Dr. Sarah Crome joins BC Cancer as a Senior Scientist within the Basic and Translational Research Program in 2025. She previously served as a Senior Scientist at the University Health Network and Associate Professor at the University of Toronto.  Dr. Crome completed her PhD with Dr. Megan Levings at the University of British Columbia, where she identified mechanism regulating human T cell differentiation and function, and her postdoctoral fellowship with Dr. Pamela Ohashi at the Princess Margaret Cancer Centre, where she identified an NK cell-like innate lymphoid cell population linked to suppression of tumour-associated T cells and poorer outcomes in ovarian cancer. She has received multiple awards for her contributions, including the Rising Star Award from the International Union of Immunological Societies, the Next Generation of Scientists Award from the Cancer Research Society, and the New Investigator Award from the Canadian Society for Immunology.

Affiliations
  • Senior Scientist, Basic and Translational Research, BC Cancer Research Institute
  • Associate Professor, Department of Immunology, Temerty Faculty of Medicine, University of Toronto
  • Senior Scientist, Toronto General Hospital Research Institute, University Health Network

Selected Publications

Endothelial dysfunction drives atherosclerotic plaque macrophage-dependent abdominal aortic aneurysm formation.

Nature immunology, 2025
Thayaparan, Danya, Emoto, Takuo, Khan, Aniqa B, Besla, Rickvinder, Hamidzada, Homaira, El-Maklizi, Mahmoud, Sivasubramaniyam, Tharini, Vohra, Shabana, Hagerman, Ash, Nejat, Sara, Needham-Robbins, Charlotte E, Wang, Tao, Lindquist, Moritz, Botts, Steven R, Schroer, Stephanie A, Taniguchi, Masayuki, Inoue, Taishi, Yamanaka, Katsuhiro, Cui, Haotian, Al-Chami, Edouard, Zhang, Hangjun, Althagafi, Marwan G, Michalski, Aja, McGrath, Joshua J C, Cass, Steven P, Luong, David, Suzuki, Yuya, Li, Angela, Abow, Amina, Heo, Rachel, Pacheco, Shaun, Chen, Emily, Chiu, Felix, Byrne, John, Furuyashiki, Tomoyuki, Husain, Mansoor, Libby, Peter, Okada, Kenji, Howe, Kathryn L, Heximer, Scott P, Yamashita, Tomoya, Wang, Bo, Rubin, Barry B, Cybulsky, Myron I, Roy, Joy, Williams, Jesse W, Crome, Sarah Q, Epelman, Slava, Hirata, Ken-Ichi, Stampfli, Martin R, Robbins, Clinton S
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Cell therapy with human interleukin 10-producing ILC2s enhances islet function and inhibits allograft rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2025
Colpitts, Sarah J, Jegatheeswaran, Sinthuja, Oakie, Amanda, Mashhouri, Siavash, Sachewsky, Nadia, Murshed, Humaira, Mathews, Jessica A, Reid, Kyle T, Misra, Paraish S, Fung, Vivian C W, Reichman, Trevor W, Nostro, M Cristina, Verchere, C Bruce, Levings, Megan K, Crome, Sarah Q
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CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment.

Cancer immunology research, 2025
Chung, Douglas C, Shakfa, Noor, Vakharia, Jehan, Warner, Kathrin, Jacquelot, Nicolas, Sayad, Azin, Han, SeongJun, Ghaedi, Maryam, Garcia-Batres, Carlos R, Sotty, Jules, Azarmina, Arvin, Nowlan, Ferris, Chen, Edward L Y, Zon, Michael, Elford, Alisha R, Wang, Ben X, Nguyen, Linh T, Mrkonjic, Miralem, Clarke, Blaise A, Bernardini, Marcus Q, Haibe-Kains, Benjamin, Ferguson, Sarah E, Crome, Sarah Q, Jackson, Hartland W, Ohashi, Pamela S
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Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity.

Nature communications, 2022
McEvoy, Caitriona M, Murphy, Julia M, Zhang, Lin, Clotet-Freixas, Sergi, Mathews, Jessica A, An, James, Karimzadeh, Mehran, Pouyabahar, Delaram, Su, Shenghui, Zaslaver, Olga, Röst, Hannes, Arambewela, Rangi, Liu, Lewis Y, Zhang, Sally, Lawson, Keith A, Finelli, Antonio, Wang, Bo, MacParland, Sonya A, Bader, Gary D, Konvalinka, Ana, Crome, Sarah Q
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A distinct innate lymphoid cell population regulates tumor-associated T cells.

Nature medicine, 2017
Crome, Sarah Q, Nguyen, Linh T, Lopez-Verges, Sandra, Yang, S Y Cindy, Martin, Bernard, Yam, Jennifer Y, Johnson, Dylan J, Nie, Jessica, Pniak, Michael, Yen, Pei Hua, Milea, Anca, Sowamber, Ramlogan, Katz, Sarah Rachel, Bernardini, Marcus Q, Clarke, Blaise A, Shaw, Patricia A, Lang, Philipp A, Berman, Hal K, Pugh, Trevor J, Lanier, Lewis L, Ohashi, Pamela S
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Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease.

Science translational medicine, 2021
Nakamura, Akihiro, Zeng, Fanxing, Nakamura, Sayaka, Reid, Kyle T, Gracey, Eric, Lim, Melissa, Leng, Lin, Jo, Sungsin, Park, Ye-Soo, Kusuda, Masaki, Machhar, Rohan, Boroojeni, Shaghayegh F, Wu, Brian, Rossomacha, Evgeny, Kim, Tae-Hwan, Ciccia, Francesco, Rockel, Jason S, Kapoor, Mohit, Inman, Robert D, Jurisica, Igor, Crome, Sarah Q, Bucala, Richard, Haroon, Nigil
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