Poul HB Sorensen, MD, PhD

 psor@interchange.ubc.ca

• Johal Chair in Childhood Cancer Research and Professor, Department of Pathology, University of British Columbia
• Senior Scientist, BC Cancer Research Centre
• Director, Division of Tumour Genetics
• Professor,  Pathology & Laboratory Medicine,  UBC

  View Publications

Department:	Molecular Oncology and Breast Cancer Program (@ the BCCRC since 2006)
Research Role:	Senior Scientist
Postdoctoral Fellows:	Dieter Fink Barak Rotblat
Graduate Students:	Paul Clarkson Gabriel Leprivier Tony Ng
Other lab members:	Jenny Potratz Valentina Evdokimova Amy Li Nataliya Melnyk Michelle Pollard
Education:	PhD, University of British Columbia, Canada, 1990 MD, University of British Columbia, Canada, 1984 BSc (Chemistry / Biochemistry), McGill University, Montreal, Canada, 1980
Birthplace:	Copenhagen, Denmark
Phone:	604-675-8000 ext.8202
Fax:	675 8218

Research Interests:

Molecular signalling pathways in childhood cancers

Cancer occurs when the molecular signals that usually regulate cell growth and division are disrupted. The molecules that are responsible for these changes in childhood tumours have not received as much attention as their counterparts in cancers that tend to affect adults. However, my laboratory has identified several molecules that are specifically altered in a range of childhood cancers. We are now in the process of determining how these molecules transmit the signals that cause cells to become cancerous. A large part of our future work will involve screening the entire human genome to find genes and proteins that interact with the signalling molecules we have identified to date. We will then verify that each identified molecule is genuinely involved in the regulation of cell growth and division by studying its role in normal and cancer cells, and in animal models that allow us to study the development and spread of various types of cancer. Every genuine interaction partner that we discover has the potential to be targeted by new chemotherapy drugs. Our eventual aim is to translate our discoveries into clinical trials of new treatments for childhood cancers that have the potential to reverse the signalling defects found in cancerous cells, and hence attack the tumour while leaving normal cells unharmed.

View my recent publications

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