Making novel discoveries in the biology underlying normal development and cancer progression.

Our Focus

Ongoing research across a wide spectrum of biomedicine and the life sciences; including biochemistry, stem cell biology, immunology, molecular genetics, molecular medicine and gene therapy.

The Terry Fox Laboratory (TFL) has expertise in diverse research areas, including mammalian systems, normal and malignant mammary tissues, lineage specification in the gut, and yeast genetics. Experimental approaches employed at TFL include genetically engineered models, patient xenograft models, in vitro cell based assays, highly dimension single cell phenotyping, molecular biology and biochemistry, DNA regulation, transcriptomics, epigenetics, and DNA repair. In recent years, TFL has placed emphasis on the development of new technologies and their use to address fundamental questions in the control of cell growth and differentiation, aging, and gene regulation.

Blood Cancer

Working with innovative model systems and patients our research addresses the root causes of leukemias and myeloma and is developing new tools for their diagnosis, characterization and treatment.

Genome Dynamics

Genes influence every aspect of human biology and disease. We are studying how our genes and genomes are faithfully maintained as we age and the complex ways in which they are regulated to control development or are dysregulated during cancer formation.

Stem Cells

Stem cells are critical components in healthy aging and tumour suppression since they enable the development and maintenance of adult tissues. We are working to understand how stem cell properties enable blood, breast and liver development and how these properties are co-opted in cancers.

Immunology

Immunology is the study of the immune system, including its functions, responses to pathogens and foreign substances, and how it protects against disease.  We are investigating the interaction of the immune system with normal and cancer cells to develop novel immunotherapies to use the body’s own immune system to fight cancer.

Research Labs & Principal Investigators

Emeritus Scientists

Scientists In Memorial

News & Events

Florian Kuchenbauer and Peter Stirling receive 2025 Cancer Research Society 2025 Operating Grants

Two BC Cancer researchers are recipients of 2025 Operating Grants from the Cancer Research Society.

Dr. Florian Kuchenbauer received a grant for the project, “Targeting APOBEC3B-induced replication stress in multiple myeloma with TP53 abnormalities.”

Dr. Peter Stirling received a grant for the project, “Inhibiting DNA2 nuclease for selective killing of ALT positive cancers.”

Recent Publications

Higher promoter methylation of the Ubiquitin Associated and SH3 domain containing A (UBASH3A) gene is associated with T-lymphocyte ontogeny and reduced susceptibility to early-onset sepsis.

The Journal of infectious diseases, 2025
Wang, Ziyi, Amenyogbe, Nelly, Ben-Othman, Rym, Cai, Bing, Lo, Mandy, Idoko, Olubukola T, Odumade, Oludare A, Falsafi, Reza, Blimkie, Travis M, An, Andy, Shannon, Casey P, Montante, Sebastiano, Dhillon, Bhavjinder K, Diray-Arce, Joann, Ozonoff, Al, Smolen, Kinga K, Brinkman, Ryan R, McEnaney, Kerry, Angelidou, Asimenia, Richmond, Peter, Tebbutt, Scott J, Kampmann, Beate, Hancock, Robert E W, Lee, Amy H Y, Levy, Ofer, Kollmann, Tobias R, Martino, David
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Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2025 Conference Workshops.

Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2025
Wallace, Paul K, Jellison, Evan R, Thornton, Sherry, Kluepfel, Kathleen, Back, Jessica, Beadnell, Thomas C, Bebes, Attila, Behrends, Jochen, Belkina, Anna C, Black, Michele, Bogdanoski, Goce, Bollati-Fogolín, Mariela, Bonte, Sarah, Van der Borght, Katrien, Brinkman, Ryan R, Brundage, Kathleen, Bushnell, Tim, Chiu, Daniel T, Chow, Norman, Ciccolella, Christopher O, Cochran, Matthew, Czechowska, Kamila, Dagla, Kleopatra, Daniel, Benjamin, de la Cruz, Gelo, Van Duyse, Julie, Font, Laura Ferrer, Fornas, Òscar, Garcia-Garcia, Sara, Gardner, Rui, Van Gassen, Sofie, Gimenes, Daniel, Grenfell, Richard, Grider-Hayes, Madeline J, Grose, Randall, Hall, Christopher, Hally, Kathryn E, Hameetman, Marjolijn, Hogg, Karen, Houston, Jessica, Irish, Jonathan M, Isterdael, Gert Van, Jaimes, Maria, Janetzki, Sylvia, Kim, Cheryl, Koladiya, Abhishek, Lamote, Jochen, Lannigan, Joanne, Leconte, Julien, Litwin, Virginia, Longhini, Ana, Loof, Nicolas, Lozano-Andrés, Estefanía, Lundsten, Kelly, Mage, Peter, Mair, Florian, Martins, Catarina Gregório, McCausland, Megan, McGuire, Helen M, Meskas, Justin, Murphy, William, Nolan, John, Oliveira, Barbara, Ordoñez-Rueda, Diana, Orlowski-Oliver, Eva, Petersen, Charlotte Christie, Poulton, Nicole J, Putri, Givanna, Quadrini, Karen J, Ramasz, Beata, Ruhrmund, Donald, Singh, Vikas V, Small, Sam J, Smith, Natalie J, Spidlen, Josef, Stegen, Camille, Tak, Tamar, Thompson, Sam, Thomson, Michael, Vocelle, Daniel, Walker, Rachael V, Walsh, Robin E, Wang, Lili, Wang, Yu-Fen, Weglarz, Meredith, Winker, Moritz, Wood, James C S, Woolard, Stacie, Yeh, Nai-Yu, Yuecel, Raif, Rajwa, Bartek
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