We are using mass cytometry (CyTOF) paired with single cell genomics approaches to characterize both inter- and intra-tumoral heterogeneity in human B-cell lymphomas. We are examining malignant B cell populations as well as infiltrating immune cell populations (predominantly T-cells). We are focusing this work on two common types of lymphoma, follicular lymphoma and diffuse large B-cell lymphoma. We access clinical specimens from the prodigious lymphoma tumor bank established at BCCA. We are performing these studies in collaboration with Sohrab Shah, Christian Steidl, and David Scott at BCCA.
*This project is currently funded by a Canadian Institutes of Health Research (CIHR) Project Scheme operating grant (2016-2021), and a Terry Fox Research Institute Program Project Grant (2016-2021).