BCCRI Careers

Job Summary:

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Reporting to the Department Head or designate, the Research Administrative Coordinator, BC Cancer Research Centre is responsible for providing support in areas of human resources, payroll, grant and research administration. This role, on behalf of Principal Investigators (PI’s) and leaders, monitors payroll and financial cost centres through to resolution of payroll issues. The Research Administrative Coordinator also provides administrative support including managing the grant application process and providing work direction to junior administrative staff in the team.

Duties/Accountablilties:

• In collaboration with the Principal Investigator(s) (PIs) coordinates the preparation and submission of grant proposals by identifying submission guidelines, collating information required and ensuring submission deadlines are met. Follows up with the granting agency on the submission of proposals, monitors post award financial accounts to ensure accuracy. Provides progress reports, highlights discrepancies and provides recommendations to resolve discrepancies and budget concerns to the PI(s) as appropriate.
• Interacts with a variety of individuals and agencies such as universities and granting agencies both national and international.  Ensures flow of information with internal and external stakeholders regarding grant related matters and makes arrangements for visiting speakers and guests.
• Human resources responsibilities include recruitment of staff by posting/advertising internally and externally (UBC), coordinating interviews and screening applications for review by hiring supervisors. Manages new hires orientation process in the department and ensures all safety and personnel documentations are in place according to policies, guidelines and legislations.
• Ensures all hiring, appointment and payroll processes such as new hire letters and timekeeping are complete for employees. Liaises with various PHSA units such as Payroll and Human Resources and in some cases, UBC to ensure a seamless process and minimize errors. Brings issues and recommendations of remedies to department head or designate for approval.
• Acts as the main contact for ordering supplies for the department and approves lab and office supplies by performing duties such as submitting purchase requisitions and obtaining authorizing signature as necessary. Manages and processes various requisitions such as travel, expense reimbursements, cheque requests, and honorariums for the Department Head and PIs. Acts as liaison with various departments of BCCA/PHSA including purchasing, stores, and finance to obtain information and follow-up on the status of outstanding issues and requests.
• Coordinates registration and travel arrangements for staff attendance at seminars and meetings. This includes completing registration (on-line or phone), abstract submission, making travel and lodging reservations, culminating expense reimbursements to the attendee and/or cost recovery from the conference organizers as appropriate.
• Provides work direction to junior and contract administrative staff including orientating new staff and assigning and reviewing work, coordinating work assignments to ensure completion, answering questions and providing support, ensuring policies and procedures are followed and providing input to performance evaluations as required.

Qualifications:

A level of education, training, and experience equivalent to a Diploma in a relevant area such as business administration or finance from a recognized college plus three (3) years’ recent related experience a research environment and in project management.

Strong interpersonal and communication skills and the ability to demonstrate good judgment, tact and discretion. Detail oriented and able to complete accurate work in a timely matter. Demonstrated time management skills and ability to assist others in meeting deadlines.  Knowledge of and experience with grant applications.  Knowledge and experience in budget preparation, tracking expenditures and identifying sources of variance. Proficient in scientific and medical terminology.  Ability to work both independently and as team leader to organize work and manage multiple priorities in a fast paced environment. Demonstrated ability to make sound decisions and resolve administrative issues/problems. Fully proficient in the use of a variety of software packages including word processing, spreadsheets and databases and related equipment. Demonstrated ability to evaluate personal work and existing systems and identify areas for improvement. Physical ability to perform the duties of the position.

JOB SUMMARY

Researchers in the Department of Molecular Oncology at the BC Cancer Research Centre use the latest technologies to rapidly identify genes that are involved in the development of cancer. This position will be involved in performing research in drug pharmacology directed at human tumours, with assays in immunodeficient mice (xenotransplants).

ORGANIZATIONAL STATUS

The successful applicant will report to the Principal Investigator or his/her delegate and may assist in overseeing technical work of students and trainees.

WORK PERFORMED

• Plans and performs experiments utilizing complex procedures and/or techniques.
• Processes tissue samples and carries out primary cell isolation as instructed.
• Carries out laboratory techniques following standard operating protocols ages, tables, graphs and charts.
• Maintains both laboratory and laboratory records of both animal data and experimental data; when require summarize results in research reports and lab presentations.
• Assists in the daily care of transgenic animals and maintains colonies of human tumour bearing immunodeficient animals.
• Carries out and oversees procedures involving immunization, oral gavage, injections, tumour innoculation, tumour volume measurements, blood and tissue collection, surgical procedures, necropsy, and post-operative care.
• Daily health monitoring and care of laboratory animals.
• Be able to recognize and resolve behavioral and/or housing issues; may provide technical instruction and training for other staff and/or trainees
• Performs other related duties as assigned.
• On a rotation basis, must be available for emergency calls 24/7 and respond appropriately.

 CONSEQUENCE OF ERROR

The work is of a complex nature, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Noncompliance with ARC regulations may result in closure of facility. Noncompliance with animal protocols may result in loss of grant funding.

SUPERVISION RECEIVED

The successful applicant will report to the Principal Investigator or designate.

SUPERVISION GIVEN

The successful applicant will assist in training graduate students/trainees including instruction in use of lab equipment and procedures and will troubleshoot experiments in their area of expertise.

QUALIFICATIONS

• Undergraduate degree in a relevant discipline or Graduation from a technical college or institute.A postgraduate degree in Science is preferred.
• CALAS certification (e.g. RLAT) is an asset.
• Minimum of 3 years related experience or the equivalent combination of education and experience.
• Experience with cell culture and aseptic technique preferred, involving both isolation and maintenance of rodent primary cultures and cell lines.
• Experience in the use and handling of hazardous materials such as biological agents and cytotoxic drugs is essential.
• Experience in the monitoring and management of human tumour bearing animals.
• A working knowledge of the CCAC guidelines and compassion and sensitivity for animals.
• Strong interpersonal skills and the ability to interact positively and productively with other team members are essential.
• Ability to communicate effectively both orally and in writing.
• The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

We are looking for a highly motivated finance coordinator to oversee and manage grant funding, supporting a multi-institutional and multidisciplinary team of cancer scientists and leading-edge cancer research across the province. If you are detail oriented, enjoy working in a fast-paced and dynamic environment, please apply! The successful candidate will have the opportunity to learn and work within the financial systems at the University of British Columbia, BC Cancer Research Institute, Provincial Health Services Authority, and Vancouver Coastal Health Research Institute. Our finance and administration staff ensure everything flows smoothly in research projects and play an important role in cancer research. Vacation starts at 20 days a year and the position is eligible for a mix of onsite and remote work. The role is for a one year term with possibility of extension. Come join our team and be part of incredible cancer discoveries!

Job Summary

The Finance Coordinator, Research Funds Services provides research financial reporting and administration on assigned grant funded programs. The Finance Coordinator, Research Funds Services monitors research projects and researches grant budgets, coordinates the development and submission of research financial reports, liaises with PHSA restricted funds finance team to ensure grants financial information is accurately maintained, monitors and tracks receipts and disbursements and assists with the management, allocation and coordination of  research funds among Partners and Stakeholders.                                 

Duties/Accountablilties

• Monitors research expenditures and reviews and analyzes research financial information of assigned grant funded programs for the Administrator,  Research Business Operations, and Research Project Managers to assist with planning budgets. This includes pulling appropriate research general ledger accounting information, performing review of research accounts and classifying financial information for reporting, invoicing and budgeting purposes. Ensures research budgets remain within allowable spending limits by tracking and monitoring receipts, disbursements and expenses of general accounts. Investigates and identifies errors/discrepancies and creates journal entries to correct accounting records and maintain research financial information integrity.
• Prepares and reviews research purchase orders and expense claims to ensure applicability and correct expense coding. Verifies appropriate back-up provided and ensures compliance with PHSA policy as well as external funding agency policies. Identifies/determines if expense claim is allowable and makes suggestions on alternative options, if necessary. Follows up with vendors on outstanding credits or erroneous billing as well as cheque payment requests and facilitates payment options by ensuring that required information is obtained (cheque payment, wire transfer, credit card, etc.)
• Performs periodic reconciliation of the research general ledger, research corporate card purchases, research capital expenditures, research payroll reports and receivables to ensure accuracy and timely follow-up.
• Prepares research billing invoices based on the general ledger on a weekly, quarterly and ad-hoc basis to ensure timely collection of revenue from external funding agencies. Ensures research payments are received in full and follows-up on outstanding bad debt accounts.
• Communicates internally with Accounts Payable, Accounts Receivable and PHSA Finance and provides direction on account coding to accurately reflect nature of research financial transaction. Monitors and reconciles research shadow accounts held at UBC and SFU by pulling the general ledger held at these institutions to ensure accurate and complete yearly reporting of funding received. Communicates with the universities regarding accounting discrepancies and generates journal entries and/or invoices to reflect accurate research financial information.
• Monitors research reporting/invoicing due dates and coordinates timelines to ensure that deadlines are met. Compiles and prepares research financial reports/invoices as needed (quarterly, yearly, etc.) and ensures that expenditures reported are in compliance with spending guidelines and GAAP (generally accepted accounting principles). Identifies under/over-expenditures and recommends options to ensure that the research project stays within budget.
• Provides support during annual and interim audits by compiling research general ledger information and ensuring proper documentation is kept on file. Provides analysis to identify/explain journal entries as required by the auditor. Coordinates periodic research financial and annual reports as required by granting agencies, PHSA , partner universities and stakeholders to ensure information is summarized according to guidelines.

                                                               

Qualifications

A level of education, training and experience equivalent to a Diploma in Accounting/Financial Management or pursuing a professional designation program and preferably three (3) years of recent related experience in a multi government institutional setting, including experience working with national and international granting and funding bodies.

Knowledge and experience in working with General Accepted Accounting Principles (GAAP) in a university/life science environment. Knowledge of grant management and familiarity with granting agencies and their guidelines and policies. Working knowledge of the university/health care funding process and procurement practices is an asset. Demonstrated ability to conduct oneself in a professional and confidential manner.  Demonstrated administrative and organizational skills.  Demonstrated ability to productively use word processing, excel spreadsheets, financial reporting and project/budget management applications.  Demonstrated ability to communicate effectively both verbally and in writing.  Ability to work independently with minimal direction. Ability to handle workload pressures and demonstrated ability to prioritize.  Ability to supervise junior staff.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged.   We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

We thank all interested applicants but at this time all graduate positions in our group have been filled. 

MSc/PhD students- RNA biology in stem cells in normal and malignant blood cancers – Vu lab

We are looking for outstanding, motivated graduate students to join our team to explore the world of RNA biology in the context of stem cell regulation during normal and malignant hematopoiesis. Our ultimate goal is to translate our knowledge and discovery of the molecular mechanism underlying disease transformation to develop innovative therapy to improve stem cell potentials or treatment of blood cancers.

Our competitive research plan encompasses of several generously supported projects involving the use of human and mouse models, primary patient samples of hematologic malignancies and cutting-edge technologies. The Vu lab is a part of Terry Fox Laboratory, the world class and highly collaborative research unit at BC Cancer and the Faculty of Pharmaceutical Sciences, UBC.  The Vu lab has a strong interest and expertise in translational cancer research with several collaborations at major international institutions worldwide. Trainees are directly involved in all aspects of project development, planning and collaborations.

Interested candidates should send a  a statement of research interest, curriculum vitae, transcripts and contact details for 3 referees to:

Ly P. Vu, PhD

Scientist, Terry Fox Laboratory, BC Cancer

Assistant Professor, Faculty of Pharmaceutical Sciences, UBC

Email: lvu[at]bccrc.ca

One postdoctoral fellow position is immediately available at the BC Cancer Research Institute in Vancouver, Canada for the development of novel radiopharmaceuticals for cancer imaging and radiotherapy. The postdoctoral fellow will conduct research in the design and synthesis of radioligands targeting biomarkers overexpressed in cancers. Research activities will involve the production and isolation of radioisotopes, peptide and multi-step organic synthesis, and radiolabeling small molecules, peptides and antibodies with various imaging and radiotherapeutic isotopes (F-18, Ga-68, Zr-89, Tc-99m, I-123, In-111, Lu-177, Ac-225 …).

Qualified candidates should have a PhD degree in organic or medicinal chemistry with experience in peptide or multi-step organic synthesis. Experience with HPLC, micro-scale reactions, and radiochemistry is strongly desirable but not required. The ability to perform research and development in a collaborative environment is required including excellent oral and written communication skills. This joint position between BC Cancer and University of British Columbia (UBC) is for a period of two years with the possibility of renewal.

Interested candidates should send a letter of application, curriculum vitae, and names of three references to: Kuo-Shyan Lin (klin@bccrc.ca). Review of applications will begin immediately and will continue until the position is filled.

Job Summary:

Dr. Philipp Lange, Canada Research Chair in Translational Proteomics of Pediatric Malignancies and his team at The University of British Columbia (UBC) in Vancouver, Canada, seek an outstanding candidate with exceptional passion to advance precision oncology for children and the fundamental understanding of proteome modulation in childhood disorders.

Organizational Status:

The successful candidate will report directly to Dr. Philipp Lange, the principal investigator, and will work in a strongly collaborative and collegial fashion with cross-functional project team members to meet research goals and objectives.

Work Performed:

The research associate will lead data analysis and reporting for multiple single case and cohort studies in the precision oncology BRAvE and PROFYLE initiatives as well as collaboration projects. In this role, they will perform statistically robust analysis and integration of molecular (proteomics, genomic, metabolomic) and phenotypic (clinical, immunophenotype, drug perturbation, …) data, write reports and engage with team members and collaborators to provide key input on experimental design, data interpretation and overall direction of the studies. The research associate will also have the opportunity to conduct experiments of their own to advance the studies.

The incumbent will represent the laboratory in national and international initiatives, lead collaborative projects, train graduate and undergraduate students, introduce new methodologies to the lab and make major contributions to grant proposals and manuscripts.

Consequence of Error:

The successful applicant is expected to exercise a considerable amount of judgment, responsibility, and initiative in determining work procedures and methods. He/she should carefully observe and evaluate their work. All works are subject to assessment by Dr. Lange. Consistent poor judgment decisions or errors can result in incorrect data interpretation and potential loss of funding.

Supervision Received:

The applicant is expected to work independently under the direction of Dr. Lange, who will be available to provide consultation on unusual problems and project developments.

Supervision Given:

Assist with training graduate students and junior lab staff; provide input on staff/co-op student selection and performance evaluation.

Qualifications:

• PhD and Postdoctoral in cancer biology, immunology or related area
• Strong publication record
• Fluent in written and spoken English and demonstrated excellence in scientific writing
• Demonstrated exceptional analytical, communication and visualization skills
• Strong statistical foundation and expertise in R or python for data analysis
• Exceptional understanding of biological mechanisms and well read
• Expertise in CRISPER genome editing, mass spectrometry, cell surface and secretome characterization are assets but not required

Research Team & Environment: Located at the BC Children’s Hospital Research Institute (BCCHRI), the leading pediatric research center in Western Canada, you will be embedded in the highly innovative and interdisciplinary research environment spanning BC Children’s Hospital, UBC and BC Cancer Agency. Vancouver repeatedly ranks among the most livable places in the world and combines excellence in research with high quality of life. Excellent opportunities for personal and professional development are provided.

The incumbent will be part of a dynamic team of experimental and computational scientists and embedded in the local BRAvE and national PROFYLE pediatric precision oncology initiatives, where they will work with basic scientists, pathologists, analysts and clinicians. They will work in the newly renovated digital-health offices with direct access to state-of-the-art compute infrastructure and software, as well as, cell and molecular biology facilities, mouse and chicken chorioallantoic membrane (CAM) modeling platforms, mass-spectrometry, next-generation sequencing, flow cytometry, imaging and compute infrastructure.

The Department of Pathology and Laboratory Medicine at UBC is a hybrid, academically intensive Department within the UBC Faculty of Medicine whose activities span a broad spectrum of teaching, research, and academic service, often performed in the milieu of clinical practice, and are ultimately devoted to improving the care, treatment, and well-being of patients.  The Department offers academic degrees at the bachelor’s (Bachelor of Medical Laboratory Science (BMLSc)) and graduate (MSc, PhD) levels with the graduate program, one of the largest in the Faculty of Medicine, which has been recognized by UBC for its quality. The Department plays a major role in the MD undergraduate program and offers an accredited residency-training program. Faculty members participate across a spectrum of research from basic investigative to translational to clinical applied research and are recognized locally, nationally and internationally for their excellence. 

How to apply:

Review of applications will begin May 1, 2022. The position will commence as soon as possible.

Please send a cover letter expressing your long-term research vision, career goals and fit for the position (detailing how you meet the requirements). PDF copies of your most impactful papers (max 3, submitted manuscripts OK) as well as your CV and contacts (full address, email and phone number) for three references to brenda.tse@ubc.ca. Please send your documents in one PDF file. Only shortlisted candidates will be contacted.

Salary will be commensurate with experience and full benefits will be provided. The term of the position may be extended pending successful review of performance and productivity and continued funding availability.

Job Summary:

Drs. Poul Sorensen, Johal Chair in Childhood Cancer Research, Philipp Lange, Canada Research Chair in Translational Proteomics of Pediatric Malignancies and Gregg Morin seek an outstanding candidate to advance molecular diagnostics in childhood cancer as part of PROFYLE, Canada’s national pediatric precision oncology initiative.

Organizational Status:

The successful candidate will report directly to Dr. Philipp Lange, the principal investigator, and will work in a strongly collaborative and collegial fashion with cross-functional project team members to meet research goals and objectives.

Work Performed:

The postdoctoral fellow will lead a project on the development of mass spectrometry based diagnostic assays for cell surface immunotherapy targets in childhood cancer. Under mentorship of Drs Philipp Lange, Poul Sorensen and Gregg Morin they will refine automated (cell surface) proteome extraction from clinical biopsies and develop PRM and MRM based mass spectrometry approaches for pre-clinical application and clinical translation. They will also have the opportunity to supervise graduate and undergraduate students, gain leadership experience in collaborative projects and contribute to grant applications.

Consequence of Error:

The successful applicant is expected to exercise a considerable amount of judgment, responsibility, and initiative in determining work procedures and methods. He/she should carefully observe and evaluate their work. All works are subject to assessment by Dr. Lange. Consistent poor judgment decisions or errors can result in incorrect data interpretation and potential loss of funding.

Supervision Received:

The applicant is expected to work independently under the direction of Drs. Lange, Sorensen and Morin who will be available to provide consultation on unusual problems and project developments.

Supervision Given:

Assist with training graduate students and junior lab staff; provide input on staff/co-op student selection and performance evaluation.

Qualifications:

• PhD in biochemistry, cancer biology, analytical chemistry or related area
• Strong publication record
• Fluent in written and spoken English and demonstrated excellence in scientific writing
• Demonstrated exceptional communication and analytical skills.
• Demonstrated hands-on expertise in protein mass spectrometry
• Strong statistical foundation and demonstrated expertise in R or python for data analysis
• Hands-on expertise in characterization cell surface proteomes, development of PRM or MRM type assays, and clinical mass spectrometry are important assets

Research Team & Environment: The incumbent will be part of a dynamic team of experimental and computational scientists and embedded in the national PROFYLE pediatric precision oncology initiative where you will work with basic scientists, pathologists, analysts and clinicians to advance precision diagnostics and treatment for children with cancer. You will be located at the BC Children’s Hospital Research Institute and BC Cancer and will have direct access to latest generation mass-spectrometry, state-of-the-art cell and molecular biology facilities, mouse and chicken chorioallantoic membrane (CAM) modeling platforms, next-generation sequencing, flow cytometry, imaging and compute infrastructure. Vancouver repeatedly ranks among the most livable places in the world and combines excellence in research with high quality of life. Excellent opportunities for personal and professional development will be provided.

The Department of Pathology and Laboratory Medicine at UBC is a hybrid, academically intensive Department within the UBC Faculty of Medicine whose activities span a broad spectrum of teaching, research, and academic service, often performed in the milieu of clinical practice, and are ultimately devoted to improving the care, treatment, and well-being of patients.  The Department offers academic degrees at the bachelor’s (Bachelor of Medical Laboratory Science (BMLSc)) and graduate (MSc, PhD) levels with the graduate program, one of the largest in the Faculty of Medicine, which has been recognized by UBC for its quality. The Department plays a major role in the MD undergraduate program and offers an accredited residency-training program. Faculty members participate across a spectrum of research from basic investigative to translational to clinical applied research and are recognized locally, nationally and internationally for their excellence. 

How to apply:

Review of applications will begin May 1st. The position will remain open until filled and commence as soon as possible. Please send the following as one PDF file to brenda.tse@ubc.ca: a cover letter expressing your long-term research vision, career goals and fit for the position (detailing how you meet the requirements); CV; contacts (full address, email and phone number) for three references; copies of your most impactful papers (max 3, submitted OK).  Only shortlisted candidates will be contacted.

JOB SUMMARY

A position is open immediately for a research engineer specializing in microscopy hardware to work with our interdisciplinary team of researchers and software developers at the British Columbia Cancer Agency (BCCA). We are seeking a passionate individual to join a team of biologists, engineers and data scientists currently developing state of the art methods for spatial imaging of RNA species in human cancers at single cell resolution. Studying tumours at the single cell level can reveal biological differences that may not be resolved when studying the tumour as a whole. The imaging methods being developed include the use of molecularly encoded super-resolution microscopy to detect single molecules of RNA in tissue specimens. The successful candidate will develop and support integrating super-resolution microscopy, fluidics and camera functions to facilitate sequential imaging of human cancers. The candidate will also work with biologists and data scientists to analyze images and identify RNA species. 

You will be on-site in the Department of Molecular Oncology at BC Cancer, working closely with software developers, students and researchers operating at the leading edge of the field of cancer genomics.  As one of the members of the CRUK Grand Challenge IMAXT, our lab has embarked on an ambitious journey of creating the world’s first virtual reality map of cancer, with this role playing a key part in the success of this project.  More information on the lab, please visit https://aparicio.molonc.ca

ORGANIZATIONAL STATUS

We are a small team of software developers and engineers  embedded within a larger cancer research lab.  You will be working closely with the researchers on multiple projects involving microscopy hardware and data generation, reporting to the project lead or designate.  You will also be involved in collaborations within BC Cancer, UBC, SFU and internationally.

WORK PERFORMED

• Development and maintenance of microscopy, fluidics and robotics hardware systems through quantitative feedback and functional requirements definition
• Development and maintenance of hardware instrumentation control software in Python, MATLAB, and C (Arduino)
• Further improvement of the existing experiment protocol and the associated instrumentation
• Assisting in generation and presentation of research results from microscopy system, such as the preparation and running of the instrumentation
• Communication with external vendors regarding the microscope and associated devices
• Participation in meetings with the larger research group
• Assisting in performing computational analysis of digital image files from the system
• Documentation and training of microscope system to other users
• Training of undergraduate students regarding the development of the microscopy system

CONSEQUENCE OF ERROR

Accountable for the correct operation of the microscopy system, failure of which will have significant research progress implications.

SUPERVISION RECEIVED

Supervision from Principal Investigator or designate. Results reviewed for achievement of overall objectives.

SUPERVISION GIVEN

May help to supervise undergraduate trainees.

QUALIFICATIONS

Essential

• Undergraduate degree in Engineering of Applied Science.  Minimum three years of related experience or the equivalent combination of education and experience
• Relevant experience in microscopy, electrical engineering, optics, fluidics and mechatronics
• Programming in Python, MATLAB, and C (Arduino).
• Strong verbal/written communication skills
• Interdisciplinary teamwork experience
• Experience working in an academic research environment

Preferred

• Graduate degree in Engineering or Applied Science
• Experience with root cause analysis
• Experience in software engineering and instrumentation design
• Experience using CAD and rapid prototyping tools
• Experience with basic circuit design and microcontrollers
• Experience working with fluidics devices and commercial epi-fluorescent microscopy
• Knowledge or experience of cellular biology and cancer biology

To apply: Please include your resume and cover letter.

JOB SUMMARY

COVID NOTE: UBC currently requires 20% of time to be spent in person, thus semi-remote.  Due to the worksite being in a hospital facility, up to date vaccinations are required.

A UBC AAPS position is open immediately for a biostatistician to join the Aparicio Lab at BC Cancer. We are seeking a creative, experienced, and dedicated individual to play a key role in developing and maintaining our cancer genomics bioinformatics workflows, housed both on-premise and in cloud infrastructure. The successful candidate will join Dr. Aparicio’s breast cancer Molecular Oncology group, and work as part of the lab’s analysis team alongside other software developers, medical researchers and bioinformaticians.  As part of the team, you will help find and develop computational solutions for problems faced by medical researchers and students in the lab, assisting them in pushing the scientific edge of cancer genomics research. Experience with survival analysis and clinical studies statistical analysis will be an advantage.

The efforts of the research group have yielded important and insightful advances in understanding of tumour evolution, specifically how cancers initiate, develop and acquire resistance to treatment. Development of software platforms to address these questions are used both internally and more widely by world-leading scientists studying cancer. More info on the research and the team we conduct can be found here: https://aparicio.molonc.ca

ORGANIZATIONAL STATUS

Working in the computational team, independently carrying out statistical analyses tasks under the instructions and oversight of the team lead or designate. 

WORK PERFORMED

• Collaborate with researchers to determine study design
• Performs statistics analyses for new and ongoing studies, including but not limited to analysis of drug sensitivity, gene expression and IHC
• Review protocols and methodologies to ensure they adhere to best statistical practices
• Visualize and display study data for interpretation and publication
• Provide consultation and training to other data analysts and researchers
• Create user-friendly scripts and programs to assist in data analysis
• Contribute to writing manuscripts and scientific presentations
• Leave comprehensive and robust documentation for protocols and scripts

CONSEQUENCE OF ERROR

Accountable for the generation and maintenance of quality protocols and results that will have significant research progress implications.

SUPERVISION RECEIVED

Supervision from team lead or designate. Results reviewed monthly and annually for achievement of overall objectives.

SUPERVISION GIVEN

May help supervise undergraduate trainees and/or researchers.

QUALIFICATIONS

Education, training and experience:

• Ph.D in Statistics or Biostatistics is preferred, but we will consider M.Sc in the same degrees with relevant work experience
• Demonstrated proficiency with statistical methods and applications in clinical research

Core skills and abilities:

• Up-to-date knowledge of statistical methodologies related to areas such as drug sensitivity, statistical modeling, survival, and clinical analysis.
• Competence in R and/or SAS programming language
• Familiarity with the development, testing, and maintenance of academic open source code
• Excellent verbal and written communication skills
• Demonstrated ability to efficiently organize work assignments and establish priorities
• Demonstrated interpersonal skills including the ability to work effectively with others in a team environment

Optional assets:

• Familiarity with genomics and bioinformatics
• Familiarity with molecular and cellular biology

To apply: please include your resume and cover letter.

Job Reference No: RPC2_R00026_2021_07_06

Canada’s Michael Smith Genome Sciences Centre (GSC) is a state-of-the-art, large scale, high throughput, clinically accredited genomics and bioinformatics facility. If you have a Bachelor's degree in Health Information Science or Computer Science—along with experience in software/system project planning, analysis and implementation—this is your opportunity to join our team as a Business Analyst providing support for cutting-edge technology projects!

Reporting to the Head of Quality and Regulatory Affairs, the Business Analyst and Project Support (BA) leads the analysis and documentation of business requirements to support projects for designated programs and services. The successful candidate for this position will work in close collaboration with other stakeholders to develop business systems enhancements, business solutions, or business processes including GSC’s bioinformatics processes. The BA functions as a Subject Matter Expert to the project team through performing gap analysis of systems and business process mapping including the identification of linkages to other business systems.  

The BA position is anchored within a team of exceptional scientists, computational biologists and programmers, which collaborate directly on the development of robust, cost efficient and competitive processes for new targeted and precision medicine analytical pipelines. By working within the GSCs bioinformatics facility, you will develop close relationships with world-renown computational and genome science technologists, cancer researchers and medical scientists; have access to one of the most robust computational and next generation genome sequencing technology facilities in Canada, all while living in one of the most beautiful, diverse and eclectic cities in the world. Your work will help to save lives and contribute to a world free from the fear of cancer.

This is an opportunity to work with highly motivated colleagues in a science-oriented, creative and dynamic environment. We offer a competitive salary, excellent benefits and significant career development opportunities.

Apply now! 

Duties and Responsibilities

• Provide key contributions to the development of solutions to ensure that business processes and/or project deliverables are consistent, accurate and timely.  
• Participate in and contribute to strategic planning. 
• Develop project plans for the design, development and implementation of new business processes; support the transition from current systems, practices and processes to an integrated system, common practices and standardized processes with current or improved functionality.  
• Ensure key results are achieved in accordance with the project plan by analyzing current business systems and processes, generating ideas and formulating recommendations/options, and supporting members of the project in prioritizing tasks and reaching decisions that are within project scope and timelines. 
• Implement or contribute to the implementation of effective processes to assess project risks, identify risk mitigation strategies and monitor risk throughout the project lifecycle. Support the Managers/Team Leads by providing regular updates on the progress as well as any areas of risk associated with the completion of the project both within the project scope and the timeline. Provide professional expertise to staff, departments, stakeholders, and guidance regarding standard process for project management.
• Coordinate and participate in the analysis, acceptance criteria definition, development, testing, training, implementation and maintenance phases of assigned bioinformatics projects. Carry out post-implementation reviews of systems and make recommendations for improvements.
• Utilize formal data gathering techniques and analysis tools such as flowcharts, diagrams, dashboards, roles and responsibility matrix (RACI) and work effort estimates. Provide details of estimated implementation costs including associated staffing requirements.
• Review, analyze and define current/future state processes, determine user and/or department requirements and contribute to the development of specifications and testing for all identified development, system modifications and installations. Perform impact analyses. 
• Provide user support, advice, guidance and orientation in situations that require interpretation and judgement. Develop content, as required, for training modules; deliver training and provide guidance to system users and department staff. Develop and maintain various business processes, policies and procedures, as well as reference documentation such as user instructions, manuals and reference materials.  
• Provide support to colleagues and users during the development, maintenance and operation of various computer systems by performing duties such as troubleshooting system software problems and testing alternative solutions. 
• Participate in the formal data collection and analysis to help identify system deficiencies and/or operational inefficiencies in order to report and develop new ways of improving business efficiencies including the data analysis related to business case developments, project proposals and other key strategic and transformative initiatives. 
• Assemble, create and maintain information systems technical and operational documentation according to departmental standards.
• Assist with preparation of Requests for Information/Proposal, development of evaluation processes and tools, and evaluation of vendor responses by serving on working groups, documenting detailed requirements and coordinating project team and vendor communications.

Qualifications

• A level of education, training and experience equivalent to a Bachelor's degree in Health Information Science, Computer Science or a related discipline—OR relevant related experience that includes software/system project planning, analysis and implementation.  
• Demonstrated ability to carry out business process mapping and fit gap analysis.  
• Excellent interpersonal, oral and written communication skills with the ability manage multiple interactions with multiple groups while working on multiple issues at the same time.  
• Superior analytical, problem-solving and system analysis skills.  
• Proven ability to plan and execute projects with stringent timelines.  
• Ability to work effectively as part of a team.  
• Demonstrated ability to provide professional expertise to staff, departments and stakeholders, and guidance regarding standard processes for software/computer system related project management.  
• Demonstrated ability to provide user support, advice and training, and other user liaison services.
• Public Service and Health Sector experience and knowledge are an asset.  

Benefits

Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.

• Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.
• Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.
• Enjoy a comprehensive benefits package, which includes statutory benefits - Canada Pension Plan, Employment Insurance and WorkSafe BC plus the BC Cancer group benefits plan which includes medical & dental extended health, and group life insurance coverage, and psychological health & safety programs and holistic wellness resources.
• Annual statutory holidays (13) with generous vacation entitlement and accruement.
• PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).
• Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.

Job Type: 

Regular, Full-Time, 7.5 hrs. per day

Salary Range: 

$72,445 - $104,140 p.a.. The starting salary for this position would be determined with consideration of the successful candidate’s relevant education and experience, and would be in alignment with the provincial compensation reference plan. 

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Business Analyst and Project Support in the subject line of your email. 

This posting will remain open until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. 

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

About the GSC

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Temporary Full-Time

We are seeking an outstanding, motivated student to join our team to assist our research efforts in normal and malignant hematopoiesis study. 

The overarching goal of our laboratory is to understand the control of stem cells in development and diseases.  Our research group is focused on uncovering novel mechanisms of post-transcriptional and translational regulation during normal and malignant hematopoiesis.  The highly competitive research plan encompasses of several largely supported projects involving the use of human and mouse models, primary patient samples of hematologic malignancies and cutting-edge technologies. By using animal models and genomic approaches for identification of novel translational regulators in leukemia (Vu et al. Nat Gen 2017, Vu et al. Nat Med 2017), the Vu lab investigates novel molecular mechanisms underpinning leukemogenesis and control of hematopoietic stem cells.  The Vu lab is a part of Terry Fox Laboratory, the world class and highly collaborative research unit at BC Cancer and the Faculty of Pharmaceutical Sciences, UBC.  The Vu lab has a strong interest and expertise in translational cancer research with several collaborations at major international institutions worldwide.

Qualified candidates should have a bachelor/or MSc degree in Life Sciences preferably in biochemistry, molecular and cell biology and working knowledge of lab skills and techniques such as pipetting, cell & tissue culture, PCR, RT-qPCR, RNA extraction, Western Blot, immunostaining & flow cytometry.  Experience working with animal models is desirable.

Salary will be commensurate with qualifications and experience.

To Apply:

Please send a statement of research interest, curriculum vitae, transcripts and contact details for 3 referees to:

Ly P. Vu, PhD

Scientist, Terry Fox Laboratory, BC Cancer

Assistant Professor, Faculty of Pharmaceutical Sciences, UBC
Email: lvu[at]bccrc.ca

This position will remain open until filled.

This is a temporary position with a possibility of extension.

Temporary Full-Time

A Postdoctoral Fellow/Research Associate position is available in the Vu Lab based in the Terry Fox Laboratory, BC Cancer, and the Faculty of Pharmaceutical Sciences, University of British Columbia working on an exciting project investigating the role of RNA modifications and translation control in pathogenesis of leukemia.

The overarching goal of our laboratory is to understand the control of stem cells in development and diseases. Our research group is focused on uncovering novel mechanisms of post-transcriptional and translational regulation during normal and malignant hematopoiesis.  The highly competitive research plan encompasses of several largely supported projects involving the use of human and mouse models, primary patient samples of hematologic malignancies and cutting-edge technologies. By using animal models and genomic approaches for identification of novel translational regulators in leukemia (Vu et al. Nat Gen 2017, Vu et al. Nat Med 2017), the Vu lab investigates novel molecular mechanisms underpinning leukemogenesis and control of hematopoietic stem cells. The Vu lab is a part of Terry Fox Laboratory, the world class and highly collaborative research unit at BC Cancer and the Faculty of Pharmaceutical Sciences, University of British Columbia.  The Vu lab has a strong interest and expertise in translational cancer research with several collaborations at major international institutions worldwide.

The successful candidate will have a PhD or MD/PhD degree (for Res Asso position: 3 years of postdoctoral experience), solid knowledge and research experience in molecular and cell biology, stem cell/cancer biology; expertise in animal models and, in particular, hematology and leukemia are assets.  A strong background in RNA biology and bioinformatics is highly desirable.

The applicant should also demonstrate the ability to work independently, conceive, initiate, organize and manage projects and supervise undergraduate/graduate students.  Excellent verbal and written communication skills are a must as well as the ability to work in a team environment. 

Salary will be commensurate with qualifications and experience.

To Apply:

Please send a letter of application, curriculum vitae, a statement of areas of expertise and strengths and the names of three referees to:

Ly P. Vu, PhD
Scientist, Terry Fox Laboratory, BC Cancer

Assistant Professor, Faculty of Pharmaceutical Sciences, UBC
Email: lvu[at]bccrc.ca

This position will remain open until filled.

This is a temporary position with a possibility of extension.

COVID NOTE: UBC currently requires 20% of time to be spent in person, thus semi-remote.  Due to the physical site being a hospital facility, COVID vaccination is required.

JOB SUMMARY

A position is open immediately for a programmer to work with our interdisciplinary team of researchers and software developers at the British Columbia Cancer Agency (BCCA). We are seeking a passionate individual to join a team of biologists, engineers and data scientists currently developing state of the art methods for spatial imaging of RNA species in human cancers at single cell resolution. Studying tumours at the single cell level can reveal biological differences that may not be resolved when studying the tumour as a whole. The imaging methods being developed include the use of molecularly encoded super-resolution microscopy to detect single molecules of RNA in tissue specimens. The successful candidate will develop and support microscopy imaging pipelines and tools integrating super-resolution microscopy, fluidics and camera functions to facilitate sequential imaging of human cancers. The candidate will also work with biologists and data scientists to analyze images and identify RNA species.

ORGANIZATIONAL STATUS

Working in a research project, both independently and reporting to the project lead in Molecular Oncology or designate, and in conjunction with investigators within the BCCA, UBC and internationally.

WORK PERFORMED

• Development and maintenance of image analysis pipelines and tools
• Support the development of microscopy systems through quantitative feedback and functional requirements definition
• Assisting in generation and presentation of research results from microscopy system
• Perform computational analysis of digital image files from the system
• Documentation and training of microscope system to other users
• Evaluate and develop machine learning techniques (Dimensionality reduction, Clustering, and Classification) and deep networks (CNNs and GCNs) for Image segmentation, Graph analysis, and Image classification 
• Working with open source computer vision libraries in Python, Matlab, or C++

CONSEQUENCE OF ERROR

Accountable for the operation of the microscopy system and downstream image analysis that will have significant research progress implications.

SUPERVISION RECEIVED

Supervision from Principal Investigator or designate. Results reviewed for achievement of overall objectives.

SUPERVISION GIVEN

May help to supervise undergraduate trainees and/or junior software technicians.

QUALIFICATIONS

Essential

• Minimum of 2 years of relevant work/research experience in computer science, signal processing, image processing, and/or optics
• Microscopy image processing experience
• Programming in PythonStrong verbal/written communication skills
• Interdisciplinary teamwork experience
• Experience working in an academic research environment

Preferred

• Microscopy engineering experience
• Undergraduate degree in engineering or computer science
• Machining and design experience
• Expertise in cellular biology and expression analysis
• Experience in software engineering and design
• Experience with scientific high performance computing environments and solutions
• Special consideration will be given to those in research areas that involve computer vision or machine learning.

Job Summary

The post holder will support and work closely with Dr. Samuel Aparicio, leader of Molecular Oncology, UBC Nan and Lorraine Robertson Chair of Breast Cancer, in developing scientific proposals, assisting in manuscript development and review, coordinating international multi-PI research studies and interacting with funders and advocates in reporting the activities of the single cell biology and drug development program. Demonstrated experience in authoring manuscripts and preparing funding applications and reports, is a requirement for the role. Preference will be given to candidates with experience in biosciences and cancer research. Ability to articulate science clearly in a written form and a high degree of independence and self organization are core skills for this post.

The Research Grants Facilitator and Writer will provide strategic planning and support for the program in single cell biology and drug development led by Dr. Samuel Aparicio. The incumbent will identify and communicate research award and funding opportunities from Canadian and international government funding agencies, private foundations and industry, as well as provide proposal development support for the Aparicio program’s research grant applications and award nominations, including writing significant portions of research proposals and grant applications. The incumbent will establish and maintain relationships with key points of contact with internal and external research and award sponsors. The incumbent will develop strategic research support plans for the single cell biology program. The incumbent will also provide authoritative advice and understanding of the mandates, priorities, processes and policies of internal UBC and major Canadian and international government and private research funding sponsors.

Organizational Status

This position reports directly to Dr. Aparicio and works closely with the program team members and collaborators to ensure that the Research Grants Facilitator and Writer's activities are integrated into the effective operation of the single cell biology research program. The position communicates directly with UBC faculty and staff, BC Cancer Research Institute (BCRI) researchers and external research sponsor personnel.

Work Performed

Facilitation of Grant Application Process and Advising

• Acts as a knowledge resource for Dr. Aparicio for research funding opportunities and actively seeks out and encourages applications for funding to improve the research program’s success in grants.
• Establish and maintain productive relationships with internal and external research sponsors in order to maintain current knowledge of the research award and funding landscape.
• Establish and maintain productive relationships with UBC and BCRI researchers, postdoctoral fellows, students and/or staff and maintain in-depth knowledge and understanding of their research within the single cell biology program.
• Identify and disseminate information regarding various granting agencies requests for applications and research funding opportunities from various agencies to the research program. When requested, investigate potential funding opportunities on a specific topic or given area.
• Provide authoritative advice to researchers and Dr. Aparicio on the eligibility criteria, deadlines, submission processes, budget requirements and other important details regarding internal and external research funding and award opportunities.
• Ensure Dr. Aparicio is aware of, and address within the program’s funding applications, University and external agency policies and procedures.
• Review research grant applications for key institutional requirements prior to the provision of Faculty­ level signatures.
• Work with faculty in the development of research grant or award nomination proposals, which may include research team coordination; grant writing; copy editing; reviewing and providing feedback on proposal design and content; providing advice on grant budgets; assisting in the writing of letters of intent and proposal support letters; and assisting faculty to ensure that key components of grant applications are complete prior to submission.
• Advise faculty and trainees within the single cell biology research program of research funding and award opportunities and research support services.
• Identify potential funding opportunities to support identified research program strategic research plans.
• Develop digital resources (e.g. budget templates, web content) to aid in the development of research proposals.
• Develop, manage, collect, and coordinate relevant grant information, research budgets, statistics, and curriculum vitae.
• Liaise effectively with UBC Office of Research Services, VP Research and Innovation, SPARC, research sponsor personnel, Research and Trust Accounting, University Industry Liaison Office, Institutional Programs Office, BCRI Office of Research Administration and Faculty and administrative staff on questions related to the acquisition and administration of research funding.
• Manage and develop necessary agreements for the single cell biology research program in conjunction with the UBC Office of Research Services/University-Industry Liaison Office and BC Cancer Technology Development Office.
• Respond to ongoing requests for regular reports by maintaining and updating information to ensure compliance with granting agencies and other external organizations.
• Develop Research Ethics Board applications and amendments as required, and ensures compliance with Research Ethics Board guidelines.
• Conduct regular literature reviews relating to research areas.  Contributes intellectual and scientific input to manuscripts for publications, provides scientific proofreading.

Facilitation of Research Knowledge Transfer and Exchange/Education

• Develop and maintain a clear engagement and communication plan for both internal and external audiences.  This includes promotion and representation of the single cell biology research program through websites and social media platforms, and the development and facilitation of workshops, conferences, guest lecturers, etc.
• Provide partners and Communications personnel with information on current research projects, recent grant awards and publications; ability to understand and effectively communicate complex scientific issues to the non-expert public, both verbally and in writing.
• Develop and implement grant writing supports for the single cell biology research program (e.g. educational sessions and workshops on grant writing, open access, partnered research, award nomination, adopting researcher digital identifiers).

Strategic Planning

• Monitor the research grant writing and research infrastructure support needs of the research program and, based on these needs, provide recommendation to Dr. Aparicio, on the ongoing requirements and possible avenues of research support.
• In collaboration with Dr. Aparicio, plays a leadership role in identifying, developing, and applying for large and complex research grant funding from various funding agencies including provincial, federal and international programs.
• Initiate and facilitate collaborations and initiatives between researchers, develop research partnerships, and identify funding opportunities.
• Identify new translational pathways, such as commercial partnerships, licencing etc. for new technologies and encourage entrepreneurial activities as appropriate.

Supervision Received

The position works with a high degree of independence under the direction of Dr. Aparicio. Works independently in accordance with objectives established by the single cell biology research program.

Supervision Given

This position does not include supervision of other staff.

Consequence of Error/Judgement

The work of the incumbent is vital to the success of the development and acquisition of research grants and awards in the single cell biology research program. The position has significant influence on the quality and effectiveness of research support services within the research program. Failure to accurately adhere to external granting agency and University research policies and procedures can result in the subsequent rejection of grant applications, the return of awarded funds, the loss of future funds and/or the inability to collect funds owed to the University, and researchers. The loss of future opportunities and funds would call into question the perceived level of research competence of the research program and investigators.

Minimum Qualifications

A post-graduate degree or equivalent professional designation with a minimum of four years of related experience, or an equivalent combination of education and experience. Otherwise, an undergraduate degree in a relevant discipline is required with a minimum of six years of related experience, or an equivalent combination of education and experience.

Preferred Qualifications

• Experience in a research environment with applied knowledge and demonstrated skill in successful research grant application development, facilitation, and administration (particularly in the health sciences) is preferred.
• Strong understanding of the language and culture of the research community and research granting agencies.
• Proven mastery of English grammar, punctuation, and scientific writing style is essential. Ability to communicate effectively verbally and in writing and to summarize relevant information in clear and succinct English, is essential.
• High degree of analytical accuracy, sound judgment and the ability to work independently.
• Superior communication skills (oral and written), excellent writing and copy-editing skills as well as experience in manuscript preparation are required.
• Strong interpersonal skills and the ability to work effectively with internal and external stakeholders who possess a wide range of education and expertise.  Ability to use independent judgment and to manage and impart information to a diverse range of internal and external stakeholders.
• Ability to exercise appropriate tact, discretion, confidentiality, and good judgment in all matters.
• Knowledge of and/or experience in project management principles, accounting and fiscal management is preferable.
• Very good knowledge of University policies and procedures related to research administration.
• A broad knowledge of University structure and operations.
• Demonstrated knowledge, skill and experience in research grant development, scientific technical writing, report writing and administration.
• Excellent knowledge of policies and procedures of research funding sponsors and agencies.
• Excellent organizational and time management skills, and demonstrated ability to coordinate research teams.
• Ability to adapt to changing priorities, multitasking and meeting deadlines.
• Experience in using a wide variety of word processing, spreadsheet, database and web applications essential; ability to learn/use sponsor grant application and reporting systems.
• Strong presentation skills using PowerPoint and other multimedia.

This is a one year appointment and depending on funding and successful progress of the research it may be renewed for additional years.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged.   We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

JOB SUMMARY

The Aparicio lab uses the latest technologies to rapidly identify genes that are involved in the development of breast cancer. Through the use of high-throughput screening methods, we will be screening cancers of diverse genotypes for sensitivity and mechanism of response to G-Quadruplex stabilizers CX5461, Pyridostatin and other related compounds. 

We are seeking a highly-motivated and highly skilled individual with expertise or experience in tissue culture, handling and working with hazardous drugs/compounds, and functional assay development/drug screening. The successful applicant will work full-time under the direction and supervision of both Dr. Samuel Aparicio, Principal Investigator, and the Laboratory Research and Operations manager. The position will provide the candidate with a high level of exposure to all current on-going project within Aparicio Lab, such as areas of single cell genomics and translational research, CRISPR-cas9 and patient derived xenograft, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally; position start date is flexible.

ORGANIZATIONAL STATUS

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Institute in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, or Laboratory and Research Operation Manager. More information on the lab, please visit https://aparicio.molonc.ca

WORK PERFORMED

• Plans, designs and performs high throughput drug/compound screening assay.
• Handle, aliquot and preparation of hazardous (possibly cytotoxic) drug compounds for use in screening assay.
• Using aseptic technique to grow and maintain various types of cell-line and primary cell cultures.
• Using a LMIS system to track and record sample data
• Developing and implementing standard operating protocols (SOPs).
• Maintains laboratory records and experimental data.
• Assist in general lab maintenance such as reagent preparation, receiving and inventory of lab supplies.
• Presents data and updates at scientific meetings, writes reports when required.
• Provide training and instruction for specialized techniques and equipment.
• Carries out any other related duties as assigned or required in keeping with the qualifications and requirements of this technician level.

CONSEQUENCE OF ERROR

The work is of a complex nature and required high level of training, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Errors may result in the permanent loss of irreplaceable tissue samples, loss of thousands of dollars of material and/or damage to equipment.  Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly. Noncompliance with biosafety and chemical safety regulations may also result in closure of facility or loss of grant funding.

SUPERVISION RECEIVED

The successful applicant will work under minimum supervision. From time to time, Principal Investigator, Research Associates or Laboratory Research and Operations Manager may provide specific instructions on unusual problems, or new project outlines. This position will report to the Principal Investigator or Laboratory Research and Operations Manager.   

SUPERVISION GIVEN

Depending on experience and expertise, the successful applicant might be assisting in training and supervision of student trainees or junior staff, including providing instruction on use of lab equipment and procedures, and will help troubleshoot experiments in their area of expertise.

QUALIFICATIONS

• A MSc in Biological Sciences (Molecular Biology or other relevant field) or BSc with 1-2 years of related experience in academic research or biotech industry settings, preference will be given to applicants with work experience in drug screen / assay development.
• A working knowledge and understanding of molecular biology and biochemistry techniques is essential; prior hands-on working experience in tissue culture, aseptic techniques, handling of hazardous drug/compound, assay development, and high-throughput screening will be considered an asset.
• Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques.
• Demonstrated understanding of experimental design, high-throughput screening methods and assay design, and optimization.
• Strong interpersonal skills, communication skills (orally and written) and the ability to interact positively and productively with other team members are essential.
• Excellent documentation and organizational skills.
• The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

To apply: please include your resume and cover letter.

JOB SUMMARY

This position involves with providing technical support in the areas of molecular biology, biochemistry and cell biology for researchers on current on-going research projects. Individual should possess a strong molecular biology and cell biology background, with experience in tissue culture, microscopy, use of confocal and fluorescence microscopes. Recent hands-on experience with antibody labeling and immunohistochemistry will be considered an asset.

The candidate will get exposure to breast and childhood cancers through working directly with two (Dr. Aparicio/Dr. Sorensen) different labs within the department. The Aparicio lab uses the latest technologies to rapidly identify genes that are involved in the development of breast cancer. Through the use of single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patient tissues, we hope to gain a better understanding of tumor microenvironment.

The Sorensen lab uses a combination of genetic and biochemical approaches to identify proteins that are specifically altered in human tumors. This led to the discovery of many novel genetic alterations in childhood cancer and breast tumors. These discoveries have been translated into new diagnostic tests for specific tumors, and have advanced our understanding of how the involved proteins transmit signals that cause cells to become cancerous.  Dr Sorensen is part of two international teams, known as the Pediatric Immunotherapy Discovery and Development Network and the St. Baldrick’s Foundation-SU2C Pediatric Cancer Dream Team, focused on identifying and developing new immunotherapies for high-risk childhood cancers.

The successful applicant will work full-time under the direction, guidance and supervision of both Dr. Samuel Aparicio and Dr. Poul Sorensen, Principal Investigators. The position will provide the candidate with exposure to breast and childhood cancers, and translational research, advanced cutting-edge microscopy technology and techniques, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally; position start date is flexible.

ORGANIZATIONAL STATUS

Aparicio and Sorensen Labs are located in the department of Molecular Oncology at BC Cancer Research Institute in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, Dr. Poul Sorensen or Laboratory and Research Operation Manager, in addition, the applicant may assist in overseeing technical work of students and trainees.

WORK PERFORMED

• Plans and performs experiments utilizing established complex standard operating procedures (SOP) and/or techniques using the Fluidigm Hyperion Imaging Mass Cytometry and Akoya Biosciences CODEX systems for investigating cancers biology and protein expression.
• Perform general histology processing (scroll cutting, dewaxing, fixing, rehydrating tissue, antigen retrieval)
• Perform immunohistochemistry technique (antibody labelling, handling and working with antibody, antibody conjugation, antibody labelling)
• Maintain cell cultures and generation of new cell line using aseptic techniques.
• Track samples, record data and work a LMIS systems.
• Provide technical expertise and support in molecular biology, cell biology, protein biochemistry, microscopy and tissue culture; including but not limited to techniques such as PCR, western blotting, cell culture, use of confocal and fluorescent microscope, antibody labeling and immunohistochemistry.
• Maintain and operation large shared infrastructure equipment.
• Assist in developing and implementing standard operating protocols (SOPs).
• Maintains laboratory records and experimental data; when require summarize results in research reports and lab presentations.
• Assist in general maintenance, reagent preparation, receiving and inventory of lab supplies.
• Carries out any other related duties as assigned or required in keeping with the qualifications and requirements of this level of technician.

CONSEQUENCE OF ERROR

The work is of a complex nature and required high level of training, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Errors may result in the permanent loss of irreplaceable tissue samples, loss of thousands of dollars of material and/or damage to equipment.  Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly. Noncompliance with biosafety and chemical safety regulations may also result in closure of facility or loss of grant funding.

SUPERVISION RECEIVED

The successful applicant will work under general/minimum supervision. From time to time, Principal Investigator(s), direct supervisor(s) or Laboratory Research and Operations Manager may provide specific instructions on unusual problems, or new project outlines. This position will report to the Principal Investigator(s) or Laboratory Research and Operations Manager or designate.   

SUPERVISION GIVEN

Depending on experience and expertise, the successful applicant maybe be required to assist in training and supervision of graduate students/trainees, including providing instruction on use of lab equipment and procedures, and will help troubleshoot experiments in their area of expertise.

QUALIFICATIONS

• A MSc in Biological Sciences (Molecular Biology or other relevant field) or BSc with 1-2 years of related experience in academic research or biotech industry settings, preference will be given to applicants with work experience in microscopy, antibody labeling and cell biology.
• A working knowledge and understanding of microscopy, cell culture, cell biology and biochemistry, histology and immunohistochemistry.
• Hands-on working experience with antibody labeling/conjugation, histology and immunohistochemistry is considered a great asset.

Experience in

• Previous hands-on experience with Akoya Bioscience CODEX system, Fluidigm Hyperion Imaging mass cytometry or Fluidgim CyToF2 or equivalent imaging equipment would be highly valued and considered great asset.
• Hands-on experience with cell culture and aseptic technique is preferred.
• Ability to perform and troubleshoot a wide variety of molecular, biochemistry and cellular biology. Experience in troubleshooting of immunocytochemistry and antibody labelling/conjugation would be an asset.
• Demonstrates understanding of experimental design histology, immunochemistry and assay optimization.
• Strong interpersonal skills, communication skills (orally and written) and the ability to interact positively and productively with other team members are essential.
• Excellent documentation and organizational skills.
• The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

To apply: Please include your resume and cover letter.

Role Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient and employee safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position. Reporting to the Clinical and Research Directors of the Centre for Lymphoid Cancer, BC Cancer Agency, the Biostatistician provides support in the areas of study design, analysis, and consulting for biological and clinical cancer research. This role oversees survival analysis and statistical modeling of clinico-biologic factors associated with patient outcomes and maintains information collected in the provincial clinical lymphoma database. The Biostatistician also provides the monitoring of lymphoid cancer interventions and lymphoid cancer health service performance indicators for use in the planning, implementation and evaluation of lymphoid cancer care in the province. The Biostatistician is responsible for tracking trends and detecting emerging issues and associations between a wide range of lymphoid cancer risk factors, health determinants, and health outcomes. The Biostatistician manages the preparation of annual, quarterly, period, and ad hoc reports and is responsible for ensuring high quality and accuracy of these reports. The Biostatistician is responsible for providing statistical support and maintains the integrity of the data to a renowned lymphoma cancer research group which consists of Clinicians, Researchers, Biologists, and Bioinformaticians on lymphoma cancer research and related projects. Key Accountabilities Develops novel statistical models to discover untapped potential in  clinical data, biological phenomena, and novel associations of clinic-biologic factors with patient outcomes. Monitors and assesses existing provincial clinical database of lymphoma patients to provide accurate and timely information. Provides regular reports and presentation of statistical analyses and results to the group Provides support for the development and collaboration of experimental design of research projects to ensure statistical rigor. Evaluates existing and emerging data analysis tools, provides recommendations regarding new tool adoption and performs risk/impact analyses in support of the planning of system development, enhancement and maintenance. Performs quantitative data analyses using advanced statistical methodologies and statistical software. Identifies and provides advice about data limitations and ensures adequate data quality for analytic purposes. Links data sources from the provincial clinical lymphoma database with other major health information systems such as the Ministry of Health (Vital Statistics, hospital discharge database, Pharmanet, Medical Services Plan). Maintains relationships with senior managers in these organizations; takes measures to protect all data and information being used to comply with protection of confidentiality and privacy policies. Develops and produces analytical outputs (e.g. reports, presentations, posters) that support the Centre for Lymphoid Cancer Agency and BCCRC Committees in the monitoring, planning and evaluation of population trends, health services utilization, and health outcomes for lymphoid cancer interventions, including health care system quality trends and variations. Develops and produces reports that monitor and benchmark cost, utilization, quality and other performance indicators and communicates findings to the BCCRC and PHSA Executives, PHSA Board, Ministry of Health and external stakeholders at the local, regional, provincial and national levels. Formulates recommendations based on findings, including strategic interventions, program and costing recommendations. Represents the Centre for Lymphoid Cancer in various meetings as a speaker or contributor. Plans, develops and delivers training programs, initiatives and materials related to lymphoid cancer research and data analyses in collaboration with BCCRC staff and other organizations throughout the province. Identifies learning needs that contribute to skill enhancement and career progression for self and fosters a working environment that stimulates learning and inquiry for self and others. Takes responsibility for keeping self-up-to-date regarding new initiatives, developments and trends in statistical analysis, renal utilization and health services issues through literature review, contact with peers at other organizations, professional associations and attendance at conferences, seminars, workshop and education programs. Communicates information and makes recommendations to the Clinical & Research Directors for evaluation and approval. Qualifications A level of education, training, and experience equivalent to a Master’s Degree in Biostatistics, Statistics, Epidemiology, Health Information Science, or Computer Science and five (5) years of experience in a health analytics, health research or health information field. Understanding of molecular biology and cancer genomics is an asset. Advanced knowledge of frequentist statistics, probability distributions, statistical inference and modeling, particularly Bayesian statistics and machine learning. Knowledge of database management principles. Exceptional knowledge of survival analysis, including cox regression, Kaplan-Meier estimation, statistical language R and experience using ‘Rmarkdown’ or an alternative statistical language. Experience in database graphical, presentation, communication and software applications, such as Linux, MS Access and SQL. Strong analytical, problem-solving and system analysis skills including the ability to comprehend complex issues and related data/information and present information in concise meaningful ways. Ability to develop complex and customized queries and reports. Ability to function in a self-directed manner. Excellent ability to communicate effectively both verbally and in writing. Demonstrated interpersonal skills with a variety of people. Excellent time management skills. Demonstrated ability to respond to the needs of stakeholders supported by an acute awareness of the impact of actions. Ability to handle multiple concurrent tasks. Physical ability to perform the duties of the job.

We are seeking a highly-motivated post-doctoral fellow (PDF) with strong leadership ability and expertise in single cell genomics and transcriptomics, and a strong background in molecular biology. The successful applicant will work full-time under the supervision of Dr. Samuel Aparicio. The position start date is flexible.

JOB SUMMARY

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patient tissues and patient-derived xenografts (PDX). A PDF position is available in the Aparicio lab based at the BC Cancer Research Center in Vancouver, Canada, collaborating on an exciting project mapping clonal dynamics in human cancers with new single cell methods. The post holder will have the opportunity to interact as part of the international CRUK Grand Challenge IMAXT project, bringing new measurement methods and computational techniques to the 3D reconstruction of tumours, and mapping drug sensitivity and drug combinations using sgRNA/CRISPR methods in vivo. The program works closely with the Shah computational biology program, based at Memorial Sloan Kettering Cancer Centre, on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage. 

ORGANIZATIONAL STATUS

The Postdoctoral Fellow will play a leadership role in the Aparicio lab, and will be reporting directly to Dr. Samuel Aparicio who is the primary investigator of the laboratory. More information on the lab, please visit https://aparicio.molonc.ca

WORK PERFORMED

• Provide leadership, strategic direction, and translational research pertaining to single cell genomics and transcriptomics, and CRISPR methods.
• Design and implement research plan to investigate the clonal dynamics in human cancer through single cell methods.
• Design and conduct animal experiments.
• Conduct in vivo testing or characterization of drugs, small molecules, knockouts or antibodies in relevant PDX animal models.
• Foster research collaborations and work jointly with academic, clinical, industry, and other partners.
• Scientifically document lab experiments, data analysis, interpretations.
• Write manuscripts, present results at internal and external meetings.
• Identify funding opportunities and if required write or assist with grant proposals.
• Lead and mentor junior trainees/students in the laboratory.

CONSEQUENCE OF ERROR

This is a senior research position that plays a critical role in the development of this novel field. PDF is accountable for the quality and integrity of the research and data, including analyses and interpretation, as well as the effective and efficient management of research projects and deliverables. This position requires innovation, strategic planning, and adaptability. Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly.

SUPERVISION RECEIVED

The PDF will work with a high degree of independence and set priorities under broad directives from Dr. Aparicio. The PDF will be expected to provide direction and mentoring in the laboratory under the supervision of Dr. Aparicio. This position will also provide the candidate with a high level of exposure to single cell genomics and translational research, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally.

SUPERVISION GIVEN

The PDF will be expected to provide mentorship and guidance to undergraduate, graduate students and other research members as required.

QUALIFICATION

• Ph.D. in biology, cell biology, molecular biology, biochemistry, genetics, genomics, or similar discipline.
• The candidate should have a solid scientific and technical background with excellent written/oral communication, interpersonal and organizational skills.
• Preference will be given to candidates with a proven track record with a minimum of 2-3 first author publications in reputable journals.
• Proficiency in cell biology, molecular biology, histology, genetics, genomics, next-generation sequencing and biochemistry techniques.
• Demonstrate the ability to work in a highly interdisciplinary environment.
• Experience with cancer research.
• Expertise and hands-on experience in animal studies, including all aspects of design, handling, breeding, tissue collection, histology, and analyses are essential.
• Familiarity with testing/characterization of small molecule or drug in vivo is preferred.
• Previous biochemical/cell biology and molecular biology experience with single cell genomics / transcriptomics, next generation sequencing, drugs screen and PDX modeling is an asset.
• Experience with statistical analyses and scientific writing. Previous experience with grant writing is an asset.
• Experience with bioinformatics approaches to biological data and familiarity with handling of genomics data is an asset.
• Applicants with experience and a strong track record with large drug target screening, single cell methods, and PDX mouse models are especially encouraged to apply.

How to Apply

Exceptional candidates should submit a cover letter outlining your research interests and fit with the laboratory’s research, curriculum vitae, and the names of three referees willing to provide letters of reference.

To apply:  Please send the above documents to careersmolonc@bccrc.ca and put “PDF (Molecular Biology), Single Cell Genomics, Aparicio lab” and your family name in the subject line.

Due to the number of resumes we receive, we are unable to confirm receipt of submissions over the phone, or provide the status of the competition. Only shortlisted candidates will be contacted.

Equity and diversity are essential to academic excellence.  An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged.  We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority. 

Job Summary

The candidate would work within a dynamic and vibrant lab with a proven track record of outstanding achievements and contributions in breast oncology research. This position allows the candidate to contribute bold and innovative research that can be translated to new understanding in the evolutionary processes that drive cancers.

This position's primary focus in the lab will be to lead and to participate in projects involving the investigation of functional genomics using sequencing and expression data for breast oncology and cancer evolution. Using the wide network of connections and collaborations of the principal investigator, and extensive biomedical resources at the institution, candidates will be able to build on the existing research of the lab to quickly start up their own research projects.

The position will provide a unique opportunity for mentoring trainees, supervising analysts and interacting with industry. This is an excellent platform to receive outstanding training to gain the important skills for a successful medical research career in academia or industry.

This funded position with the University of British Columbia, at the BC Cancer Research Centre allows the candidate to flourish under the guidance of an experienced mentor

Organizational Status

The Postdoctoral Fellow will play a leadership role in the Aparicio lab, and will be reporting directly to Dr. Samuel Aparicio who is the primary investigator of the laboratory. More information on the lab, please visit https://aparicio.molonc.ca

Work Performed

• Management and supervision of trainees;
• May be involved in recruitment and training of trainees;
• Performing regular reviews of the relevant literature;
• Planning and designing of experiments;
• Analyzing, interpreting and compiling data in study reports, presenting results, and participating in the preparation of scientific manuscripts and grant application packages;
• Updating Dr. Aparicio and the group on the status of projects during lab meetings, in email correspondence and phone conferences;
• Managing projects with key academic and industry partners.

Minimum Qualifications

• PhD degree in the computer science, bioinformatics or equivalent
• At least 4 years experience in bioinformatics research
• Experience in genomics and next-generation sequencing
• Extensive knowledge of cellular and molecular biology, biochemistry and genetics
• Experience with cancer research a plus
• Proven ability to multi-task in a deadline oriented environment with minimal supervision
• Effective oral and written communication, analytical, and interpersonal skills
• Excellent organizational skill and ability to learn new skills quickly
• Ability to work independently and within a team environment.
• Accuracy and attention to detail required
• Candidates should demonstrate the ability to work in a highly interdisciplinary environment.

Supervision Received 

• Works independently under direction of PI, Dr. Samuel Aparicio
• Opportunities to work collaboratively with Industry partners and other researchers at UBC and globally

Supervision Given

• Assists and oversees research assistants and students as required
• Assists and provides guidelines to other research members, as required

How to Apply

Exceptional candidates should submit a cover letter outlining your research interests and fit with the laboratory's research, curriculum vitae, and the names of three referees willing to provide letters of reference.

To apply:  Please send the above documents to careersmolonc@bccrc.ca and put “PDF (Bioinformatics), Next-Generating Sequencing, Aparicio lab” and your family name in the subject line.

Due to the number of resumes we receive, we are unable to confirm receipt of submissions over the phone, or provide the status of the competition. Only shortlisted candidates will be contacted.

Equity and diversity are essential to academic excellence.  An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged.  We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.