Ryan Brinkman’s research is focused on developing and applying flow cytometry bioinformatics approaches to advance our understanding of human health and disease.  His early work centered on creating data standards and a free, open source computational infrastructure to support high throughput computational statistical analysis of flow cytometry data. Recent efforts have concentrated around developing complete analysis pipelines that cover all the steps from flow cytometry data pre-processing to clinical diagnosis and biomarker discovery across all the areas where the technology is applied.  The R/BioConductor flow analysis platform now supports diverse, collaborative research and patient care projects in cancer and immunology. Dr. Brinkman's lab is now applying these methodologies to both the diagnosis of patients and discovery of biomarkers in basic research and clinical investigations including for ALS, HIV, HSV vaccines, various cancers (including leukemia and lymphoma, prostrate, oral), TB, GvHD, solid organ transplantation, atherosclerosis, cancer immunotherapy, influenza, and the International Mouse Phenotyping Consortium as well as large pharmaceutical studies.

Dr. Brinkman is also active in the community as Chair of International Society for Advancement of Cytometry's (ISAC) Data Standards Task Force, coordinating the Flow Cytometry: Critical Assessment of Population Identification Methods (FlowCAP.flowsite.org) Project and FlowRepository.org, an open public repository for sharing FCS data associated with peer-reviewed publications (currently adopted by PLoS, Nature Publishing Group and Cytometry A). Dr. Brinkman has been recognized for these efforts as a Michael Smith Foundation for Health Research Scholar, a Terry Fox Foundation New Investigator, an ISAC Scholar and most recently as the recipient of the 2018 Distinguished Service Award from ISAC.

Affiliations

Professor, Medical Genetics, University of British Columbia

Associate Faculty Member, Bioinformatics Centre, University of British Columbia

Faculty Member, Bioinformatics Training Program, CIHR/MSFHR

Associate Faculty Member, British Columbia Genome Sciences Centre

Adjunct Faculty, Molecular Biology and Biochemistry, Simon Fraser University

Adjunct Faculty, School of Computing Science, Simon Fraser University

CEO, Cytapex Bioinformatics Inc.

Credentials

B.Sc (Honours), Biology and Biotechnology, Carleton University, 1992

PhD, Genetics, University of British Columbia, 2001

Selected Publications

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

European journal of immunology, 2019
Cossarizza, Andrea, Chang, Hyun-Dong, Radbruch, Andreas, Acs, Andreas, Adam, Dieter, Adam-Klages, Sabine, Agace, William W, Aghaeepour, Nima, Akdis, Mübeccel, Allez, Matthieu, Almeida, Larissa Nogueira, Alvisi, Giorgia, Anderson, Graham, Andrä, Immanuel, Annunziato, Francesco, Anselmo, Achille, Bacher, Petra, Baldari, Cosima T, Bari, Sudipto, Barnaba, Vincenzo, Barros-Martins, Joana, Battistini, Luca, Bauer, Wolfgang, Baumgart, Sabine, Baumgarth, Nicole, Baumjohann, Dirk, Baying, Bianka, Bebawy, Mary, Becher, Burkhard, Beisker, Wolfgang, Benes, Vladimir, Beyaert, Rudi, Blanco, Alfonso, Boardman, Dominic A, Bogdan, Christian, Borger, Jessica G, Borsellino, Giovanna, Boulais, Philip E, Bradford, Jolene A, Brenner, Dirk, Brinkman, Ryan R, Brooks, Anna E S, Busch, Dirk H, Büscher, Martin, Bushnell, Timothy P, Calzetti, Federica, Cameron, Garth, Cammarata, Ilenia, Cao, Xuetao, Cardell, Susanna L, Casola, Stefano, Cassatella, Marco A, Cavani, Andrea, Celada, Antonio, Chatenoud, Lucienne, Chattopadhyay, Pratip K, Chow, Sue, Christakou, Eleni, Čičin-Šain, Luka, Clerici, Mario, Colombo, Federico S, Cook, Laura, Cooke, Anne, Cooper, Andrea M, Corbett, Alexandra J, Cosma, Antonio, Cosmi, Lorenzo, Coulie, Pierre G, Cumano, Ana, Cvetkovic, Ljiljana, Dang, Van Duc, Dang-Heine, Chantip, Davey, Martin S, Davies, Derek, De Biasi, Sara, Del Zotto, Genny, Dela Cruz, Gelo Victoriano, Delacher, Michael, Della Bella, Silvia, Dellabona, Paolo, Deniz, Günnur, Dessing, Mark, Di Santo, James P, Diefenbach, Andreas, Dieli, Francesco, Dolf, Andreas, Dörner, Thomas, Dress, Regine J, Dudziak, Diana, Dustin, Michael, Dutertre, Charles-Antoine, Ebner, Friederike, Eckle, Sidonia B G, Edinger, Matthias, Eede, Pascale, Ehrhardt, Götz R A, Eich, Marcus, Engel, Pablo, Engelhardt, Britta, Erdei, Anna, Esser, Charlotte, Everts, Bart, Evrard, Maximilien, Falk, Christine S, Fehniger, Todd A, Felipo-Benavent, Mar, Ferry, Helen, Feuerer, Markus, Filby, Andrew, Filkor, Kata, Fillatreau, Simon, Follo, Marie, Förster, Irmgard, Foster, John, Foulds, Gemma A, Frehse, Britta, Frenette, Paul S, Frischbutter, Stefan, Fritzsche, Wolfgang, Galbraith, David W, Gangaev, Anastasia, Garbi, Natalio, Gaudilliere, Brice, Gazzinelli, Ricardo T, Geginat, Jens, Gerner, Wilhelm, Gherardin, Nicholas A, Ghoreschi, Kamran, Gibellini, Lara, Ginhoux, Florent, Goda, Keisuke, Godfrey, Dale I, Goettlinger, Christoph, González-Navajas, Jose M, Goodyear, Carl S, Gori, Andrea, Grogan, Jane L, Grummitt, Daryl, Grützkau, Andreas, Haftmann, Claudia, Hahn, Jonas, Hammad, Hamida, Hämmerling, Günter, Hansmann, Leo, Hansson, Goran, Harpur, Christopher M, Hartmann, Susanne, Hauser, Andrea, Hauser, Anja E, Haviland, David L, Hedley, David, Hernández, Daniela C, Herrera, Guadalupe, Herrmann, Martin, Hess, Christoph, Höfer, Thomas, Hoffmann, Petra, Hogquist, Kristin, Holland, Tristan, Höllt, Thomas, Holmdahl, Rikard, Hombrink, Pleun, Houston, Jessica P, Hoyer, Bimba F, Huang, Bo, Huang, Fang-Ping, Huber, Johanna E, Huehn, Jochen, Hundemer, Michael, Hunter, Christopher A, Hwang, William Y K, Iannone, Anna, Ingelfinger, Florian, Ivison, Sabine M, Jäck, Hans-Martin, Jani, Peter K, Jávega, Beatriz, Jonjic, Stipan, Kaiser, Toralf, Kalina, Tomas, Kamradt, Thomas, Kaufmann, Stefan H E, Keller, Baerbel, Ketelaars, Steven L C, Khalilnezhad, Ahad, Khan, Srijit, Kisielow, Jan, Klenerman, Paul, Knopf, Jasmin, Koay, Hui-Fern, Kobow, Katja, Kolls, Jay K, Kong, Wan Ting, Kopf, Manfred, Korn, Thomas, Kriegsmann, Katharina, Kristyanto, Hendy, Kroneis, Thomas, Krueger, Andreas, Kühne, Jenny, Kukat, Christian, Kunkel, Désirée, Kunze-Schumacher, Heike, Kurosaki, Tomohiro, Kurts, Christian, Kvistborg, Pia, Kwok, Immanuel, Landry, Jonathan, Lantz, Olivier, Lanuti, Paola, LaRosa, Francesca, Lehuen, Agnès, LeibundGut-Landmann, Salomé, Leipold, Michael D, Leung, Leslie Y T, Levings, Megan K, Lino, Andreia C, Liotta, Francesco, Litwin, Virginia, Liu, Yanling, Ljunggren, Hans-Gustaf, Lohoff, Michael, Lombardi, Giovanna, Lopez, Lilly, López-Botet, Miguel, Lovett-Racke, Amy E, Lubberts, Erik, Luche, Herve, Ludewig, Burkhard, Lugli, Enrico, Lunemann, Sebastian, Maecker, Holden T, Maggi, Laura, Maguire, Orla, Mair, Florian, Mair, Kerstin H, Mantovani, Alberto, Manz, Rudolf A, Marshall, Aaron J, Martínez-Romero, Alicia, Martrus, Glòria, Marventano, Ivana, Maslinski, Wlodzimierz, Matarese, Giuseppe, Mattioli, Anna Vittoria, Maueröder, Christian, Mazzoni, Alessio, McCluskey, James, McGrath, Mairi, McGuire, Helen M, McInnes, Iain B, Mei, Henrik E, Melchers, Fritz, Melzer, Susanne, Mielenz, Dirk, Miller, Stephen D, Mills, Kingston H G, Minderman, Hans, Mjösberg, Jenny, Moore, Jonni, Moran, Barry, Moretta, Lorenzo, Mosmann, Tim R, Müller, Susann, Multhoff, Gabriele, Muñoz, Luis Enrique, Münz, Christian, Nakayama, Toshinori, Nasi, Milena, Neumann, Katrin, Ng, Lai Guan, Niedobitek, Antonia, Nourshargh, Sussan, Núñez, Gabriel, O'Connor, José-Enrique, Ochel, Aaron, Oja, Anna, Ordonez, Diana, Orfao, Alberto, Orlowski-Oliver, Eva, Ouyang, Wenjun, Oxenius, Annette, Palankar, Raghavendra, Panse, Isabel, Pattanapanyasat, Kovit, Paulsen, Malte, Pavlinic, Dinko, Penter, Livius, Peterson, Pärt, Peth, Christian, Petriz, Jordi, Piancone, Federica, Pickl, Winfried F, Piconese, Silvia, Pinti, Marcello, Pockley, A Graham, Podolska, Malgorzata Justyna, Poon, Zhiyong, Pracht, Katharina, Prinz, Immo, Pucillo, Carlo E M, Quataert, Sally A, Quatrini, Linda, Quinn, Kylie M, Radbruch, Helena, Radstake, Tim R D J, Rahmig, Susann, Rahn, Hans-Peter, Rajwa, Bartek, Ravichandran, Gevitha, Raz, Yotam, Rebhahn, Jonathan A, Recktenwald, Diether, Reimer, Dorothea, Reis E Sousa, Caetano, Remmerswaal, Ester B M, Richter, Lisa, Rico, Laura G, Riddell, Andy, Rieger, Aja M, Robinson, J Paul, Romagnani, Chiara, Rubartelli, Anna, Ruland, Jürgen, Saalmüller, Armin, Saeys, Yvan, Saito, Takashi, Sakaguchi, Shimon, Sala-de-Oyanguren, Francisco, Samstag, Yvonne, Sanderson, Sharon, Sandrock, Inga, Santoni, Angela, Sanz, Ramon Bellmàs, Saresella, Marina, Sautes-Fridman, Catherine, Sawitzki, Birgit, Schadt, Linda, Scheffold, Alexander, Scherer, Hans U, Schiemann, Matthias, Schildberg, Frank A, Schimisky, Esther, Schlitzer, Andreas, Schlosser, Josephine, Schmid, Stephan, Schmitt, Steffen, Schober, Kilian, Schraivogel, Daniel, Schuh, Wolfgang, Schüler, Thomas, Schulte, Reiner, Schulz, Axel Ronald, Schulz, Sebastian R, Scottá, Cristiano, Scott-Algara, Daniel, Sester, David P, Shankey, T Vincent, Silva-Santos, Bruno, Simon, Anna Katharina, Sitnik, Katarzyna M, Sozzani, Silvano, Speiser, Daniel E, Spidlen, Josef, Stahlberg, Anders, Stall, Alan M, Stanley, Natalie, Stark, Regina, Stehle, Christina, Steinmetz, Tobit, Stockinger, Hannes, Takahama, Yousuke, Takeda, Kiyoshi, Tan, Leonard, Tárnok, Attila, Tiegs, Gisa, Toldi, Gergely, Tornack, Julia, Traggiai, Elisabetta, Trebak, Mohamed, Tree, Timothy I M, Trotter, Joe, Trowsdale, John, Tsoumakidou, Maria, Ulrich, Henning, Urbanczyk, Sophia, van de Veen, Willem, van den Broek, Maries, van der Pol, Edwin, Van Gassen, Sofie, Van Isterdael, Gert, van Lier, René A W, Veldhoen, Marc, Vento-Asturias, Salvador, Vieira, Paulo, Voehringer, David, Volk, Hans-Dieter, von Borstel, Anouk, von Volkmann, Konrad, Waisman, Ari, Walker, Rachael V, Wallace, Paul K, Wang, Sa A, Wang, Xin M, Ward, Michael D, Ward-Hartstonge, Kirsten A, Warnatz, Klaus, Warnes, Gary, Warth, Sarah, Waskow, Claudia, Watson, James V, Watzl, Carsten, Wegener, Leonie, Weisenburger, Thomas, Wiedemann, Annika, Wienands, Jürgen, Wilharm, Anneke, Wilkinson, Robert John, Willimsky, Gerald, Wing, James B, Winkelmann, Rieke, Winkler, Thomas H, Wirz, Oliver F, Wong, Alicia, Wurst, Peter, Yang, Jennie H M, Yang, Juhao, Yazdanbakhsh, Maria, Yu, Liping, Yue, Alice, Zhang, Hanlin, Zhao, Yi, Ziegler, Susanne Maria, Zielinski, Christina, Zimmermann, Jakob, Zychlinsky, Arturo

Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report.

American journal of respiratory cell and molecular biology, 2019
Tighe, Robert M, Redente, Elizabeth F, Yu, Yen-Rei, Herold, Susanne, Sperling, Anne I, Curtis, Jeffrey L, Duggan, Ryan, Swaminathan, Suchitra, Nakano, Hideki, Zacharias, William J, Janssen, William J, Freeman, Christine M, Brinkman, Ryan R, Singer, Benjamin D, Jakubzick, Claudia V, Misharin, Alexander V

Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2018 Conference Workshops.

Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2019
Czechowska, Kamila, Lannigan, Joanne, Wang, Lili, Arcidiacono, Judith, Ashhurst, Thomas M, Barnard, Ruth M, Bauer, Steven, Bispo, Cláudia, Bonilla, Diana L, Brinkman, Ryan R, Cabanski, Maciej, Chang, Hyun-Dong, Chakrabarti, Lina, Chojnowski, Grace, Cotleur, Bunny, Degheidy, Heba, Dela Cruz, Gelo V, Eck, Steven, Elliott, John, Errington, Rachel, Filby, Andy, Gagnon, Dominic, Gardner, Rui, Green, Cherie, Gregory, Michael, Groves, Christopher J, Hall, Christopher, Hammes, Frederik, Hedrick, Michael, Hoffman, Robert, Icha, Jaroslav, Ivaska, Johanna, Jenner, Dominic C, Jones, Derek, Kerckhof, Frederiek-Maarten, Kukat, Christian, Lanham, David, Leavesley, Silas, Lee, Michael, Lin-Gibson, Sheng, Litwin, Virginia, Liu, Yanli, Molloy, Jenny, Moore, Jonni S, Müller, Susann, Nedbal, Jakub, Niesner, Raluca, Nitta, Nao, Ohlsson-Wilhelm, Betsy, Paul, Nicole E, Perfetto, Stephen, Portat, Ziv, Props, Ruben, Radtke, Stefan, Rayanki, Radhika, Rieger, Aja, Rogers, Samson, Rubbens, Peter, Salomon, Robert, Schiemann, Matthias, Sharpe, John, Sonder, Soren Ulrik, Stewart, Jennifer J, Sun, Yongliang, Ulrich, Henning, Van Isterdael, Gert, Vitaliti, Alessandra, van Vreden, Caryn, Weber, Michael, Zimmermann, Jacob, Vacca, Giacomo, Wallace, Paul, Tárnok, Attila
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