Researchers in the Department of Molecular Oncology at the BC Cancer Research Centre use the latest technologies to rapidly identify genes that are involved in the development of cancer. This position will be involved in performing research in drug pharmacology directed at human tumours, with assays in immunodeficient mice (xenotransplants).
The successful applicant will report to the Principal Investigator or his/her delegate and may assist in overseeing technical work of students and trainees.
- Plans and performs experiments utilizing complex procedures and/or techniques.
- Processes tissue samples and carries out primary cell isolation as instructed.
- Carries out laboratory techniques following standard operating protocols.
- Maintains laboratory records of both animal data and experimental data; when require summarize results in research reports and lab presentations.
- Assists senior level staff with writing and updating Standard Operating Procedures (SOPs) and Animal Ethics Certificates.
– Assists in the daily care of transgenic animals and maintains colonies of human tumour bearing immunodeficient animals.
- Carries out and oversees procedures involving immunization, oral gavage, injections, tumour inoculation, tumour volume measurements, blood and tissue collection, surgical procedures, necropsy, and post-operative care.
- Daily health monitoring and care of laboratory animals.
- Be able to recognize and resolve behavioral and/or housing issues; may provide technical instruction and training for other staff and/or trainees for those activities.
- Performs other related duties as assigned.
– On a rotation basis, must be available for emergency calls 24/7 and respond appropriately.
CONSEQUENCE OF ERROR
The work is of a complex nature, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Non compliance with ARC regulations may result in closure of facility. Non compliance with animal protocols may result in loss of grant funding.
The successful applicant will report to the Principal Investigator or designate.
The successful applicant will assist in training graduate students/trainees including instruction in use of lab equipment and procedures and will troubleshoot experiments in their area of expertise.
Undergraduate degree in a relevant discipline or Graduation from a technical college or institute. A postgraduate degree in Science is preferred. CALAS certification (e.g. RLAT) is an asset. Minimum of 3 years related experience or the equivalent combination of education and experience. Experience in the monitoring and management of human tumour bearing animals is essential and central to the role. A working knowledge of the CCAC guidelines and compassion and sensitivity for animals required. Experience with cell culture and aseptic technique preferred, involving both isolation and maintenance of rodent primary cultures and cell lines. Experience in the use and handling of hazardous materials such as biological agents, radioactive substances and/or cytotoxic drugs is essential. Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNNDNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation and western blotting. Demonstrated understanding of experimental design and assay optimization. Strong interpersonal skills and the ability to interact positively and productively with other team members are essential. Ability to communicate effectively both orally and in writing. The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively
To apply please send your CV and cover letter to email@example.com with subject line: RA/Tech 3.