Dr. Crome's research program investigates how immune responses are regulated in transplantation, autoimmunity, and cancer, with a focus on developing immunotherapies that harness or target innate lymphoid cells and Natural Killer cells.
Crome Lab
Members
Faculty/Leaders

Sarah Crome, PhD
Senior Scientist
Selected Publications
Cell therapy with human interleukin 10-producing ILC2s enhances islet function and inhibits allograft rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2025
Colpitts, Sarah J, Jegatheeswaran, Sinthuja, Oakie, Amanda, Mashhouri, Siavash, Sachewsky, Nadia, Murshed, Humaira, Mathews, Jessica A, Reid, Kyle T, Misra, Paraish S, Fung, Vivian C W, Reichman, Trevor W, Nostro, M Cristina, Verchere, C Bruce, Levings, Megan K, Crome, Sarah Q
Endothelial dysfunction drives atherosclerotic plaque macrophage-dependent abdominal aortic aneurysm formation.
Nature immunology, 2025
Thayaparan, Danya, Emoto, Takuo, Khan, Aniqa B, Besla, Rickvinder, Hamidzada, Homaira, El-Maklizi, Mahmoud, Sivasubramaniyam, Tharini, Vohra, Shabana, Hagerman, Ash, Nejat, Sara, Needham-Robbins, Charlotte E, Wang, Tao, Lindquist, Moritz, Botts, Steven R, Schroer, Stephanie A, Taniguchi, Masayuki, Inoue, Taishi, Yamanaka, Katsuhiro, Cui, Haotian, Al-Chami, Edouard, Zhang, Hangjun, Althagafi, Marwan G, Michalski, Aja, McGrath, Joshua J C, Cass, Steven P, Luong, David, Suzuki, Yuya, Li, Angela, Abow, Amina, Heo, Rachel, Pacheco, Shaun, Chen, Emily, Chiu, Felix, Byrne, John, Furuyashiki, Tomoyuki, Husain, Mansoor, Libby, Peter, Okada, Kenji, Howe, Kathryn L, Heximer, Scott P, Yamashita, Tomoya, Wang, Bo, Rubin, Barry B, Cybulsky, Myron I, Roy, Joy, Williams, Jesse W, Crome, Sarah Q, Epelman, Slava, Hirata, Ken-Ichi, Stampfli, Martin R, Robbins, Clinton S
The art of war: burning stores to fuel anti-viral immunity.
Nature metabolism, 2025
Crome, Sarah Q, Tsai, Sue
CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment.
Cancer immunology research, 2025
Chung, Douglas C, Shakfa, Noor, Vakharia, Jehan, Warner, Kathrin, Jacquelot, Nicolas, Sayad, Azin, Han, SeongJun, Ghaedi, Maryam, Garcia-Batres, Carlos R, Sotty, Jules, Azarmina, Arvin, Nowlan, Ferris, Chen, Edward L Y, Zon, Michael, Elford, Alisha R, Wang, Ben X, Nguyen, Linh T, Mrkonjic, Miralem, Clarke, Blaise A, Bernardini, Marcus Q, Haibe-Kains, Benjamin, Ferguson, Sarah E, Crome, Sarah Q, Jackson, Hartland W, Ohashi, Pamela S
Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses.
Cell reports, 2025
Reid, Kyle T, Colpitts, Sarah J, Mathews, Jessica A, Santos Carreira, Abel, Murphy, Julia M, Borovsky, Dorota T, Jegatheeswaran, Sinthuja, Cui, Wenhui, Alfaro Moya, Tommy, Sachewsky, Nadia, An, James, Xia, Yubing, Mortha, Arthur, Lee, Jong Bok, Zhang, Li, Novitzky-Basso, Igor, Mattsson, Jonas, Crome, Sarah Q
Enhanced Type 1 Interferon Signature in Axial Spondyloarthritis Patients Unresponsive to Secukinumab Treatment.
Arthritis & rheumatology (Hoboken, N.J.), 2025
Pacheco, Addison, Maguire, Sinead, Qaiyum, Zoya, Tang, Michael, Bridger, Adam, Lim, Melissa, Tavasolian, Fataneh, Yau, Enoch, Crome, Sarah Q, Haroon, Nigil, Inman, Robert D
Single-cell RNA sequencing of circulating immune cells supports inhibition of and translation as psoriatic arthritis biomarkers.
Frontiers in immunology, 2025
Garrido, Ameth N, Machhar, Rohan, Cruz-Correa, Omar F, Ganatra, Darshini, Crome, Sarah Q, Wither, Joan, Jurisica, Igor, Gladman, Dafna D
Single cell profiling of hematopoietic stem cell transplant recipients reveals TGF-β1 and IL-2 confer immunoregulatory functions to NK cells.
iScience, 2024
Mathews, Jessica A, Borovsky, Dorota T, Reid, Kyle T, Murphy, Julia M, Colpitts, Sarah J, Carreira, Abel Santos, Moya, Tommy Alfaro, Chung, Douglas C, Novitzky-Basso, Igor, Mattsson, Jonas, Ohashi, Pamela S, Crome, Sarah Q
Generation of an Inhibitory NK Cell Subset by TGF-β1/IL-15 Polarization.
Journal of immunology (Baltimore, Md. : 1950), 2024
Chung, Douglas C, Garcia-Batres, Carlos R, Millar, Douglas G, Wong, Stephanie W Y, Elford, Alisha R, Mathews, Jessica A, Wang, Ben X, Nguyen, Linh T, Shaw, Patricia A, Clarke, Blaise A, Bernardini, Marcus Q, Sacher, Adrian G, Crome, Sarah Q, Ohashi, Pamela S
Protective and pathogenic functions of innate lymphoid cells in transplantation.
Clinical and experimental immunology, 2023
Mak, Martin L, Reid, Kyle T, Crome, Sarah Q
Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity.
Nature communications, 2022
McEvoy, Caitriona M, Murphy, Julia M, Zhang, Lin, Clotet-Freixas, Sergi, Mathews, Jessica A, An, James, Karimzadeh, Mehran, Pouyabahar, Delaram, Su, Shenghui, Zaslaver, Olga, Röst, Hannes, Arambewela, Rangi, Liu, Lewis Y, Zhang, Sally, Lawson, Keith A, Finelli, Antonio, Wang, Bo, MacParland, Sonya A, Bader, Gary D, Konvalinka, Ana, Crome, Sarah Q
Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease.
Science translational medicine, 2021
Nakamura, Akihiro, Zeng, Fanxing, Nakamura, Sayaka, Reid, Kyle T, Gracey, Eric, Lim, Melissa, Leng, Lin, Jo, Sungsin, Park, Ye-Soo, Kusuda, Masaki, Machhar, Rohan, Boroojeni, Shaghayegh F, Wu, Brian, Rossomacha, Evgeny, Kim, Tae-Hwan, Ciccia, Francesco, Rockel, Jason S, Kapoor, Mohit, Inman, Robert D, Jurisica, Igor, Crome, Sarah Q, Bucala, Richard, Haroon, Nigil
A distinct innate lymphoid cell population regulates tumor-associated T cells.
Nature medicine, 2017
Crome, Sarah Q, Nguyen, Linh T, Lopez-Verges, Sandra, Yang, S Y Cindy, Martin, Bernard, Yam, Jennifer Y, Johnson, Dylan J, Nie, Jessica, Pniak, Michael, Yen, Pei Hua, Milea, Anca, Sowamber, Ramlogan, Katz, Sarah Rachel, Bernardini, Marcus Q, Clarke, Blaise A, Shaw, Patricia A, Lang, Philipp A, Berman, Hal K, Pugh, Trevor J, Lanier, Lewis L, Ohashi, Pamela S
Sponsors
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