Canada's Michael Smith Genome Sciences Centre offers scientists the opportunity to pursue careers in the field of genomic research. With close ties to the local academic communities and to scientific collaborators around the world, we offer a diverse, rich environment in state of the art genomic research activities. With our offices and labs located in Vancouver, BC, this means living in a city that often ranks at the top of list in best places to live.

HEU and HSA union members

Internal applicants please visit internaljobs.phsa.ca to apply online for internal job postings.

Assistant Bioinformatics Coordinator, Software Development

The Assistant Bioinformatics Coordinator provides supervisory and technical support to the Bioinformatics group of the Genome Sequence Centre (GSC). Ensures that the day-to-day activities of a large scale, high throughput facility meet research, data analysis throughput and software development objectives.

Job Code: ABCSD HSA Req 86652

Key Accountabilities

  • Assists the Bioinformatics Coordinator in the day to day activities of the Bioinformatics group by performing duties such as providing input on quantity and quality of work, making recommendations for improvements, workflow and procedures. 
  • Coordinates projects of the Bioinformatics group by performing duties such as chairing project-specific meetings and provides project status reports to the Bioinformatics Coordinator, with suggestions towards any required improvement of project management, task allocation and overall process.
  • Develops and implements assays to monitor project progress and measure project accomplishments to ensure that appropriate project focus is maintained and to provide feedback to staff. 
  • Provides supervisory support to the Bioinformatics group by performing duties such as:
    • Orientating new staff.
    • Providing input to the Bioinformatics Coordinator on training requirements and performing group specific training.
    • Providing input to the Bioinformatics Coordinator on the establishment of clear definitions of responsibility for employees. 
    • Assigning workload assignments and establishing work schedules.
    • Reviewing and establishing work priorities and adjusting work schedules to ensure priorities are met.
    • Completing performance reviews and addressing performance issues in conjunction with the Bioinformatics Coordinator.
  • Participates in the recruitment of staff through methods such as interviewing internal and external applicants and forwards hiring recommendations.
  • Participates in the development and implementation of quality improvement programs to ensure services are provided in the most efficient and effective way by performing duties such as:
    • Monitoring quality and quantity of service and information provided by the bioinformatics group and identifying areas for change and/or improvement.
    • Generating test metrics to evaluate progress of research programs.
    • Writing and updating Standard operating procedures pertaining to tasks and pipelines run by the group.
    • Coordinating and writing technical validation documents for new and improved pipelines and processes.
  • Assesses practical needs for identified research direction of the GSC in conjunction with the Bioinformatics Coordinator and Bioinformatics Group Leader.
  • Participates in a variety of meetings by performing duties such as providing and/or receiving information and contributing to decision making.
  • Participates, in conjunction with the Bioinformatics Coordinator, in determining the computer infrastructure necessary for successful completion of projects and ensured viability of research programs by performing duties such as providing input and recommendations regarding purchasing decisions related to hardware, software and related items for the Bioinformatics platform.
  • Interprets statistical analyses and makes recommendations for review including preparing reports on statistical findings for publication and presentation in HTML format or as advised.
  • Conducts feasibility studies for computerization by performing duties such as determining user requirements, examining and identifying problems with existing systems and recommending modifications to and/or new systems; provides details of estimated implementation costs including associated staffing requirements.
  • Performs technical functions related to the bioinformatic  department of the GSC.
  • Performs other related duties as required.

Qualifications 

Education, Training and Experience 

Graduation from a recognized Bachelor’s program in a related discipline such as Biochemistry, Genetics, Computer Science, Electrical Engineering or Physics.  A minimum of four (4) years of recent related experience including experience in computer programming and quantitative data analysis, handling biological sequence and/or mapping data, database development and data storage schemas or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders. 

Skills and Abilities 

  • Experience with computer operating systems such as Linux, MacOS.

  • Demonstrated ability to work with software languages, frameworks and databases such as Python, C, C++, Javascript, React.js, Perl , R, Postgres, MySQL, Hadoop.

  • Demonstrated ability to accept responsibility and work independently.

  • Demonstrated ability to work effectively with others in a team environment.

  • Demonstrated ability to supervise staff and schedule work.

  • Excellent organizational, leadership interpersonal and communication skills.

  • Physical ability to perform the duties of the job.

To Apply

External Applicants 

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

Internal Applicants 

Internal (HEU and HSA union members) applicants please visit internaljobs.phsa.ca to apply online for internal job postings.

Research Engineer

The BC Cancer Michael Smith Genome Sciences Centre is looking for a talented engineer with interdisciplinary skills and interests for a variety of automation and clinical device projects. This includes designing and building novel instrumentation for high throughput biological analysis as well as programming commercial liquid handlers.

Skills therefore include electromechanical design and machine shop work as well as robot-level software development. Projects require building strong partnerships with interdisciplinary groups of life scientists, and clinicians so strong communication skills are key. Knowledge of biology is valuable but not critical. Reporting to a Professional Engineer, this position enables considerable scope to learn and develop further engineering skills.

Job Code: RE 08-01-2019

Key Accountabilities 

  • Design, prototype manufacture and program electro-mechanical assemblies for novel life science instrumentation.

  • Maintain, program, and operate commercial liquid handling instrumentation

  • Communicate and work closely with a variety of groups and disciplines to troubleshoot and improve efficiency and performance of various automated pipelines

  • Develop software for novel instrumentation and data analysis 

Qualifications 

  • A bachelor’s degree in an engineering discipline, with 1-3 years of experience working in a multi-disciplinary environment

  • Exceptional communication, documentation and analysis skills

  • Experienced with C,C++/CLI, C#, MATLAB, Visual Studio

  • Hands-on experience designing, troubleshooting, and making software, mechanical and electrical systems

  • Familiarity with machining and prototyping

  • Able to work well independently with little supervision but also adept at working in groups/teams

  • Able to efficiently manage a multitude of different tasks

  • Experience with fluidics and molecular biology would be an asset

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RE 08-01-2019") in the subject line of your emailed application.

Research Programmer

The Genome Sciences Centre is seeking a temporary full time Research Programmer to work on cancer genomics projects to develop clinical assays for (1) Lymphoid cancers and (2) cancer monitoring and detection using blood samples (aka liquid biopsy). The successful applicant will work in a team to develop high-throughput, clinically accredited pipelines to aid in identifying pathogenic alterations in cancer. This project involves the development of new assays for cancer patients with the goal of individualized patient management.

Job Code: RP 07-31-2019

Key Accountabilities 

  • Design, documentation, and analysis of experiments to test new assays and new methods
  • Summary and presentation of experimental findings to stakeholders
  • Modification and development of bioinformatic pipelines to analyze genomic data yielding clinical grade variant and expression data
  • Assist in choosing and modifying targets for assay development
  • Analysis of NGS data to investigate clonality, somatic hypermutation, microsattelite instability and intergenic translocations
  • Development and assessment of bioinformatic tools for RNA-Seq expression analysis and variant calling
  • Development and assessment of bioinformatic tools for determining the clinical significance of detected variants
  • Statistical analysis to determine analytical sensitivity and specificity of obtained results
  • Development of software pipelines for analyzing next-generation sequencing data
  • Support of research staff by providing analysis and software tools
  • Contributions to the writing of research publications

Qualifications

  • Graduation from a recognized Bachelor of Science Program in Bioinformatics, Biological Sciences, Statistics, Engineering, or Computer Science.   A Master’s or Doctoral degree in a relevant field would be a strong asset. 
  • Two (2) years of recent related experience or an equivalent combination of education, training and relevant experience.

Skills and Abilities 

  • Knowledge of RNA-Seq and other genomic data analysis, including expression analysis, structural variant detection, and variant-calling.
  • Experience working in a Unix environment, including experience with shell scripting and common command-line tools
  • Expertise in one or more scripting language(s) (e.g. Python)
  • Experience working with next-generation sequencing data and tools (i.e. tools for alignment and variant-calling)
  • Expertise in statistical analysis using modern computational tools.  Experience with any relevant tools will be considered, but R and Python are preferred
  • Experience writing reports of results in accurate and concise language; expertise in scientific/technical writing is required
  • Experience with methods in high-dimensional data analysis for bioinformatics such as clustering, machine learning and data mining would be assets
  • Experience with software testing and cluster computing would be assets
  • Familiarity with cancer genetics would be an asset, as would a history of publications in relevant fields.

The successful candidate will also have:

  • Excellent verbal and written communication skills
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
  • Demonstrated ability to efficiently organize work assignments and establish priorities.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RP 07-31-2019") in the subject line of your emailed application.

Projects Coordinator

In accordance with the Mission, Vision and Values, and strategic directions of Provincial Health Services Authority patient safety is a priority and a responsibility shared by everyone at PHSA, and as such, the requirement to continuously improve quality and safety is inherent in all aspects of this position. Reporting to the Leader, Projects Management Team and working within the context of a research culture and in accordance with established policies and procedures, vision and values of the Genome Sciences Centre (GSC), the Projects Coordinator works with the Projects Managers in the management of various projects and grants at the GSC. A major focus of this position involves monitoring the budgets for various projects and grants as well as progress/milestones, and compilation and analysis of project management data to support project proposals and reports. The Projects Coordinator also coordinates communication from the project team to stakeholders, providing an important liaison role in the project team.

Job Code: PC 07-10-2019

Key Accountabilities 

Scope and Complexity 

The Projects Coordinator works closely with the Projects Managers, as well as with specific project scientists and Principal Investigators (PIs) to monitor project progress and compile data for reporting both internal and external to the organization.  This position requires analytical thinking and superior organization skills to accurately acquire, compile and communicate project information. 

The Projects Coordinator works with, and can impact, several levels of the Centre, across projects and teams, providing a link for staff on project management activities and progress, and the use of templates and tools to assist in project activities.  The Projects Coordinator requires the ability to exercise independent judgment in facilitating communication and compilation of appropriate project data.  Flexibility is required in order to respond to stakeholder’s needs, contractual requirements and strategic priorities. 

The Projects Coordinator works with the Projects Managers and Leader, Projects Management Team to monitor budgets and milestones for various projects and grants at the GSC.  The Projects Coordinator liaises with others in the Centre and in other organizations as required to gather project data related to budgets, costs, spending, milestones, activity status, communications, and other areas as determined by the Leader, Projects Management Team and Projects Manager.  The Projects Coordinator also develops tools and techniques to gather and monitor routine data on progress and status to help ensure that the project objectives/milestones, as well as reporting requirements, are met.  These strategies may include developing reporting templates, forms and other tools with Microsoft Word, Excel, and PowerPoint. 

Communications

Internally, the Projects Coordinator communicates with the Projects Managers and Projects Team Leader to provide specific data and information on project progress and status.  This position is a key member of the Projects team and works through the Projects Manager with the department heads and senior scientists to ensure that accurate data on projects is collected, compiled and reported.  The Projects Coordinator consults the Centre’s staff as required, demonstrating political sensitivity and discretion when working across all levels of the organization, among all groups and departments. 

Externally, the Projects Coordinator liaises with agencies on communication and reporting matters.  The position interacts with project staff at other institutions to facilitate and maintain collaborative relationships. 

Duties 

  • Participates on multiple projects and programs throughout the project lifespan; participates in initiatives in project management research, methodology, design, planning, implementation, integration, evaluation and ongoing monitoring. 
  • Contributes to the monitoring of budgets and progress for research projects, grants and core activities in collaboration with the Leader, Projects Management Team and Projects Managers, to ensure that funds are spent as planned and within budget and that project objectives are achieved. 
  • Compiles, analyzes, summarizes and communicates data to describe project progress and status.  Evaluates whether project objectives/milestones are met in consultation with the Leader, Projects Management Team and Projects Managers.  Identifies discrepancies between project progress and anticipated status for the attention of the Projects Team Leader. 
  • Recommends strategies and develops plans in collaboration with Projects Manager to resolve project efficiency issues where required. 
  • Liaises with agencies and collaborators on communication and reporting discrepancies and refers strategic issues to the Leader, Projects Management Team. 
  • Assists the Leader, Projects Management Team and Projects Managers in preparation of written progress reports for projects, grants and collaborations by providing updated budget summary/milestone information. 
  • Contributes to the preparation, assembly, presentation and distribution of project proposals and reports by compiling information, preparing reporting information including charts, tables and figures. 
  • Performs other related duties as assigned.

Qualifications 

A level of education, training, and experience equivalent to completion of a diploma/certificate from a recognized college (preferably in Science or Business), plus a minimum of 3 (three) years of recent related experience in project management and/or a research development management role. 

Knowledge of project management methodologies and principles, project evaluation and monitoring, and multiple project interaction and integration. Demonstrated ability to manage multiple tasks and assignments within a fast paced environment.  Demonstrated organizational, analytical and decision-making skills.  Excellent ability to organize work and communicate effectively.  Excellent communication skills both verbal and written.  Demonstrated computer literacy (Microsoft Word, Excel, PowerPoint, Project).  Ability to work under pressure of deadlines.  Ability to accept responsibility and work independently.  Must be physically able to perform the job duties.

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "PC 07-10-2019") in the subject line of your emailed application.

Research Assistant 2, Proteomics

The position is in a mass spectrometry-based proteomics group in the Genome Sciences Centre at BC Cancer. The candidate will work as part of a team performing cutting-edge translational research using a broad range of proteomics techniques. The Research Assistant 2 – Proteomics works under supervision and performs experiments by following established laboratory procedures.

Job Code: RA2 07-04-2019

Key Accountabilities 

  • Prepare samples for proteomic analysis
  • Operating facility instrumentation including off-line HPLC fractionation systems, mass spectrometers, and speed vacs
  • Perform initial data analysis
  • Assist in the development of cutting edge protocols for clinical proteomics
  • Maintain logs of samples analyzed and instrument use
  • Liaise with collaborators to coordinate sample submission and communicating results
  • Collaborate with client lab personnel
  • Maintain a details lab notebook

Qualifications 

  • A laboratory technician degree in chemical and biotechnical science with direct work experience in proteomics. 
  • Theoretical knowledge and practical experience with tandem mass spectrometry
  • Experience with state-of-the-art mass spectrometry instrumentation including Orbitraps
  • Experience with clinical sample preparation for proteomics and nucleic acid analysis
  • Experience with processing cells and tissues for global and targeted proteomics
  • Practical experience with analytical reversed phase chromatography (HPLC and nanoLC), specifically for peptide separation
  • Two (2) years recent related experience in a research laboratory

In accordance with Canadian Immigration requirements, this advertisement is first directed to Canadian citizens and permanent residents but international candidates are invited to apply. We encourage applications from all qualified individuals, including Aboriginal peoples, persons with disabilities and members of visible minorities. English is the official language used at PHSA.

To Apply

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "RA2 07-04-2019") in the subject line of your emailed application.

Computational Biologist, Software Developer

The Genome Sciences Centre is seeking a full-time Computational Biologist to join our software development team in a state of the art, high throughput genomics facility. The successful applicant will participate in developing, improving and maintaining bioinformatics tools for a high-throughput processing pipeline. We seek candidates with strong programming experience in python, or other high-level objects-oriented languages (e.g. C#, Ruby, etc.). Experience with Agile and DevOps best practices are also desirable. The role is ideally suited for a creative individual with a strong interest in software development and data analysis within an academic setting. Packaging and distribution of developed tools and analysis results to the scientific community and contribution to preparation of scientific publications are expected.

Job Code: CBSD HSA Req# 85480

Key Accountabilities

  • Expertise with Python and ability to specify, implement, test, and, maintain back end applications and systems as assigned.
  • Devises or modifies systems to solve complex problems associated with high throughput pipelines, considering computer equipment capacity and limitations, operating time and form of desired results.
  • Participates in code walk-throughs and reviews of solutions.
  • Designs & builds solution taking performance into consideration.
  • Coordinates production problem resolution for assigned applications, including working with other technical teams.
  • Evaluate third-party software and incorporate new systems into legacy systems
  • Produce thorough but concise written documentation of algorithms, validations, SOPs, and other processes and procedures as required.
  • Presenting results of software testing internally and externally
  • Literature searches, testing and validation of new data analysis software.
  • Performing other related duties as required.

Qualifications

Education, Training and Experience 

  • Graduation from a recognized Bachelor of Science Program in either Biological Sciences or Computer Science.
  • Two (2) year’s of recent related experience or an equivalent combination of education, training and experience acceptable to the GSC Group Leaders.

Skills and Abilities 

  • Proven expertise with Python and or other similar high level languages
  • Functional Knowledge of distributed version control systems, such as GIT
  • Excellent verbal and written communication skills.
  • Comfortable working in a Unix environment, including experience with shell scripting and common command-line tools
  • Demonstrated interpersonal skills including the ability to work effectively with others in a team environment.
  • Demonstrated ability to efficiently organize work assignments and establish priorities.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

To Apply

External Applicants 

Please send your resume with cover letter to bcgscjobs@bcgsc.ca.

Internal Applicants

Internal (HEU and HSA union members) applicants please visit internaljobs.phsa.ca to apply online for internal job postings.

Quality Control Specialist

BC Cancer has an opening for a temporary full time Quality Control Specialist. The Quality Control Specialist will support the manufacturing, quality control and quality assurance activities for BC Cancer's Cancer Immunotherapy Program, at BC Cancer's Deeley Research Centre (DRC) in Victoria. These systems include, but are not limited to, performing and validating quality control assays, instrument calibration/preventive maintenance, monitoring and trending quality control data, and other activities as appropriate to maintain GMP compliance for the DRC’s T-cell manufacturing facility. The Quality Control Specialist receives guidance from and reports to, BC Cancer's Cancer Immunotherapy Program's QA Manager.

Job Code: QCS 03-08-2019

 

Key Accountabilities 

  • Assisting laboratory production staff in identifying quality control (QC) issues in manufacturing processes

  • Assisting in SOP and specification development by identifying and contributing QC-related material to production SOPs

  • Working with the QA Manager and the DRC T-cell manufacturing team to draft QC-related SOPs

  • Performing daily QC tasks and duties including the following:

    • Carrying out established QC assays according to Standard Operating Procedures (SOPs)
    • Maintaining formal documentation of laboratory processes
    • Maintaining validation and QC programs for instrumentation and procedures
    • Scheduling and prioritizing repair and preventative maintenance of laboratory equipment
    • Monitoring, trending and analyzing QC data and generating analysis reports
    • Communicating QC policies, metrics and trends to program staff
    • Assisting the QA Manager in conducting QA/QC training of program staff and maintaining training records
    • Assisting the QA Manager, QA team, and T-Cell manufacturing team with external audits and associated written reports
    • Assisting the QA Manager during investigations associated with QC assay failures, identifying root causes, summarizing findings and following up with corrective/preventative actions.
    • Performing other related duties as assigned

 

Qualifications 

Education, Training and Experience

  • A Bachelor's degree from a recognized university in Biology, Chemistry, Molecular Biology or a related discipline
  • Four (4) years of recent experience applying QA/QC in an academic, biotechnology or pharmaceutical GMP manufacturing/laboratory environment
  • Prior hands-on experience with equipment qualification, QC test methods and other processes related to GMP/GLP practices
  • Hands-on experience with cell culturing techniques would be an asset
  • Knowledge of the clinical trials regulatory environment in Canada, cell therapy, immunology and/or immunotherapy would be an asset

Skills and Abilities 

  • Demonstrated ability to accept responsibility and work independently
  • Demonstrated ability to work effectively with others in a team environment
  • Demonstrated ability to organize work and establish priorities
  • Demonstrated ability to communicate effectively both orally and in writing

To Apply 

Please send your resume with cover letter to bcgscjobs@bcgsc.ca

We request that you specify the position you are applying for by identifying the Job Code only (e.g. "QCS 03-08-2019") in the subject line of your emailed application.