada's Michael Smith Genome Sciences Centre at BC Cancer.

Current projects in the laboratory revolve around improving our understanding of the mechanisms involved in the development of chemotherapy resistance and metastasis in gastrointestinal cancers (colorectal, gastric, liver and biliary cancers). The goal is to develop either novel therapeutic targets for GI cancer treatment or novel screening tools for diagnosis. We continue to use the latest genomics (including single cell sequencing), proteomics and bioinformatic approaches to identify potential targets or markers for this purpose. Learn more about research projects in the Tai lab here.

Eligibility

Interested individuals with a recent PhD or MD/PhD and strong publication records and excellent academic credentials are encouraged to apply.  Experience in molecular biology, cell biology, tissue culture and animal tumor models, is preferable.  Experience in bioinformatics is an asset.

Duration

Three years (possibility of extension).

To Apply

Please submit a cover letter, curriculum vitae, and the names of three referees willing to provide letters of reference. The cover letter should include a brief description of your previous research experience, long-term career goals and an indication of the desired length of postdoctoral position.

Please email your application to bcgscjobs@bcgsc.ca

Research Programmer

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely.  This restriction would be re-evaluated upon re-contracting*


Role Summary

The Karsan lab team at Canada’s Michael Smith Genome Sciences Centre (GSC) is seeking a research programmer to join a Genome British Columbia software automation project. The team will be working with the Karsan lab, which is responsible for developing high-throughput, clinically accredited pipelines to analyse sequenced data from genomic assays for individualized patient management of cancer. We seek candidates with strong Python software and programming skills to automate and improve existing pipelines and potentially incorporate third-party software into the system.

The role is ideally suited for a creative individual with a strong interest in software development and testing, data analysis, and automation within a high throughput academic setting.

Key responsibilities

  • Design, plan, and implement automated bioinformatics pipelines to meet the objectives of the project
  • Work with other project team members to develop and test code, and implement software
  • Evaluate third-party software and incorporate new systems into legacy systems
  • Produce thorough but concise written documentation of algorithms, validations, SOPs, and other processes and procedures as required

Qualifications

Education, training and experience

  • Graduation from a recognized Bachelor of Science Program in Computer Science. A Master’s degree in a relevant field would be a strong asset. 
  • Two (2) years of recent related experience or an equivalent combination of education, training, and experience acceptable to the project lead.

Core Skills and Abilities 

  • Expertise with Python 3.X and able to provide links to code samples via GitHub or another open repository
  • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
  • Familiarity with molecular and cellular biology
  • Excellent verbal and written communication skills.
  • Demonstrated ability to efficiently organize work assignments and establish priorities.
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.

Additional Assets

  • Familiarity in statistical analysis using modern computational tools.  Experience with any relevant tools will be considered, but R and Python are preferred
  • Familiarity with the development, testing, and maintenance of relational databases
  • Familiarity in next-generation sequencing
  • Experience with software testing
  • Experience with Agile software practices
  • Functional knowledge of distributed version control systems, such as SVN or GIT

Please email your cover letter and resume to bcgscjobs@bcgsc.ca

Please note that this position will remain posted until filled.

Postdoctoral fellow, Bioinformatics

Job Summary:

The candidate would work within a dynamic and vibrant lab with a proven track record of outstanding achievements and contributions in breast oncology research. This position allows the candidate to contribute bold and innovative research that can be translated to new understanding in the evolutionary processes that drive cancers.

This position's primary focus in the lab will be to lead and to participate in projects based on candidate's desire concentrated on investigating genetics of breast oncology, cancer evolutionary, and development of novel therapeutics. Using the wide network of connections and collaborations of the principal investigator, and extensive biomedical resources at the institution, candidates will be able to build on the existing research of the lab to quickly start up their own research projects.

The position will provide a unique opportunity for mentoring trainees, supervising analysts and interacting with industry. This is an excellent platform to receive outstanding training to gain the important skills for a successful medical research career in academia or industry.

This funded position with the University of British Columbia, at the BC Cancer Research Centre allows the candidate to flourish under the guidance of an experienced mentor

Organizational Status:

The Postdoctoral Fellow will play a leadership role in the Aparicio lab, and will be reporting directly to Dr. Samuel Aparicio who is the primary investigator of the laboratory.

Work Performed:

  • Management and supervision of trainees;
  • May be involved in recruitment and training of trainees;
  • Performing regular reviews of the relevant literature;
  • Planning and designing of experiments;
  • Analyzing, interpreting and compiling data in study reports, presenting results, and participating in the preparation of scientific manuscripts and grant application packages;
  • Updating Dr. Aparicio and the group on the status of projects during lab meetings, in email correspondence and phone conferences;
  • Managing projects with key academic and industry partners.

Minimum Qualifications:

  • PhD degree in the computer science, bioinformatics or equivalent
  • At least 4 years experience in bioinformatics research
  • Experience in genomics and next-generation sequencing
  • Extensive knowledge of cellular and molecular biology, biochemistry and genetics
  • Experience with cancer research a plus
  • Proven ability to multi-task in a deadline oriented environment with minimal supervision
  • Effective oral and written communication, analytical, and interpersonal skills
  • Excellent organizational skill and ability to learn new skills quickly
  • Ability to work independently and within a team environment.
  • Accuracy and attention to detail required
  • Candidates should demonstrate the ability to work in a highly interdisciplinary environment.

SUPERVISION RECEIVED

  • Works independently under direction of PI, Dr. Samuel Aparicio
  • Opportunities to work collaboratively with Industry partners and other researchers at UBC and globally

SUPERVISION GIVEN

  • Assists and oversees research assistants and students as required
  • Assists and provides guidelines to other research members, as required

How to Apply

Exceptional candidates should submit a cover letter outlining your research interests and fit with the laboratory's research, curriculum vitae, and the names of three referees willing to provide letters of reference.

To apply:  Please send the above documents to careersmolonc@bccrc.ca and put “PDF Bioinformatics Scientist, Aparicio lab” and your family name in the subject line.

Due to the number of resumes we receive, we are unable to confirm receipt of submissions over the phone, or provide the status of the competition. Only shortlisted candidates will be contacted.

Equity and diversity are essential to academic excellence.  An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged.  We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

Research Associate - Bioinformatics

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely.  This restriction would be re-evaluated upon re-contracting*


Role Summary

The GSC is currently looking for a senior bioinformatician to develop approaches to analyzing and sharing “big data”. This role is instrumental in the development of the CFI-funded cyberinfrastructure project, CanDIG—a state-of-the-art data sharing platform contributing to the development of an international effort to facilitate information exchange as part of the Global Alliance for Genomics & Health (GA4GH). CanDIG also supports large-scale provincial and national data sharing projects, including BC Cancer’s Personalized OncoGenomics program, the Terry Fox Research Institute (TFRI) PROFYLE project and the TFRI-led Marathon of Hope Cancer Centres Network—a major federal initiative to accelerate the adoption of precision medicine for cancer in Canada.

Based at the BC Cancer Research Institute in Vancouver, the successful incumbent will help to devise, develop and implement data sharing methods between our partner sites for cancer genome and transcriptome data. They will also research how these data can be used within Canada to improve precision medicine as it applies to the delivery of healthcare for cancer, ultimately generating a "big data" analytics platform from which further insights into the biology of cancer will be realized.  

Key Responsibilities

  • Conduct research and supervise projects 
  • Develop and use new and novel methods for the analysis of cancer genome sequence
  • Interact closely with principal investigators and clinicians about the biology and clinical history of research subjects
  • Evaluate sequence variants using software prediction tools, and apply guidelines for the interpretation of sequence variants in the context of precision medicine
  • Manage and track of next generation DNA and RNA sequence data
  • Develop innovative ways to annotate and discover relationships between cancer genes and clinical outcomes
  • Present findings at local, national and international scientific meetings
  • Write scientific manuscripts related to research findings
  • Develop research grant applications
  • Contribute to required quarterly and annual reports for research projects
  • Work with principal investigators to ensure that all scientific milestones are achieved
  • Develop computer code according to professional and industry standards
  • Perform other related duties as required

Qualifications

Education and Experience:

  • PhD in a life sciences or quantitative discipline
  • A minimum of 2 years demonstrated experience in bioinformatics, focused on genome sequence data processing and analysis

Skills and Abilities:

  • Expertise in bioinformatics, emphasizing genome sequence analysis and gene annotation
  • Knowledge of scientific tools, technologies and online resources as pertaining to cancer genomics
  • Python, Javascript and SQL programming experience
  • Previous API development projects using Open API or Rest API is a plus
  • Experience with high-performance computing
  • Experience in a supervisory role is an asset

To Apply

email cover letter and resume to: bcgscjobs@bcgsc.ca

Projects Manager

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity is essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely.  This restriction would be re-evaluated upon re-contracting*


Role Summary

The Genome Sciences Centre is seeking a Projects Manager. This role is for a Manager of research projects, grants and platforms in a research environment.

Reporting to the Head Project Management or Projects Team Leader and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and monitor and facilitate progress against these objectives and milestones. Projects will involve personalized oncogenomics, immunotherapy, collaborative services management, or other cancer genomics research.

Key Responsibilities

  • establishing budgets for research projects, grants, collaborations and core activities
  • assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
  • monitoring budgets and expenditures
  • establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives, which may include, meeting coordination and follow-up, coordination of case reviews
  • maintain accurate information on sample status, including sample and associated metadata acquisition, processing, stakeholder reporting
  • recommending strategies for improving projects management methods
  • liaising with grant/core funding agencies
  • interacting directly with research collaborators or clinical study teamsas required

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged.

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research or the biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

 Successful candidate(s) will be offered positions through Provincial Health Services Authority at level Research Project Coordinator, which is equivalent to that described above.

To Apply

email: bcgscjobs@bcgsc.ca

Research Finance Assistant

Application Deadline

What you'll do

  • Reporting to the Coordinator, Research Grants (or designate) within the administrative group in the department of Advanced Therapeutics (AT), the Research Finance Assistant is responsible for performing administrative duties in support of the financial management of academic and industrial research projects for a broad range of basic and clinical research programs.
  • Works on tasks that require analytical analysis, the ability to define and report on processes, work independently with confidential information and the ability to organize and prioritize work.
  • Communicate with internal and external stakeholders and be expected to exercise sound judgment when communicating with these groups.
  • Works with the Coordinator, Research Grants to update and report on budgets and make recommendations to ensure sustainability. The Research Finance Assistant monitors expenses such as, but not limited to, ordering/procurement, accounts payable and payroll entries in the general ledger to ensure accuracy.
  • Develop the appropriate tools and templates to best facilitate work by using a combination of spreadsheets, word processing and database software.
  • Communicates with the PHSA procurement group, PHSA research accounting group, and research personnel on any matters pertaining to accounting, budgeting and finance. 
    The Research Finance Assistant may communicate with external contacts such as scientific vendors/manufacturers, UBC and VCH financial departments and non-PHSA/BCCA research personnel.
  • Monitor budgets, provides input into the development of budgets and on enhancing efficiency for specified grants and projects
  • Summarizes monthly and quarterly financial data into reports and provides discussion on variances and discrepancies.
  • Receives invoices, matches documents and allocates invoices to grants/funds by assigning codes for payment.
  • Develops and maintains a database pertaining to procurement, accounts payable and other transactions.
  • Develops and maintains a database of grant applications and related publications. 
  • Demonstrates work methods to new, junior and coop student staff.

You bring

  • A level of education, training, and experience equivalent to completion of a Diploma/Certificate (preferably in Business)
  • 1 years recent related experience in research administration or finance role. Demonstrated ability to manage multiple tasks and assignments within a fast paced environment.
  • Demonstrated organizational, analytical and decision-making skills.
  • Excellent ability to organize work and communicate effectively.
  • Ability to exercise confidentiality. Excellent communication skills both verbal and written.
  • Demonstrated computer literacy. Ability to work under pressure.
  • Ability to accept responsibility and work independently.

MD or PhD Postdoctoral Fellow and MSc or PhD Graduate Students for translational research

We are looking for outstanding, motivated graduate students as well as postdoctoral fellows to join the Kuchenbauer Lab, who can share our passion for medicine/science and want to make a difference for patients´ lives.

Our research is mainly translational and focuses on immunotherapies such as allogenic stem cell transplantation for acute myeloid leukemia. We are driven to improve patients’ lives by addressing clinical “every day” challenges with state of the art research including preclinical animal models. Our goal is to translate our research into clinically applicable therapies. Scientific focuses are hematopoietic stem cell transplantation, hematopoietic stem cells physiology and pathophysiology as well as innovative treatment for Multiple Myeloma.

Multiple positions are available, starting as earlier as September 2018. Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to Dr. Arefeh Rouhi (arouhi@bccrc.ca).

Seeking talented students, postdoctoral fellows and lab staff

We are looking for outstanding, motivated graduate students as well as postdoctoral fellows (full time or part time) who share our passion for medicine/science and want to make a difference for patients´ lives.

Our research is mainly translational and focuses on immunotherapies such as allogenic stem cell transplantation for acute myeloid leukemia. We are driven to improve patients' lives by addressing clinical “every day” challenges with state of the art research including preclinical animal models. Our goal is to translate our research into clinically applicable therapies. Scientific focuses are hematopoietic stem cell transplantation, hematopoietic stem cells physiology and pathophysiology as well as innovative treatment for Multiple Myeloma.

Multiple positions are available, including research students or technicians.  Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to Dr. Arefeh Rouhi (arouhi[@]bccrc.ca).

Research Assistant 2, Proteomics

The position is in a mass spectrometry-based proteomics group in the Genome Sciences Centre at BC Cancer. The candidate will work as part of a team performing cutting-edge translational research using a broad range of proteomics techniques. The Research Assistant 2 – Proteomics works under supervision and performs experiments by following established laboratory procedures.

Job Code: RA2 07-04-2019

Key Accountabilities 

  • Prepare samples for proteomic analysis
  • Operating facility instrumentation including off-line HPLC fractionation systems, mass spectrometers, and speed vacs
  • Perform initial data analysis
  • Assist in the development of cutting edge protocols for clinical proteomics
  • Maintain logs of samples analyzed and instrument use
  • Liaise with collaborators to coordinate sample submission and communicating results
  • Collaborate with client lab personnel
  • Maintain a details lab notebook

Qualifications 

  • A laboratory technician degree in chemical and biotechnical science with direct work experience in proteomics. 
  • Theoretical knowledge and practical experience with tandem mass spectrometry
  • Experience with state-of-the-art mass spectrometry instrumentation including Orbitraps
  • Experience with clinical sample preparation for proteomics and nucleic acid analysis
  • Experience with processing cells and tissues for global and targeted proteomics
  • Practical experience with analytical reversed phase chromatography (HPLC and nanoLC), specifically for peptide separation
  • Two (2) years recent related experience in a research laboratory

In accordance with Canadian Immigration requirements, this advertisement is first directed to Canadian citizens and permanent residents but international candidates are invited to apply. We encourage applications from all qualified individuals, including Aboriginal peoples, persons with disabilities and members of visible minorities. English is the official language used at PHSA.

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RA2 07-04-2019") in the subject line of your emailed application.

Post-doctoral Fellow Single Cell Genomics, Molecular Biology

A postdoctoral fellowship position is available in the Aparicio lab based at the BC Cancer Research Centre in Vancouver, Canada, collaborating on an exciting project mapping clonal dynamics in human cancers with new single cell methods. 

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patients and patient-derived xenografts. The post holder will have the opportunity to interact as part of the international CRUK Grand Challenge IMAXT project, bringing new measurement methods and computational techniques to the 3D reconstruction of tumour and mapping drug sensitivity and drug combinations using sgRNA/CRISPR methods in vivo. The program works closely with the Shah lab computational biology program on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage.

How to Apply: Please send the following documents to careersmolonc@bccrc.ca and put “Single Cell Genomics, Aparicio Lab – PDF Position” and your family name in the subject line.

  • Cover Letter
  • Resume
  • Transcript
  • Work Sample

Post-doctoral Fellow

Posting is available immediately for a postdoctoral fellow with experience in cancer bioinformatics to work on an exciting new program developing non-invasive patient genomic monitoring. The successful candidate will have a degree and postgraduate training in bioinformatics, computer science, statistics, or allied subjects, with experience applying modern computational genome analysis methods. The post holder will work jointly with the groups of Dr Samuel Aparicio (UBC and BC Cancer) &  Dr Andrew Roth (UBC Computer Science and BC Cancer) on developing and implementing methods for analysis of genomic sequencing information from plasma and other fluids to monitor tumour burden and provide information for screening of high risk patients. This will be in conjunction with existing work on single cell genome analysis pioneered by the Aparicio and Shah labs in the last 5 years.

How to Apply:
Please send the following documents to careersmolonc@bccrc.ca and put "Post-doctoral Fellow – Aparicio Lab, family name) in the subject line

  • Cover Letter
  • Resume
  • Transcript
  • Work Sample

Co-op Positions

Application Deadline

2 positions available May 2020 – Dec 2020 (8 months)

Co-op position 1 - Our lab has developed in house a synthetic model of T cell acute lymphoblastic leukemia by lentiviral transduction of hematopoietic stem progenitor cells from human umbilical cord blood. One co-op student will be working on investigating how various conditions contribute to this leukemic transformation. In this position, you will learn aseptic technique for culturing human primary cells, how to produce lentivirus and transduce cells, flow cytometry techniques and analysis, mouse necropsies and cell cryopreservation. We would prefer someone with wet lab experience and is organized and detail-oriented.

Co-op position 2 - Investigating the tumour ecosystem in human non-Hodgkin’s lymphoma. Using state-of-the-art single cell analysis (mass cytometry (CyTOF), single cell RNA sequencing and high-parameter flow cytometry), this project will investigate the heterogeneity of tumour cells and their surrounding non-malignant immune and stromal cells. This work is of direct clinical relevance in providing detailed phenotypic characterizations that are required in order to define biomarkers for lymphoma classification and prognosis. In this position, you will have opportunities to learn: 1) handling and processing clinical samples, including tissue digestion and culture of human primary cells; 2) maintaining and operating the CyTOF and multi-parameter flow cytometry; 3) Multi-dimensional data analysis. We prefer applicants who are detail-oriented and have a strong interest in bioinformatics/programming as such skills will allow for more involvement in data analysis. 

Applicants may apply via their school's co-op program.
 

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