Overview

The Molecular Imaging and Therapy (MIT) Clinical Trials and Research Program at BC Cancer serves as a provincial hub for the development, evaluation, and clinical translation of new radiopharmaceuticals and molecular imaging technologies. Our team operates at the intersection of radiochemistry, functional imaging, nuclear medicine physics, and early‑phase therapeutic trials, enabling a seamless pathway from laboratory discovery to first‑in‑human studies. Our clinical trials portfolio includes the assessment of novel PET radiotracers and targeted radioligand therapies, supported by an established infrastructure for PET/CT imaging, regulatory‑approved investigational radiopharmaceutical use, and specialized theranostic trial design. We strive to advance innovation and excellence in cancer care by engaging in impactful clinical research and high-quality clinical trials. 

Mission

The Molecular Imaging and Therapy (MIT) Clinical Trials and Research Program advances innovative radiopharmaceutical imaging and therapy through integrated clinical research, quantitative imaging science, and precision dosimetry. The MIT Clinical Trials and Research Program supports the translation of novel PET radiotracers and targeted radioligand therapies from discovery to first‑in‑human trials. Our mission is to deliver safe, effective, and personalized molecular imaging and therapy innovations that improve outcomes for patients across British Columbia.

Leadership

Dr. Don Wilson, Medical Director of Molecular Imaging and Therapy, BC Cancer. 

Interested?

To explore collaboration opportunities in theranostics research and clinical trials, please contact our team: mitclinicaltrials@bccancer.bc.ca

Current Projects

177Lu-HTK03170 

A Phase I/II Study of 177Lu-HTK03170 in Metastatic, Castration-Resistant Prostate Cancer Subjects with Prostate-specific Membrane Antigen-positive Disease.

Principal Investigator: Dr. Don Wilson

Study Details: Clinicaltrials.gov

RYZ101-201 (TRACY-1) 

Phase 1b/2 open-label trial of 225Ac-DOTATATE (RYZ101) in subjects with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2 (HER2)-negative, locally advanced and unresectable or metastatic breast cancer expressing somatostatin receptors (SSTRs) and progressed after antibody-drug conjugates and/or chemotherapy (TRACY-1)

Principal Investigator : Dr. Patrick Martineau

Study Details : ClinicalTrials.gov


Imaging Specific Projects:

2049 BL40 / CXCR4PET
 

This is a prospective registry study to evaluate the diagnostic utility of 18F-BL40 PET/CT to stage patients with CXCR4-expressing tumors, localize sites of tumors and assess safety and biodistribution of this drug in PET/CT scans.
Principal Investigator: Dr. Ian Alberts
Study Details: ClinicalTrials.gov

22049 HELP / ORALFDG


This study is a prospective, open-label, single-cohort, phase I study to determine the feasibility of scanning with oral FDG.
Principal Investigator: Dr. Ian Alberts
Study Details: Clinicaltrials.gov


Providing Support to:

22049 PAnTHA / GUTPANTHA

First-in-human Study of 225Ac-PSMA-Trillium (BAY 3563254) in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC) (PAnTHA)

Principal Investigator: Dr. Corinne Maurice-Dror

Study Details: Clinicaltrials.gov


Imaging Specific Projects:

2049 BL40 / CXCR4PET
Preliminary Assessment of 18F‑BL40 in PET/CT Scans for CXCR4‑Expressing Tumors
Principal Investigator: Dr. Ian Alberts
Study Details: ClinicalTrials.gov

22049 HELP / ORALFDG
HELP Study – Towards High Throughput and Efficient Long‑axial PET With Oral [18F]FDG (HELP)
Principal Investigator: Dr. Ian Alberts
Study Details: Clinicaltrials.gov

Publications supported by the program

Harsini S, Soleimani M, Wilson D, Uribe C, Saprunoff H, Bloise I, Benard F. A Phase I/II Study of [177Lu]Lu-HTK03170 with Personalized Dosimetry in Patients with Metastatic Castration-Resistant Prostate Cancer: Clinical Trial Protocol. J Nucl Med. 2025 Jul 1;66(7):1061-1067. doi: 10.2967/jnumed.124.269064. PMID: 40306965.

Zaidi A, Ravi P, Bloise I, Harsini S, Stuart HC, Kennecke HF, Alberts I, Bénard F, Wilson D, Martineau P, Loree JM. Dual PET Imaging with [68Ga]Ga-DOTA-TOC and [18F]FDG to Localize Neuroendocrine Tumors of Unknown Origin. Curr Oncol. 2025 Sep 5;32(9):497. doi: 10.3390/curroncol32090497. PMID: 41002566; PMCID: PMC12468915.

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