Publications by Peter M. Lansdorp

2005

Lansdorp PM.Major cutbacks at chromosome ends. Trends Biochem Sci 30(7):388-95. (2005).
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Roth A, Baerlocher GM, Schertzer M, Chavez E, Duhrsen U, Lansdorp PM. Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT. Blood 106(1):43-50. Epub 2005 Mar 1. (2005).
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Yamaguchi H, Calado RT, Ly H, Kajigaya S, Baerlocher GM, Chanock SJ, Lansdorp PM, Young NS. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med 352(14):1413-24. (2005).
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2004

Baross A, Schertzer M, Zuyderduyn SD, Jones SJ, Marra MA, Lansdorp PM. Effect of TERT and ATM on gene expression profiles in human fibroblasts. Genes Chromosomes Cancer 39(4):298-310. (2004).
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Cheung I, Schertzer M, Baross A, Rose AM, Lansdorp PM, Baird DM. Strain-specific telomere length revealed by single telomere length analysis in Caenorhabditis elegans. Nucleic Acids Res 2004 Jun 24;32(11):3383-91. Print 2004. (2004).
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Ding H, Schertzer M, Wu X, Gertsenstein M, Selig S, Kammori M, Pourvali R, Poon S, Vulto I, Chavez E, Tam PP, Nagy A, Lansdorp PM. Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein. Cell 117(7):873-86. (2004).
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2003

Baerlocher GM, Lansdorp PM. Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH. Cytometry 55A(1):1-6. (2003).
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Baerlocher GM, Mak J, Roth A, Rice KS, Lansdorp PM.Telomere shortening in leukocyte subpopulations from baboons. J Leukoc Biol 73(2):289-96. (2003).
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Fogarty PF, Yamaguchi H, Wiestner A, Baerlocher GM, Sloand E, Zeng WS, Read EJ, Lansdorp PM, Young NS. Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet 362(9396):1628-30. (2003).
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Roth A, Vercauteren S, Sutherland HJ, Lansdorp PM. Telomerase is limiting the growth of acute myeloid leukemia cells. Leukemia . (2003).
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Roth A, Yssel H, Pene J, Chavez EA, Schertzer M, Lansdorp PM, Spits H, Luiten RM. Telomerase levels control the lifespan of human T lymphocytes. Blood 102(3):849-57. (2003).
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Tchirkov A, Lansdorp PM. Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia. Hum Mol Genet 12(3):227-32. (2003).
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Van Ziffle JA, Baerlocher GM, Lansdorp PM.Telomere length in subpopulations of human hematopoietic cells. Stem Cells 21(6):654-60. (2003).
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Yamaguchi H, Baerlocher GM, Lansdorp PM, Chanock SJ, Nunez O, Sloand E, Young NS.Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood 102(3):916-8. Epub 2003 Apr 3. (2003).
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Ning Y, Xu JF, Li Y, Chavez L, Riethman HC, Lansdorp PM, Weng NP. Telomere length and the expression of natural telomeric genes in human fibroblasts. Hum Mol Genet 12(11):1329-36. (2003).
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2002

Cheung I, Schertzer M, Rose A, Lansdorp PM. Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Nat Genet 31(4):405-9. (2002).
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Baerlocher GM, Mak J, Tien T, Lansdorp PM. Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls. Cytometry 47(2):89-99. (2002).
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2001

Rufer N, Brummendorf TH, Chapuis B, Helg C, Lansdorp PM, Roosnek E. Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation. Blood 97(2):575-7. (2001).
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Brummendorf TH, Maciejewski JP, Mak J, Young NS, Lansdorp PM. Telomere length in leukocyte subpopulations of patients with aplastic anemia. Blood 97(4):895-900. (2001).
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Brummendorf TH, Maciejewski JP, Mak J, Young NS, Lansdorp PM. Telomere length in leukocyte subpopulations of patients with aplastic anemia. Blood 97(4):895-900. (2001).
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Rufer N, Migliaccio M, Antonchuk J, Humphries RK, Roosnek E, Lansdorp PM. Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood 98(3):597-603. (2001).
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Rufer N, Brummendorf TH, Chapuis B, Helg C, Lansdorp PM, Roosnek E. Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation. Blood 97(2):575-7. (2001).
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2000

Lanza R, Cibelli J, Blackwell C, Cristafaldo V, Baerlocher G, Mak J, Schertzer M, Chavez E, Sawyer N, Lansdorp PM and West M. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science 288:665-669 (2000).
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Brummendorf TH, Holyoake TL, Rufer N, Barnett MJ, Schulzer M, Eaves CJ, Eaves AC, Lansdorp PM. Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry. Blood 95(6):1883-90. (2000).
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1999

Poon SS, Martens UM, Ward RK, Lansdorp PM. Telomere length measurements using digital fluorescence microscopy. Cytometry 1999 Aug 1;36(4):267-78.
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Rufer N, Brummendorf TH, Kolvraa S, Bischoff C, Christensen K, Wadsworth L, Schulzer M, Lansdorp PM. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med 190(2):157-67. (1999).
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Surralles J, Hande MP, Marcos R, Lansdorp PM. Accelerated telomere shortening in the human inactive X chromosome. Am J Hum Genet 65(6):1617-22. (1999).
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1998

Yui J, Chiu CP, Lansdorp PM. Telomerase activity in candidate stem cells from fetal liver and adult bone marrow. Blood 91(9):3255-62. (1998).
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Brummnedorf, T.H., Dragowska, W. Zijlmans, J.M.J.M., Thornbury, G. and P.M. Lansdorp. Asymmetric cell divisions sustain long-term hematopoiesis from single-sorted human fetal liver cells. J. Exp. Med. 188: 1117-1124 (1998).
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1996

Lansdorp PM, Verwoerd NP, van de Rijke FM, Dragowska V, Little MT, Dirks RW, Raap AK, Tanke HJ. Heterogeneity in telomere length of human chromosomes. Hum Mol Genet 5(5):685-91. (1996).
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