How to Apply 

Applicants interested in pursuing graduate or postdoctoral training in The Department of Molecular Oncology, please e-mail us directly at careersmolonc@bccrc.ca. Please include the following documents when applying:

  • Cover Letter
  • CV
  • Statement of your research interests and experience 
  • Transcripts 
  • Contact information for two or three references

Post-doctoral Fellow (PDF) Single Cell Genomics, Molecular Biology

We are seeking a highly-motivated post-doctoral fellow (PDF) with strong leadership ability and expertise in single cell genomics and transcriptomics, and a strong background in molecular biology. The successful applicant will work full-time under the supervision of Dr. Samuel Aparicio. The position start date is flexible.

JOB SUMMARY:

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patient tissues and patient-derived xenografts (PDX). A PDF position is available in the Aparicio lab based at the BC Cancer Research Center in Vancouver, Canada, collaborating on an exciting project mapping clonal dynamics in human cancers with new single cell methods. The post holder will have the opportunity to interact as part of the international CRUK Grand Challenge IMAXT project, bringing new measurement methods and computational techniques to the 3D reconstruction of tumours, and mapping drug sensitivity and drug combinations using sgRNA/CRISPR methods in vivo. The program works closely with the Shah computational biology program, based at Memorial Sloan Kettering Cancer Centre, on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage.

ORGANIZATIONAL STATUS:

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Center in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, and will play a senior leadership role in the laboratory.

WORK PERFORMED:

  • Provide leadership, strategic direction, and translational research pertaining to single cell genomics and transcriptomics, and CRISPR methods.
  • Design and implement research plan to investigate the clonal dynamics in human cancer through single cell methods.
  • Design and conduct animal experiments.
  • Conduct in vivo testing or characterization of drugs, small molecules, knockouts or antibodies in relevant PDX animal models.
  • Foster research collaborations and work jointly with academic, clinical, industry, and other partners.
  • Scientifically document lab experiments, data analysis, interpretations.
  • Write manuscripts, present results at internal and external meetings.
  • Identify funding opportunities and if required write or assist with grant proposals
  • Lead and mentor junior trainees/students in the laboratory

CONSEQUENCE OF ERROR:

This is a senior research position that plays a critical role in the development of this novel field. PDF is accountable for the quality and integrity of the research and data, including analyses and interpretation, as well as the effective and efficient management of research projects and deliverables. This position requires innovation, strategic planning, and adaptability. Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly.

SUPERVISION RECEIVED:

The PDF will work with a high degree of independence and set priorities under broad directives from Dr. Aparicio. The PDF will be expected to provide direction and mentoring in the laboratory under the supervision of Dr. Aparicio. This position will also provide the candidate with a high level of exposure to single cell genomics and translational research, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally.

SUPERVISION GIVEN:

The PDF will be expected to provide mentorship and guidance to undergraduate, graduate students and other research members as required.

QUALIFICATION:

  • Ph.D. in biology, cell biology, molecular biology, biochemistry, genetics, genomics, or similar discipline.
  • The candidate should have a solid scientific and technical background with excellent written/oral communication, interpersonal and organizational skills.
  • Preference will be given to candidates with a proven track record with a minimum of 2-3 first author publications in reputable journals.
  • Proficiency in cell biology, molecular biology, histology, genetics, genomics, next-generation sequencing and biochemistry techniques.
  • Demonstrate the ability to work in a highly interdisciplinary environment.
  • Experience with cancer research.
  • Expertise and hands-on experience in animal studies, including all aspects of design, handling, breeding, tissue collection, histology, and analyses are essential.
  • Familiarity with testing/characterization of small molecule or drug in vivo is preferred.
  • Previous biochemical/cell biology and molecular biology experience with single cell genomics / transcriptomics, next generation sequencing, drugs screen and PDX modeling is an asset.
  • Experience with statistical analyses and scientific writing. Previous experience with grant writing is an asset.
  • Experience with bioinformatics approaches to biological data and familiarity with handling of genomics data is an asset.
  • Applicants with experience and a strong track record with large drug target screening, single cell methods, and PDX mouse models are especially encouraged to apply.

To apply: Please send your Cover Letter, CV, Transcript and Work Sample to careersmolonc@bccrc.ca

Please put your full name and job title “Post-doctoral Fellow (PDF) Single Cell Genomics, Molecular Biology" in the subject line.

Research Administration Coordinator

Job Summary

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Reporting to the Department Head or designate, the Research Administrative Coordinator, BC Cancer Research Centre is responsible for providing support in areas of human resources, payroll, grant and research administration. This role, on behalf of Principal Investigators (PI’s) and leaders, monitors payroll and financial cost centres through to resolution of payroll issues. The Research Administrative Coordinator also provides administrative support including managing the grant application process and providing work direction to junior administrative staff in the team.

Duties/Accountablilties

  • In collaboration with the Principal Investigator(s) (PIs) coordinates the preparation and submission of grant proposals by identifying submission guidelines, collating information required and ensuring submission deadlines are met. Follows up with the granting agency on the submission of proposals, monitors post award financial accounts to ensure accuracy. Provides progress reports, highlights discrepancies and provides recommendations to resolve discrepancies and budget concerns to the PI(s) as appropriate.
  • Interacts with a variety of individuals and agencies such as universities and granting agencies both national and international.  Ensures flow of information with internal and external stakeholders regarding grant related matters and makes arrangements for visiting speakers and guests.
  • Human resources responsibilities include recruitment of staff by posting/advertising internally and externally (UBC), coordinating interviews and screening applications for review by hiring supervisors. Manages new hires orientation process in the department and ensures all safety and personnel documentations are in place according to policies, guidelines and legislations.
  • Ensures all hiring, appointment and payroll processes such as new hire letters and timekeeping are complete for employees. Liaises with various PHSA units such as Payroll and Human Resources and in some cases, UBC to ensure a seamless process and minimize errors. Brings issues and recommendations of remedies to department head or designate for approval. 
  • Acts as the main contact for ordering supplies for the department and approves lab and office supplies by performing duties such as submitting purchase requisitions and obtaining authorizing signature as necessary. Manages and processes various requisitions such as travel, expense reimbursements, cheque requests, and honorariums for the Department Head and PIs. Acts as liaison with various departments of BCCA/PHSA including purchasing, stores, and finance to obtain information and follow-up on the status of outstanding issues and requests.
  • Coordinates registration and travel arrangements for staff attendance at seminars and meetings. This includes completing registration (on-line or phone), abstract submission, making travel and lodging reservations, culminating expense reimbursements to the attendee and/or cost recovery from the conference organizers as appropriate.
  • Provides work direction to junior and contract administrative staff including orientating new staff and assigning and reviewing work, coordinating work assignments to ensure completion, answering questions and providing support, ensuring policies and procedures are followed and providing input to performance evaluations as required.

Qualifications

A level of education, training, and experience equivalent to a Diploma in a relevant area such as business administration or finance from a recognized college plus three (3) years’ recent related experience a research environment and in project management.
Strong interpersonal and communication skills and the ability to demonstrate good judgment, tact and discretion. Detail oriented and able to complete accurate work in a timely matter. Demonstrated time management skills and ability to assist others in meeting deadlines.  Knowledge of and experience with grant applications.  Knowledge and experience in budget preparation, tracking expenditures and identifying sources of variance. Proficient in scientific and medical terminology.  Ability to work both independently and as team leader to organize work and manage multiple priorities in a fast paced environment. Demonstrated ability to make sound decisions and resolve administrative issues/problems. Fully proficient in the use of a variety of software packages including word processing, spreadsheets and databases and related equipment. Demonstrated ability to evaluate personal work and existing systems and identify areas for improvement. Physical ability to perform the duties of the position.

To apply: please send your Resume and cover letter to careersmolonc@bccrc.ca

Please put “Research Administrative Coordinator” and your full name in the subject line.

Programmer, Computer Vision Developer, Microscopy

JOB SUMMARY

A position is open immediately for a research programmer to work with our interdisciplinary team of researchers and software developers at the British Columbia Cancer Agency (BCCA). We are seeking a passionate individual to join a team of biologists, engineers and data scientists currently developing state of the art methods for spatial imaging of RNA species in human cancers at single cell resolution. Studying tumours at the single cell level can reveal biological differences that may not be resolved when studying the tumour as a whole. The imaging methods being developed include the use of molecularly encoded super-resolution microscopy to detect single molecules of RNA in tissue specimens. The successful candidate will develop and support a microscopy imaging software suite integrating super-resolution microscopy, fluidics and camera functions to facilitate sequential imaging of human cancers. The candidate will also work with biologists and data scientists to analyze images and identify RNA species.

ORGANIZATIONAL STATUS

Working in a research project, both independently and reporting to the project lead in Molecular Oncology or designate, and in conjunction with investigators within the BCCA, UBC and internationally.

WORK PERFORMED

  • Development and maintenance of image analysis software suite
  • Support or development existing microscopy system
  • Assisting in generation of research results from microscopy system
  • Assisting in the computational analysis of digital image files from the system
  • Documentation and training of microscope system to other users
  • Machine learning techniques and platforms
  • Working with open source computer vision libraries

CONSEQUENCE OF ERROR

Accountable for the operation of the microscopy system and downstream image analysis that will have significant research progress implications.

SUPERVISION RECEIVED

Supervision from Principal Investigator or designate. Results reviewed for achievement of overall objectives.

SUPERVISION GIVEN

May help to supervise undergraduate trainees and/or junior software technicians.

QUALIFICATIONS

Essential

  • Minimum of 2 years of relevant work/research experience
  • Microscopy image processing experience
  • Microscopy engineering experience
  • Programming in Python or a combination of relevant languages
  • Strong verbal/written communication skills and willingness to work in a team

Preferred

  • Undergraduate degree in engineering or computer science
  • Machining and design experience
  • Expertise in cellular biology and expression analysis
  • Experience in software engineering and design
  • Experience with scientific high performance computing environments and solutions
  • Experience working in an academic research environment
  • Special consideration will be given to those in research areas that involve computer vision or machine learning.

To apply: Please send your CV and cover letter to careersmolonc@bccrc.ca

Please put your full name and job title “Programmer, Computer vision developer, Microscopy" in the subject line.

Research Asst/Tech 3

Job Summary
Researchers in the Department of Molecular Oncology at the BC Cancer Research Institute uses the latest technologies to rapidly identify genes that are involved in the development of cancer. This position will be involved in providing technical support in molecular biology, biochemistry, microscopy and robotics for current on-going research projects in the lab.

Organizational Status
The successful applicant will report to the Principal Investigator or his/her delegate and may assist in overseeing technical work of students and trainees.

Work Performed

  • Plans and performs experiments utilizing complex procedures and/or techniques
  • Processes primary tissue samples
  • Maintain cell cultures using aseptic techniques
  • Provide molecular biology support – DNA and RNA, cloning, extraction/isolation, PCR
  • Provide basic protein biochemistry support – western blotting
  • Experience with antibody labelling is preferred
  • Ability to record data and work with informatics systems that stores and display data is essential
  • Carries out laboratory techniques following standard operating protocols
  • Maintains laboratory records and experimental data; when require summarize results in research reports and lab presentations
  • Performs other related duties as assigned


Consequence of Error/Judgement
The work is of a complex nature, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Non compliance with biosafety and chemical safety regulations may result in closure of facility or loss of grant funding.

Supervision Received
The successful applicant will report to the Principal Investigator or designate.

Supervision Given
Depending on experience and expertise, the successful applicant maybe be required to assist in training of graduate students/trainees including instruction in use of lab equipment and procedures and will troubleshoot experiments in their area of expertise.

Minimum Qualifications
Completion of a relevant technical program or a university degree in a relevant discipline and a minimum three years of related experience or an equivalent combination of education and experience.

 

Preferred Qualifications

  • Working knowledge and understanding of molecular biology and biochemistry techniques is essential, with prior working experience in molecular biology in laboratory setting is considered an asset.
  • Experience with cell culture and aseptic technique preferred.
  • Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNA / DNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation, and western blotting.
  • Preference will be given to applicants with antibody labeling experience.
  • Experience in immunocytochemistry and basic data analysis in R or similar statistics package would be an asset
  • Demonstrated understanding of experimental design and assay optimization.
  • Strong interpersonal skills and the ability to interact positively and productively with other team members are essential.
  • Ability to communicate effectively both orally and in writing.
  • The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

To apply: Please send cover letter and resume to careersmolonc@bccrc.ca  – Please put your full name and the job title in the subject line.

Research Asst/Tech 4

Job Summary
Researchers in the Department of Molecular Oncology at the BC Cancer Research Institute uses the latest technologies to rapidly identify genes that are involved in the development of cancer. This senior position will be involved with working on the Single Cell genomics project, in addition, providing general technical support in molecular biology, biochemistry, microscopy and robotics for other current on-going research projects in the lab.

Organizational Status
The successful applicant will report to the Principal Investigator or his/her delegate and may assist in overseeing technical work of students and trainees.

Work Performed

  • Plans and performs experiments utilizing complex procedures and/or techniques.
  • Using of liquid handling robotics and 10x genomics platforms to investigate single cell genomics
  • Visualize and analyse cells using microscopy and flowcytometry.
  • Generation, preparation and submission of Next Generation Sequencing Libraries.
  • Track samples, record data and work with informatics systems that stores and displays data
  • Liaise with collaborators and vendors.
  • Provide technical expertise in molecular biology, protein biochemistry, virology, support and guidance to collaborators and researchers.
  • Data analysis using R script or other basic statistic analysis program
  • Provide molecular biology support – DNA and RNA, cloning, extraction/isolation, PCR
  • Provide basic protein biochemistry support – western blotting
  • Carries out laboratory techniques following standard operating protocols.
  • Maintains laboratory records and experimental data; when require summarize results in research reports and lab presentations.
  • Assist, develop or update Standard Operating Procedures (SOPs) to ensure compliance with regulatory bodies
  • Assist in general maintenance of the lab and receiving and inventory of lab supplies
  • Researches and determines the applicability of new technology and systems related to work
  • Conducts complex analysis and interpretation of data resulting from high throughput experiments.
  • Presents data at scientific meetings, writes reports and contributes to writing ethics and grant applications.
  • Carries out any other related duties as assigned or required in keeping with the qualifications and requirements of this level of technician.

Consequence of Error/Judgement
The work is of a complex nature and required high level of training, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Errors may result in the permanent loss of irreplaceable tissue samples, loss of thousands of dollars of material and/or damage to equipment.  Loss of research results could result in the failure of a funded project and put in jeopardy any future funding and the international reputation of the Laboratory. Non compliance with biosafety and chemical safety regulations may also result in closure of facility or loss of grant funding.

Supervision Received
Works under minimum supervision, receiving specific instructions only on unusual problems or when receiving new project outlines from the principal investigator. The successful applicant will report to the Principal Investigator or designate.

Supervision Given
Depending on experience and expertise, the successful applicant maybe be required to assist in training and supervision of graduate students/trainees or junior staff, including providing instruction in use of lab equipment and procedures, and will help troubleshoot experiments in their area of expertise.

Qualifications

  • Undergraduate degree in a relevant discipline or Graduation from a technical college or institute.
  • A postgraduate degree in Science is preferred but not required. Minimum of 5 years related experience or the equivalent combination of education and experience in a research lab setting.
  • A working knowledge and understanding of molecular biology and biochemistry techniques is essential, with prior working experience in molecular biology in laboratory setting is considered an asset.
  • Experience with cell culture and aseptic technique.
  • Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNA / DNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation, and western blotting.
  • Preference will be given to applicants with liquid handling robotics, single cell genomics, Next Generation Sequencing, 10x Genomics experience.
  • Experience in immunocytochemistry and basic data analysis in R or similar statistics package would be an asset
  • Demonstrated understanding of experimental design and assay optimization.
  • Strong interpersonal skills and the ability to interact positively and productively with other team members are essential.
  • Ability to communicate effectively both orally and in writing.
  • The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively

To apply: Please send cover letter and resume to careersmolonc@bccrc.ca  – Please put your full name and the job title in the subject line.

Postdoctoral fellow, Bioinformatics

Job Summary

The candidate would work within a dynamic and vibrant lab with a proven track record of outstanding achievements and contributions in breast oncology research. This position allows the candidate to contribute bold and innovative research that can be translated to new understanding in the evolutionary processes that drive cancers.

This position's primary focus in the lab will be to lead and to participate in projects involving the investigation of functional genomics using sequencing and expression data for breast oncology and cancer evolution. Using the wide network of connections and collaborations of the principal investigator, and extensive biomedical resources at the institution, candidates will be able to build on the existing research of the lab to quickly start up their own research projects.

The position will provide a unique opportunity for mentoring trainees, supervising analysts and interacting with industry. This is an excellent platform to receive outstanding training to gain the important skills for a successful medical research career in academia or industry.

This funded position with the University of British Columbia, at the BC Cancer Research Centre allows the candidate to flourish under the guidance of an experienced mentor

Organizational Status

The Postdoctoral Fellow will play a leadership role in the Aparicio lab, and will be reporting directly to Dr. Samuel Aparicio who is the primary investigator of the laboratory.

Work Performed

  • Management and supervision of trainees;
  • May be involved in recruitment and training of trainees;
  • Performing regular reviews of the relevant literature;
  • Planning and designing of experiments;
  • Analyzing, interpreting and compiling data in study reports, presenting results, and participating in the preparation of scientific manuscripts and grant application packages;
  • Updating Dr. Aparicio and the group on the status of projects during lab meetings, in email correspondence and phone conferences;
  • Managing projects with key academic and industry partners.

Minimum Qualifications

  • PhD degree in the computer science, bioinformatics or equivalent
  • At least 4 years experience in bioinformatics research
  • Experience in genomics and next-generation sequencing
  • Extensive knowledge of cellular and molecular biology, biochemistry and genetics
  • Experience with cancer research a plus
  • Proven ability to multi-task in a deadline oriented environment with minimal supervision
  • Effective oral and written communication, analytical, and interpersonal skills
  • Excellent organizational skill and ability to learn new skills quickly
  • Ability to work independently and within a team environment.
  • Accuracy and attention to detail required
  • Candidates should demonstrate the ability to work in a highly interdisciplinary environment.

Supervision Received 

  • Works independently under direction of PI, Dr. Samuel Aparicio
  • Opportunities to work collaboratively with Industry partners and other researchers at UBC and globally

Supervision Given

  • Assists and oversees research assistants and students as required
  • Assists and provides guidelines to other research members, as required

How to Apply

Exceptional candidates should submit a cover letter outlining your research interests and fit with the laboratory's research, curriculum vitae, and the names of three referees willing to provide letters of reference.

Due to the number of resumes we receive, we are unable to confirm receipt of submissions over the phone, or provide the status of the competition. Only shortlisted candidates will be contacted.

Equity and diversity are essential to academic excellence.  An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged.  We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

Email to apply: careersmolonc@bccrc.ca

Please put Bioinformatics PDF in the subject line.

Post-doctoral Fellow

Posting is available immediately for a postdoctoral fellow with experience in cancer bioinformatics to work on an exciting new program developing non-invasive patient genomic monitoring. The successful candidate will have a degree and postgraduate training in bioinformatics, computer science, statistics, or allied subjects, with experience applying modern computational genome analysis methods. The post holder will work jointly with the groups of Dr Samuel Aparicio (UBC and BC Cancer) &  Dr Andrew Roth (UBC Computer Science and BC Cancer) on developing and implementing methods for analysis of genomic sequencing information from plasma and other fluids to monitor tumour burden and provide information for screening of high risk patients. This will be in conjunction with existing work on single cell genome analysis pioneered by the Aparicio and Shah labs in the last 5 years.

How to Apply:
Please send the following documents to careersmolonc@bccrc.ca and put "Post-doctoral Fellow – Aparicio Lab, family name) in the subject line

  • Cover Letter
  • Resume
  • Transcript
  • Work Sample
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