The focus of the research in the Scott laboratory is aimed at improving outcomes of patients with lymphoid cancers through precision medicine. This involves unravelling the molecular determinants of treatment failure, applying cutting edge technology to patient biopsies, and then translating that knowledge into assays that can be used to guide treatment management. These approaches have led to the development of prognostic and predictive biomarkers for classical Hodgkin lymphoma, diffuse large B-cell lymphoma and mantle cell lymphoma that are applicable to routinely produced formalin-fixed paraffin-embedded biopsies – allowing these assays to be used in clinical practice. 

The poor outcomes seen when patients experience treatment failure have led to an emphasis on the biology of these cancers at the time point of relapse, exploring high-risk genetic features and evolution of tumors as they are exposed to immuno-chemotherapy. The Scott laboratory is now leading and co-ordinating correlative studies in clinical trials of treatment of relapsed and refractory aggressive B-cell lymphoma. Finally, the Scott laboratory has broadened the biobank at BC Cancer to enable the expansion of this research into chronic lymphocytic leukemia (CLL).

Collaborations
The translational focus of the Scott laboratory is made possible through collaborations within the BC Cancer’s Centre for Lymphoid Cancer with treating physicians and pathologists in Vancouver and across BC, along with Scientists at the BC Cancer Research Centre and the Genome Sciences Centre. The Scott laboratory is also part of international collaborative efforts, notably the Lymphoma/Leukemia Molecular Profiling Project (LLMPP) and the Lunenburg Lymphoma Biomarker Consortium (LLBC). Finally, and key to clinical translation, are the collaborations with Canadian (CCTG) and US (ECOG, Alliance andSWOG) clinical trials groups.

Members

Faculty/Leaders

Staff

Students/Trainees

Open Positions

Staff Scientist

Application Deadline

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

This is a regular full-time staff position and a non-academic option for Research Associates who have completed their term(s) at PHSA and are transitioning from the academic path to begin conducting scientific research outside the academic research stream.  It is also suitable for individuals who have gained experience at external organizations and who meet the required qualification criteria.  The staff scientist performs the duties of a Research Associate but works with more independence.

Role Summary

Working under the supervision of the Principal Investigator, these positions propose experimental hypotheses, design experimental questions and protocols, and plan, coordinate, conduct and report on assigned research projects.  They evaluate research data, revise techniques and develop new methods and approaches to solve scientific problems.

Key Accountabilities

  • Proposes experimental hypotheses for research and designs experimental questions and protocols in consultation with the Principal Investigator.
  • Applies standard scientific techniques and utilizes technical expertise and experience to plan, coordinate, conduct and report on assigned research projects.  Notifies Principal Investigator of issues related to laboratory protocols and experimental designs and recommends solutions.
  • Prepares Research Ethics Board applications and amendments as required, and ensures compliance with Research Ethics Board guidelines.
  • Develops new laboratory methods and modifies existing procedures to facilitate research projects.
  • Collects, records, analyzes, validates, interprets and organizes experimental and research data and communicates scientific findings to Principal Investigator.  Recommends research direction based on preliminary findings in consultation with the Principal Investigator.
  • Sources funding opportunities and provides input into writing research proposals and developing budget for grant applications.
  • Writes grants to secure funding in support of research projects when permitted by funding agency and supported by the Department
  • Works with department administration to monitor and report on project budget and expenditures to ensure prudent use of financial resources.
  • Conducts regular literature reviews relating to research areas.  Contributes intellectual and scientific input to manuscripts for publications.  Presents research findings at national and/or international conferences.
  • Facilitates constructive and collaborative relationships with both the Principal Investigator and internal and external research partners.

Qualifications

A level of education, training and experience equivalent to a Ph.D. in a related scientific field plus five (5) years of recent, relevant post-doctoral research experience.

Projects

Overcoming Treatment Failure in Lymphoid Cancer (TFRI-funded Program)

This team grant is a collaborative effort, which experts in lymphoid cancer biomarkers and tumor microenvironment, hematology and cancer genomics jointly aim to understand and overcome treatment failure in lymphoid cancers. The team will identify and validate target-specific molecular tests characterizing genetic changes and molecular pathways which provide the preclinical rationale for novel drug development.

Large-Scale Applied Research Project (LSARP Program)

Dr. Steidl and Scott teams have successfully won a large-scale applied research project worth $11.9 million funded by Genome Canada, Genome BC, Canadian Institutes of Health Research and BC Cancer Foundation to study the genome biology of relapsed lymphoid cancers. Our large-scale, pan-Canadian study was launched last year to discover novel, actionable markers of relapsed lymphoma from which clinically relevant assays can be developed.

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