Sohrab Shah - Research Home Page [Molecular Oncology and Breast Cancer Program : BC Cancer Research Centre]

Molecular Oncology and Breast Cancer Program

Dr. Sohrab P. Shah, PhD

sshah@bccrc.ca

Department:	Molecular Oncology and Breast Cancer Program (@ the BCCRC since 2006)
Research Role:	Postdoctoral Fellow
Advisor:	Sam Aparicio
Education:	PhD (Computer science/Bioinformatics), UBC, 2008
Phone:	604-877-6000 ext.2589

Research Interests:

My research interests are in profiling subtypes of ovarian and breast cancer with next generation sequencing technology. In particular, I develop statistical models and bioinformatics approaches to identify mutational profiles specific to the known classes of these cancers.

Selected Publications and Presentations

Sohrab P. Shah, Martin Kobel, Janine Senz, Ryan D. Morin, Blaise A. Clarke, Kimberly C. Wiegand, Gillian Leung, Abdalnasser Zayed, Erika Mehl, Steve E. Kalloger, Mark Sun, Ryan Giuliany, Erika Yorida, Steven Jones, Richard Varhol, Kenneth D. Swenerton, Dianne Miller, Philip B. Clement, Colleen Crane, Jason Madore, Diane Provencher, Peter Leung, Anna DeFazio, Jaswinder Khattra1, Gulisa Turashvili, Yongjun Zhao, Thomas Zeng, J. N. Mark Glover, Barbara Vanderhyden, Chengquan Zhao, Christine A. Parkinson, Mercedes Jimenez-Linan, David D.L. Bowtell, Anne-Marie Mes-Masson, James D. Brenton , Samuel A. Aparicio, Niki Boyd, Martin Hirst, C. Blake Gilks, Marco Marra, David G. Huntsman. Mutation of FOXL2 in granulosa cell tumors of the ovary. New England Journal of Medicine, 2009.

Sohrab P. Shah, K-John Cheung, Jr, Nathalie A. Johnson, Guillaume Alain, Randy D. Gascoyne, Douglas E. Horsman, Raymond T. Ng and Kevin P. Murphy. Model-based clustering of array CGH data Bioinformatics 2009 25(12):i30-i38 [PDF]

Shah SP. Computational methods for identification of recurrent copy number alteration patterns by array CGH. Cytogenetic and Genome Research In press.

Cheung KJ*, Shah SP*, Steidl C, Johnson N, Relander T, Telenius A, Lai B, Murphy KP, Lam W, Al-Tourah AJ, Connors JM, Ng RT, Gascoyne RD, Horsman DE. Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances. Blood. 2008 Aug 14.
(* - Contributed equally)

S P Shah, W L Lam, R T Ng, K P Murphy. Modeling recurrent DNA copy number alterations in array CGH data Bioinformatics 2007 Jul 1;23(13):i450-8 [Software] [PDF] [Talk slides from ISMB 2007]

S Shah, X Xuang, R DeLeeuw, M Khojasteh, W Lam, R Ng, K Murphy Integrating copy number polymorphisms into array CGH analysis using a robust HMM Bioinformatics 2006 Jul 15;22(14):e431-9 [Software] [PDF]

Mehrnoush Khojasteh, Bradley P. Coe, Sohrab Shah, Rabab K. Ward, Wan L. Lam, Calum MacAulay A Novel Algorithm for the Analysis of Array CGH Data ICASSP 2006

Kemmer D, Huang Y, Shah SP, Lim J, Brumm J, Yuen MM, Ling J, Xu T, Wasserman WW, Ouellette BF Ulysses - an application for the projection of molecular interactions across species. Genome Biol. 2005; 6(12): R106 [PDF][Web server]

Shah SP. Detecting common secondary structure elements in RNA sequences. MSc Thesis. May 2005 [PDF]

Shah SP, Huang Y, Xu T, Yuen MM, Ling J, Ouellette BF. Atlas - a data warehouse for integrative bioinformatics. BMC Bioinformatics. 2005 Feb 21;6(1):34 [Software]

Shah SP, He DY, Sawkins JN, Druce JC, Quon G, Lett D, Zheng GX, Xu T, Ouellette BF. Pegasys: software for executing and integrating analyses of biological sequences. BMC Bioinformatics 5(1):40. (2004). [Software]

Shah SP,McVicker GP,Mackworth AK,Rogic S,Ouellette BF. GeneComber: combining outputs of gene prediction programs for improved results. Bioinformatics 19(10):1296-7. (2003).