Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No. CB_P01067_HSA145548_Bioinfo Database Devt_2023_05_15

Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority, patient safety is a priority and a responsibility shared by everyone at PHSA. As such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Computational Biologist will participate in the analysis of sequencing data by developing, refining and adapting bioinformatics tools for a high-throughput processing pipeline.  The Computational Biologist will also participate in the development and maintenance of the production databases, which provide tracking of all of the laboratory and bioinformatics analysis pipelines at the GSC.  Additionally, the Computational Biologist will assist in the packaging and distribution of developed tools and analysis results to the scientific community, and will be contributing to the preparation of scientific publications. 

Duties

Assists in the development and maintains the core sequence analysis pipelines at GSC, including but not limited to: QC of sequencing data; Alignment of sequenced reads; Formatting and manipulation of alignment files for use by downstream pipelines (e.g. merging, reheadering); Dissemination of data to collaborators; New analyses pipelines as required. Assists in the development and maintains GSC laboratory, quality and analysis databases, including: Routine database integrity checks and database maintenance; Development of views and interfaces for data entry; Development of reports for internal users and collaborators; Investigation of new frameworks and designing new schemas and tables. Communicates with stakeholders in the lab, on analysis teams, and with external collaborators to understand and document requirements for development and to respond to questions about collaborator data and data quality. Works with upstream and lab teams generating data to be housed in the database, and with downstream users of the databases to meet requirements, and responds to internal requests for query and API support. Participates in the development and maintains ETL pipelines between GSC production databases. Manages the storage and compression of over 5Pb of internally generated sequencing data as well as the download and storage of external data. Works closely with GSC Systems team and Quality Assurance team to establish and carry out best practices for data security, and ensure compliance with ISO 27001 certification, CAP/DAP clinical accreditation requirements and other data use agreements. Tests and validates new data analysis software for analyses such as alignment, duplicate marking and merging. Participates in code walk-throughs and reviews of solutions. Participates in the design and builds database solutions, taking performance into consideration. Coordinates production problem resolution for assigned applications, including working with other technical teams. Produces thorough but concise written documentation of database tables, applications, validations, SOPs, and other processes and procedures as required. Performs other related duties as required. Qualifications Education, Training and Experience Graduation from a recognized Bachelor of Science Program in Computer Science or equivalent with significant computer science components.  Two (2) years of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders. Skills and Abilities Demonstrated expertise in database programming and database design. Demonstrated ability in Python. Experience designing and/or maintaining a relational database including knowledge of SQL or PostgreSQL, and with ORMs. Experience with REST API development. Experience with front-end web development (AngularJS, React). Functional knowledge of distributed version control systems, such as GIT. Experience developing software as part of a team, familiarity with Agile development and ticketing systems. Comfortable working in an Unix environment, including experience with shell scripting and common command-line tools. Excellent verbal and written communication skills. Demonstrated interpersonal skills including the ability to work effectively with others in a team environment. Demonstrated ability to efficiently organize work assignments and establish priorities.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No. CB_P01067_HSA145548_Bioinfo Database Devt_2023_05_15 in the subject line of your email. As this is a union position, internal applicants must visit internaljobs.phsa.ca to field their online application.l

This posting will remain online until filled.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No: RP_R00008_Karsan Lab_2023_05_03

Summary

The Karsan lab at Canada’s Michael Smith Genome Sciences Centre (GSC) are seeking a Research Programmer to join a Marathon of Hope Cancer Centre research project. The team will be working with other research programmers at the Karsan lab to perform data analysis on next-generation sequencing (NGS) data including but not limited to WGS, RNA-seq, targeted sequencing, scRNA-seq, scATAC-seq, and Bisulfite-Seq, to study of clonal evolution of blood cancers and resistance to therapy. We seek candidates with strong analytical and programming skills to research, develop, and improve existing research pipelines.

The role is ideally suited for detail-oriented individuals with a strong interest in data analysis, research, and scientific programming within a high throughput academic setting.  The Karsan lab has a history of strong publications and can offer great experience in research with full access to the GSC’s world-class compute cluster.  Additionally, the Karsan Lab has a diverse computational biology core for knowledge sharing, collaboration, and support. 

Duties/Accountabilities: 

• Design and implement bioinformatic data analysis to meet objectives of the project
• Work with other project team members to develop and test code, and implement analysis
• Collects, records, analyzes, validates, interprets and organizes experimental and research data and communicates scientific findings to the Principal Investigator.
• Evaluate and incorporate third-party software into pipelines
• Produce thorough but concise written documentation of experiments, algorithms, validations, and other procedures as required.

 Qualifications:

• Graduation from a recognized Bachelor of Science Program in Computer Science or relevant program. A Master’s degree in a relevant field would be a strong asset. 
• Two (2) years of recent related experience or an equivalent combination of education, training, and experience.

Core Skills and Abilities: 

• Expertise with scientific programming and able to provide links to code samples via GitHub
• Familiarity with cancer biology
• Excellent verbal and written communication skills
• Demonstrated ability to interpret results
• Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
• Established ability to efficiently organize work assignments and establish priorities
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.

Additional Assets:

• Familiarity in statistical analysis using modern computational tools (experience with any relevant tools will be considered, but R and Python are preferred)
• Familiarity in next-generation sequencing datasets

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using RP_R00008_Karsan Lab_2023_05_03 in the subject line of your email.

This posting will remain online until filled.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

PHSA and BC Cancer are committed to employment equity, encouraging all qualified individuals to apply. We recognize that our ability to provide the best care for our diverse patient populations relies on a rich diversity of skills, knowledge, background and experience, and value a safe, inclusive and welcoming environment.

Temporary Full-Time

We are seeking an outstanding and motivated student to assist our research efforts in neurodevelopment and brain cancer.

The overarching goal of our laboratory is to understand the molecular mechanism underpinning brain cancer initiation and progression. Our research specifically focuses on epigenetic pathways that are disrupted in high-grade gliomas, which is a lethal form of brain cancer in children and young adults. We utilize an integrative approach that leverages multiple experimental methods, including patient-derived samples, cerebral organoids, and transgenic animals, along with state-of-the-art sequencing technologies to study the genome, epigenome, and transcriptome of these diseases. The Chen lab is a part of the Terry Fox Laboratory, a world class research unit within BC Cancer, and the Department of Biochemistry & Molecular Biology at the University of British Columbia (UBC).

Qualified candidates should have a bachelor/or MSc degree in Life Sciences preferably in genetics, biochemistry, molecular and cell biology. Working knowledge of wet lab techniques such as tissue culture, PCR, RNA extraction, western Blot, immunostaining is strongly preferred.  Experience working with animal models is desirable.

Salary will be commensurate with qualifications and experience.

To Apply:

Please send a cover letter, curriculum vitae, transcript, and contact details for 3 referees to:

Carol Chen, PhD

Scientist, Terry Fox Laboratory, BC Cancer

Assistant Professor, Faculty of Biochemistry & Molecular Biology, UBC.
Email: clchen@bccrc.ca

This position will remain open until filled.

This is a temporary position with a possibility of extension.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No: SS2_R00010_Clinical Informatics_2023_05_02  

Summary

We are seeking a dynamic and innovative leader to join our team as a leader in clinical bioinformatics and cancer precision genomics. In this role, you will oversee the development and execution of cancer genome analysis with a focus on precision medicine approaches and reporting. You will lead a team of bioinformatic analysts and work closely with other teams at the Genome Sciences Centre to ensure that projects and analyses are executed on time, within budget, and to the highest standards.  The role is part of the Genome Sciences Centre’s precision medicine initiative the “Personalized Oncogenomics Program” (POG) and the Terry Fox Research Institute’s “Marathon of Hope”.

Responsibilities:

• Leadership, support and day-to-day supervision of members of the clinical informatics team
• Lead and manage a team of researchers in the design, execution, and analysis of cancer precision genomics analysis and reporting.
• Develop and implement strategies to optimize and improve cancer genomics research approaches and methodologies.
• Collaborate with leadership teams from cancer genomic studies, including the Personalized OncoGenomics Program (POG) and Precision Oncology For Young People (PROFYLE), to deliver genomics information in the area of precision oncology. This will include:
  • Delivery of whole genome and transcriptome integrative analysis genomic reports to multi-disciplinary clinical teams
  • Collaboration with stakeholders and research groups to deliver novel technologies in the context of precision oncology studies
  • Providing leadership and expertise to support program-wide decision-making and strategic planning
  • Collaborate with stakeholders to provide leadership and technical expertise for scientific publications and grant writing
• Engage with national and international collaborative genomics initiatives including large-scale genomics projects and investigator initiated clinical trials. This will include:
  • Participation in the development of clinical trial design
  • Collaborate with members of external organizations for the development of distributable software
  • Establishment and implementation of data and software sharing approaches
• Conduct bioinformatic analyses and interpretation of genomic data
• Collaborate with bioinformatics teams across the organization to help develop and improve production bioinformatics pipelines and genomics reporting in a clinical research setting.
• Collaborate with teams at the Genome Sciences Centre including those representing bioinformatics, computational biology, and data science to ensure the delivery of high-quality reports and results.
• Engage with external collaborators to identify new opportunities and foster relationships to support ongoing research efforts.
• Participate in the preparation and submission of grant proposals to fund cancer genomics research initiatives.
• Retain familiarity with the latest advances in cancer genomics research and emerging technologies and apply this knowledge to inform new research and development strategies.

Qualifications:

• PhD in Genetics, Genomics, Cancer Biology, or related field.
• 5+ years of experience in cancer genomics research, with a focus on precision medicine.
• Demonstration of leadership and management skills, with experience leading cross-functional teams.
• Familiarity with genomic data analysis approaches and data interpretation.
• Excellent communication and interpersonal skills, with the ability to work collaboratively with internal and external stakeholders.
• A strong publication record in the field of genomics.

Required skills:

• Highly collaborative and team-oriented approach is required.
• Effective oral and written communication skills
• In-depth knowledge and extensive research experience in the field of cancer biology and cancer genomics
• Proficiency in one or more common programming and/or scripting language
• Ability to manage time and engagement across diverse tasks and projects effectively while meeting expected deliverables in the allocated time-frame

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using SS2_R00010_Clinical Informatics_2023_05_02  in the subject line of your email.

This posting will remain online until filled.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

PHSA and BC Cancer are committed to employment equity, encouraging all qualified individuals to apply. We recognize that our ability to provide the best care for our diverse patient populations relies on a rich diversity of skills, knowledge, background and experience, and value a safe, inclusive and welcoming environment.

Research Assistant 3

Role Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position. Entry to this advanced working level is restricted to those who are thoroughly conversant with all of the complexities of the specific research programs and methodologies of the hiring laboratory.  They are expected to exercise initiative and independent judgment in the performance of duties such as staff supervision and scheduling of work, administrative support, and collaboration on research papers.  They are designated the responsibility of ensuring that the day to day work meets the research objectives.

Key Accountabilities

Under limited supervision, performs complex technical procedures and experiments by following established laboratory procedures according to written protocols. Provides input regarding modification of procedures as requested by Department Head, Principal Investigator, or designate. Maintains and stores cell lines and primary cultures. Maintains and stores test materials and products. Maintains inventory of laboratory supplies and equipment. Demonstrated work methods or procedures to less experienced assistants as designated; orients new staff to department. Provides day to day scheduling and supervision of assigned work. Provides significant contributions to the preparation and/or presentation of research papers. Assists the Department Head or Principal Investigator in preparing grant applications and budgets.

Qualifications

A level of education, training, and experience equivalent to graduation from a recognized Bachelor’s program in an appropriate discipline (e.g. Bachelor of Science); plus five (5) years of recent related experience in a research laboratory.

This position requires strong skills in the areas of molecular biology, protein biochemistry and cell biology, including, but not limited to, mammalian cell culture, cloning, RNA and DNA purification, lentiviral transduction, PCR Western blotting, microscopy and imaging. Working knowledge and performance of aseptic technique is essential. Expertise in the use and handling of hazardous materials such as biological agents, radioactive substances and/or cytotoxic drugs is preferred. The successful candidate must be well-organized, conscientious, understand the importance of detail in observing and recording data, and be able to multi-task and prioritize duties effectively. Experience working with pre-clinical animal models, especially mice, is a valuable asset.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No.  CSA_F00420_HEU144261_Systems_2023_04_17

Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Provides computer technical support services at the Genome Sequence Centre (GSC).  Duties include investigating and resolving hardware and software problems, installing, configuring and testing hardware and software, providing training to users and participating in GSC bioinformatic projects.

Duties

1. Maintains the computer system and network for the GSC by performing duties such as responding to system, communications and user problems, investigating problems and taking corrective action as per established procedures. Resolves user issues on the technical infrastructure. Refers problems as required Installs, configures, modifies and tests all computer hardware within the GSC network.
2. Installs, configures and upgrades server software as directed.
3. Installs and provides technical support for GSC operating systems and including UNIX-based scientific applications such as Apache, AceDB, CONSED, MySQL, Perl Modules, and other bioinformatic software.
4. Provides training to users in the use of hardware and software and prepares instructional material.
5. Works with others in the implementation of the GSC network infrastructure (servers, network, workstations, website) by installing network components and testing.
6. Installs, configures, modifies and tests all computer hardware within the GSC network.
7. Maintains printers, barcode readers and associated hardware.
8. Modifies website content as required.  Maintains hardware and runs web server software.
9. Carries out and monitors GSC wide backup and recovery procedures.
10. Provides input into the development of the GSC’s information technology infrastructure strategy which includes data, voice and video technology.
11. Under direction, monitors and maintains security profiles for computer systems by adding and deleting user names and reviewing security logs.
12. Codes, modifies, tests and maintains programs from specifications to complement systems implementation and meet technical and client support requirements.
13. Maintains an inventory of software and their version for all computers within the GSC network.
14. Writes basic computer programs to automate frequently performed tasks.
15. Performing other related duties as required.

Qualifications

Education, Training and Experience

• Completion of Grade 12 plus graduation from a recognized two (2) year systems technology diploma, plus two (2) years of recent related experience or an equivalent combination of education, training and experience.

Skills and Abilities

• Ability to type.
• Ability to communicate and deal effectively both verbally and in writing.
• Ability to work with other effectively.
• Physical ability to carry out the duties of the position.
• Ability to organize work.
• Ability to operate related equipment.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: CSA_F00420_HEU144261_Systems_2023_04_17 in the subject line of your email.

ATTN: PHSA Employees:

To be considered as a PHSA employee (internal applicant) for this position, you must apply online via your internal profile at http://internaljobs.phsa.ca   

This posting will remain online until filled.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

PHSA and BC Cancer are committed to employment equity, encouraging all qualified individuals to apply. We recognize that our ability to provide the best care for our diverse patient populations relies on a rich diversity of skills, knowledge, background and experience, and value a safe, inclusive and welcoming environment.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No: RP_R00008_JR#144048_CCGI_2023_04_12

Summary

Canada’s Michael Smith Genome Sciences Centre (GSC) of the BC Cancer Research Institute is a state-of-the-art, large scale, high throughput, clinically accredited genomics and bioinformatics facility in one of the most beautiful, diverse and eclectic cities in the world. If you are a computational scientist with experience analysing genomic data and are motivated to contribute towards the care of patients in BC—then join us!

As a Research Programmer within the Centre for Clinical Genomics Informatics team at the GSC, you will be responsible for technical support for clinical programs through development, testing and validation of clinical bioinformatics processes. The Research Programmer will report to the Process Development Coordinator and is anchored within a team of exceptional computational scientists and programmers, who collaborate directly on the development and maintenance of robust, cost efficient, and competitive clinical genomics pipelines. By working within the GSCs bioinformatics facility, you will collaborate with clinical and research computational biologists and programmers across bioinformatics groups, clinical lab staff and the quality assurance group to deliver clinical diagnostic genomic testing for patients in BC.

This is an opportunity to work with highly motivated colleagues in a science-oriented, creative and dynamic environment. We offer a competitive salary, excellent benefits and significant career development opportunities.

So, what are you waiting for? Apply now!

Duties and Responsibilities:

• Works with team members to design, plan and implement testing and development of bioinformatics software and optimize existing workflows.
• Development and maintenance of clinical genomic databases.
• Delivery of clear and concise documentation.
• Actively participate in a team-oriented approach to improve efficiency and productivity.

Qualifications

• Graduation from a recognized Bachelor’s program in an appropriate discipline such as Computer Science, Bioinformatics, Genetics, Molecular Biology or Biochemistry, and three years of recent, related experience in a research and or clinical laboratory.
• Proven expertise with Python, R, and/or other similar high-level languages.
• Functional knowledge of distributed version control systems, such as Git.
• Demonstrated experience with analysis of next generation sequencing data with an understanding of standards and guidelines for validating clinical bioinformatics analysis pipelines using these technologies.
• Comfortable working in a Linux environment, including experience with shell scripting and common command-line tools.
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
• Demonstrated ability to efficiently organize work assignments and establish priorities to meet set milestones.
• Demonstrated ability to write technical documents including validations and procedure manuals.
• Experience with bioinformatic workflow managers and database development would be considered an asset.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using RP_R00008_JR#144048_CCGI_2023_04_12 in the subject line of your email.

This posting will remain online until filled.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

Academic

 

Job Category

Faculty Non Bargaining

Job Title

Postdoctoral Research Fellow - Single Cell Genomics, drug resistance in cancer

 

Department

Aparicio Laboratory | Department of Pathology and Laboratory Medicine | Faculty of Medicine (Samuel Aparicio)

 

JOB DESCRIPTION:

Post-doctoral Fellow (PDF) Single Cell Genomics, drug resistance in cancer We are seeking a highly-motivated post-doctoral fellow (PDF) with strong leadership ability and expertise in single cell genomics and transcriptomics, and a strong background in molecular biology. The successful applicant will work full-time under the supervision of Dr. Samuel Aparicio on an exciting project decoding the role of epigenomic and genomic drug resistance. The position start date is flexible.

JOB SUMMARY:
The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patient tissues and patient-derived xenografts (PDX). The lab is highly multidisciplinary and highly productive (Laks et al, Cell 2019, Salehi et al Nature 2021, Funnell et al Nature 2022) and is well funded for single cell analysis of genomes and transcriptomes in cancer. The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patients and patient-derived xenografts. The project involves collaborating on an exciting project mapping clonal dynamics in human cancers under drug treatment with new single cell methods. The post holder will also have the opportunity to interact as part of the international Welcome LEAP Delta Tissue project and an exciting new program in the biology of epithelium from high risk carriers of BRCA1/BRCA2 mutations. These projects are bringing new measurement methods and computational techniques to the 3D reconstruction of tumours, and mapping drug sensitivity and drug combinations using sgRNA/CRISPR methods in vivo. The program works closely with UBC departments of statistics and computer science and the New York Genome Center NY, on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage.

ORGANIZATIONAL STATUS:

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Center in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, and will play a senior leadership role in the laboratory.

The Department of Pathology and Laboratory Medicine at UBC is a hybrid, academically intensive Department within the UBC Faculty of Medicine whose activities span a broad spectrum of teaching, research, and academic service, often performed in the milieu of clinical practice, and are ultimately devoted to improving the care, treatment, and well-being of patients.  The Department offers academic degrees at the bachelor’s (Bachelor of Medical Laboratory Science (BMLSc)) and graduate (MSc, PhD) levels with the graduate program, one of the largest in the Faculty of Medicine, which has been recognized by UBC for its quality. The Department plays a major role in the MD undergraduate program and offers an accredited residency-training program. Faculty members participate across a spectrum of research from basic investigative to translational to clinical applied research and are recognized locally, nationally and internationally for their excellence. 

WORK PERFORMED:
● Provide leadership, strategic direction, and translational research pertaining to single cell genomics and transcriptomics, and CRISPR methods.
● Design and implement research plan to investigate the clonal dynamics in human cancer through single cell methods.
● Design and conduct animal experiments.
● Conduct in vivo testing or characterization of drugs, small molecules, knockouts or antibodies in relevant PDX animal models.
● Foster research collaborations and work jointly with academic, clinical, industry, and other partners.
● Scientifically document lab experiments, data analysis, interpretations.
● Write manuscripts, present results at internal and external meetings.
● Identify funding opportunities and if required write or assist with grant proposals
● Lead and mentor junior trainees/students in the laboratory

CONSEQUENCE OF ERROR:
This is a senior research position that plays a critical role in the development of this novel field. PDF is accountable for the quality and integrity of the research and data, including analyses and interpretation, as well as the effective and efficient management of research projects and deliverables. This position requires innovation, strategic planning, and adaptability. Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly.

SUPERVISION RECEIVED:

The PDF will work with a high degree of independence and set priorities under broad directives from Dr. Aparicio. The PDF will be expected to provide direction and mentoring in the laboratory under the supervision of Dr. Aparicio. This position will also provide the candidate with a high level of exposure to single cell genomics and translational research, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally.

SUPERVISION GIVEN:

The PDF will be expected to provide mentorship and guidance to undergraduate, graduate students and other research members as required.

QUALIFICATION:
● Ph.D. in biology, cell biology, molecular biology, biochemistry, genetics, genomics, or similar discipline.
● The candidate should have a solid scientific and technical background with excellent written/oral communication, interpersonal and organizational skills.
● Preference will be given to candidates with a proven track record with a minimum of 2-3 first author publications in reputable journals.
● Proficiency in cell biology, molecular biology, histology, genetics, genomics, next-generation sequencing and biochemistry techniques.
● Demonstrate the ability to work in a highly interdisciplinary environment.
● Experience with cancer research.
● Expertise and hands-on experience in animal studies, including all aspects of design, handling, breeding, tissue collection, histology, and analyses are essential.
● Familiarity with testing/characterization of small molecule or drug in vivo is preferred.
● Previous biochemical/cell biology and molecular biology experience with single cell genomics / transcriptomics, next generation sequencing, drugs screen and PDX modeling is an asset.
● Experience with statistical analyses and scientific writing. Previous experience with grant writing is an asset.
● Experience with bioinformatics approaches to biological data and familiarity with handling of genomics data is an asset.
● Applicants with experience and a strong track record with large drug target screening, single cell methods, and PDX mouse models are especially encouraged to apply.

How to Apply:

Exceptional candidates should submit a cover letter outlining your research interests and fit with the laboratory's research, curriculum vitae, and the names of three referees willing to provide letters of reference.

Due to the number of resumes we receive, we are unable to confirm receipt of submissions over the phone, or provide the status of the competition. Only shortlisted candidates will be contacted.

This position is located within a health-care facility. Therefore, this positions requires successful verification of full vaccination against Covid-19 provided prior to the start date, as required by the provincial health mandate.

UBC hires on the basis of merit and is committed to employment equity. All qualified persons are encouraged to apply.

Equity and diversity are essential to academic excellence.  An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged.  We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, and/or Indigenous person.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No.   RA_R00006_POG_2023_04_25

Summary

The GSC is currently looking for a Research Associate to work on the Personalized OncoGenomics Program (POG). The goal of this program is to develop cutting-edge approaches to aid in the determination of relevant therapeutic options based on the genomic and transcriptomic information derived from a patient’s tumour. Working under the supervision of the Principal Investigator and the Group Leader, the successful incumbent will work with the project team to lead the activities on the development, implementation and performing bioinformatics analysis, as well as interpretation and communication of genomic data in a clinical context.

Duties include:

• Individualized analysis and interpretation of patient tumour sequencing data to evaluate cancer-associated pathways and identify potential clinically actionable targets.
• Communication of genomic findings to clinical teams in the form of written reports and oral presentations.
• Providing scientific direction, leading data analysis and preparation of manuscripts and/or presentation of research papers.
• Performing literature review and identifying, collecting and analyzing internal and external datasets.
• Testing and making use of software for inclusion into research projects.
• Assisting in the preparation of grants, protocols and other funding related documents.

Skills and Abilities:

• PhD in molecular genetics, molecular biology, genomics, bioinformatics or related field.
• Broad understanding of human molecular genetics and cancer biology.
• Experience working with human genomic data, particularly next generation sequencing data (WGS, RNAseq).
• Experience with a common programming language (eg. Python or R).
• Excellent oral and written communication
• Organization skills with the ability to efficiently manage time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities.
• Ability for critical thinking and independent learning.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using RA_R00006_POG_2023_04_25 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

JOB DESCRIPTION:

Post-doctoral Fellow (PDF) G-quadruplex biology and therapeutics We are seeking a highly-motivated post-doctoral fellow (PDF) with strong leadership ability and expertise in molecular biology, single cell genomics and transcriptomics, and a background in DNA drug target biology in cancer. The successful applicant will work full-time under the supervision of Dr. Samuel Aparicio. The position start date is flexible.

JOB SUMMARY:

A postdoctoral/research fellow position is available, working on an exciting international project to define additional mechanisms and target engagement of G4 ligands in cancer genomes, utilizing single cell sequencing and chemical biology methods. The Aparicio lab is developing small molecule ligands of G-quadruplex structures in DNA as a therapeutic, based on recent success from the lab demonstrating for the first time clinical proof of principle (Hilton et al, Nat. Comms 2022) for a G4 binder. The Aparicio lab is multidisciplinary environment, highly productive (Laks et al, Cell 2019, Salehi et al Nature 2021, Funnell et al Nature 2022, aparicio.molonc.ca for projects and papers) and is well funded for single cell analysis of genomes and transcriptomes in cancer. The labs has created and practices methods for sequencing single genomes, defining epigenetic states in single cells and mapping gene fitness in vivo (Eirew et al, Nat. Comms 2022). The post holder will also have the opportunity to interact as part of the international Welcome LEAP Delta Tissue project and an exciting new program in the biology of epithelium from high risk carriers of BRCA1/BRCA2 mutations. The program works closely with UBC departments of statistics and computer science and the New York Genome Center NY, on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage, beyond core experience of molecular biology and drug target biology in cancer.

ORGANIZATIONAL STATUS:

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Center in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, and will play a senior leadership role in the laboratory.

The Department of Pathology and Laboratory Medicine at UBC is a hybrid, academically intensive Department within the UBC Faculty of Medicine whose activities span a broad spectrum of teaching, research, and academic service, often performed in the milieu of clinical practice, and are ultimately devoted to improving the care, treatment, and well-being of patients.  The Department offers academic degrees at the bachelor’s (Bachelor of Medical Laboratory Science (BMLSc)) and graduate (MSc, PhD) levels with the graduate program, one of the largest in the Faculty of Medicine, which has been recognized by UBC for its quality. The Department plays a major role in the MD undergraduate program and offers an accredited residency-training program. Faculty members participate across a spectrum of research from basic investigative to translational to clinical applied research and are recognized locally, nationally and internationally for their excellence. 

WORK PERFORMED:
● Provide leadership, strategic direction, and translational research pertaining to single cell genomics and transcriptomics, and CRISPR methods.
● Design and implement research plan to investigate the clonal dynamics in human cancer through single cell methods.
● Design and conduct animal experiments.
● Conduct in vivo testing or characterization of drugs, small molecules, knockouts or antibodies in relevant PDX animal models.
● Foster research collaborations and work jointly with academic, clinical, industry, and other partners.
● Scientifically document lab experiments, data analysis, interpretations.
● Write manuscripts, present results at internal and external meetings.
● Identify funding opportunities and if required write or assist with grant proposals
● Lead and mentor junior trainees/students in the laboratory

CONSEQUENCE OF ERROR:
This is a senior research position that plays a critical role in the development of this novel field. PDF is accountable for the quality and integrity of the research and data, including analyses and interpretation, as well as the effective and efficient management of research projects and deliverables. This position
requires innovation, strategic planning, and adaptability. Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly.

SUPERVISION RECEIVED:

The PDF will work with a high degree of independence and set priorities under broad directives from Dr. Aparicio. The PDF will be expected to provide direction and mentoring in the laboratory under the supervision of Dr. Aparicio. This position will also provide the candidate with a high level of exposure to single cell genomics and translational research, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally.

SUPERVISION GIVEN:

The PDF will be expected to provide mentorship and guidance to undergraduate, graduate students and other research members as required.

QUALIFICATIONS:
● Ph.D. in biology, cell biology, molecular biology, biochemistry, genetics, genomics, or similar discipline.
● The candidate should have a solid scientific and technical background with excellent written/oral communication, interpersonal and organizational skills.
● Preference will be given to candidates with a proven track record with a minimum of 2-3 first author publications in reputable journals.
● Proficiency in cell biology, molecular biology, histology, genetics, genomics, next-generation sequencing and biochemistry techniques.
● Demonstrate the ability to work in a highly interdisciplinary environment.
● Experience with cancer research.
● Expertise and hands-on experience in animal studies, including all aspects of design, handling, breeding, tissue collection, histology, and analyses are essential.
● Familiarity with testing/characterization of small molecule or drug in vivo is preferred.
● Previous biochemical/cell biology and molecular biology experience with single cell genomics / transcriptomics, next generation sequencing, drugs screen and PDX modeling is an asset.
● Experience with statistical analyses and scientific writing. Previous experience with grant writing is an asset.
● Experience with bioinformatics approaches to biological data and familiarity with handling of genomics data is an asset.
● Applicants with experience and a strong track record with large drug target screening, single cell methods, and PDX mouse models are especially encouraged to apply.

How to Apply:

Exceptional candidates should submit a cover letter outlining your research interests and fit with the laboratory's research, curriculum vitae, and the names of three referees willing to provide letters of reference.

Due to the number of resumes we receive, we are unable to confirm receipt of submissions over the phone, or provide the status of the competition. Only shortlisted candidates will be contacted.

This position is located within a health-care facility. Therefore, this positions requires successful verification of full vaccination against Covid-19 provided prior to the start date, as required by the provincial health mandate.

UBC hires on the basis of merit and is committed to employment equity. All qualified persons are encouraged to apply.

Equity and diversity are essential to academic excellence.  An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged.  We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, and/or Indigenous person.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference Number: RP_R0008_Steif Lab_2023_02_23

We are looking for an outstanding research programmer with experience developing and applying computational workflows for high-throughput sequencing data analysis to join Dr. Adi Steif’s cancer genomics research group in Vancouver, Canada.

The successful applicant will be part of an exceptional multidisciplinary team of bioinformatic scientists and trainees, working alongside collaborators in biomedical engineering and molecular biology at the University of British Columbia. By joining the Steif Lab, you will help advance genomic technology alongside highly motivated specialists in a creative and dynamic environment. You will have access to robust high performance computing infrastructure and unique and complex single cell sequencing datasets, all while living in one of the most beautiful, diverse and eclectic cities in the world.

We offer a competitive salary, excellent benefits and significant career development opportunities.

Responsibilities

Working in a multidisciplinary team, the research programmer will develop and maintain analytical workflows for high-throughput cancer genomics. This is a one-year term appointment, with potential for renewal. Responsibilities include:

• Design and implement robust computational workflows
• Thoroughly test and maintain high-quality, well-documented code
• Regularly review the scientific literature to ensure analysis is in line with best practices
• Contribute to data preprocessing and quality control
• Develop data visualizations and contribute to biological analysis and interpretation
• Regularly update Dr. Steif, group members and collaborators on the status of projects
• Participate in and present research updates at lab meetings and team meetings
• Contribute to scientific writing, including the preparation of research manuscripts and grant applications
• May be involved in the management and supervision of trainees

Qualifications

• A B.Sc. or M.Sc. in bioinformatics, computer science, statistics or related discipline
• At least 3 years of experience in bioinformatics
• Experience in genomics and high-throughput sequencing data analysis
• Experience in cancer research is an asset
• Programming fluency in Python or R
• Experience working in a Unix/Linux computing environment
• Critical thinking and attention to detail
• Excellent verbal, written and interpersonal communication skills
• Ability to work independently and in a collaborative interdisciplinary team
• A strong work ethic, with demonstrated ability to manage time and prioritize to meet deadlines

Application

Applicants should submit: a CV; a one-page cover letter explaining how your research experience, interests and career goals align with the position; and the names and contact details of three references to bcgscjobs@bcgsc.ca, using Job Reference No: RP_R0008_Steif Lab_2023_02_23 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options are available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference Number: PDF_01553_Steif Lab_2023_02_23

This is an opportunity to advance single cell omics technology and work alongside highly motivated colleagues in a We are looking for an outstanding Postdoctoral Fellow with experience developing and applying computational methods for high-throughput omics analysis to join Dr. Adi Steif’s computational cancer genomics research group in Vancouver, Canada.

The successful applicant will be part of an exceptional multidisciplinary team of engineers, molecular biologists and bioinformatic scientists developing a new instrument for single cell omics profiling. Funded by a Genome BC Pilot Innovation Fund grant, the project is a close collaboration with the groups of Dr. Marco Marra (Medical Genetics) and Dr. Karen Cheung (Biomedical Engineering) at the University of British Columbia. The candidate will have the opportunity to work with unique and complex single cell imaging, DNA and RNA sequencing datasets, profiling tumour heterogeneity and evolution.

By joining the Steif Lab, you will develop close relationships with world-renown specialists in genomics and bioinformatics and have access to robust high performance computing and next generation sequencing facilities, all while living in one of the most beautiful, diverse and eclectic cities in the world.

We offer a competitive salary, excellent benefits and significant career development opportunities.

Responsibilities

Working in a multidisciplinary team, the postdoctoral fellow will develop and apply computational tools and analytical workflows for single cell omics analysis. This is a one-year term appointment, with potential for renewal. Responsibilities include:

• Regularly review the scientific literature
• Contribute to experimental design and planning
• Data preprocessing and quality control
• Data analysis, visualization, and biological interpretation
• Develop and maintain well-documented code
• Regularly update Dr. Steif and key collaborators on the status of projects
• Participate in and present research updates at lab meetings, team meetings and conferences
• Contribute to scientific writing, including the preparation of research manuscripts and grant applications
• May be involved in recruitment, management, and supervision of trainees

Qualification

• A PhD in bioinformatics, computer science, statistics or related discipline
• At least 2 years of research experience in bioinformatics, with a record of first-author publication
• Experience in genomics and high-throughput sequencing data analysis
• Experience in cancer research is an asset
• Programming fluency in Python or R
• Experience working in a Unix/Linux computing environment
• Critical thinking and attention to detail
• Excellent verbal, written and interpersonal communication skills
• Ability to work independently and in a collaborative interdisciplinary team
• A strong work ethic, with demonstrated ability to manage time and prioritize to meet deadlines

Application

Applicants should submit: a CV; a one-page cover letter explaining how your research experience, interests and career goals align with the position; and the names and contact details of three references to bcgscjobs@bcgsc.ca, using Job Reference No: PDF_01553_Steif Lab_2023_02_23 in the subject line of your email.

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options are available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

We are currently looking for a Postdoctoral Fellow to join Dr. Andrew Roth’s and Dr. Adi Steif’s computational cancer genomics research groups at the BC Cancer Research Institute (BCCRI).

The current position is for a candidate with experience developing and applying computational methods to analyze high throughput biological data. The successful applicant will be part of an exceptional multidisciplinary team developing and applying single cell multiomic methods to study evolution and disease transformation risk in follicular lymphoma (FL). Funded by a multi-year Terry Fox New Frontiers Program Project Grant, the project is a close collaboration with clinicians, molecular biologists and bioinformatic scientists. The candidate will have the opportunity to work with a unique and complex dataset which includes single cell DNA, RNA and epigenetic data.

This is an opportunity to work with highly motivated colleagues in a creative and dynamic environment. By joining the Roth and Steif labs at the BCCRI, you will develop close relationships with world-renown specialists in genomics and bioinformatics and have access to robust computational and sequencing technology facilities, all while living in one of the most beautiful, diverse and eclectic cities in the world.

We offer a competitive salary, excellent benefits and significant career development opportunities

What you’ll do

Working in a multidisciplinary team, the postdoctoral fellow will develop and apply scalable analytical workflows for multiomic data integration and biological interpretation. The appointment is for one year in the first instance, with potential for renewal. Responsibilities include:

• Regularly review the scientific literature
• Contribute to experimental design and planning
• Data preprocessing and quality control
• Data analysis, visualization, and biological interpretation
• Develop and maintain well-documented code
• Regularly update Drs. Roth and Steif as well as key collaborators on the status of projects
• Participate in and present research updates at lab meetings, team meetings and conferences
• Contribute to scientific writing, including the preparation of research manuscripts and grant applications
• May be involved in recruitment, management, and supervision of trainees

What you bring

• A PhD in bioinformatics, computer science, statistics or related discipline
• At least 2 years of research experience in bioinformatics, with a record of first-author publication
• Experience in genomics and high-throughput sequencing data analysis
• Experience in cancer research is an asset
• Programming fluency in Python or R
• Experience working in a Unix/Linux computing environment

You have:

• Critical thinking and attention to detail
• Excellent verbal, written and interpersonal communication skills
• Ability to work independently and in a collaborative interdisciplinary team
• A strong work ethic, with demonstrated ability to manage time and prioritize to meet deadlines
• Commitment to upholding the shared responsibility of creating lasting and meaningful reconciliation in Canada as per TRC (2015) and BC's Declaration on the Rights of Indigenous Peoples Act (2019).
• Knowledge of social, economic, political and historical realities impacting indigenous communities and familiarity with Indigenous Cultural Safety and anti-racism and accompanying reports (BC DRIPA, TRC, etc.).

What we bring

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: Temporary, Casual 
Location: 675 West 10th Avenue, Vancouver BC, V5Z 1G1
Hours of Work: Monday to Friday; 0830-1630
 

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

 

How to Apply

Applicants should submit: a CV; a one-page cover letter explaining how your research experience, interests and career goals align with the position; and the names and contact details of 3 references. 

While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

 

What we do

About the GSC:

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The Genome Sciences Centre (GSC) is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics and bioinformatics pursuing novel treatment strategies for cancer and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research.

The GSC is part of BC Cancer Research Institute and the Provincial Health Services Authority (PHSA).

BC Cancer provides comprehensive cancer control for the people of British Columbia.

BC Cancer is part of the Provincial Health Services Authority (PHSA).

(PHSA) plans, manages and evaluates specialized health services with the BC health authorities to provide equitable and cost-effective health care for people throughout the province. Our values reflect our commitment to excellence and include: Respect people – Be compassionate – Dare to innovate – Cultivate partnerships – Serve with purpose.

Learn more about PHSA and our programs: jobs.phsa.ca/programs-and-services

PHSA is committed to employment equity, encouraging all qualified individuals to apply. We recognize that our ability to provide the best care for our diverse patient populations relies on a rich diversity of skills, knowledge, background and experience, and value a safe, inclusive and welcoming environment.

Reconciliation is an ongoing process and a shared responsibility for all of us. The BC Governments’ unanimous passage of the Declaration on the Rights of Indigenous Peoples Act was a significant step forward in this journey—one that all health authorities are expected to support as we work in cooperation with Indigenous Peoples to establish a clear and sustainable path to lasting reconciliation. True reconciliation will take time and ongoing commitment to work with Indigenous Peoples as they move toward self-determination. Guiding these efforts Crown agencies must remain focused on creating opportunities that implement the Truth and Reconciliation Commission Mandate.

Job Summary
Researchers in the Department of Molecular Oncology at BC Cancer Research Institute use the latest technologies to rapidly identify genes that are involved in the development of cancer. We are seeking a highly-motivated, organized, driven individual with an interest or past experience with working with research animals in an academic setting. This entry level position will provide the successful candidate with an opportunity to work and learn within an academic research environment where continual training and learning is greatly encouraged. The core focus of this position will be handling and working with research animals, as well as, conducting research experiments on animals; hands-on training will be provided to the successful candidate. This animal tech position will be involved with performing research in drug pharmacology directed at human tumours, with assays in immunodeficient mice (xenotransplants).

Organizational Status
The successful applicant will report to the Principal Investigator or his/her delegate and may assist in overseeing technical work of students and trainees.

Work Performed

• Perform and/or oversee animal procedures involving immunization, oral gavage, injections, tumour inoculation, tumour volume measurements, blood and tissue collection, surgical procedures, necropsy, and post-operative care.
• Assist in the daily care of transgenic animals and maintains colonies of human tumour bearing immunodeficient animals.
• Daily health monitoring and care of laboratory animals.
• Plan and perform animal experiments utilizing complex procedures and/or techniques.
• Be able to recognize and resolve behavioral and/or housing issues; may provide technical instructions and training for other staff and/or trainees
• Process tissue samples and carry out primary cell isolation as instructed.
• Carry out laboratory techniques following standard operating protocols ages, tables, graphs and charts.
• Maintain both laboratory and laboratory records of both animal data and experimental data; when required to summarize results in research reports and lab presentations.
• Perform other related duties as assigned.
• On a rotation basis, must be available for emergency calls 24/7 and respond appropriately.

Minimum Qualifications
Completion of a relevant technical program or a university degree in a relevant discipline and a minimum three years of related experience or an equivalent combination of education and experience.

• Willingness to respect diverse perspectives, including perspectives in conflict with one’s own
• Demonstrates a commitment to enhancing one’s own awareness, knowledge, and skills related to equity, diversity, and inclusion

Preferred Qualifications

• Postgraduate degree in Science is preferred.
• CALAS certification (e.g. RLAT) is an asset.
• Minimum of 3 years related experience or the equivalent combination of education and experience.
• Experience with cell culture and aseptic technique preferred, involving both isolation and maintenance of rodent primary cultures and cell lines.
• Experience in the use and handling of hazardous materials such as biological agents and cytotoxic drugs is essential.
• Experience in the monitoring and management of human tumour bearing animals.
• A working knowledge of the CCAC guidelines and compassion and sensitivity for animals.
• Strong interpersonal skills and the ability to interact positively and productively with other team members are essential.
• Ability to communicate effectively both orally and in writing.
• The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No: SS_R00008_Systems_2023_02_07

The Systems Security Specialist is a subject matter expert who participates in the running of a heterogeneous compute facility for a state of the art research facility. This facility encompasses over 300 desktop seats, 12PB of networked storage and over 24000 cores of clustered high performance compute (HPC). This position will report to the Systems Manager.

Key Accountabilities

·     Configuration and tuning of Windows/Linux and Mac operation systems, installation of software onto systems

·     Maintenance of Microsoft Enterprise applications such as Exchange, Active Directory and Windows servers.

·     Responsible for monthly Windows security updates of client machines and servers

·     Advising the Systems Manager and participating in planning solutions for future directions as defined by the GSC

·     Assisting junior and intermediate team members

·     Documenting processes and maintaining knowledge bases

·     Other duties as prescribed by supervisor

Qualifications

A level of education, training, and experience equivalent to a Bachelor’s degree, or equivalent experience. Four (4) years’ experience in a systems administrator role. With a focus on Exchange, Active directory.

High level of expertise with the Windows operating system including tuning and the creation of installation repositories. Deep understanding of Windows internals will be beneficial.

Network administration experience is beneficial, as is understanding the fundamentals of inter-server connectivity.

Demonstrated proficiency in working in a high throughput service desk and being able to manage multiple projects at a time.

Self-motivated, personal accountability with the ability to work independently within a team environment following prescribed processes with the ability to give direction to junior and intermediate team members. Ability to plan, organize and coordinate a variety of activities to ensure maximum effectiveness.

Excellent oral and written communication skills with the ability to communicate effectively and tactfully with individuals at all levels, both internal and external to the GSC. Strong analytical skills. A problem solver able to dive deep into a problem without losing sight of the big picture and working with integrity, adaptability and originality. Physical ability to perform the duties of the job and lift 50 lbs.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: SS_R00008_Systems_2023_02_07 in the subject line of your email.

This posting will remain online until filled.

Important!

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options are available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No.: RPC2_R00026_JR#144095_2023_04_13

Reporting to Projects Team Leader and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and develop  strategies to monitor the progress of projects to ensure project objectives and milestones are successfully met.

Duties/Accountabilities

• Establishing budgets for research projects, grants, collaborations and core activities
• Assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
• Monitoring budgets and expenditures
• Establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives
• Recommending strategies for improving projects management methods and processesIdentifying, problem solving and working to remove barriers to successful project completion
• Liaising with grant/core funding agencies
• Interacting directly with research collaborators or clinical study teams as required
• Provides work directions to trainees and staff as appropriate.
• Performing other related duties as appropriate

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus a minimum of 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will recent experience in academic scientific research, clinical trials research, biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

Successful candidate(s) will be offered positions through Provincial Health Services Authority at the Research Project Coordinator II level, which is equivalent to that described above.

Core Skills and Abilities

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged. Demonstrated ability to manage multiple resource intense projects within a fast paced environment.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using  Job Reference No.: RPC2_R00026_JR#144095_2023_04_13 in the subject line of your email.

This posting will remain online until filled.

Please note All jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options may be available for this position upon request and is subject to change in accordance with GSC’s Operational needs and PHSA’s Flexible Work Options Policy.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens, permanent residents, applicants with a valid status to work in Canada will be given priority.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Summary

Job Reference No. CB_Ryan Morin Lab_HSA 140385_P01060_2023_02_03

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA. As such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

The Computational Biologist performs bioinformatics analyses and contributes to software development related to the operation of a large-scale clinical sequencing facility.

Duties

1. Contributes to the design, development, implementation, validation, running, and maintenance of clinical bioinformatics pipelines and related databases.
2. Contributes to incorporation of third-party software into clinical bioinformatics pipelines, including:
   1. identifying candidate software to consider
   2. comparing software candidates to aid in selection
   3. determining optimal parameters for the chosen software
   4. developing interfaces to integrate the chosen software and
   5. validating integration of the chosen software
3. Participates in the development of novel software solutions, as directed by the Assistant Bioinformatics Coordinator or Clinical Bioinformatics Coordinator.
4. Participates in peer code review.
5. Contributes to writing and updating official procedures and other documentation related to clinical bioinformatics pipelines.
6. Verifies results produced by clinical bioinformatics pipelines.
7. Performs exploratory analyses to identify potential root causes of issues encountered during production processing, and implements corrective actions as directed by the Assistant Bioinformatics Coordinator or Clinical Bioinformatics Coordinator.
8. Performs bioinformatics analyses to answer questions from the Clinical Director, Clinical Bioinformatics Coordinator, or Assistant Bioinformatics Coordinator.
9. Presents implementation plans, analysis results, and validation results internally and externally, in oral presentations and written documentation.
10. Contributes to the development of research papers by providing materials, methods, and/or analyzed data.
11. Participates in the training of others through orientation, informal instruction, and sharing of job information.
12. Performs other related duties as required.

Qualifications

Education, Training and Experience

• Graduation from a recognized Bachelor of Applied Science or Bachelor of Science Program in either Biological Sciences or Computer Science.
• Two (2) year’s of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities

• Demonstrated skill with Python or other similar high level languages
• Functional knowledge of distributed version control systems, such as Git.
• Demonstrated ability in R or other similar statistical programming languages
• Familiarity with relational databases, such as PostgreSQL, and with ORMs
• Ability to program and run analyses in a production environment
• Excellent verbal and written communication skills
• Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment
• Demonstrated ability to efficiently organize work assignments to complete required tasks on time
• Familiarity with next-generation sequencing, cancer genetics, principles of clinical testing, experimental design, statistical hypothesis testing, and/or machine learning would be considered an asset
• Ability to use related equipment

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: CB_Ryan Morin Lab_HSA 140385_P01060_2023_02_03 in the subject line of your email.

This posting will remain online until filled.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options are available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

ATTN: PHSA Employees:

To be considered as a PHSA employee (internal applicant) for this position, you must apply online via your internal profile at http://internaljobs.phsa.ca   

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No: RP_R00008_Systems_2022_12_16

Enterprise Administrator - Systems

The Enterprise Administrator is a subject matter expert who participates in the running of a heterogeneous compute facility for a state of the art research facility. This facility encompasses over 300 desktop seats, 20PB of networked storage and over 30,000 cores of clustered high performance compute (HPC). This position will report to the Systems Manager. The GSC Systems team is looking for a team member to support the current server and storage administrators with meeting our objectives.

The ideal candidate will have experience administering Linux/Windows servers and working with NFS and SMB. This role will also have a focus on enterprise storage so experience with storage clusters from vendors such as HP,IBM,Netapp,Dell etc is highly beneficial. A keenness to learn new things and grow within our team is desirable.

Key Accountabilities

· Configuration and tuning of Windows or Linux operation systems, installation of software onto systems

· Provisioning NFS and SMB shares and troubleshooting storage issues on Windows, Mac and Linux

· Maintenance of Enterprise networked storage

· Assisting the storage team in managing the hardware/software and administering the storage clusters

· Assisting the storage team with data backup and retrieval tasks

· Participate in the archiving of data to LTO tape libraries

· Assisting junior team members

· Documenting processes and maintaining knowledge bases

· Other duties as prescribed by supervisor

Qualifications

A level of education, training, and experience equivalent to a Bachelor’s degree, or equivalent experience. Two (2) years experience in Linux or Windows systems, or storage cluster administration role.

Intermediate level of expertise with the Linux operating system with preference to Centos/RedHat variants including building and configuring both physical and virtual servers . Understanding of Linux internals and CLI will be beneficial.

Experience with enterprise class storage systems, and an understanding of the fundamentals of their setup and design is an advantage.

Proficiency in scripting languages such as bash, perl and python.

Self-motivated, personal accountability with the ability to work independently within a team environment following prescribed processes with the ability to give direction to junior and intermediate team members. Ability to plan, organize and coordinate a variety of activities to ensure maximum effectiveness.

Excellent oral and written communication skills with the ability to communicate effectively and tactfully with individuals at all levels, both internal and external to the GSC. Strong analytical skills. A problem solver able to dive deep into a problem without losing sight of the big picture and working with integrity, adaptability and originality. Physical ability to perform the duties of the job and lift 50 lbs.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: RP_R00008_Systems_2022_12_16 in the subject line of your email.

This posting will remain online until filled.

Please note all jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options are available for this position upon request and is subject to change in accordance with GSC’s operational needs and PHSA’s Flexible Work Options Policy.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Do you have a background in science research — from its processes and practices to proposals & peer-review? Can you develop an award winning grant application, facilitate efficient and productive meetings, gather the right information and engage the right people at the right ti​me? We're looking for a Research Project Manager to help GSC faculty and leaders continue to deliver world-leading genomics, bioinformatics, cancer and precision medicine research.

Job Reference No.: RPC2_R00026_2023_01_20

Summary

Reporting to Projects Team Leader and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and develop  strategies to monitor the progress of projects to ensure project objectives and milestones are successfully met.

Duties/Accountabilities

• Establishing budgets for research projects, grants, collaborations and core activities
• Assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
• Monitoring budgets and expenditures
• Establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives
• Recommending strategies for improving projects management methods and processesIdentifying, problem solving and working to remove barriers to successful project completion
• Liaising with grant/core funding agencies
• Interacting directly with research collaborators or clinical study teams as required
• Provides work directions to trainees and staff as appropriate.
• Performing other related duties as appropriate

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus a minimum of 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will recent experience in academic scientific research, clinical trials research, biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

Successful candidate(s) will be offered positions through Provincial Health Services Authority at the Research Project Coordinator II level, which is equivalent to that described above.

Core Skills and Abilities

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged. Demonstrated ability to manage multiple resource intense projects within a fast paced environment.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using  Job Reference No.: RPC2_R00026_2023_01_20 in the subject line of your email.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely on a temporary basis. This restriction would be re-evaluated upon re-contracting.

Important!

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens ,permanent residents, applicants with a valid status to work in Canada will be given priority.

Please note All jobs at the GSC are based in Vancouver, British Columbia, Canada. Flexible work options are available for this position upon request and is subject to change in accordance with GSC’s Operational needs and PHSA’s Flexible Work Options Policy.

Why work at the GSC

As the first genome centre to be established within a cancer clinic, our story began by thinking outside of the box. From being the first in the world to sequence the SARS coronavirus during the 2003 global outbreak to publishing the first study demonstrating the use of whole genome sequencing to influence personalized cancer treatment planning in 2010, our passion for pushing scientific frontiers continues to this day.

Our technology platforms enable the transformative science being done at the GSC. But it is our world-class team of scientists and innovators that make it happen. By joining the GSC you will become part of a diverse and dedicated group of biologists, bioinformaticians, computer scientists, computational biologists, biochemists, engineers and clinicians. We look for people who share our core values—science, timeliness and respect—to join us in our mission to provide genomics, bioinformatics and proteomics technology and expertise for the benefit of human health and society.

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Job Reference No: GST_P00634_HSA 136835_2022_11_24

Role Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.The Genome Sciences Technologist performs various molecular biology techniques and procedures including library construction which are involved in the operation of a large scale, high throughput DNA mapping and DNA sequencing production facility.

This is a temporary full-time renewable position.

Qualifications

Education, training and experience:

Graduation from a recognized diploma program in Biotechnology, Microbiology or Biochemistry and two (2) years’ of recent related experience in a research laboratory or an equivalent combination of education, training and experience acceptable to the Genome Sciences Centre Group Leaders and Production Coordinators.

Skills and abilities:

• Knowledge of molecular biology techniques particularly DNA and RNA preparation and manipulation
• Demonstrated ability to perform detailed procedures reproducibly and accurately
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment
• Demonstrated ability to efficiently organize work assignments and establish priorities
• Basic knowledge of and ability to operate personal computers

To Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No.: GST_P00634_HSA 136835_2022_11_24 in the subject line of your email.

This posting will remain online until filled.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

About the GSC

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Apply Here