Making novel discoveries in the biology underlying normal development and cancer progression.

Our Focus

Ongoing research across a wide spectrum of biomedicine and the life sciences; including biochemistry, stem cell biology, immunology, molecular genetics, molecular medicine and gene therapy.

The Terry Fox Laboratory (TFL) has expertise in diverse research areas, including mammalian systems, normal and malignant mammary tissues, lineage specification in the gut, and yeast genetics. Experimental approaches employed at TFL include genetically engineered models, patient xenograft models, in vitro cell based assays, highly dimension single cell phenotyping, molecular biology and biochemistry, DNA regulation, transcriptomics, epigenetics, and DNA repair. In recent years, TFL has placed emphasis on the development of new technologies and their use to address fundamental questions in the control of cell growth and differentiation, aging, and gene regulation.

Blood Cancer

Working with innovative model systems and patients our research addresses the root causes of leukemias and myeloma and is developing new tools for their diagnosis, characterization and treatment.

Genome Dynamics

Genes influence every aspect of human biology and disease. We are studying how our genes and genomes are faithfully maintained as we age and the complex ways in which they are regulated to control development or are dysregulated during cancer formation.

Stem Cells

Stem cells are critical components in healthy aging and tumour suppression since they enable the development and maintenance of adult tissues. We are working to understand how stem cell properties enable blood, breast and liver development and how these properties are co-opted in cancers.

Research Labs & Principal Investigators

News & Events

Recent Publications

Single-cell profiling reveals a memory B cell-like subtype of follicular lymphoma with increased transformation risk.

Nature communications, 2022
Wang, Xuehai, Nissen, Michael, Gracias, Deanne, Kusakabe, Manabu, Simkin, Guillermo, Jiang, Aixiang, Duns, Gerben, Sarkozy, Clementine, Hilton, Laura, Chavez, Elizabeth A, Segat, Gabriela C, Wong, Rachel, Kim, Jubin, Aoki, Tomohiro, Islam, Rashedul, May, Christina, Hung, Stacy, Tyshchenko, Kate, Brinkman, Ryan R, Hirst, Martin, Karsan, Aly, Freeman, Ciara, Sehn, Laurie H, Morin, Ryan D, Roth, Andrew J, Savage, Kerry J, Craig, Jeffrey W, Shah, Sohrab P, Steidl, Christian, Scott, David W, Weng, Andrew P

Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma.

The Journal of clinical investigation, 2022
Takata, Katsuyoshi, Chong, Lauren C, Ennishi, Daisuke, Aoki, Tomohiro, Li, Michael Yu, Thakur, Avinash, Healy, Shannon, Viganò, Elena, Dao, Tao, Kwon, Daniel, Duns, Gerben, Nielsen, Julie S, Ben-Neriah, Susana, Tse, Ethan, Hung, Stacy S, Boyle, Merrill, Mun, Sung Soo, Bourne, Christopher M, Woolcock, Bruce, Telenius, Adèle, Kishida, Makoto, Rai, Shinya, Zhang, Allen W, Bashashati, Ali, Saberi, Saeed, D'Antonio, Gianluca, Nelson, Brad H, Shah, Sohrab P, Hoodless, Pamela A, Melnick, Ari M, Gascoyne, Randy D, Connors, Joseph M, Scheinberg, David A, Béguelin, Wendy, Scott, David W, Steidl, Christian
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