Research Interests:

Drug resistance is one of the main treatment barriers in cancer therapy. Understanding how resistance emerges and how to overcome it are crucial to the development of new therapeutics. I am interested in understanding the molecular mechanisms of drug resistance as well as relapse in acute myeloid leukemia (AML) and multiple myeloma (MM). Factors such as tumor heterogeneity as well as cell intrinsic and microenvironmental changes lead to drug refraction. Understanding these mechanisms and creating novel drug combinations targeting multiple tumorigenic pathways, will result in a more specific, efficient and sustained therapy with potentially less side-effects.

Education

  • PhD, Medical Genetics, Faculty of Medicine, University of British Columbia and Terry Fox Laboratory, BC Cancer, Vancouver, BC, Canada. (Supervisor: Dixie Mager)
  • BSc, Genetics (Honours), Faculty of Science, University of British Columbia and Terry Fox Laboratory, BC Cancer Vancouver, BC, Canada. (Supervisor: Dixie Mager)

Post-doctoral Training

  • Internal Medicine III, Clinical Comprehensive Centre, University Hospital Ulm and DKFZ, Heidelberg, Germany (Mentors: Claudia Scholl and Stefan Fröhling)
  • Institute for Experimental Cancer Research, Clinical Comprehensive Centre, University Hospital Ulm, Germany (Mentor: Christian Buske)
  • Terry Fox Laboratory, BC Cancer, Vancouver, BC, Canada (Mentor: Dixie Mager)

Professional Experience

  • Staff Scientist, Terry Fox Laboratory, BC Cancer (2018 - present)
  • Principal Investigator, Collaborative Research Center (SFB 1074, project A5), University Hospital, Ulm, Germany (2012-2018)
  • Principal Investigator, Deutsche Forschungsgemeinschaft (DFG), Institute for Experimental Cancer Research, Clinical Comprehensive Centre, University Hospital Ulm (2011-2014)
  • Young Principal Investigator, Start-up grant (Baustein), Internal Medicine III, University Hospital Ulm (2011-2012)
Affiliations

Staff Scientist, Terry Fox Laboratory, BC Cancer (2018 - present)

Lecturer, University Hospital Ulm, Master Online Advanced Oncology (2010-ongoing)

Credentials

PhD, Medical Genetics, Faculty of Medicine, University of British Columbia

BSc, Genetics (Honours), Faculty of Science, University of British Columbia

Selected Publications

MicroRNA-708 is a novel regulator of the Hoxa9 program in myeloid cells.

Leukemia, 2019
Schneider, Edith, Pochert, Nicole, Ruess, Christoph, MacPhee, Liam, Escano, Leo, Miller, Christina, Krowiorz, Kathrin, Delsing Malmberg, Erik, Heravi-Moussavi, Alireza, Lorzadeh, Alireza, Ashouri, Arghavan, Grasedieck, Sarah, Sperb, Nadine, Kumar Kopparapu, Pradeep, Iben, Sebastian, Staffas, Anna, Xiang, Ping, Rösler, Reinhild, Kanduri, Meena, Larsson, Erik, Fogelstrand, Linda, Döhner, Hartmut, Döhner, Konstanze, Wiese, Sebastian, Hirst, Martin, Keith Humphries, R, Palmqvist, Lars, Kuchenbauer, Florian, Rouhi, Arefeh

Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018
Bhayadia, Raj, Krowiorz, Kathrin, Haetscher, Nadine, Jammal, Razan, Emmrich, Stephan, Obulkasim, Askar, Fiedler, Jan, Schwarzer, Adrian, Rouhi, Arefeh, Heuser, Michael, Wingert, Susanne, Bothur, Sabrina, Döhner, Konstanze, Mätzig, Tobias, Ng, Michelle, Reinhardt, Dirk, Döhner, Hartmut, Zwaan, C Michel, van den Heuvel Eibrink, Marry, Heckl, Dirk, Fornerod, Maarten, Thum, Thomas, Humphries, R Keith, Rieger, Michael A, Kuchenbauer, Florian, Klusmann, Jan-Henning

Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia.

Haematologica, 2018
Schneider, Edith, Staffas, Anna, Röhner, Linda, Malmberg, Erik D, Ashouri, Arghavan, Krowiorz, Kathrin, Pochert, Nicole, Miller, Christina, Wei, Stella Yuan, Arabanian, Laleh, Buske, Christian, Döhner, Hartmut, Bullinger, Lars, Fogelstrand, Linda, Heuser, Michael, Döhner, Konstanze, Xiang, Ping, Ruschmann, Jens, Petriv, Oleh I, Heravi-Moussavi, Alireza, Hansen, Carl L, Hirst, Martin, Humphries, R Keith, Rouhi, Arefeh, Palmqvist, Lars, Kuchenbauer, Florian

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Cancer cell, 2017
Mohr, Sebastian, Doebele, Carmen, Comoglio, Federico, Berg, Tobias, Beck, Julia, Bohnenberger, Hanibal, Alexe, Gabriela, Corso, Jasmin, Ströbel, Philipp, Wachter, Astrid, Beissbarth, Tim, Schnütgen, Frank, Cremer, Anjali, Haetscher, Nadine, Göllner, Stefanie, Rouhi, Arefeh, Palmqvist, Lars, Rieger, Michael A, Schroeder, Timm, Bönig, Halvard, Müller-Tidow, Carsten, Kuchenbauer, Florian, Schütz, Ekkehard, Green, Anthony R, Urlaub, Henning, Stegmaier, Kimberly, Humphries, R Keith, Serve, Hubert, Oellerich, Thomas
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