Application Deadline

Job Summary:

Drs. Poul Sorensen, Johal Chair in Childhood Cancer Research, Philipp Lange, Canada Research Chair in Translational Proteomics of Pediatric Malignancies and Gregg Morin seek an outstanding candidate to advance molecular diagnostics in childhood cancer as part of PROFYLE, Canada’s national pediatric precision oncology initiative.

Organizational Status:

The successful candidate will report directly to Dr. Philipp Lange, the principal investigator, and will work in a strongly collaborative and collegial fashion with cross-functional project team members to meet research goals and objectives.

Work Performed:

The postdoctoral fellow will lead a project on the development of mass spectrometry based diagnostic assays for cell surface immunotherapy targets in childhood cancer. Under mentorship of Drs Philipp Lange, Poul Sorensen and Gregg Morin they will refine automated (cell surface) proteome extraction from clinical biopsies and develop PRM and MRM based mass spectrometry approaches for pre-clinical application and clinical translation. They will also have the opportunity to supervise graduate and undergraduate students, gain leadership experience in collaborative projects and contribute to grant applications.

Consequence of Error:

The successful applicant is expected to exercise a considerable amount of judgment, responsibility, and initiative in determining work procedures and methods. He/she should carefully observe and evaluate their work. All works are subject to assessment by Dr. Lange. Consistent poor judgment decisions or errors can result in incorrect data interpretation and potential loss of funding.

Supervision Received:

The applicant is expected to work independently under the direction of Drs. Lange, Sorensen and Morin who will be available to provide consultation on unusual problems and project developments.

Supervision Given:

Assist with training graduate students and junior lab staff; provide input on staff/co-op student selection and performance evaluation.

Qualifications:

  • PhD in biochemistry, cancer biology, analytical chemistry or related area
  • Strong publication record
  • Fluent in written and spoken English and demonstrated excellence in scientific writing
  • Demonstrated exceptional communication and analytical skills.
  • Demonstrated hands-on expertise in protein mass spectrometry
  • Strong statistical foundation and demonstrated expertise in R or python for data analysis
  • Hands-on expertise in characterization cell surface proteomes, development of PRM or MRM type assays, and clinical mass spectrometry are important assets

Research Team & Environment: The incumbent will be part of a dynamic team of experimental and computational scientists and embedded in the national PROFYLE pediatric precision oncology initiative where you will work with basic scientists, pathologists, analysts and clinicians to advance precision diagnostics and treatment for children with cancer. You will be located at the BC Children’s Hospital Research Institute and BC Cancer and will have direct access to latest generation mass-spectrometry, state-of-the-art cell and molecular biology facilities, mouse and chicken chorioallantoic membrane (CAM) modeling platforms, next-generation sequencing, flow cytometry, imaging and compute infrastructure. Vancouver repeatedly ranks among the most livable places in the world and combines excellence in research with high quality of life. Excellent opportunities for personal and professional development will be provided.

The Department of Pathology and Laboratory Medicine at UBC is a hybrid, academically intensive Department within the UBC Faculty of Medicine whose activities span a broad spectrum of teaching, research, and academic service, often performed in the milieu of clinical practice, and are ultimately devoted to improving the care, treatment, and well-being of patients.  The Department offers academic degrees at the bachelor’s (Bachelor of Medical Laboratory Science (BMLSc)) and graduate (MSc, PhD) levels with the graduate program, one of the largest in the Faculty of Medicine, which has been recognized by UBC for its quality. The Department plays a major role in the MD undergraduate program and offers an accredited residency-training program. Faculty members participate across a spectrum of research from basic investigative to translational to clinical applied research and are recognized locally, nationally and internationally for their excellence. 

How to apply:

Review of applications will begin May 1st. The position will remain open until filled and commence as soon as possible. Please send the following as one PDF file to brenda.tse@ubc.ca: a cover letter expressing your long-term research vision, career goals and fit for the position (detailing how you meet the requirements); CV; contacts (full address, email and phone number) for three references; copies of your most impactful papers (max 3, submitted OK).  Only shortlisted candidates will be contacted.

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