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Canada's Michael Smith Genome Sciences Centre

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Embo Journal 28, 9, 6 May 2009. Cover

Embo Journal 28

Canada's Michael Smith Genome Sciences Centre commenced operation at the BC Cancer Agency in 1999, with a mandate to develop and deploy genomics technologies in support of the life sciences, and in particular cancer research.

Today the Genome Sciences Centre specializes in large scale ultra high throughput sequencing applications. With more than 25 of the latest sequencing instruments and a state of the art data & computation centre, the GSC is poised to decode cancer genomes, epigenomes & transcriptomes, and apply this knowledge for the benefit of cancer patients.

Recognizing the diverse applications of genomics approaches, the Genome Sciences Centre also provides technology platform access to Genome Canada and Genome BC projects working in the areas of human health, the environment, forestry, agriculture, and aquaculture. 

The Genome Sciences Centre has played a leading role in many large scale published genomics initiatives. A selection of these include:

2010

  • Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet.  2010 Feb ;42(2):181-185. (Featured in News and Views, Nat Genet.  2010 Feb;42(2):100-101.)
    Nature 461, 7265, 8 October 2009. Cover

    Nature 461

  • Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med. 2010 Jan;16(1):49-58. 

2009

  • A first look at the entire human methylome. Nat Biotechnol. 2009 Dec;27(12):1130-1132.
  • Mutational evolution and RNA editing in a lobular breast tumour profiled at single nucleotide resolution. Nature. 2009 Oct 8;461(7265):809-813
  • Mutation of the FOXL2 gene in granulosa cell tumors of the ovary. N Engl J Med. 2009 Jun 25;360(26):2719-2729.
  • The Genome Sequence of Taurine Cattle: A window to ruminant biology and evolution. Science. 2009 Apr 24;324(5926):522-528.
  • Genetic variants at 6p21.33 influence follicular lymphoma risk. Nature Genetics. 2009 Aug;41(8):873-5. Epub 2009 Jul 20.
  • The Bovine Genome Sequencing and Analysis Consortium. The Genome Sequence of Taurine Cattle: A window to ruminant biology and evolution. Science. 2009 24;324(5926):522-8. 

2008

  • A conifer genomics resource of 200,000 spruce (Picea spp.) ESTs and 6,464 high-quality, sequence-finished full-length cDNAs for Sitka spruce (Picea sitchensis). BMC Genomics. 2008 Oct 14;9(1):484.
  • Epigenetics and Human Disease. Int J Biochem Cell Biol. 2008 Sep 24
    Genome Research 18, 4, April 2008. Cover

    Genome Research 18

  • Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila oogenesis. J Cell Biol. 2008 Sep 22;182(6):1127-39. Epub 2008 Sep 15.
  • From cytogenetics to next-generation sequencing technologies: advances in the detection of genome rearrangements in tumors. Biochem. Cell Biol. 2008 Apr; 86(2): 81-91.
  • Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res. 2008 Apr;18(4):610-621.
  • Synthetic genomes brought closer to life. Nat Biotechnol. 2008 Mar;26(3):296-297.
  • ALEXA – A microarray design platform for alternative expression analysis. Nat Methods. 2008 Feb 5(2):118.

2007

  • Identification and analysis of internal promoters in Caenorhabditis elegans operons. Genome Res. 2007 Oct;17(10):1478-1485.
  • physical map of the bovine genome. Genome Biol. 2007 Aug 14;8(8):R165.
  • Genome-wide profiles of STAT1 DNA association in HeLa S3 cells using chromatin immunoprecipitation and massively parallel sequencing. Nat Methods. 2007 Aug;4(8):651-7.
  • Broad Institute Genome Sequencing Platform and Broad Institute Whole Genome Assembly Team and , Marshall Graves JA, Ponting CP, Breen M, Samollow PB, Lander ES, and Lindblad-Toh K. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature.  May 10;447(7141):167-177.
  • Evolutionary and biomedical insights from the rhesus macaque genome. Science. 2007 Apr 13;316(5822):222-234.
    Genome Research 17, 10, October 2007. Cover

    Genome Research 17

2006

  • The Genome of the Sea Urchin Strongylocentrotus purpuratus. Science 10 Nov 2006; 314(5801):941-952.
  • The genome of black cottonwood, Populus trichocarpa. Science. 2006 Sep 15;313(5793):1596-1604.
  • Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling. Genome Res. 2006 Jun;16(6):796-803.
  • Genomics of hybrid poplar (Populus trichocarpa x deltoids) interacting with forest tent caterpillars (Malacosoma disstria): normalized and full-length cDNA libraries, expressed sequence tags (ESTs), and a cDNA microarray for the study of insect-induced defenses in poplar. Mol Ecol. 2006 Apr; 15(5):1275-1297.
  • Amino-terminus domain of the androgen receptor as a molecular target to prevent the hormonal progression of prostate cancer. J Cell Biochem. 2006 May 1;98(1):36-53.

2005

  • A physical map of the genome of Atlantic salmon, Salmo salar. Genomics. 2005 Oct;86(4):396-404.
  • An application of peer-to-peer technology to the discovery, use and assessment of bioinformatics programs. Nat Methods. 2005 Aug;2(8):563.
  • The Genome of the Kinetoplastid parasite, Leishmania major. Science. 2005 Jul 15;309(5733):436-442.
    Nature 428, 6982, 1 April 2004. Cover

    Nature 408

  • Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-731.
  • Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature. 2005. Mar 24;434(7032):462-9.
  • The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans. Science. 2005 Feb 25;307(5713):1321-1324.
  • Mapping segmental and sequence variations among laboratory mice using BAC array CGH. Genome Res. 2005 Feb;15(2):302-11.
  • Mutations in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. (2005). Nature Genetics 37(4):418-422. Epub 2005 Feb 27

2004

  • A physical map of the chicken genome. Nature. 2004 Dec 9;432(7018):761-4
  • A novel avian influenza H7N3 strain associated with an Avian Influenza Outbreak in British Columbia. Emerg Infect Dis. 2004 Dec;10(12):2192-2195.
  • The ENCODE Project Consortium. The ENCODE (ENCyclopedia of DNA Elements) Project. Science. 2004 Oct 22;306(5696):636-640.
  • Genome sequence of the brown Norway rat yields insights into mammalian evolution. Nature. 2004 Apr 1;428(6982):493-521.
    Nature 409, 6822, 15 February 2001. Cover

    Nature 409

  • A tiling resolution DNA Microarray with complete coverage of the human genome.  Nat Genet. 2004 Mar;36(3):299-303.

2003

  • The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics. PLoS Biol. 2003 Nov;1(2):E45.
  • The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-164.
  • The genome sequence of the SARS-associated coronavirus. Science. 2003 May 30;300(5624):1399-1404.
  • Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells, Nat Med.  (2003B) Apr;9(4):369-71.

2002 

  • Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA. 2002 Dec 24;99(26):16899-16903.
  • A physical map of the mouse genome. Nature. 2002 Aug 15;418 (6899):743-750.
  • The genome sequence of the malaria mosquito Anopheles gambiae. Science. 2002. 298:129-49.
    Science Vol. 287, no. 5461, 24 March 2000.

    Science 287

  • Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Science. 2002. 298:149-59.
  • A Comparison of Whole-Genome Shotgun-Derived Mouse Chromosome 16 and the Human Genome. Science. 2002. 296: 1661-71.

2001 

  • An SSLP marker-anchored BAC framework map of the mouse genome. Communication. Nat Genet. 2001Oct;29(2):133-134.
  • A physical map of the human genome. Nature. 2001 Feb 15;409(6822):934-941.  
  • The International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature. 2001 Feb 15;409(6822):860-921.  

2000

  • Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature. 2000 Dec 14;408(6814):796-815.
  • Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature. 2000 Dec 14;408(6814):823-826.
  • The complete sequence of a heterochromatic island from a higher eukaryote. Cell. 2000 Feb 4;100(3):377-386.

    Science Vol. 282, no. 5396,1 December 1998.

    Science 282

  • The genome sequence of Drosophila melanogaster.  Science. 287:2185-95. 2000.

1999

  • Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.  Nature. 1999;402:769-776.
  • Genetic definition and sequence analysis of Arabidopsis centromeres. Science. 1999; 286:2468-2474.

    • 1998

  • The C. elegans Genome Sequencing Consortium. Genome sequence of the nematode Caenorhabditis elegans: A platform for investigating biology. Science. 1998;282:2012-2018.

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Please visit the Genome Sciences Centre website for additional information

 

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Cover image credits

Embo Journal 28, 9, 6 May 2009. Cover

Reprinted by permission from Macmillan Publishers Ltd: Nature 461, 7265, 8 October 2009. Cover

Genome Research 18, 4, April 2008. Cover

Genome Research 17, 10, October 2007. Cover

Reprinted by permission from Macmillan Publishers Ltd: Nature 428, 6982, 1 April 2004. Cover

Reprinted by permission from Macmillan Publishers Ltd: Nature 409, 6822, 15 February 2001. Cover

From Science Vol. 287, no. 5461, 24 March 2000. Drawings Courtesy of the Archives, California Institute of Technology. Reprinted with permission from AAAS.

From Science Vol. 282, no. 5396,1 December 1998. Reprinted with permission from AAAS.