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Canada's Michael Smith Genome Sciences Centre

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Canada's Michael Smith Genome Sciences Centre commenced operations at the BC Cancer Agency in 1999, with a mandate to develop and deploy genomics technologies in support of the life sciences, and in particular cancer research.

Today the Genome Sciences Centre specializes in large-scale, ultra high-throughput sequencing applications. With more than 16 sequencing instruments and a state of the art data and computation centre, the GSC decodes cancer genomes, epigenomes & transcriptomes, and is poised to apply this knowledge for the direct benefit of cancer patients.

Recognizing the diverse applications of genomics approaches, the Genome Sciences Centre also provides technology platform access to Genome Canada and Genome BC projects working in the areas of human health, the environment, forestry, agriculture, and aquaculture.

The Genome Sciences Centre has played a leading role in many large scale genomics initiatives.

Selection of papers by Genome Sciences Centre scientists

Full lists of publications are available on our faculty members' websites)

2015

2014

 2013

 2012

2011

2010

2009

2008

2007

  • Identification and analysis of internal promoters in Caenorhabditis elegans operons. Genome Res. 2007 Oct;17(10):1478-1485.
  • physical map of the bovine genome. Genome Biol. 2007 Aug 14;8(8):R165.
  • Genome-wide profiles of STAT1 DNA association in HeLa S3 cells using chromatin immunoprecipitation and massively parallel sequencing. Nat Methods. 2007 Aug;4(8):651-7.
  • Broad Institute Genome Sequencing Platform and Broad Institute Whole Genome Assembly Team and , Marshall Graves JA, Ponting CP, Breen M, Samollow PB, Lander ES, and Lindblad-Toh K. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature.  May 10;447(7141):167-177.
  • Evolutionary and biomedical insights from the rhesus macaque genome. Science. 2007 Apr 13;316(5822):222-234.

2006

  • The Genome of the Sea Urchin Strongylocentrotus purpuratus. Science 10 Nov 2006; 314(5801):941-952.
  • The genome of black cottonwood, Populus trichocarpa. Science. 2006 Sep 15;313(5793):1596-1604.
  • Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling. Genome Res. 2006 Jun;16(6):796-803.
  • Genomics of hybrid poplar (Populus trichocarpa x deltoids) interacting with forest tent caterpillars (Malacosoma disstria): normalized and full-length cDNA libraries, expressed sequence tags (ESTs), and a cDNA microarray for the study of insect-induced defenses in poplar. Mol Ecol. 2006 Apr; 15(5):1275-1297.
  • Amino-terminus domain of the androgen receptor as a molecular target to prevent the hormonal progression of prostate cancer. J Cell Biochem. 2006 May 1;98(1):36-53.

2005

  • A physical map of the genome of Atlantic salmon, Salmo salar. Genomics. 2005 Oct;86(4):396-404.
  • An application of peer-to-peer technology to the discovery, use and assessment of bioinformatics programs. Nat Methods. 2005 Aug;2(8):563.
  • The Genome of the Kinetoplastid parasite, Leishmania major. Science. 2005 Jul 15;309(5733):436-442.
  • Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-731.
  • Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature. 2005. Mar 24;434(7032):462-9.
  • The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans. Science. 2005 Feb 25;307(5713):1321-1324.
  • Mapping segmental and sequence variations among laboratory mice using BAC array CGH. Genome Res. 2005 Feb;15(2):302-11.
  • Mutations in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. (2005). Nature Genetics 37(4):418-422. Epub 2005 Feb 27

2004

  • A physical map of the chicken genome. Nature. 2004 Dec 9;432(7018):761-4
  • A novel avian influenza H7N3 strain associated with an Avian Influenza Outbreak in British Columbia. Emerg Infect Dis. 2004 Dec;10(12):2192-2195.
  • The ENCODE Project Consortium. The ENCODE (ENCyclopedia of DNA Elements) Project. Science. 2004 Oct 22;306(5696):636-640.
  • Genome sequence of the brown Norway rat yields insights into mammalian evolution. Nature. 2004 Apr 1;428(6982):493-521.
  • A tiling resolution DNA Microarray with complete coverage of the human genome.  Nat Genet. 2004 Mar;36(3):299-303.

2003

  • The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics. PLoS Biol. 2003 Nov;1(2):E45.
  • The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-164.
  • The genome sequence of the SARS-associated coronavirus. Science. 2003 May 30;300(5624):1399-1404.
  • Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells, Nat Med.  (2003B) Apr;9(4):369-71.

2002 

  • Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA. 2002 Dec 24;99(26):16899-16903.
  • A physical map of the mouse genome. Nature. 2002 Aug 15;418 (6899):743-750.
  • The genome sequence of the malaria mosquito Anopheles gambiae. Science. 2002. 298:129-49.
  • Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Science. 2002. 298:149-59.
  • A Comparison of Whole-Genome Shotgun-Derived Mouse Chromosome 16 and the Human Genome. Science. 2002. 296: 1661-71.

2001 

  • An SSLP marker-anchored BAC framework map of the mouse genome. Communication. Nat Genet. 2001Oct;29(2):133-134.
  • A physical map of the human genome. Nature. 2001 Feb 15;409(6822):934-941.  
  • The International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature. 2001 Feb 15;409(6822):860-921.  

2000

  • Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature. 2000 Dec 14;408(6814):796-815.
  • Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature. 2000 Dec 14;408(6814):823-826.
  • The complete sequence of a heterochromatic island from a higher eukaryote. Cell. 2000 Feb 4;100(3):377-386.
  • The genome sequence of Drosophila melanogaster.  Science. 287:2185-95. 2000.

1999

  • Sequence and analysis of chromosome 4 of the plant Arabidopsis thalianaNature. 1999;402:769-776.
  • Genetic definition and sequence analysis of Arabidopsis centromeres. Science. 1999; 286:2468-2474.
  • 1998

  • The C. elegans Genome Sequencing Consortium. Genome sequence of the nematode Caenorhabditis elegans: A platform for investigating biology. Science. 1998;282:2012-2018.
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Please visit the Genome Sciences Centre website for additional information

 

    Labwork2

 

Cover image credits

Embo Journal 28, 9, 6 May 2009. Cover

Reprinted by permission from Macmillan Publishers Ltd: Nature 461, 7265, 8 October 2009. Cover

Genome Research 18, 4, April 2008. Cover

Genome Research 17, 10, October 2007. Cover

Reprinted by permission from Macmillan Publishers Ltd: Nature 428, 6982, 1 April 2004. Cover

Reprinted by permission from Macmillan Publishers Ltd: Nature 409, 6822, 15 February 2001. Cover

From Science Vol. 287, no. 5461, 24 March 2000. Drawings Courtesy of the Archives, California Institute of Technology. Reprinted with permission from AAAS.

From Science Vol. 282, no. 5396,1 December 1998. Reprinted with permission from AAAS.