The Genome Sciences Centre Department within the British Columbia Cancer Agency in Vancouver, British Columbia, Canada has an opening for a post-doctoral fellow in the laboratory of Dr. Gregg Morin, to study the mechanisms-of-action of pharmacological inhibition of proteins that regulate pre-mRNA splicing. The scientist will join a collaboration with Drs. Samuel Aparicio and Sohrab Shah that is using global genomic technologies to identify changes in alternative splicing due to inhibition of several classes of enzymes that regulate spliceosome function. The objective is to investigate how these enzymes regulate genome-wide spliceosomal function and splice site choice.
The position will perform laboratory research to design and interpret experiments using biochemical, proteomic, molecular and genomic tools to investigate the functional mechanisms of enzyme inhibition on the spliceosome and its regulatory proteins in human cancer cells. The candidate should have experience in ribonucleoprotein biochemistry, mammalian tissue culture, enzymatic assays, recombinant protein purification, molecular biology, and RNAi. Experience in the structure/function analysis of RNPs or enzymes and a comprehensive understanding of splicing and spliceosome function are essential.
The successful scientist will join the laboratory of Dr. Gregg Morin in the Michael Smith Genome Sciences Centre at the BC Cancer Agency. In collaboration with the laboratories of Dr. Samuel Aparicio and Dr. Sohrab Shah, the team has access to exceptional tools for next generation sequencing, bioinformatics, and advanced proteomics.
The Genome Sciences Centre provides a stimulating working environment and is located at the new British Columbia Cancer Research Centre in Vancouver, one of the world’s most livable and attractive cities.
All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.
Additional information can be obtained at www.bcgsc.ca.
Applicants should send a cover letter, curriculum vitae, and names of three referees by email, fax or mail to:
Dr. Gregg B. Morin
Genome Sciences Centre, BC Cancer
675 West 10th Avenue
Vancouver, BC, V6S 1L3, Canada