Regulatory Science Lab | Cancer Control Research

The Regulatory Science Lab is an innovative program of research focused on the sustainability, value and social impacts of precision medicine. Our research initiatives identify community-defined risks and benefits of precision medicine, its cost-effectiveness, and what policy changes can support the responsible and equitable application of multi-omics. Our research studies estimate preference-based utility and acceptability of multi-omic technologies, as well as include value for money assessments.

Projects

Canadian Network for Learning Healthcare Systems and Cost-Effective 'Omics Innovation (CLEO)

CLEO logo

Who we are:

Leads

Dean Regier

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Deciphering the genome biology of relapsed lymphoid cancers to improve patient management

The PACER lab leads the health economics activities of this multi-year research project in collaboration with researchers from the Genome Sciences Centre and the Centre for Lymphoid Cancer.

Leads

Dean Regier

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Multi-country economic analyses of genomics-driven healthcare for children with rare diseases

The GeneSolve study, recently funded by Genome British Columbia, examines the value of genomic sequencing for diagnosing childhood rare diseases.

Leads

Dean Regier

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Cost-effectiveness of BC Cancer’s Personalized OncoGenomics Program

BC Cancer’s Personalized OncoGenomics (POG) Program is a world-leading initiative applying whole-genome and transcriptome analysis (WGTA) to inform real-time treatment decisions for patients with advanced, hard-to-treat cancers. Using a mixed methods approach, Dr.

Leads

Dean Regier

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Enhancing shared decision making for hereditary cancer susceptibility genetic testing

The CIHR-funded Catalyst project applies a mixed methods approach to enhancing shared decision-making in context to the return of genetic test results for hereditary cancer syndromes.

Leads

Dean Regier

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Members

Faculty/Leaders

Dr. Dean Regier, PhD

Senior Scientist

604-675-8000 ext. 7079

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Staff

Leslie Brown, MSc

Research Methodologist

604-675-8000 * 7637

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Vicki Cormack, BA, BEd

Research Projects Coordinator

604-675-8000 ext. 7058

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Dr. Gemma Cupples, PhD

Health Economist

604-675-8000 ext.7628

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Morgan Ehman, MPH

Health Economist

604-675-8000 ext. 7071

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Dr. Ted Grover, PhD

Research Methodologist

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Mike Guron, MDS

Research Methodologist Programmer

604-675-8000 ext 7061

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Emanuel Krebs, MA

Staff scientist

604-675-8075

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Dr. Reka Pataky, PhD

Senior Health Economist

604-675-8000 ext. 7054

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Jesman Punian, MPH

Research Methodologist

604-675-8000 ext. 7646

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Nirupama Tamvada, MSc

Research Methodologist

604-675-8074

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Deirdre Weymann, MA

Staff scientist

604-675-8000 ext. 7066

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Post-Docs

Dr. Ekaterina (Katya) Bezrukova, PhD

POSTDOCTORAL RESEARCHER

604-6765-8000 ext. 7059

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Students/Trainees

Andrew Fullerton

MPH STUDENT, SCHOOL OF POPULATION AND PUBLIC HEALTH, UBC

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Steve E. Kalloger, PhD Candidate

Adjunct Professor

604-889-0997

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Kenny Zhou

BSC STUDENT, COMPUTER SCIENCE AND STATISTICS, UBC

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Selected Publications

A perspective on life-cycle health technology assessment and real-world evidence for precision oncology in Canada.

NPJ precision oncology, 2022

Regier, Dean A, Pollard, Samantha, McPhail, Melanie, Bubela, Tania, Hanna, Timothy P, Ho, Cheryl, Lim, Howard J, Chan, Kelvin, Peacock, Stuart J, Weymann, Deirdre

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Real-world diagnostic outcomes and cost-effectiveness of genome-wide sequencing for developmental and seizure disorders: Evidence from Canada.

Genetics in medicine : official journal of the American College of Medical Genetics, 2024

Regier, Dean A, Loewen, Rosalie, Chan, Brandon, Ehman, Morgan, Pollard, Samantha, Friedman, Jan M, Stockler-Ipsiroglu, Sylvia, van Karnebeek, Clara, Race, Simone, Elliott, Alison M, Dragojlovic, Nick, Lynd, Larry D, Weymann, Deirdre

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Health Care Costs After Genome-Wide Sequencing for Children With Rare Diseases in England and Canada.

JAMA network open, 2024

Weymann, Deirdre, Buckell, John, Fahr, Patrick, Loewen, Rosalie, Ehman, Morgan, Pollard, Samantha, Friedman, Jan M, Stockler-Ipsiroglu, Sylvia, Elliott, Alison M, Wordsworth, Sarah, Buchanan, James, Regier, Dean A

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Addressing immortal time bias in precision medicine: Practical guidance and methods development.

Health services research, 2025

Weymann, Deirdre, Krebs, Emanuel, Regier, Dean A

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Clinical Effectiveness and Cost-Effectiveness of Multigene Panel Sequencing in Advanced Melanoma: A Population-Level Real-World Target Trial Emulation.

JCO precision oncology, 2025

Krebs, Emanuel, Weymann, Deirdre, Ho, Cheryl, Weppler, Alison, Bosdet, Ian, Karsan, Aly, Hanna, Timothy P, Pollard, Samantha, Regier, Dean A

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Putting the substance in substantial evidence: an evidence-based approach to flexible drug regulation.

Frontiers in medicine, 2025

Krebs, Emanuel, Bubela, Tania, McPhail, Melanie, McCabe, Christopher, Regier, Dean A

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