Dr. Crome's research program investigates how immune responses are regulated in transplantation, autoimmunity, and cancer, with a focus on developing immunotherapies that harness or target innate lymphoid cells and Natural Killer cells.

Members

Faculty/Leaders

Selected Publications

Cell therapy with human interleukin 10-producing ILC2s enhances islet function and inhibits allograft rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2025
Colpitts, Sarah J, Jegatheeswaran, Sinthuja, Oakie, Amanda, Mashhouri, Siavash, Sachewsky, Nadia, Murshed, Humaira, Mathews, Jessica A, Reid, Kyle T, Misra, Paraish S, Fung, Vivian C W, Reichman, Trevor W, Nostro, M Cristina, Verchere, C Bruce, Levings, Megan K, Crome, Sarah Q

Endothelial dysfunction drives atherosclerotic plaque macrophage-dependent abdominal aortic aneurysm formation.

Nature immunology, 2025
Thayaparan, Danya, Emoto, Takuo, Khan, Aniqa B, Besla, Rickvinder, Hamidzada, Homaira, El-Maklizi, Mahmoud, Sivasubramaniyam, Tharini, Vohra, Shabana, Hagerman, Ash, Nejat, Sara, Needham-Robbins, Charlotte E, Wang, Tao, Lindquist, Moritz, Botts, Steven R, Schroer, Stephanie A, Taniguchi, Masayuki, Inoue, Taishi, Yamanaka, Katsuhiro, Cui, Haotian, Al-Chami, Edouard, Zhang, Hangjun, Althagafi, Marwan G, Michalski, Aja, McGrath, Joshua J C, Cass, Steven P, Luong, David, Suzuki, Yuya, Li, Angela, Abow, Amina, Heo, Rachel, Pacheco, Shaun, Chen, Emily, Chiu, Felix, Byrne, John, Furuyashiki, Tomoyuki, Husain, Mansoor, Libby, Peter, Okada, Kenji, Howe, Kathryn L, Heximer, Scott P, Yamashita, Tomoya, Wang, Bo, Rubin, Barry B, Cybulsky, Myron I, Roy, Joy, Williams, Jesse W, Crome, Sarah Q, Epelman, Slava, Hirata, Ken-Ichi, Stampfli, Martin R, Robbins, Clinton S

CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment.

Cancer immunology research, 2025
Chung, Douglas C, Shakfa, Noor, Vakharia, Jehan, Warner, Kathrin, Jacquelot, Nicolas, Sayad, Azin, Han, SeongJun, Ghaedi, Maryam, Garcia-Batres, Carlos R, Sotty, Jules, Azarmina, Arvin, Nowlan, Ferris, Chen, Edward L Y, Zon, Michael, Elford, Alisha R, Wang, Ben X, Nguyen, Linh T, Mrkonjic, Miralem, Clarke, Blaise A, Bernardini, Marcus Q, Haibe-Kains, Benjamin, Ferguson, Sarah E, Crome, Sarah Q, Jackson, Hartland W, Ohashi, Pamela S

Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity.

Nature communications, 2022
McEvoy, Caitriona M, Murphy, Julia M, Zhang, Lin, Clotet-Freixas, Sergi, Mathews, Jessica A, An, James, Karimzadeh, Mehran, Pouyabahar, Delaram, Su, Shenghui, Zaslaver, Olga, Röst, Hannes, Arambewela, Rangi, Liu, Lewis Y, Zhang, Sally, Lawson, Keith A, Finelli, Antonio, Wang, Bo, MacParland, Sonya A, Bader, Gary D, Konvalinka, Ana, Crome, Sarah Q

Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease.

Science translational medicine, 2021
Nakamura, Akihiro, Zeng, Fanxing, Nakamura, Sayaka, Reid, Kyle T, Gracey, Eric, Lim, Melissa, Leng, Lin, Jo, Sungsin, Park, Ye-Soo, Kusuda, Masaki, Machhar, Rohan, Boroojeni, Shaghayegh F, Wu, Brian, Rossomacha, Evgeny, Kim, Tae-Hwan, Ciccia, Francesco, Rockel, Jason S, Kapoor, Mohit, Inman, Robert D, Jurisica, Igor, Crome, Sarah Q, Bucala, Richard, Haroon, Nigil

A distinct innate lymphoid cell population regulates tumor-associated T cells.

Nature medicine, 2017
Crome, Sarah Q, Nguyen, Linh T, Lopez-Verges, Sandra, Yang, S Y Cindy, Martin, Bernard, Yam, Jennifer Y, Johnson, Dylan J, Nie, Jessica, Pniak, Michael, Yen, Pei Hua, Milea, Anca, Sowamber, Ramlogan, Katz, Sarah Rachel, Bernardini, Marcus Q, Clarke, Blaise A, Shaw, Patricia A, Lang, Philipp A, Berman, Hal K, Pugh, Trevor J, Lanier, Lewis L, Ohashi, Pamela S

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