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Assistant Professor (Tenure Track) | Department of Radiology

The Department of Radiology at The University of British Columbia (UBC) along with its partners, the BC Cancer Research Institute (BC Cancer) and TRIUMF invite applications for a full-time faculty position in the field of radiotracer and probe development for molecular imaging and therapy of cancers, at the rank of Assistant Professor (tenure track). This position will be based at the BC Cancer Research Institute.

Apply online now. The anticipated start date is July 1, 2022 or upon a date to be mutually agreed. Applications will be accepted until the position is filled.

Research Animal Technician 2

JOB SUMMARY

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position. These positions supervise designated staff by scheduling and assigning work, and assist in daily animal care operations by leading various health monitoring and colony management programs, trouble-shooting minor issues and performing other administrative tasks. These positions also maintain the daily care of laboratory mice and perform various surgical procedures and laboratory techniques.

                                               

DUTIES/ACCOUNTABILITIES

• Develops, implements, reviews and updates animal care standard operating procedures for assigned area.

• Leads various animal care programs such as health monitoring and colony management.

• Maintains current knowledge of, and ensures compliance with, animal care regulations.

• Supervises designated staff by scheduling and assigning work, providing orientation and training and monitoring performance.

• Maintains daily care of laboratory mice including maintaining adequate food and water levels and observing mice for general health conditions.

• Performs surgeries and techniques including blood collection, surgical implantations, tumour implantation, injection of solutions, collection of tissues and organs and embryo manipulations, and cryopreservation.

• Performs laboratory techniques such as media preparation, cell culture and hormone preparation, and polymerase chain reaction analysis as required.

• Leads training programs, prepares and gives presentations and orients and trains staff and animal users on proper animal care theory, protocols, techniques and procedures.

• Changes and cleans animal cages, bottles and racks.

• Performs general cleaning of animal facilities including disinfecting equipment, walls, floors, rooms, etc.

• Performs census duties such as counting cages and reporting cage numbers.

• Receives and processes laboratory animal care supplies.

                                               

QUALIFICATIONS

A level of education, training, and experience equivalent to graduation from a recognized program in Animal Health or Veterinary Technology, or a Bachelor’s program in an appropriate discipline (e.g. Animal Science); plus five (5) years of recent related experience in a research laboratory, including two (2) years in a supervisory capacity.

Research Project Manager

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No: RPC_R00022_Projects_2022_09_20

Summary

Reporting to Projects Team Leader and working closely with the Principal Investigators and Project Leaders, you will play a key role in managing research projects and grants within the context of a research culture with established policies and procedures, vision and values. The major focus of this position is to work with the Principal Investigators and Project leaders to establish the objectives, milestones, and budgets for various research projects and grants, and monitor and facilitate progress against these objectives and milestones.

Duties/Accountabilities

  • Establishing budgets for research projects, grants, collaborations and core activities
  • Assisting with preparing grants, progress reports, statement of work documents, compliance documents, sample status or analysis reports
  • Monitoring budgets and expenditures
  • Establishing, monitoring, and coordinating project progress, milestones, deadlines and objectives
  • Recommending strategies for improving projects management methods and processes
  • Liaising with grant/core funding agencies
  • Interacting directly with research collaborators or clinical study teams as required
  • Performing other related duties as appropriate

Qualifications

While equivalencies will be considered, ideally you bring a degree in Science (preferably Genetics, Biochemistry, Microbiology or Computer Science) plus 5 years' recent related experience in project management and/or research development management.

Certification as a Project Management professional will help you make the short list, as will experience in academic scientific research, clinical trials research, biotech or software industry. Proficiency with MS Word, Excel and Project is essential and you should have excellent organizational, analytical and verbal and written communication skills.

Successful candidate(s) will be offered positions through Provincial Health Services Authority at the Research Project Coordinator level, which is equivalent to that described above.

Core Skills and Abilities

Excellent written and verbal communication skills and proactive interactions with collaborators are a must to perform successfully in this position. Active participation in laboratory meetings and seminars relevant to the project activities is highly encouraged.

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No: RPC_R00022_Projects_2022_09_20 in the subject line of your email.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working on a hybrid basis, both remotely within BC and onsite in the GSC office in Vancouver on a temporary basis. This restriction would be re-evaluated upon re-contracting.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Research Programmer - Birol Lab/Bioinformatics Technology Lab

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Job Reference No. RP_R00008_Birol Lab_2022_09_08

Summary

The Genome Sciences Centre (GSC) is a leading international organization for genomics and bioinformatics research. Our mandate is to advance knowledge in those areas, and to realize the social and economic benefits of genomics research. The Research Programmer analyzes large-scale genomics data and provides support for research projects in the Bioinformatics Technology Lab (BTL) / Genome Sciences Centre - BC Cancer through developing software, data models, analysis pipelines, and documentation. The successful candidate will work independently in a multidisciplinary environment, and participate as a project team member on specific genome research projects to develop / test code and help analyze large volumes of genomics data.

Key Accountabilities


• Develop and implement data analysis pipelines / algorithms
• Work with the BTL’s Python and C/C++ code base (improve existing modules, create new ones, etc.)
• Analyze large scale genomics and next-generation sequence datasets
• Investigate complex biological problems in which analysis of sequence data requires in-depth evaluation
• Collaborate to develop and test code, implement software and data analysis pipelines
• Prepare programming documentation in accordance with prescribed standards
• Conduct literature reviews, and provide input and recommendations to the Principal Investigator and
Group Leader regarding new computer applications, bioinformatics software or statistical techniques
• Participate in weekly lab meetings and present work for review by others
• Provide contributions to the preparation and/or presentation of research manuscripts

Qualifications

• B.A./B.S., M.S, or Ph.D. in Computer Science, Bioinformatics, Engineering or a related field
• Minimum 2 years of experience in computer programming
• Experience developing bioinformatics pipelines and/or tools is a must
• Proficient in C/C++
• Experience with at least one scripting language (Python, PERL, R, etc.)
• Experience with good software engineering and version control practices (code review, unit testing, etc.)
• Experience working in a Unix/Linux environment
• Experience with analyzing very large datasets (1TB+ scale)
• Experience with next-generation sequencing data analysis (DNA, RNA) is a must
• Knowledge of microbial and human genetics will be considered assets

The successful applicant will be part of a team of research scientists working in a dynamic environment to primarily develop and apply data analysis algorithms and protocols to analyze genome data. You will be contributing to advancing science, cancer and genome research locally and worldwide.  

Application

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Job Reference No. RP_R00008_Birol Lab_2022_09_08 in the subject line of your email.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working both remotely and onsite on a temporary basis. This restriction would be re-evaluated upon re-contracting.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Research Associate

Job Reference No: RA_R00006_Evgin Lab_2022_07_29

Canada’s Michael Smith Genome Sciences Centre (GSC) is a state-of-the-art, large scale, high throughput, clinically accredited genomics and bioinformatics facility. If you have a PhD degree in a life sciences or quantitative discipline and experience with lab research, along with an interest in genomics and improving cancer care, you could become an integral member of our team.

The GSC's Evgin lab is seeking a Research Associate. The Evgin lab uses mouse models of cancer to investigate the in vivo interplay between the immune system and cancer. Specifically, the team is interested in how the function and plasticity chimeric antigen receptor (CAR) T cells are regulated by the tumour microenvironment, and how to leverage combination therapy (including oncolytic viruses and vaccines) and CRISPR editing to overcome these challenges. We are looking for a motivated, creative, and meticulous individual who has a strong understanding of molecular biology and immunology to contribute to our research program.

This is your opportunity to work with highly motivated colleagues in a science-oriented, creative and dynamic environment. As a Research Associate in the Evgin Lab, you will develop close relationships with world-renown computational and genome science technologists, cancer researchers and medical scientists. We offer a competitive salary, excellent benefits and significant career development opportunities.

Duties 

  • Perform experiments that include basic molecular and biochemical bench-work, generate plasmids and produce retrovirus/lentivirus, and perform cell culture of mouse and human cells.
  • Follow detailed, time-sensitive and challenging protocols to generate lymphoma mouse models and adoptive transfer experiments.
  • Conduct flow-based immunologic phenotyping experiments and tumor measurements by a variety of in vivo and ex vivo approaches.
  • Maintain banks of cell lines, plasmids, viruses (etc).
  • Work with team members and collaborators regarding data generation and project coordination.
  • General laboratory management such as maintenance of supplies and inventory.
  • Contribute to scientific publications, patents, and funding proposals.
  • Perform other related duties as required.

Qualifications

  • PhD degree in a life sciences or quantitative discipline or equivalent combination of education and experience.
  • A Minimum of three (3) years of recent related experience in a research laboratory.

Skills & Abilities

  • A strong background in molecular biology including DNA isolation/purification, construct design and cloning is required.
  • Experience working with primary immune cells and along with CRISPR-based genetic engineering is desirable.
  • Experience with flow cytometry and standard immunologic techniques is desirable.
  • Experience with retrovirus, lentivirus, VSV or vaccinia based viral vectors is desirable.
  • Experience with mouse handling and injections is helpful.
  • Outstanding organization skills, attention to detail, as well as the ability to maintain detailed documentation is required.
  • Experience using graphing programs such as Prism, Excel, etc.
  • Ability to collaborate proficiently and communicate effectively with colleagues and management teams.
  • Ability to contribute in a meaningful way to scientific discourse.
  • Ability to think critically and learn independently.

Apply Now!

Please submit a CV and a one-page cover letter highlighting relevant research experience, interests and goals to bcgscjobs@bcgsc.ca, using Job Reference Number RA_R00006_Evgin Lab_2022_07_29 in the subject line of your email.

This posting will remain online until filled.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

 

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Research Administration Coordinator

Job Summary:

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position.

Reporting to the Department Head or designate, the Research Administrative Coordinator, BC Cancer Research Centre is responsible for providing support in areas of human resources, payroll, grant and research administration. This role, on behalf of Principal Investigators (PI’s) and leaders, monitors payroll and financial cost centres through to resolution of payroll issues. The Research Administrative Coordinator also provides administrative support including managing the grant application process and providing work direction to junior administrative staff in the team.

Duties/Accountablilties:

  • In collaboration with the Principal Investigator(s) (PIs) coordinates the preparation and submission of grant proposals by identifying submission guidelines, collating information required and ensuring submission deadlines are met. Follows up with the granting agency on the submission of proposals, monitors post award financial accounts to ensure accuracy. Provides progress reports, highlights discrepancies and provides recommendations to resolve discrepancies and budget concerns to the PI(s) as appropriate.
  • Interacts with a variety of individuals and agencies such as universities and granting agencies both national and international.  Ensures flow of information with internal and external stakeholders regarding grant related matters and makes arrangements for visiting speakers and guests.
  • Human resources responsibilities include recruitment of staff by posting/advertising internally and externally (UBC), coordinating interviews and screening applications for review by hiring supervisors. Manages new hires orientation process in the department and ensures all safety and personnel documentations are in place according to policies, guidelines and legislations.
  • Ensures all hiring, appointment and payroll processes such as new hire letters and timekeeping are complete for employees. Liaises with various PHSA units such as Payroll and Human Resources and in some cases, UBC to ensure a seamless process and minimize errors. Brings issues and recommendations of remedies to department head or designate for approval.
  • Acts as the main contact for ordering supplies for the department and approves lab and office supplies by performing duties such as submitting purchase requisitions and obtaining authorizing signature as necessary. Manages and processes various requisitions such as travel, expense reimbursements, cheque requests, and honorariums for the Department Head and PIs. Acts as liaison with various departments of BCCA/PHSA including purchasing, stores, and finance to obtain information and follow-up on the status of outstanding issues and requests.
  • Coordinates registration and travel arrangements for staff attendance at seminars and meetings. This includes completing registration (on-line or phone), abstract submission, making travel and lodging reservations, culminating expense reimbursements to the attendee and/or cost recovery from the conference organizers as appropriate.
  • Provides work direction to junior and contract administrative staff including orientating new staff and assigning and reviewing work, coordinating work assignments to ensure completion, answering questions and providing support, ensuring policies and procedures are followed and providing input to performance evaluations as required.

Qualifications:

A level of education, training, and experience equivalent to a Diploma in a relevant area such as business administration or finance from a recognized college plus three (3) years’ recent related experience a research environment and in project management.

Strong interpersonal and communication skills and the ability to demonstrate good judgment, tact and discretion. Detail oriented and able to complete accurate work in a timely matter. Demonstrated time management skills and ability to assist others in meeting deadlines.  Knowledge of and experience with grant applications.  Knowledge and experience in budget preparation, tracking expenditures and identifying sources of variance. Proficient in scientific and medical terminology.  Ability to work both independently and as team leader to organize work and manage multiple priorities in a fast paced environment. Demonstrated ability to make sound decisions and resolve administrative issues/problems. Fully proficient in the use of a variety of software packages including word processing, spreadsheets and databases and related equipment. Demonstrated ability to evaluate personal work and existing systems and identify areas for improvement. Physical ability to perform the duties of the position.

Research Assistant/Tech 3 – Animal Research Technician

JOB SUMMARY

Researchers in the Department of Molecular Oncology at the BC Cancer Research Centre use the latest technologies to rapidly identify genes that are involved in the development of cancer. This position will be involved in performing research in drug pharmacology directed at human tumours, with assays in immunodeficient mice (xenotransplants).

ORGANIZATIONAL STATUS

The successful applicant will report to the Principal Investigator or his/her delegate and may assist in overseeing technical work of students and trainees.

WORK PERFORMED

  • Plans and performs experiments utilizing complex procedures and/or techniques.
  • Processes tissue samples and carries out primary cell isolation as instructed.
  • Carries out laboratory techniques following standard operating protocols ages, tables, graphs and charts.
  • Maintains both laboratory and laboratory records of both animal data and experimental data; when require summarize results in research reports and lab presentations.
  • Assists in the daily care of transgenic animals and maintains colonies of human tumour bearing immunodeficient animals.
  • Carries out and oversees procedures involving immunization, oral gavage, injections, tumour innoculation, tumour volume measurements, blood and tissue collection, surgical procedures, necropsy, and post-operative care.
  • Daily health monitoring and care of laboratory animals.
  • Be able to recognize and resolve behavioral and/or housing issues; may provide technical instruction and training for other staff and/or trainees
  • Performs other related duties as assigned.
  • On a rotation basis, must be available for emergency calls 24/7 and respond appropriately.

 CONSEQUENCE OF ERROR

The work is of a complex nature, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Noncompliance with ARC regulations may result in closure of facility. Noncompliance with animal protocols may result in loss of grant funding.

SUPERVISION RECEIVED

The successful applicant will report to the Principal Investigator or designate.

SUPERVISION GIVEN

The successful applicant will assist in training graduate students/trainees including instruction in use of lab equipment and procedures and will troubleshoot experiments in their area of expertise.

QUALIFICATIONS

  • Undergraduate degree in a relevant discipline or Graduation from a technical college or institute.A postgraduate degree in Science is preferred.
  • CALAS certification (e.g. RLAT) is an asset.
  • Minimum of 3 years related experience or the equivalent combination of education and experience.
  • Experience with cell culture and aseptic technique preferred, involving both isolation and maintenance of rodent primary cultures and cell lines.
  • Experience in the use and handling of hazardous materials such as biological agents and cytotoxic drugs is essential.
  • Experience in the monitoring and management of human tumour bearing animals.
  • A working knowledge of the CCAC guidelines and compassion and sensitivity for animals.
  • Strong interpersonal skills and the ability to interact positively and productively with other team members are essential.
  • Ability to communicate effectively both orally and in writing.
  • The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

Finance Coordinator, Research Funds Services

We are looking for a highly motivated finance coordinator to oversee and manage grant funding, supporting a multi-institutional and multidisciplinary team of cancer scientists and leading-edge cancer research across the province. If you are detail oriented, enjoy working in a fast-paced and dynamic environment, please apply! The successful candidate will have the opportunity to learn and work within the financial systems at the University of British Columbia, BC Cancer Research Institute, Provincial Health Services Authority, and Vancouver Coastal Health Research Institute. Our finance and administration staff ensure everything flows smoothly in research projects and play an important role in cancer research. Vacation starts at 20 days a year and the position is eligible for a mix of onsite and remote work. The role is for a one year term with possibility of extension. Come join our team and be part of incredible cancer discoveries!

Job Summary

The Finance Coordinator, Research Funds Services provides research financial reporting and administration on assigned grant funded programs. The Finance Coordinator, Research Funds Services monitors research projects and researches grant budgets, coordinates the development and submission of research financial reports, liaises with PHSA restricted funds finance team to ensure grants financial information is accurately maintained, monitors and tracks receipts and disbursements and assists with the management, allocation and coordination of  research funds among Partners and Stakeholders.                                 

Duties/Accountablilties

  • Monitors research expenditures and reviews and analyzes research financial information of assigned grant funded programs for the Administrator,  Research Business Operations, and Research Project Managers to assist with planning budgets. This includes pulling appropriate research general ledger accounting information, performing review of research accounts and classifying financial information for reporting, invoicing and budgeting purposes. Ensures research budgets remain within allowable spending limits by tracking and monitoring receipts, disbursements and expenses of general accounts. Investigates and identifies errors/discrepancies and creates journal entries to correct accounting records and maintain research financial information integrity.
  • Prepares and reviews research purchase orders and expense claims to ensure applicability and correct expense coding. Verifies appropriate back-up provided and ensures compliance with PHSA policy as well as external funding agency policies. Identifies/determines if expense claim is allowable and makes suggestions on alternative options, if necessary. Follows up with vendors on outstanding credits or erroneous billing as well as cheque payment requests and facilitates payment options by ensuring that required information is obtained (cheque payment, wire transfer, credit card, etc.)
  • Performs periodic reconciliation of the research general ledger, research corporate card purchases, research capital expenditures, research payroll reports and receivables to ensure accuracy and timely follow-up.
  • Prepares research billing invoices based on the general ledger on a weekly, quarterly and ad-hoc basis to ensure timely collection of revenue from external funding agencies. Ensures research payments are received in full and follows-up on outstanding bad debt accounts.
  • Communicates internally with Accounts Payable, Accounts Receivable and PHSA Finance and provides direction on account coding to accurately reflect nature of research financial transaction. Monitors and reconciles research shadow accounts held at UBC and SFU by pulling the general ledger held at these institutions to ensure accurate and complete yearly reporting of funding received. Communicates with the universities regarding accounting discrepancies and generates journal entries and/or invoices to reflect accurate research financial information.
  • Monitors research reporting/invoicing due dates and coordinates timelines to ensure that deadlines are met. Compiles and prepares research financial reports/invoices as needed (quarterly, yearly, etc.) and ensures that expenditures reported are in compliance with spending guidelines and GAAP (generally accepted accounting principles). Identifies under/over-expenditures and recommends options to ensure that the research project stays within budget.
  • Provides support during annual and interim audits by compiling research general ledger information and ensuring proper documentation is kept on file. Provides analysis to identify/explain journal entries as required by the auditor. Coordinates periodic research financial and annual reports as required by granting agencies, PHSA , partner universities and stakeholders to ensure information is summarized according to guidelines.

                                                               

Qualifications

A level of education, training and experience equivalent to a Diploma in Accounting/Financial Management or pursuing a professional designation program and preferably three (3) years of recent related experience in a multi government institutional setting, including experience working with national and international granting and funding bodies.

Knowledge and experience in working with General Accepted Accounting Principles (GAAP) in a university/life science environment. Knowledge of grant management and familiarity with granting agencies and their guidelines and policies. Working knowledge of the university/health care funding process and procurement practices is an asset. Demonstrated ability to conduct oneself in a professional and confidential manner.  Demonstrated administrative and organizational skills.  Demonstrated ability to productively use word processing, excel spreadsheets, financial reporting and project/budget management applications.  Demonstrated ability to communicate effectively both verbally and in writing.  Ability to work independently with minimal direction. Ability to handle workload pressures and demonstrated ability to prioritize.  Ability to supervise junior staff.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged.   We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

MSc/PhD Students - Scott Lab

Application Deadline

The Scott Lab is seeking highly motivated MSc and/or PhD students to work on the genomics of mature B-cell lymphomas. Principal Investigator Dr. David Scott is a renowned clinician scientist who has led international collaborations to improve classification and understanding of lymphomas. Our group has generated sequencing data from thousands of patient samples across many lymphoma types that are ready to be analyzed and published. Ongoing projects in the lab are going beyond traditional omics to deepen our understanding of aggressive lymphomas through single-cell multi-omics, long-read Oxford Nanopore sequencing and DNA methylation analyses, and spatial imaging and sequencing technologies, working at the cutting edge of translational cancer research. We are generously funded through organizations such as the Terry Fox Research Institute, Genome BC, BC Cancer Foundation, Lymphoma Research Foundation, and the NIH. 

As part of the Centre for Lymphoid Cancer, the Scott Lab collaborates closely with many clinicians and scientists with diverse research programs. Trainees are involved in all stages of their project, including planning, development, and collaboration.  All trainees have opportunities to present in internal seminar series and are encouraged to attend and present at international conferences. Students will enrol in the UBC Pathology and Laboratory Medicine or Interdisciplinary Oncology (IOP) graduate programs. 

The ideal candidate would have demonstrated experience and/or aptitude in bioinformatics, genomics, and statistics. Experience programming in R and/or Python would be an asset but not required. Interested applicants should send a cover letter and CV to: 

lhilton@bccrc.ca and dscott8@bccancer.bc.ca

This is an ongoing posting and applications are welcome any time. 

MSc/PhD Students - Vu Lab

MSc/PhD students- RNA biology in stem cells in normal and malignant blood cancers – Vu lab

We are looking for outstanding, motivated graduate students to join our team to explore the world of RNA biology in the context of stem cell regulation during normal and malignant hematopoiesis. Our ultimate goal is to translate our knowledge and discovery of the molecular mechanism underlying disease transformation to develop innovative therapy to improve stem cell potentials or treatment of blood cancers.

Our competitive research plan encompasses of several generously supported projects involving the use of human and mouse models, primary patient samples of hematologic malignancies and cutting-edge technologies. The Vu lab is a part of Terry Fox Laboratory, the world class and highly collaborative research unit at BC Cancer and the Faculty of Pharmaceutical Sciences, UBC.  The Vu lab has a strong interest and expertise in translational cancer research with several collaborations at major international institutions worldwide. Trainees are directly involved in all aspects of project development, planning and collaborations.

Interested candidates should send a  a statement of research interest, curriculum vitae, transcripts and contact details for 3 referees to:

Ly P. Vu, PhD

Scientist, Terry Fox Laboratory, BC Cancer

Assistant Professor, Faculty of Pharmaceutical Sciences, UBC

Email: lvu[at]bccrc.ca

Research Programmer – Data Scientist

Job Reference No. RP_R00008_Karsan Lab_2022_05_31

Canada’s Michael Smith Genome Sciences Centre (GSC) is a state-of-the-art, large scale, high throughput, clinically accredited genomics and bioinformatics facility. Dr. Aly Karsan and the Karsan Lab team are seeking a Research Programmer to join a Marathon of Hope Cancer Centre research project.  

The successful applicant will be working with other research programmers in the Karsan lab to develop data analysis pipelines for various next-generation sequencing (NGS) data such as—but not limited to—scRNA-Seq, targeted sequencing, ATAC-Seq, and BS-Seq. We seek candidates with strong analytical and programming skills to research, develop, and improve our research pipelines for studying cancer evolution. The role is ideally suited to detail-oriented individuals with a strong interest in data analysis, research, and scientific programming within a high throughput academic setting. 

By working within the Karasn Lab at the GSC, you will develop close relationships with world-renown specialists in bioinformatics and have access to one of the most robust computational and next generation genome sequencing technology facilities in Canada. The Karsan lab has a history of strong publications and a diverse computational biology core for knowledge sharing, collaboration, and support. 

This is a non-union position funded by a BC Cancer Foundation Grant. We offer a competitive salary, excellent benefits and significant career development opportunities.  

Responsibilities 

  • Design and implement bioinformatic data pipelines to meet objectives of the project.
  • Work with other project team members to develop and test code and implement analysis.
  • Evaluate and incorporate third-party software into pipelines.
  • Produce thorough but concise written documentation of experiments, algorithms, validations and other procedures as required.

Qualifications

  • Graduation from a recognized Bachelor of Science Program in Computer Science or relevant program. A Master’s degree in a relevant field would be a strong asset. 
  • Two (2) years of recent related experience or an equivalent combination of education, training and experience.

Core Skills and Abilities: 

  • Expertise with scientific programming and ablility to provide links to code samples via GitHub.
  • Familiarity with molecular and cellular biology.
  • Excellent verbal and written communication skills.
  • Demonstrated ability to interpret results.
  • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools.
  • Established ability to efficiently organize work assignments and establish priorities.
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.

Additional Assets:

  • Familiarity in statistical analysis using modern computational tools (experience with any relevant tools will be considered, but R and Python are preferred).
  • Familiarity in next-generation sequencing datasets.
  • Understanding of cancer biology.
  • Functional knowledge of distributed version control systems, such as SVN or GIT.

How to Apply

Applicants should submit: a CV; a one-page cover letter highlighting relevant research experience, interests and goals; and the names and contact details of three (3) references.

Please send your application to bcgscjobs@bcgsc.ca and include the job reference number in the subject line of the email. While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

We believe that equity and diversity are essential for the advancement of human knowledge and science.  We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

About the GSC

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Postdoctoral Fellow – Bioinformatics

Job Reference Number: PDF_01553_Steif Lab_2022_05_16

Canada’s Michael Smith Genome Sciences Centre (GSC) is a state-of-the-art, large scale, high throughput, clinically accredited genomics and bioinformatics facility. We are currently looking for a Postdoctoral Fellow to join Dr. Adi Steif’s computational biology group.

The successful incumbent will lead the analysis of single cell data from a novel instrument, under development in collaboration with the groups of Dr. Karen Cheung (Biomedical Engineering) and Dr. Marco Marra (GSC / Medical Genetics). Funded by Genome BC, the project aims to improve the scalability and accuracy of cell isolation, in order to investigate tumour cellular diversity and evolution.

The position is anchored within a team of exceptional scientists, computational biologists and programmers, which collaborate directly on improving genome sequencing technology, interpretation and application. By working within the Steif Lab at the GSC, you will develop close relationships with world-renown specialists in bioinformatics and have access to one of the most robust computational and next generation genome sequencing technology facilities in Canada, all while living in one of the most beautiful, diverse and eclectic cities in the world.

This is an opportunity to work with highly motivated colleagues in a science-oriented, creative and dynamic environment. We offer a competitive salary, excellent benefits and significant career development opportunities.

Apply now!

Responsibilities

Working in a multidisciplinary team, the postdoctoral fellow will contribute to experimental design and protocol optimization. They will develop scalable analytical workflows in a high-performance computing environment to characterize the genomes and transcriptomes of cancer cells. This is a one-year term appointment, with potential for renewal.

  • Regular review of the scientific literature
  • Contribute to experimental design and planning
  • Data preprocessing and quality control
  • Data analysis, visualization, and biological interpretation
  • Develop and maintain well-documented code
  • Regularly update Dr. Steif and key collaborators on the status of projects
  • Participate in and present research updates at lab meetings and team meetings
  • Contribute to scientific writing, including the preparation of research manuscripts and grant applications
  • May be involved in recruitment, management, and supervision of trainees

Qualifications

  • A PhD in bioinformatics, biostatistics, computer science or related discipline
  • At least 3 years of research experience in computational biology, with a record of first-author publication
  • Experience in genomics and the analysis of sequencing data
  • Knowledge of molecular biology and genetics
  • Experience in cancer research is an asset
  • Programming fluency in Python or R
  • Experience working in a Unix/Linux environment
  • Critical thinking and attention to detail
  • Excellent verbal, written and interpersonal communication skills
  • Ability to work independently and in a collaborative interdisciplinary team
  • A strong work ethic, with demonstrated ability to manage time and prioritize to meet deadlines

How to Apply

Applicants should submit: a CV; a one-page cover letter highlighting relevant research experience, interests and goals; and the names and contact details of 3 references. 

Please send your application to bcgscjobs@bcgsc.ca and include the job reference number in the subject line of the email. While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.

We believe that equity and diversity are essential for the advancement of human knowledge and science.   We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

About the GSC

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

The GSC is part of BC Cancer Research Institute and the Provincial Health Services Authority (PHSA). Please note that as per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

Postdoctoral Fellow (Radiochemistry), Lin lab

One postdoctoral fellow position is immediately available at the BC Cancer Research Institute in Vancouver, Canada for the development of novel radiopharmaceuticals for cancer imaging and radiotherapy. The postdoctoral fellow will conduct research in the design and synthesis of radioligands targeting biomarkers overexpressed in cancers. Research activities will involve the production and isolation of radioisotopes, peptide and multi-step organic synthesis, and radiolabeling small molecules, peptides and antibodies with various imaging and radiotherapeutic isotopes (F-18, Ga-68, Zr-89, Tc-99m, I-123, In-111, Lu-177, Ac-225 …).

Qualified candidates should have a PhD degree in organic or medicinal chemistry with experience in peptide or multi-step organic synthesis. Experience with HPLC, micro-scale reactions, and radiochemistry is strongly desirable but not required. The ability to perform research and development in a collaborative environment is required including excellent oral and written communication skills. This joint position between BC Cancer and University of British Columbia (UBC) is for a period of two years with the possibility of renewal.

Interested candidates should send a letter of application, curriculum vitae, and names of three references to: Kuo-Shyan Lin (klin@bccrc.ca). Review of applications will begin immediately and will continue until the position is filled.

Assistant Professor (Tenure Track) | Department of Radiology

Application Deadline

The Department of Radiology at The University of British Columbia (UBC) along with its partners, the BC Cancer Research Institute (BC Cancer) and TRIUMF invite applications for a full-time faculty position in the field of radiotracer and probe development for molecular imaging and therapy of cancers, at the rank of Assistant Professor (tenure track). This position will be based at the BC Cancer Research Institute.

The anticipated start date is July 1, 2022 or upon a date to be mutually agreed. Applications will be accepted until the position is filled.

Research Associate - Cancer Proteomics & Personalized Medicine

Application Deadline

Job Summary:

Dr. Philipp Lange, Canada Research Chair in Translational Proteomics of Pediatric Malignancies and his team at The University of British Columbia (UBC) in Vancouver, Canada, seek an outstanding candidate with exceptional passion to advance precision oncology for children and the fundamental understanding of proteome modulation in childhood disorders.

Organizational Status:

The successful candidate will report directly to Dr. Philipp Lange, the principal investigator, and will work in a strongly collaborative and collegial fashion with cross-functional project team members to meet research goals and objectives.

Work Performed:

The research associate will lead data analysis and reporting for multiple single case and cohort studies in the precision oncology BRAvE and PROFYLE initiatives as well as collaboration projects. In this role, they will perform statistically robust analysis and integration of molecular (proteomics, genomic, metabolomic) and phenotypic (clinical, immunophenotype, drug perturbation, …) data, write reports and engage with team members and collaborators to provide key input on experimental design, data interpretation and overall direction of the studies. The research associate will also have the opportunity to conduct experiments of their own to advance the studies.

The incumbent will represent the laboratory in national and international initiatives, lead collaborative projects, train graduate and undergraduate students, introduce new methodologies to the lab and make major contributions to grant proposals and manuscripts.

Consequence of Error:

The successful applicant is expected to exercise a considerable amount of judgment, responsibility, and initiative in determining work procedures and methods. He/she should carefully observe and evaluate their work. All works are subject to assessment by Dr. Lange. Consistent poor judgment decisions or errors can result in incorrect data interpretation and potential loss of funding.

Supervision Received:

The applicant is expected to work independently under the direction of Dr. Lange, who will be available to provide consultation on unusual problems and project developments.

Supervision Given:

Assist with training graduate students and junior lab staff; provide input on staff/co-op student selection and performance evaluation.

Qualifications:

  • PhD and Postdoctoral in cancer biology, immunology or related area
  • Strong publication record
  • Fluent in written and spoken English and demonstrated excellence in scientific writing
  • Demonstrated exceptional analytical, communication and visualization skills
  • Strong statistical foundation and expertise in R or python for data analysis
  • Exceptional understanding of biological mechanisms and well read
  • Expertise in CRISPER genome editing, mass spectrometry, cell surface and secretome characterization are assets but not required

Research Team & Environment: Located at the BC Children’s Hospital Research Institute (BCCHRI), the leading pediatric research center in Western Canada, you will be embedded in the highly innovative and interdisciplinary research environment spanning BC Children’s Hospital, UBC and BC Cancer Agency. Vancouver repeatedly ranks among the most livable places in the world and combines excellence in research with high quality of life. Excellent opportunities for personal and professional development are provided.

The incumbent will be part of a dynamic team of experimental and computational scientists and embedded in the local BRAvE and national PROFYLE pediatric precision oncology initiatives, where they will work with basic scientists, pathologists, analysts and clinicians. They will work in the newly renovated digital-health offices with direct access to state-of-the-art compute infrastructure and software, as well as, cell and molecular biology facilities, mouse and chicken chorioallantoic membrane (CAM) modeling platforms, mass-spectrometry, next-generation sequencing, flow cytometry, imaging and compute infrastructure.

The Department of Pathology and Laboratory Medicine at UBC is a hybrid, academically intensive Department within the UBC Faculty of Medicine whose activities span a broad spectrum of teaching, research, and academic service, often performed in the milieu of clinical practice, and are ultimately devoted to improving the care, treatment, and well-being of patients.  The Department offers academic degrees at the bachelor’s (Bachelor of Medical Laboratory Science (BMLSc)) and graduate (MSc, PhD) levels with the graduate program, one of the largest in the Faculty of Medicine, which has been recognized by UBC for its quality. The Department plays a major role in the MD undergraduate program and offers an accredited residency-training program. Faculty members participate across a spectrum of research from basic investigative to translational to clinical applied research and are recognized locally, nationally and internationally for their excellence. 

How to apply:

Review of applications will begin May 1, 2022. The position will commence as soon as possible.

Please send a cover letter expressing your long-term research vision, career goals and fit for the position (detailing how you meet the requirements). PDF copies of your most impactful papers (max 3, submitted manuscripts OK) as well as your CV and contacts (full address, email and phone number) for three references to brenda.tse@ubc.ca. Please send your documents in one PDF file. Only shortlisted candidates will be contacted.

Salary will be commensurate with experience and full benefits will be provided. The term of the position may be extended pending successful review of performance and productivity and continued funding availability.

Postdoctoral Research Fellow - Cancer Diagnostics & Cell Surface Proteomics

Application Deadline

Job Summary:

Drs. Poul Sorensen, Johal Chair in Childhood Cancer Research, Philipp Lange, Canada Research Chair in Translational Proteomics of Pediatric Malignancies and Gregg Morin seek an outstanding candidate to advance molecular diagnostics in childhood cancer as part of PROFYLE, Canada’s national pediatric precision oncology initiative.

Organizational Status:

The successful candidate will report directly to Dr. Philipp Lange, the principal investigator, and will work in a strongly collaborative and collegial fashion with cross-functional project team members to meet research goals and objectives.

Work Performed:

The postdoctoral fellow will lead a project on the development of mass spectrometry based diagnostic assays for cell surface immunotherapy targets in childhood cancer. Under mentorship of Drs Philipp Lange, Poul Sorensen and Gregg Morin they will refine automated (cell surface) proteome extraction from clinical biopsies and develop PRM and MRM based mass spectrometry approaches for pre-clinical application and clinical translation. They will also have the opportunity to supervise graduate and undergraduate students, gain leadership experience in collaborative projects and contribute to grant applications.

Consequence of Error:

The successful applicant is expected to exercise a considerable amount of judgment, responsibility, and initiative in determining work procedures and methods. He/she should carefully observe and evaluate their work. All works are subject to assessment by Dr. Lange. Consistent poor judgment decisions or errors can result in incorrect data interpretation and potential loss of funding.

Supervision Received:

The applicant is expected to work independently under the direction of Drs. Lange, Sorensen and Morin who will be available to provide consultation on unusual problems and project developments.

Supervision Given:

Assist with training graduate students and junior lab staff; provide input on staff/co-op student selection and performance evaluation.

Qualifications:

  • PhD in biochemistry, cancer biology, analytical chemistry or related area
  • Strong publication record
  • Fluent in written and spoken English and demonstrated excellence in scientific writing
  • Demonstrated exceptional communication and analytical skills.
  • Demonstrated hands-on expertise in protein mass spectrometry
  • Strong statistical foundation and demonstrated expertise in R or python for data analysis
  • Hands-on expertise in characterization cell surface proteomes, development of PRM or MRM type assays, and clinical mass spectrometry are important assets

Research Team & Environment: The incumbent will be part of a dynamic team of experimental and computational scientists and embedded in the national PROFYLE pediatric precision oncology initiative where you will work with basic scientists, pathologists, analysts and clinicians to advance precision diagnostics and treatment for children with cancer. You will be located at the BC Children’s Hospital Research Institute and BC Cancer and will have direct access to latest generation mass-spectrometry, state-of-the-art cell and molecular biology facilities, mouse and chicken chorioallantoic membrane (CAM) modeling platforms, next-generation sequencing, flow cytometry, imaging and compute infrastructure. Vancouver repeatedly ranks among the most livable places in the world and combines excellence in research with high quality of life. Excellent opportunities for personal and professional development will be provided.

The Department of Pathology and Laboratory Medicine at UBC is a hybrid, academically intensive Department within the UBC Faculty of Medicine whose activities span a broad spectrum of teaching, research, and academic service, often performed in the milieu of clinical practice, and are ultimately devoted to improving the care, treatment, and well-being of patients.  The Department offers academic degrees at the bachelor’s (Bachelor of Medical Laboratory Science (BMLSc)) and graduate (MSc, PhD) levels with the graduate program, one of the largest in the Faculty of Medicine, which has been recognized by UBC for its quality. The Department plays a major role in the MD undergraduate program and offers an accredited residency-training program. Faculty members participate across a spectrum of research from basic investigative to translational to clinical applied research and are recognized locally, nationally and internationally for their excellence. 

How to apply:

Review of applications will begin May 1st. The position will remain open until filled and commence as soon as possible. Please send the following as one PDF file to brenda.tse@ubc.ca: a cover letter expressing your long-term research vision, career goals and fit for the position (detailing how you meet the requirements); CV; contacts (full address, email and phone number) for three references; copies of your most impactful papers (max 3, submitted OK).  Only shortlisted candidates will be contacted.

Research Engineer, Microscopy

Application Deadline

JOB SUMMARY

A position is open immediately for a research engineer specializing in microscopy hardware to work with our interdisciplinary team of researchers and software developers at the British Columbia Cancer Agency (BCCA). We are seeking a passionate individual to join a team of biologists, engineers and data scientists currently developing state of the art methods for spatial imaging of RNA species in human cancers at single cell resolution. Studying tumours at the single cell level can reveal biological differences that may not be resolved when studying the tumour as a whole. The imaging methods being developed include the use of molecularly encoded super-resolution microscopy to detect single molecules of RNA in tissue specimens. The successful candidate will develop and support integrating super-resolution microscopy, fluidics and camera functions to facilitate sequential imaging of human cancers. The candidate will also work with biologists and data scientists to analyze images and identify RNA species. 

You will be on-site in the Department of Molecular Oncology at BC Cancer, working closely with software developers, students and researchers operating at the leading edge of the field of cancer genomics.  As one of the members of the CRUK Grand Challenge IMAXT, our lab has embarked on an ambitious journey of creating the world’s first virtual reality map of cancer, with this role playing a key part in the success of this project.  More information on the lab, please visit https://aparicio.molonc.ca

ORGANIZATIONAL STATUS

We are a small team of software developers and engineers  embedded within a larger cancer research lab.  You will be working closely with the researchers on multiple projects involving microscopy hardware and data generation, reporting to the project lead or designate.  You will also be involved in collaborations within BC Cancer, UBC, SFU and internationally.

WORK PERFORMED

  • Development and maintenance of microscopy, fluidics and robotics hardware systems through quantitative feedback and functional requirements definition
  • Development and maintenance of hardware instrumentation control software in Python, MATLAB, and C (Arduino)
  • Further improvement of the existing experiment protocol and the associated instrumentation
  • Assisting in generation and presentation of research results from microscopy system, such as the preparation and running of the instrumentation
  • Communication with external vendors regarding the microscope and associated devices
  • Participation in meetings with the larger research group
  • Assisting in performing computational analysis of digital image files from the system
  • Documentation and training of microscope system to other users
  • Training of undergraduate students regarding the development of the microscopy system

CONSEQUENCE OF ERROR

Accountable for the correct operation of the microscopy system, failure of which will have significant research progress implications.

SUPERVISION RECEIVED

Supervision from Principal Investigator or designate. Results reviewed for achievement of overall objectives.

SUPERVISION GIVEN

May help to supervise undergraduate trainees.

QUALIFICATIONS

Essential

  • Undergraduate degree in Engineering of Applied Science.  Minimum three years of related experience or the equivalent combination of education and experience
  • Relevant experience in microscopy, electrical engineering, optics, fluidics and mechatronics
  • Programming in Python, MATLAB, and C (Arduino).
  • Strong verbal/written communication skills
  • Interdisciplinary teamwork experience
  • Experience working in an academic research environment

Preferred

  • Graduate degree in Engineering or Applied Science
  • Experience with root cause analysis
  • Experience in software engineering and instrumentation design
  • Experience using CAD and rapid prototyping tools
  • Experience with basic circuit design and microcontrollers
  • Experience working with fluidics devices and commercial epi-fluorescent microscopy
  • Knowledge or experience of cellular biology and cancer biology

To apply: Please include your resume and cover letter.

Biostatistician, PhD/MSc - Hybrid (Full-time) - UBC Vancouver / BC Cancer

Application Deadline

JOB SUMMARY

COVID NOTE: UBC currently requires 20% of time to be spent in person, thus semi-remote.  Due to the worksite being in a hospital facility, up to date vaccinations are required.

A UBC AAPS position is open immediately for a biostatistician to join the Aparicio Lab at BC Cancer. We are seeking a creative, experienced, and dedicated individual to play a key role in developing and maintaining our cancer genomics bioinformatics workflows, housed both on-premise and in cloud infrastructure. The successful candidate will join Dr. Aparicio’s breast cancer Molecular Oncology group, and work as part of the lab’s analysis team alongside other software developers, medical researchers and bioinformaticians.  As part of the team, you will help find and develop computational solutions for problems faced by medical researchers and students in the lab, assisting them in pushing the scientific edge of cancer genomics research. Experience with survival analysis and clinical studies statistical analysis will be an advantage.

The efforts of the research group have yielded important and insightful advances in understanding of tumour evolution, specifically how cancers initiate, develop and acquire resistance to treatment. Development of software platforms to address these questions are used both internally and more widely by world-leading scientists studying cancer. More info on the research and the team we conduct can be found here: https://aparicio.molonc.ca

ORGANIZATIONAL STATUS

Working in the computational team, independently carrying out statistical analyses tasks under the instructions and oversight of the team lead or designate. 

WORK PERFORMED

  • Collaborate with researchers to determine study design
  • Performs statistics analyses for new and ongoing studies, including but not limited to analysis of drug sensitivity, gene expression and IHC
  • Review protocols and methodologies to ensure they adhere to best statistical practices
  • Visualize and display study data for interpretation and publication
  • Provide consultation and training to other data analysts and researchers
  • Create user-friendly scripts and programs to assist in data analysis
  • Contribute to writing manuscripts and scientific presentations
  • Leave comprehensive and robust documentation for protocols and scripts

CONSEQUENCE OF ERROR

Accountable for the generation and maintenance of quality protocols and results that will have significant research progress implications.

SUPERVISION RECEIVED

Supervision from team lead or designate. Results reviewed monthly and annually for achievement of overall objectives.

SUPERVISION GIVEN

May help supervise undergraduate trainees and/or researchers.

QUALIFICATIONS

Education, training and experience:

  • Ph.D in Statistics or Biostatistics is preferred, but we will consider M.Sc in the same degrees with relevant work experience
  • Demonstrated proficiency with statistical methods and applications in clinical research

Core skills and abilities:

  • Up-to-date knowledge of statistical methodologies related to areas such as drug sensitivity, statistical modeling, survival, and clinical analysis.
  • Competence in R and/or SAS programming language
  • Familiarity with the development, testing, and maintenance of academic open source code
  • Excellent verbal and written communication skills
  • Demonstrated ability to efficiently organize work assignments and establish priorities
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment

Optional assets:

  • Familiarity with genomics and bioinformatics
  • Familiarity with molecular and cellular biology

To apply: please include your resume and cover letter.

Postdoctoral Fellow–Bioinformatics

Job Reference No: PDF_01553_Jones Lab_2021_10_01

Canada’s Michael Smith Genome Sciences Centre (GSC) is a state-of-the-art, large scale, high throughput, clinically accredited genomics and bioinformatics facility. We are currently looking for a Post-Doctoral Fellow to work on the Genome Canada funded LSARP, “Canada’s Earth BioGenome project”. 

The successful incumbent will work with the project team to lead the activities on the development, application and validation of novel approaches and workflows in the area of integrated de novo genome assembly over multiple sequencing technologies. They will develop automated bioinformatics workflow as well as assembly submission. They will also work closely together with Earth BioGenome Project (EBP) consortium on the sequencing and assembly standards. The successful incumbent will work with project leaders to ensure all scientific milestones are achieved and contribute to progress reporting as required. There will be expectations to represent the project within the global EBP consortium and the development of outreach materials and website information. Opportunities will exist for further research on the genomic information developed and for scholarly publication.​

The position is anchored within a team of exceptional scientists, computational biologists and programmers, which collaborate directly on improving genome sequencing technology, interpretation and application. By working within Dr. Steven Jones' lab at the GSC , you will develop close relationships with world-renown specialists in bioinformatics and have access to one of the most robust computational and next generation genome sequencing technology facilities in Canada, all while living in one of the most beautiful, diverse and eclectic cities in the world. 

This is an opportunity to work with highly motivated colleagues in a science-oriented, creative and dynamic environment. We offer a competitive salary, excellent benefits and significant career development opportunities. Apply now!

Duties

  • Work with multidisciplinary scientists at the GSC and collaborators to analyze whole genome and transcriptome sequence data and set up collaborative working plans.
  • Develop and maintain bioinformatics pipelines for genome assembly and data analysis.
  • Produce written documentation of algorithms, validations, SOPs and other processes related to pipeline updates and procedures as required.
  • Present results of bioinformatics software testing internally and externally.
  • Perform literature searches, testing and validation of new data analysis software related to bioinformatics pipelines.
  • Perform other related duties as required.

Qualifications

  • Knowledge of genomics, genome assembly and genome analysis software.
  • Fluency in one or more programming languages, such as Python, Javascript and SQL.
  • Experience working in a UNIX/Linus environment and writing shell scripts.
  • Previous API development projects using Open API or Rest API is a plus.
  • Excellent communication and organization skills and ability to efficiently manage time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities.
  • Ability for critical thinking and independent learning.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using PDF_01553_Jones Lab_2021_10_01 in the subject line of your email.

This posting will remain online until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that equity, diversity and inclusivity are essential for the advancement of human knowledge and science.

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

About the GSC

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Business Analyst and Project Support

Job Reference No: RPC2_R00026_2021_07_06

Canada’s Michael Smith Genome Sciences Centre (GSC) is a state-of-the-art, large scale, high throughput, clinically accredited genomics and bioinformatics facility. If you have a Bachelor's degree in Health Information Science or Computer Science—along with experience in software/system project planning, analysis and implementation—this is your opportunity to join our team as a Business Analyst providing support for cutting-edge technology projects!

Reporting to the Head of Quality and Regulatory Affairs, the Business Analyst and Project Support (BA) leads the analysis and documentation of business requirements to support projects for designated programs and services. The successful candidate for this position will work in close collaboration with other stakeholders to develop business systems enhancements, business solutions, or business processes including GSC’s bioinformatics processes. The BA functions as a Subject Matter Expert to the project team through performing gap analysis of systems and business process mapping including the identification of linkages to other business systems.  

The BA position is anchored within a team of exceptional scientists, computational biologists and programmers, which collaborate directly on the development of robust, cost efficient and competitive processes for new targeted and precision medicine analytical pipelines. By working within the GSCs bioinformatics facility, you will develop close relationships with world-renown computational and genome science technologists, cancer researchers and medical scientists; have access to one of the most robust computational and next generation genome sequencing technology facilities in Canada, all while living in one of the most beautiful, diverse and eclectic cities in the world. Your work will help to save lives and contribute to a world free from the fear of cancer.

This is an opportunity to work with highly motivated colleagues in a science-oriented, creative and dynamic environment. We offer a competitive salary, excellent benefits and significant career development opportunities.

Apply now! 

Duties and Responsibilities

  • Provide key contributions to the development of solutions to ensure that business processes and/or project deliverables are consistent, accurate and timely.  
  • Participate in and contribute to strategic planning. 
  • Develop project plans for the design, development and implementation of new business processes; support the transition from current systems, practices and processes to an integrated system, common practices and standardized processes with current or improved functionality.  
  • Ensure key results are achieved in accordance with the project plan by analyzing current business systems and processes, generating ideas and formulating recommendations/options, and supporting members of the project in prioritizing tasks and reaching decisions that are within project scope and timelines. 
  • Implement or contribute to the implementation of effective processes to assess project risks, identify risk mitigation strategies and monitor risk throughout the project lifecycle. Support the Managers/Team Leads by providing regular updates on the progress as well as any areas of risk associated with the completion of the project both within the project scope and the timeline. Provide professional expertise to staff, departments, stakeholders, and guidance regarding standard process for project management.
  • Coordinate and participate in the analysis, acceptance criteria definition, development, testing, training, implementation and maintenance phases of assigned bioinformatics projects. Carry out post-implementation reviews of systems and make recommendations for improvements.
  • Utilize formal data gathering techniques and analysis tools such as flowcharts, diagrams, dashboards, roles and responsibility matrix (RACI) and work effort estimates. Provide details of estimated implementation costs including associated staffing requirements.
  • Review, analyze and define current/future state processes, determine user and/or department requirements and contribute to the development of specifications and testing for all identified development, system modifications and installations. Perform impact analyses. 
  • Provide user support, advice, guidance and orientation in situations that require interpretation and judgement. Develop content, as required, for training modules; deliver training and provide guidance to system users and department staff. Develop and maintain various business processes, policies and procedures, as well as reference documentation such as user instructions, manuals and reference materials.  
  • Provide support to colleagues and users during the development, maintenance and operation of various computer systems by performing duties such as troubleshooting system software problems and testing alternative solutions. 
  • Participate in the formal data collection and analysis to help identify system deficiencies and/or operational inefficiencies in order to report and develop new ways of improving business efficiencies including the data analysis related to business case developments, project proposals and other key strategic and transformative initiatives. 
  • Assemble, create and maintain information systems technical and operational documentation according to departmental standards.
  • Assist with preparation of Requests for Information/Proposal, development of evaluation processes and tools, and evaluation of vendor responses by serving on working groups, documenting detailed requirements and coordinating project team and vendor communications.

Qualifications

  • A level of education, training and experience equivalent to a Bachelor's degree in Health Information Science, Computer Science or a related discipline—OR relevant related experience that includes software/system project planning, analysis and implementation.  
  • Demonstrated ability to carry out business process mapping and fit gap analysis.  
  • Excellent interpersonal, oral and written communication skills with the ability manage multiple interactions with multiple groups while working on multiple issues at the same time.  
  • Superior analytical, problem-solving and system analysis skills.  
  • Proven ability to plan and execute projects with stringent timelines.  
  • Ability to work effectively as part of a team.  
  • Demonstrated ability to provide professional expertise to staff, departments and stakeholders, and guidance regarding standard processes for software/computer system related project management.  
  • Demonstrated ability to provide user support, advice and training, and other user liaison services.
  • Public Service and Health Sector experience and knowledge are an asset.  

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Business Analyst and Project Support in the subject line of your email. 

This posting will remain open until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. 

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

About the GSC

Canada’s Michael Smith Genome Sciences Centre (GSC)

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Process Development Coordinator—Centre for Clinical Genomics (CCG)

JOB ID: PCD_E00375_Clinical_2021_08_11

Canada’s Michael Smith Genome Sciences Centre (GSC) is a state-of-the-art, large scale, high throughput, clinically accredited genomics and bioinformatics facility with extensive, world-renowned expertise in adopting cutting edge technology for genomics applications combined with innovative and internationally-recognized bioinformatic capabilities.

If you are a computational scientist with clinical laboratory experience, who has designed and performed computational experiments that generate clinically relevant results, who understands and can improve upon process development and programming workflows, and is motivated to contribute towards scientific endeavours that will ensure that cancer patients continue to receive the best standard-of-care in the world—then join us!

As a Process Development Coordinator within the Centre for Clinical Genomics (CCG) at the GSC, reporting to the Centre for Clinical Genomics Informatics team lead, you will be responsible for improving and expanding the array of active clinical germline, tumour and cell-free DNA panel sequencing assays. The PDC will develop new clinical procedures and bioinformatic workflows, monitor and review performance within the clinical production process, and where applicable, improve existing analyses; monitor results and compare them to best-practice standards; and always strive to streamline efficiency, maximize quality and balance cost. The PDC collaborates closely with key stakeholders for the clinical processes including the clinical director, bioinformatics groups and quality assurance group. You will need to be prepared to take initiative, to think critically and solve complex problems, to build and nurture collaborative relationships across departments, and to learn continuously.

The position is anchored within a team of exceptional scientists, computational biologists and programmers, which collaborate directly on the development of robust, cost efficient, and competitive processes for new targeted and precision medicine analytical pipelines. By working within the GSCs bioinformatics facility, you will develop close relationships with world-renown computational and genome science technologists, cancer researchers and medical scientists; have access to one of the most robust computational and next generation genome sequencing technology facilities in Canada, all while living in one of the most beautiful, diverse and eclectic cities in the world. Your work will help to save lives and contribute to a world free from the fear of cancer.

This is an opportunity to work with highly motivated colleagues in a science-oriented, creative and dynamic environment. We offer a competitive salary, excellent benefits and significant career development opportunities.

Apply now!

Duties and Responsibilities

Oversees the development and testing of clinical bioinformatics production processes by:

  • Designing and performing experiments pertaining to the delivery of clinical panel sequencing data.  This includes, but is not limited to, the development and testing of new analyses, protocol optimization, Quality Assurance and Quality Control, testing of prototypes and related activities.
  • The PDC continually monitors performance of protocols within the production process and identifies areas for improvement. All activities will yield documented recommendations and implementation plans.
  • Troubleshooting existing clinical computational processes where necessary. Makes recommendations and adjustments and reports problems.
  • Training designated members of the clinical bioinformatics group in new or optimized analysis workflows. Writes or revises protocols accordingly.
  • Performing technical functions related to the Bioinformatics groups of the GSC.

Qualifications

  • Graduation from a recognized Bachelor’s program in an appropriate discipline such as Computer Science, Bioinformatics, Genetics, Molecular Biology or Biochemistry—OR, an acceptable equivalent combination of education, training and experience.
  • Proven expertise with Python and/or other similar high-level languages.
  • Demonstrated ability in R or other similar statistical programming languages and in statistical analysis.
  • Functional knowledge of distributed version control systems, such as Git.
  • Demonstrated experience with next generation/ third generation sequencing technology with an in-depth understanding of standards and guidelines for validating clinical bioinformatics analysis pipelines using these technologies.
  • Excellent verbal and written communication skills.
  • Comfortable working in a Linux environment, including experience with shell scripting and common command-line tools.
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
  • Experience liaising with multiple stakeholders to support consensus goals.
  • Demonstrated ability to efficiently organize work assignments and establish priorities to meet set milestones.
  • Demonstrated ability to write technical documents including validations and procedure manuals.
  • Excellent analytical skills.
  • Demonstrated ability to accept responsibility and work independently.
  • Experience with bioinformatic workflow managers eg Nextflow would be considered an asset.
  • Management experience is also an asset.

Apply

Please submit a detailed cover letter and resume to bcgscjobs@bcgsc.ca, using Business Analyst and Project Support in the subject line of your email. 

This posting will remain open until filled.

Due to current COVID-19 restrictions, the position would require working remotely within British Columbia on a temporary basis with an ability to come to the normal workplace within reasonable notice. This restriction would be re-evaluated after finalization of reopening plans.

As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.

We believe that diversity and inclusivity are essential for the advancement of human knowledge and science. 

We welcome all applicants and provide all employees with equal opportunity for advancement, regardless of race, colour, ancestry, place of origin, political belief, religion, marital status, family status, physical or mental disability, sex, sexual orientation, gender identity or expression, age, conviction of a criminal or summary conviction offence unrelated to their employment.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Canada's Michael Smith Genome Sciences Centre

Today’s Research. Tomorrow’s Medicine.

The GSC is a department of the BC Cancer Research Institute and a high-throughput genome sequencing facility. We are leaders in genomics, proteomics and bioinformatics in pursuit of novel treatment strategies for cancers and other diseases.

Among the world’s first genome centres to be established within a cancer clinic, for more than two decades our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.

Among the GSC’s most significant accomplishments are the first publication to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first published sequence of the SARS coronavirus genome and major contributions to the first physical map of the human genome as part of the Human Genome Project.

By joining the GSC you will become part of an exceptional and diverse team of scientists, clinicians, experts and professionals operating at the leading edge of clinical research. We look for people who share our core values—science, timeliness, respect—to join us on our mission to use genome science for the betterment of health and society.

Centre for Clinical Genomics

The Centre for Clinical Genomics (CCG) is based within Canada's Michael Smith Genome Sciences Centre (GSC) and is supported by the Provincial Health Services Authority (PHSA). Further partnerships with the clinical laboratories of the Lower Mainland Pathology & Laboratory Medicine Services provide extensive diagnostic experience and consultation. These partners work together to ensure timely and accurate delivery of clinically-actionable information required to ensure excellent patient care.

Clinical genomic testing is rapidly becoming a standard of care for many hereditary and acquired conditions and this integrated partnership will see that demand met with quality service provision. As this testing demand grows, we require novel strategies to address testing capacity and capability. The CCG is well-placed to implement novel genomic technologies, and harness the significant bioinformatic expertise residing at the GSC for data analysis and interpretation.

The CCG provides high throughput sequencing for genomic diagnostics in CAP (College of American Pathologists) accredited laboratories. The combination of technical, informatic and clinical expertise ensures that genomic diagnostics will be delivered with high-quality and confidence.

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