The overarching goal of our laboratory is to understand the control of stem cells in development and diseases. Our research group is focused on uncovering novel mechanisms of post-transcriptional and translational regulation during normal and malignant hematopoiesis. We aim to develop innovative therapeutic approaches targeting these regulatory pathways in cancer.

While disruption of genetic and epigenetic mechanisms and altered signaling networks are commonly studied, the role post-transcriptional and translational regulation in tumorigenesis has only recently recognized. We are particularly interested in defining the regulation of mRNA decay and translation mediated by poly(A) tail length and RNA deadenylation complexes in the context of normal and leukemia stem cells. Despite the central role of mRNA decay and poly(A) tails in regulating and coupling RNA metabolism and translation, it is virtually unknown how these processes contribute to drive and maintain the self-renewal and oncogenic gene expression programs in stem cells and cancer. Our work will provide insights into this largely unexplored area and enable development of new therapies. The laboratory employs human and mouse models; a broad range of molecular biology methods and a global approach using next generation sequencing techniques to decipher regulation of gene expression at multiple layers from transcription to mRNA biogenesis and translation.

Affiliations

Assistant Professor, Molecular Biology and Biochemistry, Simon Fraser University

Affiliate Assistant Professor, Medical Genetics, University of British Columbia

Credentials

Current Positions

Scientist, Terry Fox Laboratory

Assistant Professor, Molecular Biology and Biochemistry, Simon Fraser University

Affiliate Assistant Professor, Medical Genetics, University of British Columbia

Education

B.Sc., Molecular Biology, College of Science – The Honor Program for Talented Students, Vietnam National University, Hanoi, Vietnam.

Ph.D., Cancer Biology, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, US.

Damon Runyon-Sohn Pediatric Postdoctoral Fellow, Memorial Sloan Kettering Cancer Center, New York, US.

Selected Publications

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.

Nature medicine, 2017
Vu, Ly P, Pickering, Brian F, Cheng, Yuanming, Zaccara, Sara, Nguyen, Diu, Minuesa, Gerard, Chou, Timothy, Chow, Arthur, Saletore, Yogesh, MacKay, Matthew, Schulman, Jessica, Famulare, Christopher, Patel, Minal, Klimek, Virginia M, Garrett-Bakelman, Francine E, Melnick, Ari, Carroll, Martin, Mason, Christopher E, Jaffrey, Samie R, Kharas, Michael G

Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.

Nature genetics, 2017
Vu, Ly P, Prieto, Camila, Amin, Elianna M, Chhangawala, Sagar, Krivtsov, Andrei, Calvo-Vidal, M Nieves, Chou, Timothy, Chow, Arthur, Minuesa, Gerard, Park, Sun Mi, Barlowe, Trevor S, Taggart, James, Tivnan, Patrick, Deering, Raquel P, Chu, Lisa P, Kwon, Jeong-Ah, Meydan, Cem, Perales-Paton, Javier, Arshi, Arora, Gönen, Mithat, Famulare, Christopher, Patel, Minal, Paietta, Elisabeth, Tallman, Martin S, Lu, Yuheng, Glass, Jacob, Garret-Bakelman, Francine E, Melnick, Ari, Levine, Ross, Al-Shahrour, Fatima, Järås, Marcus, Hacohen, Nir, Hwang, Alexia, Garippa, Ralph, Lengner, Christopher J, Armstrong, Scott A, Cerchietti, Leandro, Cowley, Glenn S, Root, David, Doench, John, Leslie, Christina, Ebert, Benjamin L, Kharas, Michael G

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.

Nature chemical biology, 2011
Moulick, Kamalika, Ahn, James H, Zong, Hongliang, Rodina, Anna, Cerchietti, Leandro, Gomes DaGama, Erica M, Caldas-Lopes, Eloisi, Beebe, Kristin, Perna, Fabiana, Hatzi, Katerina, Vu, Ly P, Zhao, Xinyang, Zatorska, Danuta, Taldone, Tony, Smith-Jones, Peter, Alpaugh, Mary, Gross, Steven S, Pillarsetty, Nagavarakishore, Ku, Thomas, Lewis, Jason S, Larson, Steven M, Levine, Ross, Erdjument-Bromage, Hediye, Guzman, Monica L, Nimer, Stephen D, Melnick, Ari, Neckers, Len, Chiosis, Gabriela
Back to top