Dr. Carol Chen was born in Taipei, Taiwan and grew up in Calgary, Alberta. She obtained her PhD in the lab of Dr. Matthew Lorincz at the University of British Columbia, where she studied chromatin mechanism of transcription, specifically looking at histone phosphorylation. She then completed a post-doc fellowship in the lab of Dr. Nada Jabado at McGill University, where she studied histone mutations found in cancer and germline developmental disorders. In 2023, she joined Terry Fox Laboratory at BC Cancer to start her own independent research group. Her lab will study epigenetic mechanisms of brain tumors and neurodevelopmental disorders using a combination of primary clinical samples, experimental models, and computational-based approaches.

Education

2018-2023: Post-doctoral fellow, Dr. Nada Jabado’s Laboratory, Department of Human Genetics, McGill University, Montreal Canada

2012-2018: Ph.D, Dr. Matthew Lorincz’s Laboratory, Department of Medical Genetics, The University of British Columbia, Vancouver Canada

2007-2011: B.Sc, Department of Cell Biology & Genetics, The University of British Columbia, Vancouver Canada

Affiliations

Selected Publications

Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration.

Cell, 2023
Khazaei, Sima, Chen, Carol C L, Andrade, Augusto Faria, Kabir, Nisha, Azarafshar, Pariya, Morcos, Shahir M, França, Josiane Alves, Lopes, Mariana, Lund, Peder J, Danieau, Geoffroy, Worme, Samantha, Adnani, Lata, Nzirorera, Nadine, Chen, Xiao, Yogarajah, Gayathri, Russo, Caterina, Zeinieh, Michele, Wong, Cassandra J, Bryant, Laura, Hébert, Steven, Tong, Bethany, Sihota, Tianna S, Faury, Damien, Puligandla, Evan, Jawhar, Wajih, Sandy, Veronica, Cowan, Mitra, Nakada, Emily M, Jerome-Majewska, Loydie A, Ellezam, Benjamin, Gomes, Carolina Cavalieri, Denecke, Jonas, Lessel, Davor, McDonald, Marie T, Pizoli, Carolyn E, Taylor, Kathryn, Cocanougher, Benjamin T, Bhoj, Elizabeth J, Gingras, Anne-Claude, Garcia, Benjamin A, Lu, Chao, Campos, Eric I, Kleinman, Claudia L, Garzia, Livia, Jabado, Nada
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Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.

Cell, 2020
Chen, Carol C L, Deshmukh, Shriya, Jessa, Selin, Hadjadj, Djihad, Lisi, Véronique, Andrade, Augusto Faria, Faury, Damien, Jawhar, Wajih, Dali, Rola, Suzuki, Hiromichi, Pathania, Manav, A, Deli, Dubois, Frank, Woodward, Eleanor, Hébert, Steven, Coutelier, Marie, Karamchandani, Jason, Albrecht, Steffen, Brandner, Sebastian, De Jay, Nicolas, Gayden, Tenzin, Bajic, Andrea, Harutyunyan, Ashot S, Marchione, Dylan M, Mikael, Leonie G, Juretic, Nikoleta, Zeinieh, Michele, Russo, Caterina, Maestro, Nicola, Bassenden, Angelia V, Hauser, Peter, Virga, József, Bognar, Laszlo, Klekner, Almos, Zapotocky, Michal, Vicha, Ales, Krskova, Lenka, Vanova, Katerina, Zamecnik, Josef, Sumerauer, David, Ekert, Paul G, Ziegler, David S, Ellezam, Benjamin, Filbin, Mariella G, Blanchette, Mathieu, Hansford, Jordan R, Khuong-Quang, Dong-Anh, Berghuis, Albert M, Weil, Alexander G, Garcia, Benjamin A, Garzia, Livia, Mack, Stephen C, Beroukhim, Rameen, Ligon, Keith L, Taylor, Michael D, Bandopadhayay, Pratiti, Kramm, Christoph, Pfister, Stefan M, Korshunov, Andrey, Sturm, Dominik, Jones, David T W, Salomoni, Paolo, Kleinman, Claudia L, Jabado, Nada
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