How to Apply 

Applicants interested in pursuing graduate or postdoctoral training in The Department of Molecular Oncology, please e-mail us directly at careersmolonc@bccrc.ca. Please include the following documents when applying:

  • Cover Letter
  • CV
  • Statement of your research interests and experience 
  • Transcripts 
  • Contact information for two or three references

Graduate Student Position at the BC Cancer Research Centre, Vancouver, Canada

One graduate student position is available at the Department of Molecular Oncology, BC Cancer Research Centre for the development of novel radiopharmaceuticals for detection and radiotherapy of cancer. The graduate student candidate will register through the Interdisciplinary Oncology Program (www.iop.ca), University of British Columbia, and pursue either a MS or PhD degree.

The student candidate will conduct research on the design and synthesis of imaging probes and radiotherapeutic agents targeting biomarkers overexpressed in cancers. Research activities will involve the production and isolation of radioisotopes, peptide and multi-step organic synthesis, and radiolabeling small molecules, peptides and antibodies with imaging or radiotherapeutic isotopes.

Qualified candidates should have a bachelor degree preferably in chemistry with interests in organic or medicinal chemistry. The ability to conduct research in a collaborative environment is required including good oral and written communication skills in English. For more information regarding application for the Interdisciplinary Oncology Program at the University of British Columbia, please check the following website: www.iop.ca

Before applying, interested student candidates should first contact:

Kuo-Shyan Lin, PhD

Senior Scientist, BC Cancer Research Centre

Associate Professor, University of British Columbia

E-mail: klin@bccrc.ca

Research Programmer

Job Information

Classification Title: Information Systems & Technology (A)

Business Title: Research Programmer

Department: Pathology

Job Summary

A position with the Department of Pathology and Laboratory Medicine of the University of British Columbia is open immediately for a research programmer to work with our interdisciplinary team of researchers and software developers within the Department of Molecular Oncology at BC Cancer, part of the Provincial Health Services Authority. We are seeking a creative, experienced, and dedicated individual to play a key role in the bioinformatics analysis of computational genomic research data.

The research programmer will work with other team members and researchers in the department to conduct computational analysis, ranging from routine runs to novel discovery tasks.  With detailed instructions, you will be finding and applying bioinformatics algorithms to computational genomics problems.  When appropriate, your solutions will be deployed in full production processes, and you will work closely with other programmers to ensure the successful implementation and  deployment of automated workflows and analyses.

You will be on-site in the Department of Molecular Oncology at BC Cancer, working closely with software developers, students and researchers operating at the leading edge of the field of cancer genomics.  Our department has recently made meaningful advances in the understanding of tumour evolution and the software platforms developed in the lab will be used by world-leading scientists at BC Cancer and international collaborators to gain insight into how cancers initiate, develop and acquire resistance to treatment. More information on the department and research we conduct can be found here http://molonc.bccrc.ca/

Organizational Status

We are a small team of software developers and scientists embedded within a larger cancer research department.  You will be working with students and researchers to tackle genomics problems, and collaborating with developers and bioinformaticians on the team to develop high-throughput and automated analysis solutions.  You will be reporting to the bioinformatics team lead or designate.

Work Performed

Research and implement bioinformatics solution as requested

Perform simple to complex bioinformatics analysis and requests with supervision

As a team member, develop, test and automate bioinformatics solutions

Handle bioinformatics data retrieval, processing and dissemination requests

Assist researchers in computational, statistical and visualization tasks for publication

Consequences of Error

You will be receiving instructions from researchers, students and collaborators and will be responsible for the correctness of your work.  Failure to perform may result in setbacks to research and operational activity.

Supervision Received

You will be supervised by the bioinformatics team lead or designate.

Supervision Given

You will help advise and recommend best course of actions to other members of the lab on subjects pertaining to bioinformatics analysis and your field of expertise.

Education / Work Experience

Essential

BSc in bioinformatics, computer science, or equivalent

Minimum 2 year of additional relevant work/educational experience in genomics

Proven bioinformatics research experience

Experience with data analysis in R and Python

Experience with command-line interfaces and scripting in UNIX operating systems

Experience designing and creating analysis workflows and pipelines

Experience with next-generation sequencing (NGS) data

Preferred

MSc in bioinformatics, computer science or equivalent

Experience with scientific high performance computing environments

Experience with bioinformatics data management solutions

Post-Doctoral Fellow (Bioinformatics)

Exciting postdoctoral training opportunity with the OVCARE Program at the University of British Columbia and the Department of Molecular Oncology at BC Cancer, studying the cellular origins of ovarian and other gynecological cancers through single cell sequencing technologies. The Department of Pathology at the University of British Columbia invites applications for a Postdoctoral Fellow. The successful applicant will work with Dr. Andrew Roth and Dr. David Huntsman as a part of the multidisciplinary OVCARE team (BC's Gynecological Cancer Research Program, ovcare.ca) and bioinformatics team of the BC Cancer’s Department of Molecular Oncology (http://molonc.bccrc.ca). 

We are studying the early events in ovarian cancer initiation by genetically manipulating organoids derived from normal tissues and transgenic mice. Our interest lies in dissecting the relative contributions of and interactions between cell of origin, mutation and microenvironment on the development of the common cancers of the uterus , ovary and fallopian tube. For this particular project, ARID1A (a member of the SWI/SNF chromatin remodeling complex) is knocked out and mutant PIK3CA (a kinase involved in intracellular signaling) is introduced into the cells. Organoids are grown out from cells containing these genetic manipulations and single cell RNAseq, DNAseq and ATACseq will be performed. The successful candidate will integrate these datasets, as well as co-supervise students assigned to analyze other single cell sequencing datasets. We are looking for someone who has strong communication and leadership skills and who will work well in a group setting.

Qualifications

- PhD in Bioinformatics, Computer Science, Statistics or related fields.

- Experience working with large genomic datasets.

- Experience managing data from multiple sources and running bioinformatics pipelines.

- Experience working with single cell RNA-Seq and/or single cell DNA-Seq.

- Strong background in data science, machine learning preferred.

- Programming skills in R and/or Python required.

The position will commence as soon as possible. The initial appointment will be for a one-year term, with potential for annual renewal. Salary will be commensurate with qualifications and experience.

Research Animal Technician 2

Role Summary 

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

These positions supervise designated staff by scheduling and assigning work, and assist in daily animal care operations by leading various health monitoring and colony management programs, trouble-shooting minor issues and performing other administrative tasks. These positions also maintain the daily care of laboratory mice and perform various surgical procedures and laboratory techniques.

Key Accountabilities

• Develops, implements, reviews and updates animal care standard operating procedures for assigned area.
• Leads various animal care programs such as health monitoring and colony management.
• Maintains current knowledge of, and ensures compliance with, animal care regulations.
• Supervises designated staff by scheduling and assigning work, providing orientation and training and monitoring performance.
• Maintains daily care of laboratory mice including maintaining adequate food and water levels and observing mice for general health conditions.
• Performs surgeries and techniques including blood collection, surgical implantations, tumour implantation, injection of solutions, collection of tissues and organs and embryo manipulations, and cryopreservation.
• Performs laboratory techniques such as media preparation, cell culture and hormone preparation, and polymerase chain reaction analysis as required.
• Leads training programs, prepares and gives presentations and orients and trains staff and animal users on proper animal care theory, protocols, techniques and procedures.
• Changes and cleans animal cages, bottles and racks.
• Performs general cleaning of animal facilities including disinfecting equipment, walls, floors, rooms, etc.
• Performs census duties such as counting cages and reporting cage numbers.
• Receives and processes laboratory animal care supplies.

Qualifications

A level of education, training, and experience equivalent to graduation from a recognized program in Animal Health or Veterinary Technology, or a Bachelor’s program in an appropriate discipline (e.g. Animal Science); plus five (5) years of recent related experience in a research laboratory, including two (2) years in a supervisory capacity.

To apply: Please send cover letter and resume to careersmolonc@bccrc.ca – Please put “Research Assistant Tech 2_full name” in the subject line.

Administrative Coordinator

Application Deadline

Reporting to the Department Head or designate, the Administrative Coordinator, BC Cancer Research Centre is responsible for providing support in areas of human resources, payroll, grant and research administration. This role, on behalf of Principal Investigators (PI’s) and leaders, monitors payroll and financial cost centres through to resolution of payroll issues. The Administrative Coordinator also provides administrative support including managing the grant application process and providing work direction to junior administrative staff in the team.
 

Key Accountabilities

  • In collaboration with the Principal Investigator(s) (PIs) coordinates the preparation and submission of grant proposals by identifying submission guidelines, collating information required and ensuring submission deadlines are met. Follows up with the granting agency on the submission of proposals, monitors post award financial accounts to ensure accuracy. Provides progress reports, highlights discrepancies and provides recommendations to resolve discrepancies and budget concerns to the PI(s) as appropriate.
     
  • Interacts with a variety of individuals and agencies such as universities and granting agencies both national and international. Ensures flow of information with internal and external stakeholders regarding grant related matters and makes arrangements for visiting speakers and guests.
     
  • Human resources responsibilities include recruitment of staff by posting/advertising internally and externally (UBC), coordinating interviews and screening applications for review by hiring supervisors. Manages new hires orientation process in the department and ensures all safety and personnel documentations are in place according to policies, guidelines and legislations.
     
  • Ensures all hiring, appointment and payroll processes such as new hire letters and timekeeping are complete for employees. Liaises with various PHSA units such as Payroll and Human Resources and in some cases, UBC to ensure a seamless process and minimize errors. Brings issues and recommendations of remedies to department head or designate for approval.
     
  • Acts as the main contact for ordering supplies for the department and approves lab and office supplies by performing duties such as submitting purchase requisitions and obtaining authorizing signature as necessary. Manages and processes various requisitions such as travel, expense reimbursements, cheque requests, and honorariums for the Department Head and PIs. Acts as liaison with various departments of BCCA/PHSA including purchasing, stores, and finance to obtain information and follow-up on the status of outstanding issues and requests.
     
  • Coordinates registration and travel arrangements for staff attendance at seminars and meetings. This includes completing registration (on-line or phone), abstract submission, making travel and lodging reservations, culminating expense reimbursements to the attendee and/or cost recovery from the conference organizers as appropriate.
     
  • Provides work direction to junior and contract administrative staff including orientating new staff and assigning and reviewing work, coordinating work assignments to ensure completion, answering questions and providing support, ensuring policies and procedures are followed and providing input to performance evaluations as required.


Qualifications

A level of education, training, and experience equivalent to a Diploma in a relevant area such as business administration or finance from a recognized college plus three (3) years’ recent related experience a research environment and in project management.

Strong interpersonal and communication skills and the ability to demonstrate good judgment, tact and discretion. Detail oriented and able to complete accurate work in a timely matter. Demonstrated time management skills and ability to assist others in meeting deadlines.  Knowledge of and experience with grant applications.  Knowledge and experience in budget preparation, tracking expenditures and identifying sources of variance. Proficient in scientific and medical terminology.  Ability to work both independently and as team leader to organize work and manage multiple priorities in a fast paced environment. Demonstrated ability to make sound decisions and resolve administrative issues/problems. Fully proficient in the use of a variety of software packages including word processing, spreadsheets and databases and related equipment. Demonstrated ability to evaluate personal work and existing systems and identify areas for improvement. Physical ability to perform the duties of the position.

To apply: Please send cover letter and resume to careersmolonc@bccrc.ca  – Please put “Admin Coordinator” and your full name and Job title in the subject line.

Post-doctoral Fellow Single Cell Genomics, Molecular Biology

A postdoctoral fellowship position is available in the Aparicio lab based at the BC Cancer Research Centre in Vancouver, Canada, collaborating on an exciting project mapping clonal dynamics in human cancers with new single cell methods. 

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patients and patient-derived xenografts. The post holder will have the opportunity to interact as part of the international CRUK Grand Challenge IMAXT project, bringing new measurement methods and computational techniques to the 3D reconstruction of tumour and mapping drug sensitivity and drug combinations using sgRNA/CRISPR methods in vivo. The program works closely with the Shah lab computational biology program on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage.

How to Apply: Please send the following documents to careersmolonc@bccrc.ca and put “Single Cell Genomics, Aparicio Lab – PDF Position” and your family name in the subject line.

  • Cover Letter
  • Resume
  • Transcript
  • Work Sample

Post-doctoral Fellow

Posting is available immediately for a postdoctoral fellow with experience in cancer bioinformatics to work on an exciting new program developing non-invasive patient genomic monitoring. The successful candidate will have a degree and postgraduate training in bioinformatics, computer science, statistics, or allied subjects, with experience applying modern computational genome analysis methods. The post holder will work jointly with the groups of Dr Samuel Aparicio (UBC and BC Cancer) &  Dr Andrew Roth (UBC Computer Science and BC Cancer) on developing and implementing methods for analysis of genomic sequencing information from plasma and other fluids to monitor tumour burden and provide information for screening of high risk patients. This will be in conjunction with existing work on single cell genome analysis pioneered by the Aparicio and Shah labs in the last 5 years.

How to Apply:
Please send the following documents to careersmolonc@bccrc.ca and put "Post-doctoral Fellow – Aparicio Lab, family name) in the subject line

  • Cover Letter
  • Resume
  • Transcript
  • Work Sample

Post-doctoral Fellow – SWI/SNF Chromatic Remodeling Complexes and Cancer Progression

Postdoctoral Research Fellow – SWI/SNF Chromatic Remodeling Complexes and Cancer Progression

BC’s Gynecological Cancer Research Program (OVCARE)
Department of Pathology, Faculty of Medicine
University of British Columbia, Vancouver, Canada

Exciting postdoctoral training opportunity studying targeted therapies for ovarian and other gynecological cancers with the OVCARE Program at the University of British Columbia and BC Cancer.

The Department of Pathology at the University of British Columbia invites applications for a Postdoctoral Fellow. The successful applicant will work with the multidisciplinary OVCARE team (BC’s Gynecological Cancer Research Program) directed by Dr. David Huntsman. This position will be translational and interdisciplinary in nature aimed at deciphering the role of cancer-associated mutations, especially those related to the SWI/SNF chromatin remodeling complexes, in tumourigenesis and their potential as druggable targets.

Applicants should have a PhD or MD/PhD with a strong background and publication record in a relevant field (e.g. genetics, cellular and molecular biology). The position will rely heavily on in vitro and in vivo models of cancer so demonstrated expertise in this area is required. In addition, either experience in bioinformatics would be an asset. The position will commence as soon as possible. Excellent verbal and written communication skills are required. The initial appointment will be for a one-year term, with potential for annual renewal. Salary will be commensurate with qualifications and experience.

Qualified candidates should send (by email) a statement of research interest, curriculum vitae and contact details for 3 referees to:

Yemin Wang, PhD
BC’s Gynecological Cancer Research Program
University of British Columbia and BC Cancer

675 West 10th Avenue
Vancouver, BC V5Z 1L3
Email: yewang@bccrc.ca

Breast Pathology Fellowship

Breast Pathology Fellowship
Providence Health Care, Department of Pathology and Laboratory Medicine

One Year Term (with potential extension)

This unique fellowship is comprised of both clinical and research components in equal parts and provides an opportunity to gain research experience as a fellow. Fellows will divide their time between BC Cancer Agency, Mount Saint Joseph and St. Paul’s Hospitals and rotate through the clinical pathology laboratory and the research laboratory at BC Cancer. Fellows work closely with the breast multidisciplinary team, actively participating in rounds and providing service and consultation to clinicians in matter relating to breast diseases. It is expected that the fellow participates in collaborative research, with an option to conduct individual research, all under the guidance of a faculty member and/or pathologist]. This includes research proposals, submitting abstracts to scientific meetings and preparing manuscripts for publication in peer-reviewed journals.

Candidates with the following qualifications/experience are preferred:

  • Canadian citizenship or permanent residency.
  • MSc or PhD.
  • Research experience, especially molecular biology.

Salary will be commensurate with qualifications and experience.

To apply for this rewarding career development opportunity, please forward (1) a letter of application outlining your areas of interest, (2) a copy of your current CV, and (3) names and contact information of three references, to:

PHSA Talent Acquisition
careers@phsa.ca

Post-doctoral fellow in the Biochemistry and Chemical Biology of Spliceosome Regulation

The Genome Sciences Centre Department within the British Columbia Cancer Agency in Vancouver, British Columbia, Canada has an opening for a post-doctoral fellow in the laboratory of Dr. Gregg Morin, to study the mechanisms-of-action of pharmacological inhibition of proteins that regulate pre-mRNA splicing. The scientist will join a collaboration with Drs. Samuel Aparicio and Sohrab Shah that is using global genomic technologies to identify changes in alternative splicing due to inhibition of several classes of enzymes that regulate spliceosome function. The objective is to investigate how these enzymes regulate genome-wide spliceosomal function and splice site choice.

The position will perform laboratory research to design and interpret experiments using biochemical, proteomic, molecular and genomic tools to investigate the functional mechanisms of enzyme inhibition on the spliceosome and its regulatory proteins in human cancer cells. The candidate should have experience in ribonucleoprotein biochemistry, mammalian tissue culture, enzymatic assays, recombinant protein purification, molecular biology, and RNAi. Experience in the structure/function analysis of RNPs or enzymes and a comprehensive understanding of splicing and spliceosome function are essential.

The successful scientist will join the laboratory of Dr. Gregg Morin in the Michael Smith Genome Sciences Centre at the BC Cancer Agency. In collaboration with the laboratories of Dr. Samuel Aparicio and Dr. Sohrab Shah, the team has access to exceptional tools for next generation sequencing, bioinformatics, and advanced proteomics.

The Genome Sciences Centre provides a stimulating working environment and is located at the new British Columbia Cancer Research Centre in Vancouver, one of the world’s most livable and attractive cities.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Additional information can be obtained at www.bcgsc.ca.

Applicants should send a cover letter, curriculum vitae, and names of three referees by email, fax or mail to:

Dr. Gregg B. Morin
Genome Sciences Centre, BC Cancer
675 West 10th Avenue
Vancouver, BC, V6S 1L3, Canada
Email: bcgscjobs@bcgsc.ca
Fax: 604-675-8178

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