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2009

1. Heuser M, Yap DB, Leung M, de Algara TR, Tafech A, McKinney S, Dixon J, Thresher R, Colledge B, Carlton M, Humphries RK, Aparicio SA. Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation. Blood. 113(7):1432-43. Epub 2008 Oct 14. (2009).
    [View Abstract - PubMed 18854576]  Request Paper

2. Shah SP, Kobel M, Senz J, Morin RD, Clarke BA, Wiegand KC, Leung G, Zayed A, Mehl E, Kalloger SE, Sun M, Giuliany R, Yorida E, Jones S, Varhol R, Swenerton KD, Miller D, Clement PB, Crane C, Madore J, Provencher D, Leung P, Defazio A, Khattra J, Turashvili G, Zhao Y, Zeng T, Glover JN, Vanderhyden B, Zhao C, Parkinson CA, Jimenez-Linan M, Bowtell DD, Mes-Masson AM, Brenton JD, Aparicio SA, Boyd N, Hirst M, Gilks CB, Marra M, Huntsman DG. Mutation of FOXL2 in Granulosa-Cell Tumors of the Ovary. N Engl J Med. 2009 Jun 10. (2009).
    [View Abstract - PubMed 19516027]  Request Paper

3. Turashvili G, Leung S, Turbin D, Montgomery K, Gilks B, West R, Carrier M, Huntsman D, Aparicio S. Inter-observer reproducibility of HER2 immunohistochemical assessment and concordance with fluorescent in situ hybridization (FISH): pathologist assessment compared to quantitative image analysis. BMC Cancer. 9(1):165. (2009).
    [View Abstract - PubMed 19476653]  Request Paper

4. Turashvili G, McKinney S, Martin L, Gelmon KA, Watson P, Boyd N, Aparicio S. Columnar cell lesions, mammographic density and breast cancer risk. Breast Cancer Res Treat. 115(3):561-71. Epub 2008 Jun 28. (2009).
    [View Abstract - PubMed 18587641]  Request Paper

2008

5. Eirew P, Stingl J, Raouf A, Turashvili G, Aparicio S, Emerman JT, Eaves CJ. A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med. 14(12):1384-9. Epub 2008 Nov 23. (2008).
    [View Abstract - PubMed 19029987]  Request Paper

6. Poon SS, Wong JT, Saunders DN, Ma QC, McKinney S, Fee J, Aparicio SA. Intensity calibration and automated cell cycle gating for high-throughput image-based siRNA screens of mammalian cells. Cytometry A. 73(10):904-17. (2008).
    [View Abstract - PubMed 18698634]  Request Paper

7. Raouf A, Zhao Y, To K, Stingl J, Delaney A, Barbara M, Iscove N, Jones S, McKinney S, Emerman J, Aparicio S, Marra M, Eaves C. Transcriptome analysis of the normal human mammary cell commitment and differentiation process. Cell Stem Cell. 3(1):109-18. (2008).
    [View Abstract - PubMed 18593563]  Request Paper

8. Vessey JP, Macchi P, Stein JM, Mikl M, Hawker KN, Vogelsang P, Wieczorek K, Vendra G, Riefler J, Tubing F, Aparicio SA, Abel T, Kiebler MA. A loss of function allele for murine Staufen1 leads to impairment of dendritic Staufen1-RNP delivery and dendritic spine morphogenesis. Proc Natl Acad Sci U S A. 105(42):16374-9. Epub 2008 Oct 15. (2008).
    [View Abstract - PubMed 18922781]  Request Paper

2007

9. Chin SF, Wang Y, Thorne NP, Teschendorff AE, Pinder SE, Vias M, Naderi A, Roberts I, Barbosa-Morais NL, Garcia MJ, Iyer NG, Kranjac T, Robertson JF, Aparicio S, Tavaré S, Ellis I, Brenton JD, Caldas C. Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers. Oncogene 26(13):1959-1970 (2007).
    [View Abstract - PubMed 17001317]  Request Paper

10. Iyer NG, Xian J, Chin SF, Bannister AJ, Daigo Y, Aparicio S, Kouzarides T, Caldas C. p300 is required for orderly G1/S transition in human cancer cells. Oncogene 26(1):21-29 (2007).
     [View Abstract - PubMed 16878158]  Request Paper

11. Naderi A, Teschendorff AE, Barbosa-Morais NL, Pinder SE, Green AR, Powe DG, Robertson JF, Aparicio S, Ellis IO, Brenton JD, Caldas C. A gene-expression signature to predict survival in breast cancer across independent data sets. Oncogene 26(10):1507-1516 (2007).
     [View Abstract - PubMed 16936776]  Request Paper

12. Prentice LM, Klausen C, Kalloger S, Koebel M, McKinney S, Santos JL, Kenney C, Mehl E, Gilks CB, Leung P, Swenerton K, Huntsman DG, Aparicio SA. Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma BMC Medicine 5(1): 33 (2007).
     [View Abstract - PubMed 18005407]  Request Paper

13. Stratford AL, Habibi G, Astanehe A, Jiang H, Hu K, Park E, Shadeo A, Buys TP, Lam W, Pugh T, Marra M, Nielsen TO, Klinge U, Mertens PR, Aparicio S, Dunn SE. Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy. Breast Cancer Res 9(5):R61 (2007).
     [View Abstract - PubMed 17875215]  Request Paper

14. d'Anglemont de Tassigny X, Fagg LA, Dixon JP, Day K, Leitch HG, Hendrick AG, Zahn D, Franceschini I, Caraty A, Carlton MB, Aparicio SA, Colledge WH. Hypogonadotrophic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci USA 104(25):10714-10719 (2007).
     [View Abstract - PubMed 17563351]  Request Paper

2006

15. Barbosa-Morais NL, Carmo-Fonseca M, Aparicio S. Systematic genome-wide annotation of spliceosomal proteins reveals differential gene family expansion. Genome Res 16(1):66-77 (2006).
     [View Abstract - PubMed 16344558]  Request Paper

16. Teschendorff AE, Naderi A, Barbosa-Morais NL, Pinder SE, Ellis IO, Aparicio S, Brenton JD, Caldas C. A consensus prognostic gene expression classifier for ER positive breast cancer. Genome Biol :7(10):R101 (2006).
     [View Abstract - PubMed 17076897]  Request Paper

2005

17. Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. Diabetes 54(6):1706-1716 (2005).
     [View Abstract - PubMed 15919792]  Request Paper

18. Messager S, Chatzidaki EE, Ma D, Hendrick AG, Zahn D, Dixon J, Thresher RR, Malinge I, Lomet D, Carlton MB, Colledge WH, Caraty A, Aparicio SA. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci USA 102(5):1761-1766 (2005).
     [View Abstract - PubMed 15665093]  Request Paper

19. Semple RK, Achermann JC, Ellery J, Farooqi IS, Karet FE, Stanhope RG, O'Rahilly S, Aparicio SA. Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism. J Clin Endocrinol Metab 90(3):1849-1855 (2005).
     [View Abstract - PubMed 15598687]  Request Paper

2004

20. Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, Carlton MB, O'Rahilly S. Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc Natl Acad Sci USA 101(13):4695-4700 (2004).
     [View Abstract - PubMed 15070780]  Request Paper

21. Christoffels A, Koh EG, Chia JM, Brenner S, Aparicio S, Venkatesh B. Fugu genome analysis provides evidence for a whole-genome duplication early during the evolution of ray-finned fishes. Mol Biol Evol 21(6):1146-1151 (2004).
     [View Abstract - PubMed 15014147]  Request Paper

22. Iyer NG, Chin SF, Ozdag H, Daigo Y, Hu DE, Cariati M, Brindle K, Aparicio S, Caldas C. p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels. Proc Natl Acad Sci USA 101(19):7386-7391 (2004).
     [View Abstract - PubMed 15123817]  Request Paper

23. Naderi A, Ahmed AA, Barbosa-Morais NL, Aparicio S, Brenton JD, Caldas C. Expression microarray reproducibility is improved by optimising purification steps in RNA amplification and labelling. BMC Genomics 5(1):9 (2004).
     [View Abstract - PubMed 15005798]  Request Paper

2003

24. Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell 115(5):523-535 (2003).
     [View Abstract - PubMed 14651845]  Request Paper

25. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS Jr, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF Jr, Aparicio SA, Colledge WH. The GPR54 gene as a regulator of puberty. N Engl J Med 349(17) 1614-1627 (2003).
     [View Abstract - PubMed 14573733]  Request Paper

2002

26. Aparicio S, Chapman J, Stupka E, Putnam N, Chia JM, Dehal P, Christoffels A, Rash S, Hoon S, Smit A, Gelpke MD, Roach J, Oh T, Ho IY, Wong M, Detter C, Verhoef F, Predki P, Tay A, Lucas S, Richardson P, Smith SF, Clark MS, Edwards YJ, Doggett N, Zharkikh A, Tavtigian SV, Pruss D, Barnstead M, Evans C, Baden H, Powell J, Glusman G, Rowen L, Hood L, Tan YH, Elgar G, Hawkins T, Venkatesh B, Rokhsar D, Brenner S. Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science 297(5585):1301-1310 (2002).
     [View Abstract - PubMed 12142439]  Request Paper

27. Caldas C, Aparicio SA. The molecular outlook. Nature 415(6871) 484-485 (2002).
     [View Abstract - PubMed 11831227]  Request Paper

2008

1. Turashvili G, Hayes M, Gilks B, Watson P, Aparicio S. Are columnar cell lesions the earliest histologically detectable non-obligate precursor of breast cancer? Virchows Arch. 452(6):589-98. Epub 2008 Apr 24. (2008).
    [View Abstract - PubMed 18437416]  Request Paper

2005

2. Aparicio SA. Kisspeptins and GPR54--the new biology of the mammalian GnRH axis. Cell Metab 1(5): 293-296 (2005).
    [View Abstract - PubMed 16054076]  Request Paper

2004

3. Aparicio SA, Powell J. Genetic approaches to unraveling G protein-coupled receptor biology. Curr Opin Drug Discov Devel 7(5):658-664 (2004).
    [View Abstract - PubMed 15503868]  Request Paper

2005

1. Aparicio S. Genome Archaeology - an overview. in Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics: Wiley & Sons Ltd. (2005).
    Request Paper