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2007

1. Dragowska WH, Verreault M, Yapp DT, Warburton C, Edwards L, Ramsay EC, Huxham LA, Minchinton AI, Gelmon K, Bally MB. Decreased levels of hypoxic cells in gefitinib treated ER(+) HER-2 overexpressing MCF-7 breast cancer tumors are associated with hyperactivation of the mTOR pathway: therapeutic implications for combination therapy with rapamycin. Breast Cancer Res Treat. . (2007).
    [View Abstract - PubMed 17347776]  Request Paper

2. Kyle AH, Huxham LA, Yeoman DM, Minchinton AI. Limited tissue penetration of taxanes: a mechanism for resistance in solid tumors. Clin Cancer Res. 13(9):2804-10. (2007).
    [View Abstract - PubMed 17473214]  Request Paper

2006

3. Baker JH, Huxham LA, Kyle AH, Lam KK, Minchinton AI. Vascular-specific quantification in an in vivo Matrigel chamber angiogenesis assay. Microvasc Res. 71(2):69-75. Epub 2006 Mar 20. (2006).
    [View Abstract - PubMed 16545400]  Request Paper

4. Huxham LA, Kyle AH, Baker JH, McNicol KL, Minchinton AI. Tirapazamine causes vascular dysfunction in HCT-116 tumour xenografts. Radiother Oncol. 78(2):138-45. Epub 2006 Feb 7. (2006).
    [View Abstract - PubMed 16455148]  Request Paper

5. Minchinton AI, Tannock IF. Drug penetration in solid tumours. Nat Rev Cancer. 6(8):583-92. (2006).
    [View Abstract - PubMed 16862189]  Request Paper

2004

6. Dragowska WH, Warburton C, Yapp DT, Minchinton AI, Hu Y, Waterhouse DN, Gelmon K, Skov K, Woo J, Masin D, Huxham LA, Kyle AH, Bally MB. HER-2/neu overexpression increases the viable hypoxic cell population within solid tumors without causing changes in tumor vascularization. Mol Cancer Res. 2(11):606-19. (2004).
    [View Abstract - PubMed 15561777]  Request Paper

7. Huxham LA, Kyle AH, Baker JH, Nykilchuk LK, Minchinton AI. Microregional effects of gemcitabine in HCT-116 xenografts. Cancer Res 2004 Sep 15;64(18):6537-41. (2004).
    [View Abstract - PubMed 15374965]  Request Paper

8. Kyle AH, Huxham LA, Chiam AS, Sim DH, Minchinton AI. Direct assessment of drug penetration into tissue using a novel application of three-dimensional cell culture. Cancer Res 2004 Sep 1;64(17):6304-9. (2004).
    [View Abstract - PubMed 15342419]  Request Paper

2003

9. Aquino-Parsons C, Ries CR, Minchinton AI, D'yachkova Y. The effect of deep inspiration breath-hold on tumour oxygenation. Clin Oncol (R Coll Radiol) 2003 Oct;15(7):386-93. (2003).
    [View Abstract - PubMed 14570086]  Request Paper

10. Kyle AH, Huxham LA, Baker JH, Burston HE, Minchinton AI. Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent. Cancer Res 2003 Sep 15;63(18):5707-11. (2003).
     [View Abstract - PubMed 14522888]  Request Paper

2002

11. Minchinton AI, Tonn DA, Sutherland DP, Kyle AH. Carbogen breathing after irradiation enhances the effectiveness of tirapazamine in SiHa tumors but not SCCVII tumors in mice. Radiat Res 2002 Jul;158(1):94-100. (2002).
     [View Abstract - PubMed 12071808]  Request Paper

2000

12. Aquino-Parsons C, Green A, Minchinton AI. Oxygen tension in primary gynaecological tumours: the influence of carbon dioxide concentration. Radiother Oncol 2000 Oct;57(1):45-51. (2000).
     [View Abstract - PubMed 11033188]  Request Paper

1999

13. Aquino-Parsons, C., Lim, P., Green, A. & Minchinton, A. I.. Carbogen Inhalation in Cervical Cancer: Assessment of Oxygenation Change Gynecol Oncol, 74, 259-264 (1999).
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14. Kyle, A. & Minchinton, A. I.. Measurement of delivery and metabolism of tirapazamine through tumour tissue using the multilayered cell culture model Cancer Chemother Pharmacol, 43, 213-220 (1999).
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15. Kyle, A. H., Chan, C. T. & Minchinton, A. I.. Characterization of three-dimensional tissue cultures using electrical impedance spectroscopy Biophys J, 76, 2640-8 (1999).
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1998

16. Nemoto, K., Pickles, T., Minchinton, A. I. & Lam, G. K. Y.. The relative biological effectiveness of the modulated proton beam at TRIUMF Radiation Medicine, 16, 43-46 (1998).
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1997

17. Minchinton, A. I., Wendt, K. R., Clow, K. A. and Fryer, K. A.. Multilayers of cells growing on a permeable support: An in vitro tumour model. Acta Oncologica, 36, 13-16. (1997).
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1996

18. Minchinton, A. I. & Fryer, K. H.. Fluctuations in the oxygenation of experimental tumours. Adv. Exp. Med. Biol., 388, 353-356. (1996).
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19. Minchinton, A. I., Fryer, K. H., Wendt, K. R., Clow, K. A. & Hayes, M. M. M.. The effect of thalidomide on experimental tumours and metastases. Anti-Cancer Drugs, 7, 339-343. (1996).
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1995

20. Skarsgard, L. D., Acheson, D. K., Vinczan, A., Wouters, B. G., Heinrichs, B. E., Loblaw, D. A., Minchinton, A. I. & Chaplin, D. J.. Cytotoxic effect of RB 6145 in human tumour cell lines: dependence on hypoxia, extra- and intracellular pH and drug uptake. Br. J. Cancer, 72, 1479-86. (1995).
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1994

21. Macnab, A. J., Minchinton, A. I., Gagnon, R., Fryer, K. H., Seear, M. D., Roland, E. H. & Hill, A.. Comparison of forearm oxygenation during ischemis by near infrared spectroscopy and pO2 histography. Pediat. Res., 36, 26. (1994).
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22. Wilder, R. B., McGann, J. K., Sutherland, W. R., Waller, E. K., Minchinton, A. I., Goris, M. L. & Knox, S. J.. The hypoxic cytotoxin SR 4233 increases the effectiveness of radioimmunotherapy in mice with human non-hodgkin's lymphoma xenografts. Int. J. Radiat. Oncol. Biol. Phys., 28, 119-126. (1994).
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1992

23. Giaccia AJ, Auger EA, Koong A, Terris DJ, Minchinton AI, Hahn GM, Brown JM. Activation of the heat shock transcription factor by hypoxia in normal and tumor cell lines in vivo and in vitro. Int J Radiat Oncol Biol Phys 23(4):891-7. (1992).
     [View Abstract - PubMed 1618682]  Request Paper

24. Giaccia, A. J., Auger, E. A., Koong, A., Terris, D. J., Minchinton, A. I., Hahn, G. M. & Brown, J. M.. Activation of the heat shock transcription factor by hypoxia in normal and tumor cell lines in vivo and in vitro. Int. J. Radiat. Oncol. Biol. Phys., 23, 891-897. (1992).
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25. Giaccia, A. J., Biedermann, K. A., Tosto, L. M., Minchinton, A. I., Kovacs, M. S. & Brown, J. M.. Characterization of a CHO cell line resistant to killing by the hypoxic cell cytotoxin SR 4233. Int. J. Radiat. Oncol. Biol. Physics, 22, 681-4. (1992).
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26. Minchinton, A. I. & Brown, J. M.. Enhancement of the cytotoxicity of SR 4233 to normal and malignant tissues by hypoxic breathing. Br. J. Cancer, 66, 1053-1058. (1992).
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27. Minchinton, A. I. & Brown, J. M.. Improving the effectiveness of the bioreductive antitumour agent SR 4233 by induced hypoxia. Adv. Exp. Med. Biol., 317, 171-181. (1992).
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28. Minchinton, A. I., Lemmon, M. J., Tracy, M., Pollart, D. J., Martinez, A. P., Tosto, L. M. & Brown, J. M.. Second generation 1,2,4-benzotriazine 1,4-di-N-oxide bioreductive anti-tumor agents: Pharmacology and activity in vitro and in vivo. Int. J. Radiat. Oncol. Biol. Phys, 22, 701-705. (1992).
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29. Stone HB, Minchinton AI, Lemmon M, Menke D, Brown JM. Pharmacological modification of tumor blood flow: lack of correlation between alteration of mean arterial blood pressure and changes in tumor perfusion. Int J Radiat Oncol Biol Phys 22(1):79-86. (1992).
     [View Abstract - PubMed 1530755]  Request Paper

30. Terris, D. T., Minchinton, A. I., Dunphy, E. P. & Brown, J. M.. Computerized histographic oxygen tension measurements of murine tumors. Adv. Exp. Med. Biol., 317, 153-159. (1992).
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1991

31. Giaccia, A. J., Biedermann, K. A., Tosto, L. M., Minchinton, A. I., Kovacs, M. S. & Brown, J. M.. Characterization of a CHO cell line resistant to killing by the hypoxic cell cytotoxin SR 4233. Int. J. Radiat. Oncol. Biol. Phys., 22, 681-684. (1991).
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32. Minchinton, A. I. & Chaplin, D. J.. Spatial characterization of glutathione depletion in the KHT sarcoma using flow cytometry. Int. J. Radiat. Biol., 59, 1425-1433. (1991).
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1990

33. Minchinton, A. I., Durand, R. E. & Chaplin, D. J.. Intermittent blood flow in the KHT sarcoma - flow cytometry studies using Hoechst 33342. Br. J. Cancer, 62, 195-200. (1990).
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1989

34. Chaplin, D. J., Trotter, M. J., Durand, R. E., Olive, P. L. & Minchinton, A. I.. Evidence for intermittent radiobiological hypoxia in experimental tumour systems. Biomedica Biochemica Acta, 48, 255-259. (1989).
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1987

35. McNally, N. J., de Ronde, J., Minchinton, A. I. & Hinchliffe, M.. The relationship between the misonidazole "pre-incubation" effect and misonidazole-induced depletion of cellular GSH. Br. J. Radiol., 60, 96-99. (1987).
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1986

36. Dische, S., Saunders, M. I., Bennett, M. H., Dunphy, E. P., DesRochers, C., Stratford, M. R. L., Minchinton, A. I. & Wardman, P.. A comparison of tumour concentrations obtainable with misonidazole and Ro 03-8799. Br. J. Radiol., 59, 911-917. (1986).
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37. Dische, S., Saunders, M. I., Dunphy, E. P., Bennet, M. H., DesRochers, C., Stratford, M. R. L. & Minchinton, A. I.. Concentration achieved in human tumours after administration of misonidazole, SR 2508 and Ro 03-8799. Int. J. Radiat. Oncol. Biol. Phys., 12, 1109-1111. (1986).
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38. Minchinton, A. I. & Stratford, M. R. L.. A comparison of tumour and normal tissue levels of acidic, basic and neutral 2-nitroimidazole radiosensitizers in mice. Int. J. Radiat. Oncol. Biol. Phys., 12, 1117-1120. (1986).
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1985

39. Shrieve, D. C., Denekamp, J. & Minchinton, A. I.. Effects of glutathione depletion by buthionine sulphoximine on radiosensitization by oxygen and misonidazole in vitro. Rad. Res., 102, 283-294. (1985).
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40. Terry, N. H. A., Stratford, M. R. L. & Minchinton, A. I.. Misonidazole toxicity and pharmacokinetics in mice: dependence on strain and size. In Eur. J. Cancer Clin. Oncol. (Vol. 21, pp. 845-851). (1985).
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1984

41. Minchinton AI. Measurements of glutathione and other thiols in cells and tissues: a simplified procedure based on the HPLC separation of monobromobimane derivatives of thiols. Int J Radiat Oncol Biol Phys 1984 Sep;10(9):1503-6. (1984).
     [View Abstract - PubMed 6480442]  Request Paper

42. Minchinton, A. I.. Measurements of glutathione and other thiols in cells and tissues: A simplified procedure based on the HPLC separation of monobromobumane derivatives. Int. J. Radiat. Oncol. Biol. Phys., 10, 1503-1506. (1984).
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43. Minchinton, A. I., Rojus, A., Smith, K. A., Soranson, J. A., Shrieve, D. C., Jones, N. R. & Bremne, J. C.. Glutathione depletion in tissues after administration of buthionine sulphoximine. Int. J. Radiat. Oncol. Biol. Phys., 10, 1261-1264. (1984).
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44. Rojas, A., Smith, K. A., Soranson, J. A., Minchinton, A. I., Middleton, R. W. & Denekamp, J.. Enhancement of misonidazole radiosensitization by buthionine sulphoximine. In Radiother. Oncol. (Vol. 2, pp. 325-332). (1984).
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45. Saunders, M. I., Anderson, P. J., Bennett, M. H., Dische, S., Minchinton, A. I., Stratford, M. R. L. & Tothill, M.. The clinical testing of Ro 03 8799 - Pharmacokinetics, toxicology, tissue and tumour concentrations. In Int. J. Radiat. Oncol. Biol. Phys. (Vol. 10, pp. 1759-1763). (1984).
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1983

46. Dewey, D. L., Gaugas, J. M., Stratford, M. R. & Minchinton, A. I.. Differential toxicity of methylglyoxal-bis [guanylhydrazone]. J. Pathol., 139, 141-149. (1983).
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47. Hill, S. A., Fowler, J. F., Minchinton, A. I., Stratford, M. R. L. & Denekamp, J.. Radiosensitization of a mouse tumour by Ro 03-8799: acute and protracted administration. Int. J. Radiat. Biol., 44, 143-150. (1983).
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1982

48. Clarke, E. D., Dennis, M. F., Jones, N. R., Minchinton, A. I., Stratford, M. R. L. & Wardman, P.. The importance of pH induced concentration gradients on the use of nitroimidazole radiosensitizers with basis and acidic substituents. Br. J. Radiol., 55, 657. (1982).
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49. Denekamp, J., Michael, B. D., Minchinton, A. I., Smithen, C. E., Stewart, F. A., Stratford, M. R. L. & Terry, N. H. A.. Comparative studies of hypoxic cell radiosensitization using artificially hypoxic stain in vivo. Br. J. Cancer, 45, 247-255. (1982).
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50. Dische, S., Saunders, M. I., Anderson, P., Stratford, M. R. L. & Minchinton, A. I.. Clinical experience with nitroimidazoles as radiosensitizers. Int. J. Radiat. Oncol. Biol. Phys., 8, 335-338. (1982).
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51. Stratford, M. R. L., Minchinton, A. I., Dische, S., Saunders, M. I. & Anderson, P.. Desmethylmisonidazole (Ro 05-9963): Clinical pharmacokinetics after multiple oral administration. Int. J. Radiat. Oncol. Biol. Phys., 8, 377-379. (1982).
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52. Stratford, M. R. L., Minchinton, A. I., Hill, S. A., McNally, N. J. & Williams, M. V.. Pharmacokinetic studies using multiple administration of Ro 03-8799, a 2-nitroimidazole radiosensitizer. Int. J. Radiat. Oncol. Biol. Phys., 8, 469-471. (1982).
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53. Wardman, P., Anderson, R. F., Clarke, E. D., Jones, N. R., Minchinton, A. I., Patel, K. B., Stratford, M. R. L. & Watts, M. E.. Reduction of nitroimidazoles in model chemical and biological systems. Int. J. Radiat. Oncol. Biol. Phys., 8, 777-780. (1982).
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54. Williams MV, Denekamp J, Minchinton AI, Stratford MR. In vivo assessment of basic 2-nitroimidazole radiosensitizers. Br J Cancer 1982 Jul;46(1):127-37. (1982).
     [View Abstract - PubMed 7104192]  Request Paper

55. Williams, M. V., Denekamp, J., Minchinton, A. I. & Stratford, M. R. L.. In vivo testing of a 2-nitroimidazole radiosensitizer (Ro 03- 8799) using repeated administration. In Int. J. Radiat. Oncol. Biol. Phys. (Vol. 8, pp. 477-481). (1982).
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1981

56. Dische, S., Saunders, M. I., Riley, P. J., Hauck, J., Bennett, M. H., Stratford, M. R. L. & Minchinton, A. I.. The concentration of desmethylmisonidazole in human tumours and in cerebrospinal fluid. Br. J. Cancer, 43, 344-349. (1981).
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1980

57. Dische, S., Fowler, J. F., Saunders, M. I., Stratford, M. R. L., Anderson, P., Minchinton, A. I. & Lee, M. E.. A drug for improved radiosensitization in radiotherapy. Br. J. Cancer, 42, 153-155. (1980).
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1999

1. Minchinton, A. I., Fryer, K. H., Lim, P. & Aquino-Parsons, C.. Effect of breathing carbogen on the oxygen tension of murine and human tumours measured using an Eppendorf pO2 histograph In A. Eke & D. T. Delpy (Eds.), Oxygen Transport to Tissue (pp. 507-514). New York: Plenum (1999).
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1995

2. Minchinton, A. I.. Differences in the tumour oxygen tension in mice and man. In P. W. Vaupel, D. K. Kelleher, & Günderoth (Eds.), Tumour Oxygenation (pp. 211-218). Stuttgart: Gustav Fischer Verlag. (1995).
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1994

3. Terris, D. J. & Minchinton, A. I.. Computerized histographic characterization of changes in tissue pO2 induced by erythropoietin. In Hogan (Eds.), Oxygen transport to tissue (pp. 613-618). New York: Plenum. (1994).
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1986

4. Minchinton, A. I., Rojas, A., Smith, K. A., Soranson, J. A., Shrieve, D. C., Jones, N. R. & Bremner, J. C.. Glutatione depletion in tissues after administration of buthionine sulphoximine. Cancer Yearbook, 376-377. (1986).
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1982

5. Sealy, R., Williams, A., Cridland, S., Stratford, M., Minchinton, A. I. & Hallet, C.. A report on misonidazole in a randomized trial in neck cancer. In Int. J. Rad. Oncol. Biol. Phys. (Vol. 8, pp. 339-342). (1982).
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6. Stratford, M. R. L., Minchinton, A. I., Stewart, F. A. & Randhawa, V. S.. Pharmacokinetic studies on some novel (2-nitro-1-imidazolyl) propanolamine radiosensitizers. In A. Breccia, C. Rimondi, & G. E. D. Adams (Eds.), Advanced topics on radiosensitizers of hypoxic cells - Nato Advanced Study Institute, Life Sciences (pp. 165-169). (1982).
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1981

7. Rich, T. A., Dische, S., Saunders, M. I., Stratford, M. R. L. & Minchinton, A. I.. A serial study of the concentration of misonidazole in human tumours correlated with histologic structure. Int. J. Radiat. Oncol. Biol. Phys., 7, 197-203. (1981).
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1980

8. Rich, T. A., Saunders, M. I., Stratford, M. R. L. & Minchinton, A. I.. Influence of necrosis on the concentration of misonidazole in human tumours. In L. W. Brady (Eds.), Radiation Sensitizers: Their use in the clinical management of cancer (pp. 411-413). New York: Masson. (1980).
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9. Sealy, R., Williams, A., Levin, W., Blair, R., Flockhart, I. R., Stratford, M., Minchinton, A. I. & Cridland, S.. Progress in investigations in the use of misonidazole in head and neck cancer as a hypoxic cell radiosensitizer and in combination with hyperbaric oxygen. In L. W. Brady (Eds.), Radiation Sensitizers: Their use in the clinical management of cancer (pp. 361-365). New York: Masson. (1980).
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10. Wardman, P., Clarke, E. D., Jacobs, R. S., Minchinton, A. I., Stratford, M. R. L., Watts, M. E., Woodcock, M., Moazzam, M., Parrich, J., Wallace, R. G. & Smithen, C. E.. The development of hypoxic cell radiosensitizers: The second and third generations. In L. W. Brady (Eds.), Radiation sensitizers: Their use in the clinical management of cancer (pp. 83-90). New York: Masson. (1980).
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