For more than 30 years, this program has engaged in innovative local and international multi-disciplinary research to identify and improve our understanding of risk factors for cancer. In recent years, there has been an increasing focus on generation of data on molecular markers (e.g. germline genetic variants, epigenetic marks, metabolites etc.) to improve our understanding of the mechanisms by which risk factors are associated with cancer so that targets for intervention can be identified. Risk factors of interest have included numerous occupational and environmental factors (e.g. nightshift work, UV radiation, pesticides) as well as lifestyle factors (e.g. obesity, tobacco, alcohol).
We have launched a birth cohort study in China to support studies of early life exposure to pollutants and impact on chronic disease.
We previously identified that melatonin suppression in nightshift workers is associated with reduced capacity for repair of oxidative DNA damage, which may contribute to increased risks of cancer in this group.
BC Cancer Foundation is the fundraising partner of BC Cancer, which includes BC Cancer Research. Together with our donors, we are changing cancer outcomes for British Columbians by funding innovative research and personalized treatment and care.