We recently published a landmark study showing how the genomes of ovarian cancer histotypes reflect the DNA repair abnormalities they harbour. We are interested in how to optimize the computational discovery of genome-wide structural and point mutational signatures and how signatures can identify treatment opportunities for ovarian and breast cancers. This work is being carried out at bulk and single cell resolution. In addition, we are working in translation capacity to develop a robust genome-wide test to stratify ovarian cancers in the clinic.
Mutational signatures in DNA repair deficient cancers
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