Objective: Evaluation of the long term protection of primary HPV testing for cervix screening in a large cohort of BC women
In this randomized clinical trial that included 19,009 women, screening with HPV testing resulted in a significantly lower incidence of cervical intraepithelial neoplasia (CIN) grade 3+ at 48 months following randomization (2.3/1000) than screening by liquid-based cytology (5.5/1000).
HPV-based screening was associated with a lower likelihood of CIN3+ at 48 months, but further research is needed to determine long-term clinical outcomes and what is the most cost-effective strategy.
Ogilvie G, van Niekerk D, Krajden M et al. Effect of Screening with Primary Cervical HPV Testing vs. Cytology Testing on High-Grade Cervical Intraepithelial Neoplasia at 48 months: The HPV FOCAL Randomized clinical Trial. JAMA. 2018;320(1):43-52. doi:10.1001/jama.2018.7464