How to Apply 

Applicants interested in pursuing graduate or postdoctoral training in The Department of Molecular Oncology, please e-mail us directly at careersmolonc@bccrc.ca. Please include the following documents when applying:

  • Cover Letter
  • CV
  • Statement of your research interests and experience 
  • Transcripts 
  • Contact information for two or three references

Research Assistant/Tech 3

JOB SUMMARY

Researchers in the Department of Molecular Oncology at the BC Cancer Research Centre use the latest technologies to rapidly identify genes that are involved in the development of cancer. This position will be involved in performing research in drug pharmacology directed at human tumours, with assays in immunodeficient mice (xenotransplants).

ORGANIZATIONAL STATUS

The successful applicant will report to the Principal Investigator or his/her delegate and may assist in overseeing technical work of students and trainees.

WORK PERFORMED

- Plans and performs experiments utilizing complex procedures and/or techniques.

- Processes tissue samples and carries out primary cell isolation as instructed.

- Carries out laboratory techniques following standard operating protocols.

- Maintains laboratory records of both animal data and experimental data; when require summarize results in research reports and lab presentations.

- Assists senior level staff with writing and updating Standard Operating Procedures (SOPs) and Animal Ethics Certificates.

– Assists in the daily care of transgenic animals and maintains colonies of human tumour bearing immunodeficient animals.

- Carries out and oversees procedures involving immunization, oral gavage, injections, tumour inoculation, tumour volume measurements, blood and tissue collection, surgical procedures, necropsy, and post-operative care.

- Daily health monitoring and care of laboratory animals.

- Be able to recognize and resolve behavioral and/or housing issues; may provide technical instruction and training for other staff and/or trainees for those activities.

- Performs other related duties as assigned.

– On a rotation basis, must be available for emergency calls 24/7 and respond appropriately.

CONSEQUENCE OF ERROR

The work is of a complex nature, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Non compliance with ARC regulations may result in closure of facility. Non compliance with animal protocols may result in loss of grant funding.

SUPERVISION RECEIVED

The successful applicant will report to the Principal Investigator or designate.

SUPERVISION GIVEN

The successful applicant will assist in training graduate students/trainees including instruction in use of lab equipment and procedures and will troubleshoot experiments in their area of expertise.

QUALIFICATIONS

Undergraduate degree in a relevant discipline or Graduation from a technical college or institute. A postgraduate degree in Science is preferred. CALAS certification (e.g. RLAT) is an asset. Minimum of 3 years related experience or the equivalent combination of education and experience. Experience in the monitoring and management of human tumour bearing animals is essential and central to the role. A working knowledge of the CCAC guidelines and compassion and sensitivity for animals required. Experience with cell culture and aseptic technique preferred, involving both isolation and maintenance of rodent primary cultures and cell lines. Experience in the use and handling of hazardous materials such as biological agents, radioactive substances and/or cytotoxic drugs is essential. Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNNDNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation and western blotting. Demonstrated understanding of experimental design and assay optimization. Strong interpersonal skills and the ability to interact positively and productively with other team members are essential. Ability to communicate effectively both orally and in writing. The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively

APPLICATION INSTRUCTIONS

To apply please send your CV and cover letter to careersmolonc@bccrc.ca with subject line: RA/Tech 3.

Administrative Coordinator

Application Deadline

Reporting to the Department Head or designate, the Administrative Coordinator, BC Cancer Research Centre is responsible for providing support in areas of human resources, payroll, grant and research administration. This role, on behalf of Principal Investigators (PI’s) and leaders, monitors payroll and financial cost centres through to resolution of payroll issues. The Administrative Coordinator also provides administrative support including managing the grant application process and providing work direction to junior administrative staff in the team.

Key Accountabilities

  • In collaboration with the Principal Investigator(s) (PIs) coordinates the preparation and submission of grant proposals by identifying submission guidelines, collating information required and ensuring submission deadlines are met. Follows up with the granting agency on the submission of proposals, monitors post award financial accounts to ensure accuracy. Provides progress reports, highlights discrepancies and provides recommendations to resolve discrepancies and budget concerns to the PI(s) as appropriate.
  • Interacts with a variety of individuals and agencies such as universities and granting agencies both national and international. Ensures flow of information with internal and external stakeholders regarding grant related matters and makes arrangements for visiting speakers and guests.
  • Human resources responsibilities include recruitment of staff by posting/advertising internally and externally (UBC), coordinating interviews and screening applications for review by hiring supervisors. Manages new hires orientation process in the department and ensures all safety and personnel documentations are in place according to policies, guidelines and legislations.
  • Ensures all hiring, appointment and payroll processes such as new hire letters and timekeeping are complete for employees. Liaises with various PHSA units such as Payroll and Human Resources and in some cases, UBC to ensure a seamless process and minimize errors. Brings issues and recommendations of remedies to department head or designate for approval.
  • Acts as the main contact for ordering supplies for the department and approves lab and office supplies by performing duties such as submitting purchase requisitions and obtaining authorizing signature as necessary. Manages and processes various requisitions such as travel, expense reimbursements, cheque requests, and honorariums for the Department Head and PIs. Acts as liaison with various departments of BCCA/PHSA including purchasing, stores, and finance to obtain information and follow-up on the status of outstanding issues and requests.
  • Coordinates registration and travel arrangements for staff attendance at seminars and meetings. This includes completing registration (on-line or phone), abstract submission, making travel and lodging reservations, culminating expense reimbursements to the attendee and/or cost recovery from the conference organizers as appropriate.
  • Provides work direction to junior and contract administrative staff including orientating new staff and assigning and reviewing work, coordinating work assignments to ensure completion, answering questions and providing support, ensuring policies and procedures are followed and providing input to performance evaluations as required.


Qualifications

A level of education, training, and experience equivalent to a Diploma in a relevant area such as business administration or finance from a recognized college plus three (3) years’ recent related experience a research environment and in project management.

Strong interpersonal and communication skills and the ability to demonstrate good judgment, tact and discretion. Detail oriented and able to complete accurate work in a timely matter. Demonstrated time management skills and ability to assist others in meeting deadlines.  Knowledge of and experience with grant applications.  Knowledge and experience in budget preparation, tracking expenditures and identifying sources of variance. Proficient in scientific and medical terminology.  Ability to work both independently and as team leader to organize work and manage multiple priorities in a fast paced environment. Demonstrated ability to make sound decisions and resolve administrative issues/problems. Fully proficient in the use of a variety of software packages including word processing, spreadsheets and databases and related equipment. Demonstrated ability to evaluate personal work and existing systems and identify areas for improvement. Physical ability to perform the duties of the position.

To apply: Please send cover letter and resume to careersmolonc@bccrc.ca  – Please put “Admin Coordinator” and your full name and Job title in the subject line.

Post-Doctoral Fellow (Bioinformatics)

Exciting postdoctoral training opportunity with the OVCARE Program at the University of British Columbia and the Department of Molecular Oncology at BC Cancer, studying the cellular origins of ovarian and other gynecological cancers through single cell sequencing technologies. The Department of Pathology at the University of British Columbia invites applications for a Postdoctoral Fellow. The successful applicant will work with Dr. Andrew Roth and Dr. David Huntsman as a part of the multidisciplinary OVCARE team (BC's Gynecological Cancer Research Program, ovcare.ca) and bioinformatics team of the BC Cancer’s Department of Molecular Oncology (http://molonc.bccrc.ca). 

We are studying the early events in ovarian cancer initiation by genetically manipulating organoids derived from normal tissues and transgenic mice. Our interest lies in dissecting the relative contributions of and interactions between cell of origin, mutation and microenvironment on the development of the common cancers of the uterus , ovary and fallopian tube. For this particular project, ARID1A (a member of the SWI/SNF chromatin remodeling complex) is knocked out and mutant PIK3CA (a kinase involved in intracellular signaling) is introduced into the cells. Organoids are grown out from cells containing these genetic manipulations and single cell RNAseq, DNAseq and ATACseq will be performed. The successful candidate will integrate these datasets, as well as co-supervise students assigned to analyze other single cell sequencing datasets. We are looking for someone who has strong communication and leadership skills and who will work well in a group setting.

Qualifications

- PhD in Bioinformatics, Computer Science, Statistics or related fields.

- Experience working with large genomic datasets.

- Experience managing data from multiple sources and running bioinformatics pipelines.

- Experience working with single cell RNA-Seq and/or single cell DNA-Seq.

- Strong background in data science, machine learning preferred.

- Programming skills in R and/or Python required.

The position will commence as soon as possible. The initial appointment will be for a one-year term, with potential for annual renewal. Salary will be commensurate with qualifications and experience.

Post-doctoral Fellow Single Cell Genomics, Molecular Biology

A postdoctoral fellowship position is available in the Aparicio lab based at the BC Cancer Research Centre in Vancouver, Canada, collaborating on an exciting project mapping clonal dynamics in human cancers with new single cell methods. 

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patients and patient-derived xenografts. The post holder will have the opportunity to interact as part of the international CRUK Grand Challenge IMAXT project, bringing new measurement methods and computational techniques to the 3D reconstruction of tumour and mapping drug sensitivity and drug combinations using sgRNA/CRISPR methods in vivo. The program works closely with the Shah lab computational biology program on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage.

How to Apply: Please send the following documents to careersmolonc@bccrc.ca and put “Single Cell Genomics, Aparicio Lab – PDF Position” and your family name in the subject line.

  • Cover Letter
  • Resume
  • Transcript
  • Work Sample

Post-doctoral Fellow

Posting is available immediately for a postdoctoral fellow with experience in cancer bioinformatics to work on an exciting new program developing non-invasive patient genomic monitoring. The successful candidate will have a degree and postgraduate training in bioinformatics, computer science, statistics, or allied subjects, with experience applying modern computational genome analysis methods. The post holder will work jointly with the groups of Dr Samuel Aparicio (UBC and BC Cancer) &  Dr Andrew Roth (UBC Computer Science and BC Cancer) on developing and implementing methods for analysis of genomic sequencing information from plasma and other fluids to monitor tumour burden and provide information for screening of high risk patients. This will be in conjunction with existing work on single cell genome analysis pioneered by the Aparicio and Shah labs in the last 5 years.

How to Apply:
Please send the following documents to careersmolonc@bccrc.ca and put "Post-doctoral Fellow – Aparicio Lab, family name) in the subject line

  • Cover Letter
  • Resume
  • Transcript
  • Work Sample
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