Our lab is motivated by studying cancer through the lens of evolution. We are engaged in several studies that span both temporal and spatial multi-sample studies of our cancers of interest. Observing the dynamics of genomically-defined clones reflected in timeseries biopsies of patient tumours, patient-derived xenografts, or through spreading of clones across anatomical sites is a key area of interest for our lab. For example in recent work, we have identified clonal expansion patterns underpinning histological transformation in follicular lymphoma, mapped the spread of clones within the peritoneal cavity of ovarian cancers and identified reproducible clonal dynamics in patient derived breast cancer xenografts. Our current questions relate to drug selection and the interplay between malignant cells and the tumour microenvironment.
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