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2007

1. Jin W, Yun C, Martin MJ, Sorensen PHB, and Kim, SJ. Cellular transformation and activation of the PI3K-Akt cascade by the ETV6-NTRK3 chimeric tyrosine kinase requires c-Src. Cancer Research 67:3192-3200 (2007).
    [View Abstract - PubMed 17409427]  Request Paper

2. Kang HG, Zhang J, Jenabi J, Keshelava N, May WA, Reynolds CP, Triche TJ, and Sorensen PH. E-cadherin cell-cell adhesion in sarcoma cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase. Cancer Research 67:3094-3105 (2007).
    [View Abstract - PubMed 17409416]  Request Paper

3. Li Z, Tognon C, Godinho FJ, Yasaitis L, Hock H, Herschkowitz JI, Lannon CL, Cho E, Kim SJ, Bronson RT, Perou CM, Sorensen PH, and Orkin SH. ETV6-NTRK3 fusion oncogene initiates breast cancer from bipotent alveolar progenitors via activation of AP1 complex. Cancer Cell 12:542-58 (2007).
    [View Abstract - PubMed 18068631]  Request Paper

4. Ng TL, O'Sullivan MJ, Pallen CJ, Hayes M, Clarkson PW, Winstanley M, Sorensen PH, Nielsen TO, Horsman DE. Ewing Sarcoma with novel translocation t(2;16) producing an in- frame fusion of FUS and FEV. J Mol Diagn 9:459-63 (2007).
    [View Abstract - PubMed 17620387]  Request Paper

5. Parham DM, Qualman S, Teot L, Barr FG, Morotti R, Sorensen PH, Triche TJ, and Meyer W. Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. Am J Pathol 31:895-901 (2007).
    [View Abstract - PubMed 17527077]  Request Paper

6. Pratscher B, Friedrich C, Goger W, Allen M, Fink D, Thallinger C, Wolscheck M, Frei K, Schofer C, Pehamberger H, Wachek V, Sorensen PH, Muller M, Jansen B, Lucas T. Characterization of NKIP: a novel, Na⁺/K⁺-ATPase interacting protein mediates neural differentiation and apoptosis. Exp Cell Research (2007).
    [View Abstract - PubMed 18096156]  Request Paper

7. Zhang L, Anglesio MS, Zhang F, Yang G, Sarao R, Cronin S, Hara H, Evdokimova V, Nghien M, Arya S, Wada T, Liu PP, Sorensen PHB, and Penninger JM. The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med. 13:1060-1069 (2007).
    [View Abstract - PubMed 17694067]  Request Paper

2006

8. Evdokimova V, Ruzanov P, Anglesio MS, Zhang F, Ovchinnikov L, Buckley J, Triche TJ, and Sorensen PHB. Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species. Mol Cell Biol 26:277-92 (2006).
    [View Abstract - PubMed 16354698]  Request Paper

9. Huang CC, Cutcliffe C, Coffin CM, Sorensen PH, Beckwith B, Perlman E. Classification of malignant pediatric renal tumors by gene expression. Pediatric Blood and Cancer 46:728-38 (2006).
    [View Abstract - PubMed 16425275]  Request Paper

10. Martin MJ, Melnyk N, Pollard M, Bowden M, Gleave M, and Sorensen PHB. The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase. Mol Cell Biol 26:1754-69 (2006).
     [View Abstract - PubMed 16478996]  Request Paper

2005

11. Jin W, Kim BC, Tognon C, Lee HJ, Pate Sl, Lannon CL, Triche TJ , Sorensen PHB, and Kim SJ. The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-β signaling by binding to the TGF-β type II receptor Proc Nat Acad Sci USA 102:16239-44 (2005).
     [View Abstract - PubMed 16258068]  Request Paper

12. Lucas T, Pratscher B, Fink D, Wolschek M, Samorapoompichit P, Schofer C, Pehamberger H, Muller M, Sorensen P, Jansen B. The human orthologue of a novel apoptosis response gene induced during rat myelomonocytic stem cell apoptosis maps to 20q13.12. Stem Cells Dev 14:556-63 (2005).
     [View Abstract - PubMed 16305340]  Request Paper

13. Sorokin AV, Skabkin MA, Guryanov SG, Selutina AA, Nazimov IV, Richard C, Th'ng J, Yau J, Sorensen PHB, Ovchinnikov LP and Evdokimova V. Proteasome-mediated cleavage of the multifunctional protein YB-1 is linked to DNA-damage stress response. EMBO J 24:3602-12 (2005).
     [View Abstract - PubMed 16193061]  Request Paper

2004

14. Anglesio MS, Evdokimova V, Melynk N, Zhang L, Fernandez C, Gruday PE, Leach S, Marra MA, Brooks-Wilson AR, Penninger J, and Sorensen PHB. Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumour versus normal kidney. Hum Mol Genet 13:2061-74 (2004).
     [View Abstract - PubMed 15254018]  Request Paper

15. Lannon CL, Martin MJ, Tognon CE, Jin W, Kim SK, and Sorensen PHB. A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the PTB domain of IRS-1: an essential interaction for transformation. J Biol Chem 279:6225-34 (2004).
     [View Abstract - PubMed 14668342]  Request Paper

16. Makretsov N, He M, Hayes M, Chia S, Horsman D, Sorensen PHB, Huntsman D. A fluorescence in situ hybridization study of ETV6-NTRK3 fusion gene in secretary breast carcinoma. Genes, Chromosomes and Cancer 40:152-157 (2004).
     [View Abstract - PubMed 15101049]  Request Paper

17. Tognon CE, Mackereth CD, Somasiri AM, McIntosh LP, Sorensen PHB. Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity. Mol Cell Biol 24:4636-50 (2004).
     [View Abstract - PubMed 15143160]  Request Paper

18. Zhang J, Hu S, Schofield DE, Sorensen PHB, Triche TJ. Selective usage of D-Type cyclins by Ewing's tumors and rhabdomyosarcomas. Cancer Res 17:6026-34 (2004).
     [View Abstract - PubMed 15342383]  Request Paper

2003

19. Bayani J, Zielenska M, Paridita A, Al-Romaih K, Karaskova J, Harrison K, Bridge JA, Sorensen P, Thorner P, Squire JA. Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17 and 20 in osteosarcomas. Genes Chromosomes Cancer 36:7-16 (2003).
     [View Abstract - PubMed 12461745]  Request Paper

20. Diallo R, Schaefer K-L, Ankfalvi A, Decker T, Ruhnke M, Wulfing P, Jackisch C, Luttges J, Sorensen PHB, Singh M, Proremba C. Secretory carcinoma of the breast: a distinct variant of invasive ductal carcinoma assessed by comparative genomic hybridization and immunohistochemistry. Hum Pathol 34:1299-305 (2003).
     [View Abstract - PubMed 14691916]  Request Paper

21. Diallo R, Tognon C, Knezevich SR, Sorensen PHB, Poremba C. Secretory carcinoma of the breast: a genetically defined carcinoma entity. Verh Dtsch Ges Pathol 193-203 (2003).
     [View Abstract - PubMed 16888913]  Request Paper

22. McCahon E, Sorensen PHB, Davis JH, Rogers PC, Schultz KR . Non-resectable congenital tumors with the ETV6-NTRK3 gene fusion are highly responsive to chemotherapy. Med Pediatr Onc 40:288-92 (2003).
     [View Abstract - PubMed 12652616]  Request Paper

23. Nielsen TO, Hsu FD, O'Connell JX, Gilks CB, Sorensen PHB, Linn S, West RB, Liu CL, Botstein D, Brown PO, and van de Rijn M. Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology. Am J Pathol 163: 1449-1456 (2003).
     [View Abstract - PubMed 14507652]  Request Paper

2002

24. Alessandri AJ, Reid GSD, Bader SA, Massing BG, Sorensen PHB, Schultz KR. ETV6 (TEL)-acute myeloid leukaemia (AML)1 pre-B acute lymphoblastic leukaemia cells are associated with a distinct antigen-presenting phenotype. Brit J Haematology 116:1-7 (2002).
     [View Abstract - PubMed 11841426]  Request Paper

25. Barr FG, Qualman SJ, Macris MH, Melnyk N, Lawlor ER, Strzelecki DM, Triche TJ, Bridge JA, and Sorensen PHB. Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions. Cancer Res 62:4704-10 (2002).
     [View Abstract - PubMed 12183429]  Request Paper

26. Bridge JA, Liu J, Qualman SJ, Suijkerbuijk R, Wenger G, Zhang J, Wan X, Baker KS, Sorensen PHB, Barr FG . Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes. Genes, Chromosomes and Cancer 33:310-321 (2002).
     [View Abstract - PubMed 11807989]  Request Paper

27. Lawlor ER, Scheel C, Irving J, and Sorensen PHB. Anchorage independent growth signaling in Ewing tumor cells differs from signaling in adherent monolayers. Oncogene 21:307-18 (2002).
     [View Abstract - PubMed 11803474]  Request Paper

28. Lestou VS, O'Connell J, Robichaudl M, Salskil C, Mathers J, Maguire J,Chudoba I, Sorensen PHB, Lam W, Horsman DE. Cryptic t(X;18), ins(6;18) and SYT-SSX2 gene fusion in a case of intraneural monophasic synovial sarcoma. Cancer Genet Cytogenet 138:153-156 (2002).
     [View Abstract - PubMed 12505262]  Request Paper

29. Morrison KB, Tognon CE, Garnett MJ, Deal C, and Sorensen PHB. ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation. Oncogene 21:5684-5695 (2002).
     [View Abstract - PubMed 12173038]  Request Paper

30. Sorensen PHB, Lynch JC, Qualman SJ, Tirabosco R, Lim JF, Maurer H, Crist W, Bridge J, Triche TJ, and Barr FG. PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. J Clin Onc 11:2672-9 (2002).
     [View Abstract - PubMed 12039929]  Request Paper

31. Syed S, Haque AK, Hawkins HK, Sorensen PHB, Cowan DF. Desmoplastic small round cell tumor of the lung. Arch Pathol Lab Med 126:1226-8 (2002).
     [View Abstract - PubMed 12296765]  Request Paper

32. Tognon C, Knezevich SR, Huntsman D, Roskelley CD, Melnyk N, Mathers J, Becker L, Carneiro F, MacPherson N, Horsman D, Poremba C and Sorensen PHB. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell 2:367-76 (2002).
     [View Abstract - PubMed 12450792]  Request Paper

2006

1. Evdokimova V, Ovchinnikov LP, and Sorensen PH. Y-box binding protein 1: providing a new angle on translational regulation. Cell Cycle 5:1143-7 (2006).
    [View Abstract - PubMed 16721060]  Request Paper

2005

2. Lannon CL and Sorensen PHB. ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Seminars in Cancer Biology 15:215-23 (2005).
    [View Abstract - PubMed 15826836]  Request Paper

2006

1. Triche TJ, Hicks J and Sorensen PHB. Diagnostic Pathology of Pediatric malignancies. in Principles and Practice of Pediatric Oncology, 5th Edition. Pizzo PA, Poplack DG, Eds. Lippincott-Raven Publishers (2006).
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2004

2. Tognon CE, Huntsman D, and Sorensen PHB. Expression of the ETV6-NTRK3 gene fusion in human secretory breast carcinoma. handbooks: immunohistochemistry and in situ hybridization of human carcinomas. Elsevier Science/Academic Press, Volume II 493-503 (2004).
    Request Paper

2002

3. Sorensen PHB. ETV6-NTRK3 gene fusions in spindle cell tumors of early childhood. in Translocations in Solid Tumours. Cooper, C, Ed. Landes Biosciences 119-132 (2002).
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4. Triche TJ, and Sorensen PHB. Molecular pathology of pediatric malignancies. in Principles and Practice of Pediatric Oncology, 4th Edition. Pizzo, PA, and Poplack, DG, Eds. Lippincott-Raven Publishers (2002).
    Request Paper