Ryan Brinkman’s research is focused on developing and applying flow cytometry bioinformatics approaches to advance our understanding of human health and disease.  His early work centered on creating data standards and a free, open source computational infrastructure to support high throughput computational statistical analysis of flow cytometry data. Recent efforts have concentrated around developing complete analysis pipelines that cover all the steps from flow cytometry data pre-processing to clinical diagnosis and biomarker discovery across all the areas where the technology is applied.  The R/BioConductor flow analysis platform now supports diverse, collaborative research and patient care projects in cancer and immunology. Dr. Brinkman's lab is now applying these methodologies to both the diagnosis of patients and discovery of biomarkers in basic research and clinical investigations including for ALS, HIV, HSV vaccines, various cancers (including leukemia and lymphoma, prostrate, oral), TB, GvHD, solid organ transplantation, atherosclerosis, cancer immunotherapy, influenza, and the International Mouse Phenotyping Consortium as well as large pharmaceutical studies.

Dr. Brinkman is also active in the community as Chair of International Society for Advancement of Cytometry's (ISAC) Data Standards Task Force, coordinating the Flow Cytometry: Critical Assessment of Population Identification Methods (FlowCAP.flowsite.org) Project and FlowRepository.org, an open public repository for sharing FCS data associated with peer-reviewed publications (currently adopted by PLoS, Nature Publishing Group and Cytometry A). Dr. Brinkman has been recognized for these efforts as a Michael Smith Foundation for Health Research Scholar, a Terry Fox Foundation New Investigator, an ISAC Scholar and most recently as the recipient of the 2018 Distinguished Service Award from ISAC.

Affiliations

Professor, Medical Genetics, University of British Columbia

Associate Faculty Member, Bioinformatics Centre, University of British Columbia

Faculty Member, Bioinformatics Training Program, CIHR/MSFHR

Associate Faculty Member, British Columbia Genome Sciences Centre

Adjunct Faculty, Molecular Biology and Biochemistry, Simon Fraser University

Adjunct Faculty, School of Computing Science, Simon Fraser University

Managing Director, Cytapex Bioinformatics Inc.

Credentials

B.Sc (Honours), Biology and Biotechnology, Carleton University, 1992

PhD, Genetics, University of British Columbia, 2001

Selected Publications

Multi-Omic Data Integration Allows Baseline Immune Signatures to Predict Hepatitis B Vaccine Response in a Small Cohort.

Frontiers in immunology, 2020
Shannon, Casey P, Blimkie, Travis M, Ben-Othman, Rym, Gladish, Nicole, Amenyogbe, Nelly, Drissler, Sibyl, Edgar, Rachel D, Chan, Queenie, Krajden, Mel, Foster, Leonard J, Kobor, Michael S, Mohn, William W, Brinkman, Ryan R, Le Cao, Kim-Anh, Scheuermann, Richard H, Tebbutt, Scott J, Hancock, Robert E W, Koff, Wayne C, Kollmann, Tobias R, Sadarangani, Manish, Lee, Amy Huei-Yi
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Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea.

Frontiers in pediatrics, 2020
Idoko, Olubukola T, Smolen, Kinga K, Wariri, Oghenebrume, Imam, Abdulazeez, Shannon, Casey P, Dibassey, Tida, Diray-Arce, Joann, Darboe, Alansana, Strandmark, Julia, Ben-Othman, Rym, Odumade, Oludare A, McEnaney, Kerry, Amenyogbe, Nelly, Pomat, William S, van Haren, Simon, Sanchez-Schmitz, Guzmán, Brinkman, Ryan R, Steen, Hanno, Hancock, Robert E W, Tebbutt, Scott J, Richmond, Peter C, van den Biggelaar, Anita H J, Kollmann, Tobias R, Levy, Ofer, Ozonoff, Al, Kampmann, Beate
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