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2005

1. Lansdorp PM. Major cutbacks at chromosome ends. Trends Biochem Sci 30(7):388-95. (2005).
    [View Abstract - PubMed 15936947]  Request Paper

2. Ly H, Schertzer M, Jastaniah W, Davis J, Yong SL, Ouyang Q, Blackburn EH, Parslow TG, Lansdorp PM. Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita. Blood 106(4):1246-52. Epub 2005 May 10. (2005).
    [View Abstract - PubMed 15886322]  Request Paper

3. Roth A, Baerlocher GM, Schertzer M, Chavez E, Duhrsen U, Lansdorp PM. Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT. Blood 106(1):43-50. Epub 2005 Mar 1. (2005).
    [View Abstract - PubMed 15741219]  Request Paper

4. Yamaguchi H, Calado RT, Ly H, Kajigaya S, Baerlocher GM, Chanock SJ, Lansdorp PM, Young NS. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med 352(14):1413-24. (2005).
    [View Abstract - PubMed 15814878]  Request Paper

2004

5. Baross A, Schertzer M, Zuyderduyn SD, Jones SJ, Marra MA, Lansdorp PM. Effect of TERT and ATM on gene expression profiles in human fibroblasts. Genes Chromosomes Cancer 39(4):298-310. (2004).
    [View Abstract - PubMed 14978791]  Request Paper

6. Cheung I, Schertzer M, Baross A, Rose AM, Lansdorp PM, Baird DM. Strain-specific telomere length revealed by single telomere length analysis in Caenorhabditis elegans. Nucleic Acids Res 2004 Jun 24;32(11):3383-91. Print 2004. (2004).
    [View Abstract - PubMed 15247331]  Request Paper

7. Ding H, Schertzer M, Wu X, Gertsenstein M, Selig S, Kammori M, Pourvali R, Poon S, Vulto I, Chavez E, Tam PP, Nagy A, Lansdorp PM. Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein. Cell 117(7):873-86. (2004).
    [View Abstract - PubMed 15210109]  Request Paper

2003

8. Baerlocher GM, Lansdorp PM. Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH. Cytometry 55A(1):1-6. (2003).
    [View Abstract - PubMed 12938182]  Request Paper

9. Baerlocher GM, Mak J, Roth A, Rice KS, Lansdorp PM. Telomere shortening in leukocyte subpopulations from baboons. J Leukoc Biol 73(2):289-96. (2003).
    [View Abstract - PubMed 12554806]  Request Paper

10. Fogarty PF, Yamaguchi H, Wiestner A, Baerlocher GM, Sloand E, Zeng WS, Read EJ, Lansdorp PM, Young NS. Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet 362(9396):1628-30. (2003).
     [View Abstract - PubMed 14630445]  Request Paper

11. Roth A, Vercauteren S, Sutherland HJ, Lansdorp PM. Telomerase is limiting the growth of acute myeloid leukemia cells. Leukemia . (2003).
     [View Abstract - PubMed 14562114]  Request Paper

12. Roth A, Yssel H, Pene J, Chavez EA, Schertzer M, Lansdorp PM, Spits H, Luiten RM. Telomerase levels control the lifespan of human T lymphocytes. Blood 102(3):849-57. (2003).
     [View Abstract - PubMed 12689947]  Request Paper

13. Tchirkov A, Lansdorp PM. Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia. Hum Mol Genet 12(3):227-32. (2003).
     [View Abstract - PubMed 12554677]  Request Paper

14. Van Ziffle JA, Baerlocher GM, Lansdorp PM. Telomere length in subpopulations of human hematopoietic cells. Stem Cells 21(6):654-60. (2003).
     [View Abstract - PubMed 14595125]  Request Paper

15. Yamaguchi H, Baerlocher GM, Lansdorp PM, Chanock SJ, Nunez O, Sloand E, Young NS. Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood 102(3):916-8. Epub 2003 Apr 3. (2003).
     [View Abstract - PubMed 12676774]  Request Paper

2002

16. Cheung I, Schertzer M, Rose A, Lansdorp PM. Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Nat Genet 31(4):405-9. (2002).
     [View Abstract - PubMed 12101400]  Request Paper

17. Verfaillie CM, Pera MF, Lansdorp PM. Stem cells: hype and reality. Hematology (Am Soc Hematol Educ Program) :369-91. (2002).
     [View Abstract - PubMed 12446433]  Request Paper

2001

18. Brummendorf TH, Maciejewski JP, Mak J, Young NS, Lansdorp PM. Telomere length in leukocyte subpopulations of patients with aplastic anemia. Blood 97(4):895-900. (2001).
     [View Abstract - PubMed 11159514]  Request Paper

19. Hande MP, Balajee AS, Tchirkov A, Wynshaw-Boris A, Lansdorp PM. Extra-chromosomal telomeric DNA in cells from Atm(-/-) mice and patients with ataxia-telangiectasia. Hum Mol Genet 10(5):519-28 (with cover image) (2001).
     [View Abstract - PubMed 11181576]  Request Paper

20. Poon SS, Lansdorp PM. Measurements of telomere length on individual chromosomes by image cytometry. Methods Cell Biol 64:69-96. (2001).
     [View Abstract - PubMed 11070833]  Request Paper

21. Rufer N, Brummendorf TH, Chapuis B, Helg C, Lansdorp PM, Roosnek E. Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation. Blood 97(2):575-7. (2001).
     [View Abstract - PubMed 11154240]  Request Paper

2000

22. Brummendorf TH, Holyoake TL, Rufer N, Barnett MJ, Schulzer M, Eaves CJ, Eaves AC, Lansdorp PM. Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry. Blood 95(6):1883-90. (2000).
     [View Abstract - PubMed 10706851]  Request Paper

23. Lansdorp PM. Repair of telomeric DNA prior to replicative senescence. Mech Ageing Dev 118(1-2):23-34. (2000).
     [View Abstract - PubMed 10989122]  Request Paper

24. Lanza R, Cibelli J, Blackwell C, Cristafaldo V, Baerlocher G, Mak J, Schertzer M, Chavez E, Sawyer N, Lansdorp PM and West M. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science 288:665-669 (2000).
     [View Abstract - PubMed 10784448]  Request Paper

25. Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol 10(22):1459-62. (2000).
     [View Abstract - PubMed 11102810]  Request Paper

26. Martens UM, Chavez EA, Poon SS, Schmoor C, Lansdorp PM. Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp Cell Res 256(1):291-9. (2000).
     [View Abstract - PubMed 10739676]  Request Paper

1999

27. Hande MP, Samper E, Lansdorp P, Blasco MA. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J Cell Biol 144(4):589-601. (1999).
     [View Abstract - PubMed 10037783]  Request Paper

28. Rufer N, Brummendorf TH, Kolvraa S, Bischoff C, Christensen K, Wadsworth L, Schulzer M, Lansdorp PM. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med 190(2):157-67. (1999).
     [View Abstract - PubMed 10432279]  Request Paper

29. Surralles J, Hande MP, Marcos R, Lansdorp PM. Accelerated telomere shortening in the human inactive X chromosome. Am J Hum Genet 65(6):1617-22. (1999).
     [View Abstract - PubMed 10577915]  Request Paper

30. Wan TS, Martens UM, Poon SS, Tsao SW, Chan LC, Lansdorp PM. Absence or low number of telomere repeats at junctions of dicentric chromosomes. Genes Chromosomes Cancer 24(1):83-6. (1999).
     [View Abstract - PubMed 9892113]  Request Paper

31. d'Adda di Fagagna F, Hande MP, Tong WM, Lansdorp PM, Wang ZQ, Jackson SP. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nat Genet 23(1):76-80. (1999).
     [View Abstract - PubMed 10471503]  Request Paper

1998

32. Brummnedorf, T.H., Dragowska, W. Zijlmans, J.M.J.M., Thornbury, G. and P.M. Lansdorp. Asymmetric cell divisions sustain long-term hematopoiesis from single-sorted human fetal liver cells. J. Exp. Med. 188: 1117-1124 (1998).
     [View Abstract - PubMed 9743530]  Request Paper

33. Martens UM, Zijlmans JM, Poon SS, Dragowska W, Yui J, Chavez EA, Ward RK, Lansdorp PM. Short telomeres on human chromosome 17p. Nat Genet 18(1):76-80. (1998).
     [View Abstract - PubMed 9425906]  Request Paper

34. Rufer N., Dragowska, W. Thornbury, G. Roosnek, E. and P. M. Lansdorp. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nature Biotechnology 16:743-747 (1998).
     [View Abstract - PubMed 9702772]  Request Paper

35. Yui J, Chiu CP, Lansdorp PM. Telomerase activity in candidate stem cells from fetal liver and adult bone marrow. Blood 91(9):3255-62. (1998).
     [View Abstract - PubMed 9558381]  Request Paper

1997

36. Blasco, M.A., H.-W. Lee, M.P. Hande, E. Samper, P.M. Lansdorp, R.A. DePinho and C.W. Greider. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91: 25-34 (with cover image) (1997).
     [View Abstract - PubMed 9335332]  Request Paper

37. Lansdorp PM. Self-renewal of stem cells. Biol Blood Marrow Transplant 3(4):171-8. (1997).
     [View Abstract - PubMed 9360778]  Request Paper

38. Zijlmans JM, Martens UM, Poon SS, Raap AK, Tanke HJ, Ward RK, Lansdorp PM. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci U S A 94(14):7423-8. (1997).
     [View Abstract - PubMed 9207107]  Request Paper

1996

39. Chiu CP, Dragowska W, Kim NW, Vaziri H, Yui J, Thomas TE, Harley CB, Lansdorp PM. Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells 14(2):239-48. (1996).
     [View Abstract - PubMed 8991544]  Request Paper

40. Lansdorp PM, Verwoerd NP, van de Rijke FM, Dragowska V, Little MT, Dirks RW, Raap AK, Tanke HJ. Heterogeneity in telomere length of human chromosomes. Hum Mol Genet 5(5):685-91. (1996).
     [View Abstract - PubMed 8733138]  Request Paper

41. Rebel VI, Miller CL, Eaves CJ, Lansdorp PM. The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts. Blood 87(8):3500-7. (1996).
     [View Abstract - PubMed 8605370]  Request Paper

1995

42. Lansdorp PM. Developmental changes in the function of hematopoietic stem cells. Exp Hematol 23(3):187-91. (1995).
     [View Abstract - PubMed 7875237]  Request Paper

43. Sauvageau G, Thorsteinsdottir U, Eaves CJ, Lawrence HJ, Largman C, Lansdorp PM, Humphries RK. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 9(14):1753-65. (1995).
     [View Abstract - PubMed 7622039]  Request Paper

1994

44. Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci U S A 91(21):9857-60. (1994).
     [View Abstract - PubMed 7937905]  Request Paper

1993

45. Lansdorp PM, Dragowska W, Mayani H. Ontogeny-related changes in proliferative potential of human hematopoietic cells. J Exp Med 178(3):787-91. (1993).
     [View Abstract - PubMed 7688789]  Request Paper

1992

46. Lansdorp PM, Dragowska W. Long-term erythropoiesis from constant numbers of CD34+ cells in serum-free cultures initiated with highly purified progenitor cells from human bone marrow. J Exp Med 175(6):1501-9. (1992).
     [View Abstract - PubMed 1375263]  Request Paper

1990

47. Lansdorp PM, Sutherland HJ, Eaves CJ. Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow. J Exp Med 172(1):363-6. (1990).
     [View Abstract - PubMed 1694223]  Request Paper

1989

48. Sutherland HJ, Eaves CJ, Eaves AC, Dragowska W, Lansdorp PM. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 74(5):1563-70. (1989).
     [View Abstract - PubMed 2790186]  Request Paper

1988

49. van den Engh G, Trask B, Lansdorp P, Gray J. Improved resolution of flow cytometric measurements of Hoechst- and chromomycin-A3-stained human chromosomes after addition of citrate and sulfite. Cytometry 9(3):266-70. (1988).
     [View Abstract - PubMed 2454178]  Request Paper

1986

50. Lansdorp PM, Aalberse RC, Bos R, Schutter WG, Van Bruggen EF. Cyclic tetramolecular complexes of monoclonal antibodies: a new type of cross-linking reagent. Eur J Immunol 16(6):679-83. (1986).
     [View Abstract - PubMed 3459660]  Request Paper