Dr. Katey Enfield grew up in British Columbia and received her PhD from UBC under the supervision of Dr. Wan Lam, where she employed a multiomics approach to discover and characterize oncogenes and tumour suppressor genes in lung cancer. Dr. Enfield then undertook a postdoctoral fellowship at the Francis Crick Institute in London, UK, in Professor Charles Swanton's lab, where she studied the reciprocal relationships between cancer-intrinsic genomic alterations and the immune response in the TRACERx study. Dr. Enfield developed expertise in highly multiplexed approaches for the spatial profiling of the lung tumour microenvironment and studied mechanisms underlying B cell responses to lung cancer. Dr. Enfield was recruited to UBC/BCCRI in September 2024 where her lab, embedded within the PRO-Lung research network, aims to continue to build our understanding of the evolving relationship between lung tumours and the immune response. Dr. Enfield’s lab will apply methods to study local and systemic immune responses in lung cancer patients and cancer models, including studying the spatial organisation of the tumour microenvironment and how that contributes to patient outcomes and response to therapies.

Katey's lab is located on the 9th floor and her office is located on the 10th floor.

https://pathology.ubc.ca/2024/09/10/enfield-katey/

Affiliations

University of British Columbia 

Credentials

Current appointments

Assistant Professor, Pathology and Laboratory Medicine, University of British Columbia

Visiting Scientist, Francis Crick Institute

Training

BSc, Microbiology, University of Victoria, 2005-2009

PhD, Interdisciplinary Oncology, University of British Columbia, 2010-2017

Post-Doctoral Fellow, Genetics, BC Cancer Research Institute, 2017-2018

Post-Doctoral Fellow, Cancer Evolution and Genome Instability, Francis Crick Institute, 2018-2024

Selected awards

Marie Skłodowska-Curie Actions Individual Fellowship, Horizon Europe, 2019-2021

Betty Rice Award for Research Excellence in Lung Cancer, Canada, 2018

AACR Scholar-in-Training Award, AACR-IASLC Lung Cancer Translational Science from the Bench to the Clinic, USA, 2018

Lloyd Skarsgard Research Excellence Prize, BCCRI, 2017

Young Investigator Award, IASLC 18th Conference of Lung Cancer, Japan, 2017

Adi Gazdar Lectureship Award, IASLC 18th Conference of Lung Cancer, Japan, 2017

Four Year Doctoral Fellowship, UBC, 2012-2016

CIHR Banting and Best Canada Graduate Scholarship Doctoral Award, Canada, 2012-2015

Selected Publications

Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer.

Cancer discovery, 2024
Enfield, Katey S S, Colliver, Emma, Lee, Claudia, Magness, Alastair, Moore, David A, Sivakumar, Monica, Grigoriadis, Kristiana, Pich, Oriol, Karasaki, Takahiro, Hobson, Philip S, Levi, Dina, Veeriah, Selvaraju, Puttick, Clare, Nye, Emma L, Green, Mary, Dijkstra, Krijn K, Shimato, Masako, Akarca, Ayse U, Marafioti, Teresa, Salgado, Roberto, Hackshaw, Allan, , , Jamal-Hanjani, Mariam, van Maldegem, Febe, McGranahan, Nicholas, Glass, Benjamin, Pulaski, Hanna, Walk, Eric, Reading, James L, Quezada, Sergio A, Hiley, Crispin T, Downward, Julian, Sahai, Erik, Swanton, Charles, Angelova, Mihaela

Antibodies against endogenous retroviruses promote lung cancer immunotherapy.

Nature, 2023
Ng, Kevin W, Boumelha, Jesse, Enfield, Katey S S, Almagro, Jorge, Cha, Hongui, Pich, Oriol, Karasaki, Takahiro, Moore, David A, Salgado, Roberto, Sivakumar, Monica, Young, George, Molina-Arcas, Miriam, de Carné Trécesson, Sophie, Anastasiou, Panayiotis, Fendler, Annika, Au, Lewis, Shepherd, Scott T C, Martínez-Ruiz, Carlos, Puttick, Clare, Black, James R M, Watkins, Thomas B K, Kim, Hyemin, Shim, Seohee, Faulkner, Nikhil, Attig, Jan, Veeriah, Selvaraju, Magno, Neil, Ward, Sophia, Frankell, Alexander M, Al Bakir, Maise, Lim, Emilia L, Hill, Mark S, Wilson, Gareth A, Cook, Daniel E, Birkbak, Nicolai J, Behrens, Axel, Yousaf, Nadia, Popat, Sanjay, Hackshaw, Allan, , , , , Hiley, Crispin T, Litchfield, Kevin, McGranahan, Nicholas, Jamal-Hanjani, Mariam, Larkin, James, Lee, Se-Hoon, Turajlic, Samra, Swanton, Charles, Downward, Julian, Kassiotis, George

EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk.

Oncogene, 2014
Wilson, I M, Vucic, E A, Enfield, K S S, Thu, K L, Zhang, Y A, Chari, R, Lockwood, W W, Radulovich, N, Starczynowski, D T, Banáth, J P, Zhang, M, Pusic, A, Fuller, M, Lonergan, K M, Rowbotham, D, Yee, J, English, J C, Buys, T P H, Selamat, S A, Laird-Offringa, I A, Liu, P, Anderson, M, You, M, Tsao, M S, Brown, C J, Bennewith, K L, MacAulay, C E, Karsan, A, Gazdar, A F, Lam, S, Lam, W L
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