Dr. Wan Lam's Laboratory is primarily focused on understanding the molecular events that lead to cancer progression. His team has developed novel whole genome technologies and bioinformatics methodologies for tracking genetic, epigenetic, and gene expression changes in order to identify genes and signaling pathways that govern cancer progression and treatment response processes. He studies a variety of cancer types, with emphasis on lung cancer. His internationally recognized molecular systems biology team has discovered actionable pathways uniquely disrupted in the squamous cell carcinoma, adenocarcinoma, and small cell lung carcinoma subtypes of lung cancer. His team has also identified coding and non-coding RNA gene disruptions that link COPD and lung cancer, predict drug sensitivity in malignancy, and elucidate the diverse mechanisms of lung cancer development in smokers, former smokers, and non-smokers.
Dr. Kim Lonergan
Chunmei (May) Zhang
Dr. Mateus de Camargo Barros Filho, PhD
Dr. Spencer D. Martin, PhD
Dr. Greg Stewart, PhD
Nature communications, 2019
Discovery of Previously Undetected MicroRNAs in Mesothelioma and Their Use as Tissue-of-Origin Markers.
American journal of respiratory cell and molecular biology, 2019
Journal of human genetics, 2019
Hyperspectral cell sociology reveals spatial tumor-immune cell interactions associated with lung cancer recurrence.
Journal for immunotherapy of cancer, 2019
PloS one, 2019
Aberrant Expression of Pseudogene-Derived lncRNAs as an Alternative Mechanism of Cancer Gene Regulation in Lung Adenocarcinoma.
Frontiers in genetics, 2019
Human genomics, 2018
Environment international, 2018
International journal of genomics, 2018
Trends in immunology, 2018
Scientific reports, 2018
Scientific data, 2017
Expert review of respiratory medicine, 2017
Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung cancer patient outcome.
Molecular cancer, 2016
Molecular cancer, 2016
Genomics data, 2015
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