Careers

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values — science, timeliness, respect — to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: PCD_E00375_2021_08_11

Reporting to the Bioinformatics Group Leader the Process Development Coordinator (PDC) will support the development, testing and validation of clinical bioinformatics processes at the Genome Sciences Centre (GSC)—a large scale, high throughput biologics facility. The PDC will develop new Clinical procedures and bioinformatic workflows, monitor and review performance within the clinical production process, and where applicable, improve existing analyses.

Scope and complexity

The PDC monitors existing processes and recommends and/or develops new processes in support of the clinical sequencing objectives at the GSC. The PDC designs and performs informatic experiments to validate either existing methods or novel methods providing new functionality. The successful candidate will strive to streamline existing functionality, and maximize output quality and efficiency while balancing costs. Monitoring of results and comparison to outlined standards will be performed.

The PDC collaborates closely with key stakeholders for the clinical process including the clinical director, bioinformatics groups and quality assurance group.

Duties/Accountabilities

Oversees the development and testing of clinical bioinformatics production processes by:

1. Designing and performing experiments pertaining to the generation of clinically relevant results.  This includes, but is not limited to, the development and testing of new analyses, protocol optimization, Quality Assurance and Quality Control, testing of prototypes and related activities. The PDC continually monitors performance of protocols within the production process and identifies areas for improvement. All activities will yield documented recommendations and implementation plans.
2. Troubleshooting existing clinical computational processes where necessary. Makes recommendations and adjustments and reports problems.
3. Training designated members of the clinical bioinformatics group in new or optimized analysis workflows. Writes or revises protocols accordingly.
4. Performing technical functions related to the Bioinformatics groups of the GSC.
5. Other related duties as necessary.
    

Qualifications

• Graduation from a recognized Bachelor’s program in an appropriate discipline such as Computer Science, Bioinformatics, Genetics, Molecular Biology or Biochemistry (PhD) preferred).
• Five (5) years of recent related experience in a research and or clinical laboratory including supervisory experience

OR

An equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and knowledge

• Proven expertise with Python and/or other similar high level languages.
• Demonstrated ability in R or other similar statistical programming languages and in statistical analysis.
• Functional knowledge of distributed version control systems, such as Git.
• Demonstrated experience with next generation/ third generation sequencing technology with an in-depth understanding of standards and guidelines for validating clinical bioinformatics analysis pipelines using these technologies.
• Excellent verbal and written communication skills.
• Comfortable working in a Linux environment, including experience with shell scripting and common command-line tools.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
• Experience liaising with multiple stakeholders to support consensus goals.
• Demonstrated ability to efficiently organize work assignments and establish priorities to meet set milestones.
• Demonstrated ability to write technical documents including validations and procedure manuals
• Excellent analytical skills
• Demonstrated ability to accept responsibility and work independently.
• Experience with bioinformatic workflow managers eg Nextflow would be considered an asset.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Process Development Coordinator-Clinical_PCD_E00375_2021_08_11 in the subject line of your email.

This posting will remain online until filled.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis. This restriction would be re-evaluated upon re-contracting

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values — science, timeliness, respect — to join us on our mission to use genome science for the betterment of health and society.

Summary

This position is for a temporary 18-month leave replacement.

Job Reference No: RPC-R00022-2021-08-11

Do you have a background in science research — from its processes and practices to proposals & peer-review? Can you develop an award winning grant application, facilitate efficient and productive meetings, gather the right information and engage the right people at the right ti​me? We're looking for a Research Project Manager to help GSC faculty and leaders continue to deliver world-leading genomics, bioinformatics, cancer and precision medicine research.

Reporting to the Head, Project Management or Projects Team Leader and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and monitor and facilitate progress against these objectives and milestones. Projects will involve personalized oncogenomics, collaborative services management, or other cancer genomics research.

Duties/Accountabilities

• Establishing budgets for research projects, grants, collaborations and core activities
• Assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
• Monitoring budgets and expenditures
• Establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives, which may include, meeting coordination and follow-up, coordination of case reviews
• Maintaining accurate information on sample status, including sample and associated metadata acquisition, processing, stakeholder reporting
• recommending strategies for improving projects management methods and processes
• Liaising with grant/core funding agencies
• Interacting directly with research collaborators or clinical study teams as required

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research, clinical trials research, biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

Successful candidate(s) will be offered positions through Provincial Health Services Authority at level Research Project Coordinator, which is equivalent to that described above

Core Skills and Abilities

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Project Manager in the subject line of your email.

This posting will remain online until filled.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary of Responsibilities

Reporting to the Genome Sciences Centre (GSC) Operations Leader or designate and working within the context of a research culture and in accordance with established policies and procedures, vision and values of the Genome Sciences Centre (GSC), the Laboratory Coordinator coordinates a variety of activities within the GSC Laboratory, including maintaining and implementing safety and security policies, and purchasing laboratory supplies, equipment and services.

Scope and Complexity

The Laboratory Coordinator is a key member of the GSC and provides leadership and direction to staff within the area of providing day to day guidance and ensuring an effective operation is maintained and efficient services are provided. Collaborates and facilitates with other GSC staff and Agency staff on issues impacting the laboratory.

The Laboratory Coordinator operates in a complex research environment where considerable judgement and problem solving is used to develop solutions to operational issues within the laboratory. This position ensures processes and standards are in place to assist, clarify and guide GSC staff to make sound operational decisions.

Guidelines for this role are in the form of policy statements with direction on overall objectives received from the Operations Leader.

Communications

Internal Contacts

Internal contacts include ongoing communication with a wide variety of staff at various levels within the GSC and the Agency. Contact primarily involves interaction with GSC management staff and staff from Purchasing, Housekeeping, Stores, Plant Maintenance, Security, Finance and Research Centre Scientists.  The Laboratory Coordinator provides information and guides others in a specialized area of expertise to define, clarify and provide assistance to achieve operational goals.

External Contacts

External contacts include ongoing contact with a variety of outside individuals and agencies such as vendors, staff from the University of British Columbia (UBC) including staff from the Department of Medical Genetics, Biotech Labs, Finance and Co-op Education and staff from the Simon Fraser University, the University of Victoria and from Genome B.C. Contact primarily involves obtaining and exchanging information related to contracting, materials sourcing and outreach.

Duties/Accountabilities

1. Participates in the formulation of goals and objectives and the setting of policies and procedures for the Laboratory as a key member of the management team.  Upon approval implements approved policies and procedures.
2. Implements safety and security policies and procedures in accordance with current regulations regarding laboratory working conditions.  Communicates information to staff and maintains related records.
3. Oversees the day to day operation of the laboratory.  Establishes priorities and provides guidance and technical advice by facilitating resolutions and by monitoring work activities to ensure the standards of the area are maintained.  Monitors the work of the area to ensure the quality and quantity of services are being provided. 
4. Provides leadership to staff.  Responsibilities include supporting staff as a mentor and facilitator, establishing clear definitions of responsibilities for each employee, identifying staff education/development needs and developing, implementing and evaluating orientation, training and education programs.  Monitors performance, provides ongoing feedback, encourages continuous improvement and increased staff morale.
5. Participates in operational recruitment, including interviews and providing feedback on prospective hires.
6. Coordinates access control to various locations in accordance with departmental and regulatory requirements.
7. Participates in the on-boarding of new GSC staff in coordination with the Operations Leader, ensuring physical space is allocated and documentation via computer databases is maintained.
8. Maintains policies and procedures for purchasing equipment and supplies for the GSC in accordance with BCCA policies, including initiating new policies and procedures for approval and revising existing policies and procedures.  Liaises with purchasing staff of the BCCA to complete orders.  Maintains documentation for equipment inventory through methods such as updating computer databases.
9. Participates in re-modelling projects or space issues within the laboratory in coordination with the Operations Leader.
10. Provides orientations for housekeeping staff regarding expected standards, and safety and operational policies of the laboratories.
11. Negotiates with suppliers and vendors for financially optimal purchases, equipment leasing and consumable supply contracts.  Monitors cost, schedule and scope of contracts to ensure quality and quantity at best value.  Develops new supply sources where vendor and suppliers do not meet the needs of the GSC.
12. Responds to requests for maintenance and repair of equipment by reviewing the work needed and arranging for the appropriate repair person to complete the work by completing a repair requisition and calling the service department of the appropriate company.  At completion, ensures the work has been completed satisfactorily
13. Participates in a variety of committees including the safety committee.
14. Participates in emergency on-call rotations.
15. Performs other related duties as assigned, in cooperation with lab coordinators

Qualifications

Bachelor’s degree (preferably in life sciences) plus three (3) years of experience in a research or laboratory environment.

Strong interpersonal skills coupled with excellent written and oral communication skills. Demonstrable judgement and discretion.  Ability to prioritize and exercise initiative.  Ability to work under pressure with a diverse group of persons, policies and procedures.  Knowledge of a variety of computerized software products such as word processing, spreadsheet, database applications, scheduling, e-mail and internet.  Ability to work as a team member.  Detail oriented.  Problem solving capabilities.  Physical ability to perform the duties of the job.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: PC_E00812_2021_08_11in the subject line of your email.

This posting will remain online until filled.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis. This restriction would be re-evaluated upon re-contracting.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: RP_R00008_2021_07_30

The GSC is looking for an enthusiastic and self-motivated Research Programmer to work on the next generation of federated genome and health data sharing platform, CanDIG—a Canadian data-sharing platform contributing to the development of an international effort to facilitate information exchange as part of the Global Alliance for Genomics & Health (GA4GH). CanDIG also supports large-scale provincial and national data sharing projects, including BC Cancer’s Personalized OncoGenomics program, the Terry Fox Research Institute's (TFRI) PROFYLE project and the TFRI-led Marathon of Hope Cancer Centres Network—a major federal initiative to accelerate the adoption of precision medicine for cancer in Canada. This role requires a combination of interest in DNA technology and a strong background in software development.

Qualifications

The successful candidate will have an undergraduate degree in computer science, bioinformatics or a related subject.

Abilities

• 2+ years of experience in Python programming.
• Previous experience or exposure in the bioinformatics settings.
• Full stack web development experience with web frameworks such as Flask or Django.
• Previous experience in designing, implementing and testing REST APIs.
• General understanding or previous experience in microservice architecture and development.
• General knowledge in Unix environment, Version Control (Git), and Agile methodologies. 
• The position requires working with a wide variety of researchers, software developers and clinicians, thus excellent communication skills are essential.

Assets

• Experience or knowledge in handling genomics data files.
• Prior experience in developing front-end applications using React.js.
• Experience building rich queries using GraphQL or other data query language.
• Experience working with distributed systems.
• Basic understanding of DNA technology or previous work experience with genetic data is a plus, but not required for the position.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: RP_R00008_2021_07_30 in the subject line of your email.

This posting will remain online until filled.

Important

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis. This restriction would be re-evaluated upon re-contracting.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: CB_HSA#111679_P01066_2021_07_13

In accordance with the Mission, Vision and Values, and strategic directions of PHSA, safety, including both patient and employee safety, is a priority and a responsibility shared by everyone at PHSA. As such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Computational Biologist participates in developing, improving and maintaining bioinformatics tools for high-throughput processing pipelines. The Computational Biologist specifies, implements, tests and maintains bioinformatics computer applications and systems, and participates in the code walk-throughs and design and review of bioinformatics software solutions. The Computational Biologist will also assist in the packaging and distribution of developed tools and analysis results to the scientific community, and will contribute to the preparation of scientific publications.

Duties

• Codes in Python and specifies, implements, tests, and maintains bioinformatics pipelines and applications as assigned.
• Assists with devising or modifying systems to solve complex problems associated with high throughput pipelines, considering computer equipment capacity and limitations, operating time and form of desired results.
• Participates in code walk-throughs and reviews of the coded solutions to PEP8 standards.
• Participates in the design and build of database and software solutions taking performance into consideration.
• Coordinates production problem resolution for assigned applications, including working with other technical teams.
• Evaluates third-party software and incorporates new systems into legacy systems.
• Produces written documentation of algorithms, validations, SOPs, and other processes related to pipeline updates and procedures as required.
• Presents results of bioinformatics software testing internally and externally.
• Performs literature searches, testing and validation of new data analysis software related to bioinformatics pipelines.
• Performs other related duties as required.

Qualifications

Education, Training and Experience

• Graduation from a recognized Bachelor of Applied Science or Bachelor of Science Program in either Computer Science, Biological Sciences, or equivalent program.
• Two (2) years of recent related experience in a bioinformatic setting or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

• Demonstrated expertise with Python or other similar high level languages for application in data analysis.
• Demonstrated ability to program and run analysis in a high throughput bioinformatics production environment.
• Functional knowledge of distributed version control systems, such as GIT.
• Functional knowledge of Agile development and ticketing systems.
• Demonstrated ability to work with bioinformatics workflow managers (e.g. Nextflow).
• Excellent verbal and written communication skills.
• Demonstrated ability to work in an Unix environment, including experience with shell scripting and common command-line tools.
• Demonstrated ability to develop software as part of a team.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
• Demonstrated ability to efficiently organize work assignments and establish priorities.

How to apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: CB_HSA#111679_P01066_2021_07_13 in the subject line of your email. 

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. 

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis. This restriction would be re-evaluated after reopening plans.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: CB_HSA#111678_P01066_2021_07_13

In accordance with the Mission, Vision and Values, and strategic directions of PHSA, safety, including both patient and employee safety, is a priority and a responsibility shared by everyone at PHSA. As such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Computational Biologist participates in developing, improving and maintaining bioinformatics tools for high-throughput processing pipelines. The Computational Biologist specifies, implements, tests and maintains bioinformatics computer applications and systems, and participates in the code walk-throughs and design and review of bioinformatics software solutions. The Computational Biologist will also assist in the packaging and distribution of developed tools and analysis results to the scientific community, and will contribute to the preparation of scientific publications.

Duties

• Codes in Python and specifies, implements, tests, and maintains bioinformatics pipelines and applications as assigned.
• Assists with devising or modifying systems to solve complex problems associated with high throughput pipelines, considering computer equipment capacity and limitations, operating time and form of desired results.
• Participates in code walk-throughs and reviews of the coded solutions to PEP8 standards.
• Participates in the design and build of database and software solutions taking performance into consideration.
• Coordinates production problem resolution for assigned applications, including working with other technical teams.
• Evaluates third-party software and incorporates new systems into legacy systems.
• Produces written documentation of algorithms, validations, SOPs, and other processes related to pipeline updates and procedures as required.
• Presents results of bioinformatics software testing internally and externally.
• Performs literature searches, testing and validation of new data analysis software related to bioinformatics pipelines.
• Performs other related duties as required.

Qualifications

Education, Training and Experience

• Graduation from a recognized Bachelor of Applied Science or Bachelor of Science Program in either Computer Science, Biological Sciences, or equivalent program.
• Two (2) years of recent related experience in a bioinformatic setting or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

• Demonstrated expertise with Python or other similar high level languages for application in data analysis.
• Demonstrated ability to program and run analysis in a high throughput bioinformatics production environment.
• Functional knowledge of distributed version control systems, such as GIT.
• Functional knowledge of Agile development and ticketing systems.
• Demonstrated ability to work with bioinformatics workflow managers (e.g. Nextflow).
• Excellent verbal and written communication skills.
• Demonstrated ability to work in an Unix environment, including experience with shell scripting and common command-line tools.
• Demonstrated ability to develop software as part of a team.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
• Demonstrated ability to efficiently organize work assignments and establish priorities.

How to apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: CB_HSA#111678_P01066_2021_07_13 in the subject line of your email. 

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. 

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis. This restriction would be re-evaluated after reopening plans.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: RPC2_R00026_2021_07_06

Reporting to the Manager, QA/QC, the Business Analyst and Project Support (BA) leads the analysis and documentation of business requirements to support projects for designated programs/services. This position works in close collaboration with other stakeholders to develop business systems enhancements, business solutions, or business processes including GSC’s bioinformatics processes. The BA functions as a Subject Matter Expert (SME) to the project team through performing gap analysis of systems and business process mapping including the identification of linkages to other business systems.  

The BA will:

• Provide key contributions to the development of solutions to ensure that business processes and/or project deliverables are consistent, accurate, and timely.  
• Participate in and contributes to strategic planning. 
• Develop project plans for the design, development, and implementation of new business processes, and supports the transition from current systems, practices and processes to an integrated system, common practices, and standardized processes with current or improved functionality.  

Responsibilities

• Ensures key results are achieved in accordance with the project plan by analyzing current business systems and processes, generating ideas and formulating recommendations/options, and supporting members of the project in prioritizing tasks and reaching decisions that are within project scope and timelines. 
• Implements or contributes to the implementation of effective processes to assess project risks, identifies risk mitigation strategies and monitors risk throughout the project lifecycle. Supports the Managers/Team Leads by providing regular updates on the progress as well as any areas of risk associated with the completion of the project both within the project scope and the timeline. Provides professional expertise to staff, departments, stakeholders, and guidance regarding standard process for project management.
• Coordinates and participates in the analysis, acceptance criteria definition, development, testing, training, implementation, and maintenance phases of assigned bioinformatics projects. Carries out post-implementation reviews of systems and makes recommendations for improvements.
• Utilizes formal data gathering techniques and analysis tools such as flowcharts, diagrams, dashboards, roles and responsibility matrix (RACI), and work effort estimates. Provides details of estimated implementation costs including associated staffing requirements.
• Reviews, analyzes and defines current/future state processes, determines user and/or department requirements and contributes to the development of specifications and testing for all identified development, system modifications, and installations. Performs impact analyses. 
• Provides user support, advice and guidance, and orientation in situations that require interpretation and judgement Develops content, as required, for training modules, delivers training, and provides and guidance to system users and department staff. Develops and maintains various business processes, policies and procedures, as well as reference documentation such as user instructions, manuals, and reference materials.  
• Provides support to colleagues and users during the development, maintenance and operation of various computer systems by performing duties such as troubleshooting system software problems and testing alternative solutions. 
• Participates in the formal data collection and analysis to help identify system deficiencies and/or operational inefficiencies in order to report and develop new ways of improving business efficiencies including the data analysis related to business case developments, project proposals, and other key strategic and transformative initiatives. 
• Assembles, creates and maintains information systems technical and operational documentation according to departmental standards.
• Assists with preparation of Requests for Information/Proposal, development of evaluation processes and tools, and evaluation of vendor responses by serving on working groups, documenting detailed requirements, and coordinating project team and vendor communications.

Education and skills

• A level of education, training, and experience equivalent to a Bachelor's degree in Health Information Science, Computer Science, or a related discipline, plus five (5) years recent related experience which includes software/system project planning, analysis and implementation.  
• Demonstrated ability to carry out business process mapping and fit gap analysis.  
• Excellent interpersonal, oral, and written communication skills with the ability manage multiple interactions with multiple groups while working on multiple issues at the same time.  
• Superior analytical, problem-solving and system analysis skills.  
• Proven ability to plan and execute projects with stringent timelines.  
• Ability to work effectively as part of a team.  
• Demonstrated ability to provide professional expertise to staff, departments and GSC stakeholders, and guidance regarding standard processes for software/computer system related project management.  
• Demonstrated ability to provide user support, advice and training, and other user liaison services.
• Public Service and Health Sector experience and knowledge are an asset.  

How to apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Business Analyst and Project Support in the subject line of your email. 

This posting will remain open until filled.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. 

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis. This restriction would be re-evaluated after reopening plans.

Role Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient and employee safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position. Reporting to the Clinical and Research Directors of the Centre for Lymphoid Cancer, BC Cancer Agency, the Biostatistician provides support in the areas of study design, analysis, and consulting for biological and clinical cancer research. This role oversees survival analysis and statistical modeling of clinico-biologic factors associated with patient outcomes and maintains information collected in the provincial clinical lymphoma database. The Biostatistician also provides the monitoring of lymphoid cancer interventions and lymphoid cancer health service performance indicators for use in the planning, implementation and evaluation of lymphoid cancer care in the province. The Biostatistician is responsible for tracking trends and detecting emerging issues and associations between a wide range of lymphoid cancer risk factors, health determinants, and health outcomes. The Biostatistician manages the preparation of annual, quarterly, period, and ad hoc reports and is responsible for ensuring high quality and accuracy of these reports. The Biostatistician is responsible for providing statistical support and maintains the integrity of the data to a renowned lymphoma cancer research group which consists of Clinicians, Researchers, Biologists, and Bioinformaticians on lymphoma cancer research and related projects. Key Accountabilities Develops novel statistical models to discover untapped potential in  clinical data, biological phenomena, and novel associations of clinic-biologic factors with patient outcomes. Monitors and assesses existing provincial clinical database of lymphoma patients to provide accurate and timely information. Provides regular reports and presentation of statistical analyses and results to the group Provides support for the development and collaboration of experimental design of research projects to ensure statistical rigor. Evaluates existing and emerging data analysis tools, provides recommendations regarding new tool adoption and performs risk/impact analyses in support of the planning of system development, enhancement and maintenance. Performs quantitative data analyses using advanced statistical methodologies and statistical software. Identifies and provides advice about data limitations and ensures adequate data quality for analytic purposes. Links data sources from the provincial clinical lymphoma database with other major health information systems such as the Ministry of Health (Vital Statistics, hospital discharge database, Pharmanet, Medical Services Plan). Maintains relationships with senior managers in these organizations; takes measures to protect all data and information being used to comply with protection of confidentiality and privacy policies. Develops and produces analytical outputs (e.g. reports, presentations, posters) that support the Centre for Lymphoid Cancer Agency and BCCRC Committees in the monitoring, planning and evaluation of population trends, health services utilization, and health outcomes for lymphoid cancer interventions, including health care system quality trends and variations. Develops and produces reports that monitor and benchmark cost, utilization, quality and other performance indicators and communicates findings to the BCCRC and PHSA Executives, PHSA Board, Ministry of Health and external stakeholders at the local, regional, provincial and national levels. Formulates recommendations based on findings, including strategic interventions, program and costing recommendations. Represents the Centre for Lymphoid Cancer in various meetings as a speaker or contributor. Plans, develops and delivers training programs, initiatives and materials related to lymphoid cancer research and data analyses in collaboration with BCCRC staff and other organizations throughout the province. Identifies learning needs that contribute to skill enhancement and career progression for self and fosters a working environment that stimulates learning and inquiry for self and others. Takes responsibility for keeping self-up-to-date regarding new initiatives, developments and trends in statistical analysis, renal utilization and health services issues through literature review, contact with peers at other organizations, professional associations and attendance at conferences, seminars, workshop and education programs. Communicates information and makes recommendations to the Clinical & Research Directors for evaluation and approval. Qualifications A level of education, training, and experience equivalent to a Master’s Degree in Biostatistics, Statistics, Epidemiology, Health Information Science, or Computer Science and five (5) years of experience in a health analytics, health research or health information field. Understanding of molecular biology and cancer genomics is an asset. Advanced knowledge of frequentist statistics, probability distributions, statistical inference and modeling, particularly Bayesian statistics and machine learning. Knowledge of database management principles. Exceptional knowledge of survival analysis, including cox regression, Kaplan-Meier estimation, statistical language R and experience using ‘Rmarkdown’ or an alternative statistical language. Experience in database graphical, presentation, communication and software applications, such as Linux, MS Access and SQL. Strong analytical, problem-solving and system analysis skills including the ability to comprehend complex issues and related data/information and present information in concise meaningful ways. Ability to develop complex and customized queries and reports. Ability to function in a self-directed manner. Excellent ability to communicate effectively both verbally and in writing. Demonstrated interpersonal skills with a variety of people. Excellent time management skills. Demonstrated ability to respond to the needs of stakeholders supported by an acute awareness of the impact of actions. Ability to handle multiple concurrent tasks. Physical ability to perform the duties of the job.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values — science, timeliness, respect — to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: RPC-R00022-2021-05-28

Do you have a background in science research — from its processes and practices to proposals & peer-review? Can you develop an award winning grant application, facilitate efficient and productive meetings, gather the right information and engage the right people at the right ti​me? We're looking for a Research Project Manager to help GSC faculty and leaders continue to deliver world-leading genomics, bioinformatics, cancer and precision medicine research.

Reporting to the Head, Project Management or Projects Team Leader and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and monitor and facilitate progress against these objectives and milestones. Projects will involve personalized oncogenomics, collaborative services management, or other cancer genomics research.

Duties/Accountabilities

• Establishing budgets for research projects, grants, collaborations and core activities
• Assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
• Monitoring budgets and expenditures
• Establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives, which may include, meeting coordination and follow-up, coordination of case reviews
• Maintaining accurate information on sample status, including sample and associated metadata acquisition, processing, stakeholder reporting
• recommending strategies for improving projects management methods and processes
• Liaising with grant/core funding agencies
• Interacting directly with research collaborators or clinical study teams as required

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research, clinical trials research, biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

Successful candidate(s) will be offered positions through Provincial Health Services Authority at level Research Project Coordinator, which is equivalent to that described above

Core Skills and Abilities

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Project Manager in the subject line of your email.

This posting will remain online until filled.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis. This restriction would be re-evaluated upon re-contracting

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: RP_R00008_ 2021_05_19

Dr. Aly Karsan and the Karsan lab team at Genome Sciences Centre (GSC) are seeking a Research Programmer to join a Marathon of Hope Cancer Centre research project. The team will be working with other research programmers at the Karsan lab for developing data analysis pipelines for various next-generation sequencing (NGS) data such as but not limited to scRNA-Seq, targeted sequencing, ATAC-Seq, and BS-Seq, for the study of cancer evolution. We seek candidates with strong analytical and programming skills to research, develop, and improve our research pipelines.

The role is ideally suited for detail-oriented individuals with a strong interest in data analysis, research, and scientific programming within a high throughput academic setting.  The Karsan lab has a history of strong publications and can offer great experience in research with full access to the GSC’s world-class compute cluster.  Additionally, the Karsan Lab has a diverse computational biology core for knowledge sharing, collaboration, and support. 

Duties/Accountabilities

• Design and implement bioinformatic data pipelines to meet objectives of the project
• Work with other project team members to develop and test code, and implement analysis
• Evaluate and incorporate third-party software into pipelines
• Produce thorough but concise written documentation of experiments, algorithms, validations, and other procedures as required.

 Qualifications

• Graduation from a recognized Bachelor of Science Program in Computer Science or relevant program. A Master’s degree in a relevant field would be a strong asset. 
• Two (2) years of recent related experience or an equivalent combination of education, training, and experience.

Core Skills and Abilities

• Expertise with scientific programming and able to provide links to code samples via GitHub
• Familiarity with molecular and cellular biology
• Excellent verbal and written communication skills
• Demonstrated ability to interpret results
• Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
• Established ability to efficiently organize work assignments and establish priorities
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.

Additional Assets

• Familiarity in statistical analysis using modern computational tools (experience with any relevant tools will be considered, but R and Python are preferred)
• Familiarity in next-generation sequencing datasets
• Understanding of cancer biology
• Functional knowledge of distributed version control systems, such as SVN or GIT

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Research Programmer – Data Scientist, Karsan Lab in the subject line of your email.

This posting will remain online until filled.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Due to COVID-19 restrictions, the position would require working remotely on a temporary basis. This will be re-evaluated once plans to return to the office are made.

Position Description

The post holder will support and work closely with Dr Aparicio, leader of Molecular Oncology, UBC Nan and Lorraine Robertson Chair of Breast Cancer, in developing scientific proposals, assisting in manuscript development and review, coordinating international multi-PI research studies and interacting with funders and advocates in reporting the activities of the program. A PhD with demonstrated experience in authoring manuscripts, preparing funding applications and reports, is a requirement for the role. Preference will be given to candidates with experience in biosciences and cancer research. Ability to articulate science clearly in a written form and a high degree of independence and self organization are core skills for this post.

Major responsibilities include

• Provide input into writing research proposals and writes significant portions of grant applications.
• Develops and recommends project budgets, monitors expenditure of funds relative to budget, ensures appropriate, transparent justifications for expenditures. Participates in the development and implementation of new projects, by developing new material, researching and sourcing equipment and recommending staffing and resource requirements.
• Manages and develops necessary agreements for the Aparicio program in conjunction with the BC Cancer Technology Development Office and UBC Office of Research Services/University-Industry Liaison Office.
• Responds to ongoing requests for regular reports by maintaining and updating information to ensure compliance with granting agencies and other external organizations.
• Serves as a primary point of liaison between researchers, administrators, and funding agencies REBs, national and international health organizations, educational institutions, government and private agencies.
• Identifies opportunities for developing new initiatives, grants and projects that enhance funding of research in the Aparicio program. This may include, but is not limited to funding from external organizations such as MSFHR, CIHR, Genome Canada, CFI, NSERC, NCIC, LRF, NIH, the provincial government and industry.
• Assists with Research Ethics Board applications and amendments as required, and ensures compliance with Research Ethics Board guidelines.
• Develops and maintains a clear engagement and communication plan for both internal and external audiences.  This includes promotion and representation of Aparicio program research through websites and social media platforms, and the development and facilitation of workshops, conferences, guest lecturers, etc.
• Identifies new translational pathways, such as commercial partnerships, licencing etc. for new technologies and encourage entrepreneurial activities as appropriate.
• Conducts regular literature reviews relating to research areas.  Contributes intellectual and scientific input to manuscripts for publications, provides scientific proofreading. 

Eligibility requirement

Interested individuals with a PhD or MD/PhD, a strong publication record and excellent academic credentials are encouraged to apply. Experience in grant preparation and scientific manuscript preparation is required.

• Strong interpersonal skills and the ability to work effectively with internal and external stakeholders who possess a wide range of education and expertise. 
• Ability to use independent judgment and to manage and impart information to a diverse range of internal and external stakeholders.
• Ability to exercise appropriate tact, discretion, confidentiality, and good judgment in all matters.
• Knowledge of and/or experience in project management principles, accounting and fiscal management is preferable.

This is a one year appointment and depending on funding and successful progress of the research it may be renewed for additional years.

UBC hires on the basis of merit and is committed to employment equity. All qualified persons are encouraged to apply. UBC is strongly committed to diversity within its community and especially welcomes applications from visible minority group members, women, Aboriginal persons, persons with disabilities, persons of any sexual orientation or gender identity, and others who may contribute to the further diversification of ideas. However, Canadians and permanent residents of Canada will be given priority.

We thank all interested applicants for their interest, however, only those applicants short-listed will be contacted for an interview.

We are seeking a highly-motivated post-doctoral fellow (PDF) with strong leadership ability and expertise in single cell genomics and transcriptomics, and a strong background in molecular biology. The successful applicant will work full-time under the supervision of Dr. Samuel Aparicio. The position start date is flexible.

JOB SUMMARY:

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patient tissues and patient-derived xenografts (PDX). A PDF position is available in the Aparicio lab based at the BC Cancer Research Center in Vancouver, Canada, collaborating on an exciting project mapping clonal dynamics in human cancers with new single cell methods. The post holder will have the opportunity to interact as part of the international CRUK Grand Challenge IMAXT project, bringing new measurement methods and computational techniques to the 3D reconstruction of tumours, and mapping drug sensitivity and drug combinations using sgRNA/CRISPR methods in vivo. The program works closely with the Shah computational biology program, based at Memorial Sloan Kettering Cancer Centre, on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage.

ORGANIZATIONAL STATUS:

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Center in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, and will play a senior leadership role in the laboratory.

WORK PERFORMED:

• Provide leadership, strategic direction, and translational research pertaining to single cell genomics and transcriptomics, and CRISPR methods.
• Design and implement research plan to investigate the clonal dynamics in human cancer through single cell methods.
• Design and conduct animal experiments.
• Conduct in vivo testing or characterization of drugs, small molecules, knockouts or antibodies in relevant PDX animal models.
• Foster research collaborations and work jointly with academic, clinical, industry, and other partners.
• Scientifically document lab experiments, data analysis, interpretations.
• Write manuscripts, present results at internal and external meetings.
• Identify funding opportunities and if required write or assist with grant proposals
• Lead and mentor junior trainees/students in the laboratory

CONSEQUENCE OF ERROR:

This is a senior research position that plays a critical role in the development of this novel field. PDF is accountable for the quality and integrity of the research and data, including analyses and interpretation, as well as the effective and efficient management of research projects and deliverables. This position requires innovation, strategic planning, and adaptability. Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly.

SUPERVISION RECEIVED:

The PDF will work with a high degree of independence and set priorities under broad directives from Dr. Aparicio. The PDF will be expected to provide direction and mentoring in the laboratory under the supervision of Dr. Aparicio. This position will also provide the candidate with a high level of exposure to single cell genomics and translational research, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally.

SUPERVISION GIVEN:

The PDF will be expected to provide mentorship and guidance to undergraduate, graduate students and other research members as required.

QUALIFICATION:

• Ph.D. in biology, cell biology, molecular biology, biochemistry, genetics, genomics, or similar discipline.
• The candidate should have a solid scientific and technical background with excellent written/oral communication, interpersonal and organizational skills.
• Preference will be given to candidates with a proven track record with a minimum of 2-3 first author publications in reputable journals.
• Proficiency in cell biology, molecular biology, histology, genetics, genomics, next-generation sequencing and biochemistry techniques.
• Demonstrate the ability to work in a highly interdisciplinary environment.
• Experience with cancer research.
• Expertise and hands-on experience in animal studies, including all aspects of design, handling, breeding, tissue collection, histology, and analyses are essential.
• Familiarity with testing/characterization of small molecule or drug in vivo is preferred.
• Previous biochemical/cell biology and molecular biology experience with single cell genomics / transcriptomics, next generation sequencing, drugs screen and PDX modeling is an asset.
• Experience with statistical analyses and scientific writing. Previous experience with grant writing is an asset.
• Experience with bioinformatics approaches to biological data and familiarity with handling of genomics data is an asset.
• Applicants with experience and a strong track record with large drug target screening, single cell methods, and PDX mouse models are especially encouraged to apply.

To apply: Please send your Cover Letter, CV, Transcript and Work Sample to careersmolonc@bccrc.ca

Please put your full name and job title “Post-doctoral Fellow (PDF) Single Cell Genomics, Molecular Biology" in the subject line.

Job Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Reporting to the Department Head or designate, the Research Administrative Coordinator, BC Cancer Research Centre is responsible for providing support in areas of human resources, payroll, grant and research administration. This role, on behalf of Principal Investigators (PI’s) and leaders, monitors payroll and financial cost centres through to resolution of payroll issues. The Research Administrative Coordinator also provides administrative support including managing the grant application process and providing work direction to junior administrative staff in the team.

Duties/Accountablilties

• In collaboration with the Principal Investigator(s) (PIs) coordinates the preparation and submission of grant proposals by identifying submission guidelines, collating information required and ensuring submission deadlines are met. Follows up with the granting agency on the submission of proposals, monitors post award financial accounts to ensure accuracy. Provides progress reports, highlights discrepancies and provides recommendations to resolve discrepancies and budget concerns to the PI(s) as appropriate.
• Interacts with a variety of individuals and agencies such as universities and granting agencies both national and international.  Ensures flow of information with internal and external stakeholders regarding grant related matters and makes arrangements for visiting speakers and guests.
• Human resources responsibilities include recruitment of staff by posting/advertising internally and externally (UBC), coordinating interviews and screening applications for review by hiring supervisors. Manages new hires orientation process in the department and ensures all safety and personnel documentations are in place according to policies, guidelines and legislations.
• Ensures all hiring, appointment and payroll processes such as new hire letters and timekeeping are complete for employees. Liaises with various PHSA units such as Payroll and Human Resources and in some cases, UBC to ensure a seamless process and minimize errors. Brings issues and recommendations of remedies to department head or designate for approval. 
• Acts as the main contact for ordering supplies for the department and approves lab and office supplies by performing duties such as submitting purchase requisitions and obtaining authorizing signature as necessary. Manages and processes various requisitions such as travel, expense reimbursements, cheque requests, and honorariums for the Department Head and PIs. Acts as liaison with various departments of BCCA/PHSA including purchasing, stores, and finance to obtain information and follow-up on the status of outstanding issues and requests.
• Coordinates registration and travel arrangements for staff attendance at seminars and meetings. This includes completing registration (on-line or phone), abstract submission, making travel and lodging reservations, culminating expense reimbursements to the attendee and/or cost recovery from the conference organizers as appropriate.
• Provides work direction to junior and contract administrative staff including orientating new staff and assigning and reviewing work, coordinating work assignments to ensure completion, answering questions and providing support, ensuring policies and procedures are followed and providing input to performance evaluations as required.

Qualifications

A level of education, training, and experience equivalent to a Diploma in a relevant area such as business administration or finance from a recognized college plus three (3) years’ recent related experience a research environment and in project management.
Strong interpersonal and communication skills and the ability to demonstrate good judgment, tact and discretion. Detail oriented and able to complete accurate work in a timely matter. Demonstrated time management skills and ability to assist others in meeting deadlines.  Knowledge of and experience with grant applications.  Knowledge and experience in budget preparation, tracking expenditures and identifying sources of variance. Proficient in scientific and medical terminology.  Ability to work both independently and as team leader to organize work and manage multiple priorities in a fast paced environment. Demonstrated ability to make sound decisions and resolve administrative issues/problems. Fully proficient in the use of a variety of software packages including word processing, spreadsheets and databases and related equipment. Demonstrated ability to evaluate personal work and existing systems and identify areas for improvement. Physical ability to perform the duties of the position.

To apply: please send your Resume and cover letter to careersmolonc@bccrc.ca

Please put “Research Administrative Coordinator” and your full name in the subject line.

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely on a temporary basis.

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Role Summary

A Post-doctoral position is available immediately for a highly motivated recent PhD or MD/PhD graduate to join a dynamic translational research group, headed by Dr. Isabella Tai, Associate Professor in the Division of Gastroenterology, University of British Columbia and Senior Scientist at Canada's Michael Smith Genome Sciences Centre at BC Cancer.

Current projects in the laboratory revolve around improving our understanding of the mechanisms involved in the development of chemotherapy resistance and metastasis in gastrointestinal cancers (colorectal, gastric, liver and biliary cancers). The goal is to develop either novel therapeutic targets for GI cancer treatment or novel screening tools for diagnosis. We continue to use the latest genomics (including single cell sequencing), proteomics and bioinformatic approaches to identify potential targets or markers for this purpose. Learn more about research projects in the Tai lab here.

Eligibility

Interested individuals with a recent PhD or MD/PhD and strong publication records and excellent academic credentials are encouraged to apply.  Experience in molecular biology, cell biology, tissue culture and animal tumor models, is preferable.  Experience in bioinformatics is an asset.

Duration

Three years (possibility of extension).

To Apply

Please submit a cover letter, curriculum vitae, and the names of three referees willing to provide letters of reference. The cover letter should include a brief description of your previous research experience, long-term career goals and an indication of the desired length of postdoctoral position.

Please email your application to bcgscjobs@bcgsc.ca

About us
Canada's Michael Smith Genome Sciences Centre (GSC) at BC Cancer is an international leader in genomics, proteomics, and bioinformatics for precision medicine. By developing and deploying genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets, and helping the world realize the social and economic benefits of genome science

Learn more about how the GSC is Bringing Genomics to Life.

Why work at the GSC
As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole-genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC, but it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers, and clinicians. We look for people who share our core values—science, timeliness, and respect—to join us in our mission to provide genomics, bioinformatics, and proteomics technology and expertise for the benefit of human health and society.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

*Due to COVID-19 restrictions, the position would require working remotely on a temporary basis.

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Role Summary

The Karsan lab team at Canada’s Michael Smith Genome Sciences Centre (GSC) is seeking a research programmer to join a Genome British Columbia software automation project. The team will be working with the Karsan lab, which is responsible for developing high-throughput, clinically accredited pipelines to analyse sequenced data from genomic assays for individualized patient management of cancer. We seek candidates with strong Python software and programming skills to automate and improve existing pipelines and potentially incorporate third-party software into the system.

The role is ideally suited for a creative individual with a strong interest in software development and testing, data analysis, and automation within a high throughput academic setting.

Key responsibilities

• Design, plan, and implement automated bioinformatics pipelines to meet the objectives of the project
• Work with other project team members to develop and test code, and implement software
• Evaluate third-party software and incorporate new systems into legacy systems
• Produce thorough but concise written documentation of algorithms, validations, SOPs, and other processes and procedures as required

Qualifications

Education, training and experience

• Graduation from a recognized Bachelor of Science Program in Computer Science. A Master’s degree in a relevant field would be a strong asset. 
• Two (2) years of recent related experience or an equivalent combination of education, training, and experience acceptable to the project lead.

Core Skills and Abilities 

• Expertise with Python 3.X and able to provide links to code samples via GitHub or another open repository
• Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
• Familiarity with molecular and cellular biology
• Excellent verbal and written communication skills.
• Demonstrated ability to efficiently organize work assignments and establish priorities.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.

Additional Assets

• Familiarity in statistical analysis using modern computational tools.  Experience with any relevant tools will be considered, but R and Python are preferred
• Familiarity with the development, testing, and maintenance of relational databases
• Familiarity in next-generation sequencing
• Experience with software testing
• Experience with Agile software practices
• Functional knowledge of distributed version control systems, such as SVN or GIT

To Apply

Please email your cover letter and resume to bcgscjobs@bcgsc.ca

Please note that this position will remain posted until filled.

Job Summary

The candidate would work within a dynamic and vibrant lab with a proven track record of outstanding achievements and contributions in breast oncology research. This position allows the candidate to contribute bold and innovative research that can be translated to new understanding in the evolutionary processes that drive cancers.

This position's primary focus in the lab will be to lead and to participate in projects involving the investigation of functional genomics using sequencing and expression data for breast oncology and cancer evolution. Using the wide network of connections and collaborations of the principal investigator, and extensive biomedical resources at the institution, candidates will be able to build on the existing research of the lab to quickly start up their own research projects.

The position will provide a unique opportunity for mentoring trainees, supervising analysts and interacting with industry. This is an excellent platform to receive outstanding training to gain the important skills for a successful medical research career in academia or industry.

This funded position with the University of British Columbia, at the BC Cancer Research Centre allows the candidate to flourish under the guidance of an experienced mentor

Organizational Status

The Postdoctoral Fellow will play a leadership role in the Aparicio lab, and will be reporting directly to Dr. Samuel Aparicio who is the primary investigator of the laboratory.

Work Performed

• Management and supervision of trainees;
• May be involved in recruitment and training of trainees;
• Performing regular reviews of the relevant literature;
• Planning and designing of experiments;
• Analyzing, interpreting and compiling data in study reports, presenting results, and participating in the preparation of scientific manuscripts and grant application packages;
• Updating Dr. Aparicio and the group on the status of projects during lab meetings, in email correspondence and phone conferences;
• Managing projects with key academic and industry partners.

Minimum Qualifications

• PhD degree in the computer science, bioinformatics or equivalent
• At least 4 years experience in bioinformatics research
• Experience in genomics and next-generation sequencing
• Extensive knowledge of cellular and molecular biology, biochemistry and genetics
• Experience with cancer research a plus
• Proven ability to multi-task in a deadline oriented environment with minimal supervision
• Effective oral and written communication, analytical, and interpersonal skills
• Excellent organizational skill and ability to learn new skills quickly
• Ability to work independently and within a team environment.
• Accuracy and attention to detail required
• Candidates should demonstrate the ability to work in a highly interdisciplinary environment.

Supervision Received 

• Works independently under direction of PI, Dr. Samuel Aparicio
• Opportunities to work collaboratively with Industry partners and other researchers at UBC and globally

Supervision Given

• Assists and oversees research assistants and students as required
• Assists and provides guidelines to other research members, as required

How to Apply

Exceptional candidates should submit a cover letter outlining your research interests and fit with the laboratory's research, curriculum vitae, and the names of three referees willing to provide letters of reference.

Due to the number of resumes we receive, we are unable to confirm receipt of submissions over the phone, or provide the status of the competition. Only shortlisted candidates will be contacted.

Equity and diversity are essential to academic excellence.  An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged.  We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

Email to apply: careersmolonc@bccrc.ca

Please put Bioinformatics PDF in the subject line.

We are looking for outstanding, motivated graduate students as well as postdoctoral fellows to join the Kuchenbauer Lab, who can share our passion for medicine/science and want to make a difference for patients´ lives.

Our research is mainly translational and focuses on immunotherapies such as allogenic stem cell transplantation for acute myeloid leukemia. We are driven to improve patients’ lives by addressing clinical “every day” challenges with state of the art research including preclinical animal models. Our goal is to translate our research into clinically applicable therapies. Scientific focuses are hematopoietic stem cell transplantation, hematopoietic stem cells physiology and pathophysiology as well as innovative treatment for Multiple Myeloma.

Multiple positions are available, starting as soon as possible. Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to Dr. Arefeh Rouhi (arouhi@bccrc.ca).

We are looking for outstanding, motivated graduate students as well as postdoctoral fellows (full time or part time) who share our passion for medicine/science and want to make a difference for patients´ lives.

Our research is mainly translational and focuses on immunotherapies such as allogenic stem cell transplantation for acute myeloid leukemia. We are driven to improve patients' lives by addressing clinical “every day” challenges with state of the art research including preclinical animal models. Our goal is to translate our research into clinically applicable therapies. Scientific focuses are hematopoietic stem cell transplantation, hematopoietic stem cells physiology and pathophysiology as well as innovative treatment for Multiple Myeloma.

Multiple positions are available, including research students or technicians.  Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to Dr. Arefeh Rouhi (arouhi[@]bccrc.ca).

Ongoing recruitment.

Possible projects: Role of leukemia stem cells in T-ALL, examining the tumor ecosytem in lymphomas, or pathogenetic mechanisms in T-ALL.

Interested applicants may submit letter of interest and CV to aweng@bccrc.ca.