Making novel discoveries in the biology underlying normal development and cancer progression.

Our Focus

Ongoing research across a wide spectrum of biomedicine and the life sciences; including biochemistry, stem cell biology, immunology, molecular genetics, molecular medicine and gene therapy.

The Terry Fox Laboratory (TFL) has expertise in diverse research areas, including mammalian systems, normal and malignant mammary tissues, lineage specification in the gut, and yeast genetics. Experimental approaches employed at TFL include genetically engineered models, patient xenograft models, in vitro cell based assays, highly dimension single cell phenotyping, molecular biology and biochemistry, DNA regulation, transcriptomics, epigenetics, and DNA repair. In recent years, TFL has placed emphasis on the development of new technologies and their use to address fundamental questions in the control of cell growth and differentiation, aging, and gene regulation.

Blood Cancer

Working with innovative model systems and patients our research addresses the root causes of leukemias and myeloma and is developing new tools for their diagnosis, characterization and treatment.

Genome Dynamics

Genes influence every aspect of human biology and disease. We are studying how our genes and genomes are faithfully maintained as we age and the complex ways in which they are regulated to control development or are dysregulated during cancer formation.

Stem Cells

Stem cells are critical components in healthy aging and tumour suppression since they enable the development and maintenance of adult tissues. We are working to understand how stem cell properties enable blood, breast and liver development and how these properties are co-opted in cancers.

Research Labs & Principal Investigators

Emeritus Scientists

News & Events

Leo Escano receives CIHR Canada Graduate Scholarships – Doctoral Program Award

Congratulations to Leo Escano (Terry Fox Laboratory), for receiving a Canada Graduate Scholarships – Doctoral Program Award (CGS-D) from the Canadian Institutes of Health Research (CIHR).

The award is tied to his project titled, "Elucidating the mechanisms of immune escape in Cytogenetically Normal AMLs.”

The CIHR CGS-D provides special recognition and support to students who are pursuing a doctoral degree in a health-related field in Canada.

Please join us in congratulating Leo on this achievement!

Recent Publications

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis.

Cancer cell, 2024
Barisic, Darko, Chin, Christopher R, Meydan, Cem, Teater, Matt, Tsialta, Ioanna, Mlynarczyk, Coraline, Chadburn, Amy, Wang, Xuehai, Sarkozy, Margot, Xia, Min, Carson, Sandra E, Raggiri, Santo, Debek, Sonia, Pelzer, Benedikt, Durmaz, Ceyda, Deng, Qing, Lakra, Priya, Rivas, Martin, Steidl, Christian, Scott, David W, Weng, Andrew P, Mason, Christopher E, Green, Michael R, Melnick, Ari

Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22.

Molecular therapy. Oncology, 2024
McComb, Scott, Arbabi-Ghahroudi, Mehdi, Hay, Kevin A, Keller, Brian A, Faulkes, Sharlene, Rutherford, Michael, Nguyen, Tina, Shepherd, Alex, Wu, Cunle, Marcil, Anne, Aubry, Annie, Hussack, Greg, Pinto, Devanand M, Ryan, Shannon, Raphael, Shalini, van Faassen, Henk, Zafer, Ahmed, Zhu, Qin, Maclean, Susanne, Chattopadhyay, Anindita, Gurnani, Komal, Gilbert, Rénald, Gadoury, Christine, Iqbal, Umar, Fatehi, Dorothy, Jezierski, Anna, Huang, Jez, Pon, Robert A, Sigrist, Mhairi, Holt, Robert A, Nelson, Brad H, Atkins, Harold, Kekre, Natasha, Yung, Eric, Webb, John, Nielsen, Julie S, Weeratna, Risini D
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