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2009

1. Fu Y, Chang A, Chang L, Niessen K, Eapen S, Setiadi A, Karsan A. Differential regulation of TGFbeta signaling pathways by notch in human endothelial cells. J Biol Chem. 2009 May 27. (2009).
    [View Abstract - PubMed 19473993]  Request Paper

2. Vercauteren SM, Bashashati A, Wu D, Brinkman RR, Eaves C, Eaves A, Karsan A. Reduction in multi-lineage and erythroid progenitors distinguishes myelodysplastic syndromes from non-malignant cytopenias. Leuk Res. 2009 May 2. (2009).
    [View Abstract - PubMed 19414193]  Request Paper

2008

3. Karsan A. Notch and integrin affinity: a sticky situation. Sci Signal.1(2):pe2. (2008).
    [View Abstract - PubMed 18270166]  Request Paper

4. Niessen K, Fu Y, Chang L, Hoodless PA, McFadden D, Karsan A. A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, Karsan A.. Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J Cell Biol. 182(2):315-25 (2008).
    [View Abstract - PubMed 18270166]  Request Paper

5. Niessen K, Karsan A.. Notch signaling in cardiac development. Circ Res.102(10):1169-81 Toll-free link to full text (2008).
    [View Abstract - PubMed 18497317]  Request Paper

6. Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, Karsan A.. High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood (2008).
    [View Abstract - PubMed 18663149]  Request Paper

2007

7. Larrivee B, Karsan A. Involvement of marrow-derived endothelial cells in vascularization. Handb Exp Pharmacol. (180):89-114. (2007).
    [View Abstract - PubMed 17554506]  Request Paper

8. Leong KG, Niessen K, Kulic I, Raouf A, Eaves C, Pollet I, Karsan A. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition J Exp Med. Nov 26;204(12):2935-48 (2007).
    [View Abstract - PubMed 17984306]  Request Paper

9. Niessen K, Karsan A. Notch Signaling in the Developing Cardiovascular System. Am J Physiol Cell Physiol. Toll-free link to full text (2007).
    [View Abstract - PubMed 17376817]  Request Paper

10. Zhande R, Dauphinee SM, Thomas JA, Yamamoto M, Akira S, Karsan A.. FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction Mol Cell Biol. 27(21):7394-404 (2007).
     [View Abstract - PubMed 17785432]  Request Paper

11. Zhande R, Karsan A. Erythropoietin promotes survival of primary human endothelial cells through PI3K-dependent, NF-kappaB-independent upregulation of Bcl-xL. Am J Physiol Heart Circ Physiol. 292(5):H2467-74. Epub 2007 Jan 19. (2007).
     [View Abstract - PubMed 17237249]  Request Paper

2006

12. Dauphinee SM, Karsan A. Lipopolysaccharide signaling in endothelial cells. Lab Invest. 86(1):9-22. (2006).
     [View Abstract - PubMed 16357866]  Request Paper

13. Larrivee B, Olive PL, Karsan A. Tissue distribution of endothelial cells in vivo following intravenous injection. Exp Hematol. 34(12):1741-5. (2006).
     [View Abstract - PubMed 17157171]  Request Paper

14. Leong KG, Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood. 107(6):2223-33. Epub 2005 Nov 15. (2006).
     [View Abstract - PubMed 16291593]  Request Paper

15. Murphy S, Larrivee B, Pollet I, Craig KS, Williams DE, Huang XH, Abbott M, Wong F, Curtis C, Conrads TP, Veenstra T, Puri M, Hsiang Y, Roberge M, Andersen RJ, Karsan A. Identification of sokotrasterol sulfate as a novel proangiogenic steroid. Circ Res. 99(3):257-65. Epub 2006 Jun 22. (2006).
     [View Abstract - PubMed 16794189]  Request Paper

16. Noseda M, Fu Y, Niessen K, Wong F, Chang L, McLean G, Karsan A. Smooth Muscle alpha-actin is a direct target of Notch/CSL. Circ Res. 98(12):1468-70. Epub 2006 Jun 1. (2006).
     [View Abstract - PubMed 16741155]  Request Paper

17. Noseda M, Karsan A. Notch and minichromosome maintenance (MCM) proteins: integration of two ancestral pathways in cell cycle control. Cell Cycle. 5(23):2704-9. Epub 2006 Dec 1. (2006).
     [View Abstract - PubMed 17172856]  Request Paper

2005

18. Harfouche R, Malak NA, Brandes RP, Karsan A, Irani K, Hussain SN. Roles of reactive oxygen species in angiopoietin-1/tie-2 receptor signaling. FASEB J. 19(12):1728-30. Epub 2005 Jul 27. (2005).
     [View Abstract - PubMed 16049136]  Request Paper

19. Hood BL, Lucas DA, Kim G, Chan KC, Blonder J, Issaq HJ, Veenstra TD, Conrads TP, Pollet I, Karsan A. Quantitative analysis of the low molecular weight serum proteome using 18O stable isotope labeling in a lung tumor xenograft mouse model. J Am Soc Mass Spectrom. 16(8):1221-30. (2005).
     [View Abstract - PubMed 15979327]  Request Paper

20. Karsan A. The role of notch in modeling and maintaining the vasculature. Can J Physiol Pharmacol 83(1):14-23. (2005).
     [View Abstract - PubMed 15759046]  Request Paper

21. Karsan A, Blonder J, Law J, Yaquian E, Lucas DA, Conrads TP, Veenstra T. Proteomic analysis of lipid microdomains from lipopolysaccharide-activated human endothelial cells. J Proteome Res 4(2):349-57. (2005).
     [View Abstract - PubMed 15822910]  Request Paper

22. Karsan A, Eigl BJ, Flibotte S, Gelmon K, Switzer P, Hassell P, Harrison D, Law J, Hayes M, Stillwell M, Xiao Z, Conrads TP, Veenstra T. Analytical and preanalytical biases in serum proteomic pattern analysis for breast cancer diagnosis. Clin Chem. 51(8):1525-8. Epub 2005 Jun 10. (2005).
     [View Abstract - PubMed 15951319]  Request Paper

23. Karsan A, Harlan JM. The blood vessel wall In Hematology, Basic Principles and Practice 4th Edition Churchill Livingston, New York (2005).
     Request Paper

24. Karsan A, Pollet I, Yu LR, Chan KC, Conrads TP, Lucas DA, Andersen R, Veenstra T. Quantitative proteomic analysis of sokotrasterol sulfate-stimulated primary human endothelial cells. Mol Cell Proteomics 4(2):191-204. Epub 2004 Dec 20. (2005).
     [View Abstract - PubMed 15611527]  Request Paper

25. Larrivee B, Niessen K, Pollet I, Corbel SY, Long M, Rossi FM, Olive PL, Karsan A. Minimal contribution of marrow-derived endothelial precursors to tumor vasculature. J Immunol. 175(5):2890-9. (2005).
     [View Abstract - PubMed 16116175]  Request Paper

26. Larrivee B, Pollet I, Karsan A. Activation of vascular endothelial growth factor receptor-2 in bone marrow leads to accumulation of myeloid cells: role of granulocyte-macrophage colony-stimulating factor. J Immunol. 175(5):3015-24. (2005).
     [View Abstract - PubMed 16116189]  Request Paper

27. Noseda M, Niessen K, McLean G, Chang L, Karsan A. Notch-dependent cell cycle arrest is associated with downregulation of minichromosome maintenance proteins. Circ Res. 97(2):102-4. Epub 2005 Jun 23. (2005).
     [View Abstract - PubMed 15976316]  Request Paper

2004

28. Larrivee B, Karsan A. Isolation and culture of primary endothelial cells. Methods Mol Biol 290:315-30. (2004).
     [View Abstract - PubMed 15361671]  Request Paper

29. MacKenzie F, Duriez P, Larrivee B, Chang L, Pollet I, Wong F, Yip C, Karsan A. Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa. Blood 104(6):1760-8. Epub 2004 Jun 08. (2004).
     [View Abstract - PubMed 15187023]  Request Paper

30. MacKenzie F, Duriez P, Wong F, Noseda M, Karsan A. Notch4 Inhibits Endothelial Apoptosis via RBP-J{kappa}-dependent and -independent Pathways. J Biol Chem 279(12):11657-11663. Epub 2003 Dec 29. (2004).
     [View Abstract - PubMed 14701863]  Request Paper

31. Noseda M, Chang L, McLean G, Grim JE, Clurman BE, Smith LL, Karsan A. Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression. Mol Cell Biol 24(20):8813-22. (2004).
     [View Abstract - PubMed 15456857]  Request Paper

32. Noseda M, McLean G, Niessen K, Chang L, Pollet I, Montpetit R, Shahidi R, Dorovini-Zis K, Li L, Beckstead B, Durand RE, Hoodless PA, Karsan A. Notch Activation Results in Phenotypic and Functional Changes Consistent With Endothelial-to-Mesenchymal Transformation. Circ Res . (2004).
     [View Abstract - PubMed 14988227]  Request Paper

33. Wong F, Hull C, Zhande R, Law J, Karsan A. Lipopolysaccharide initiates a TRAF6-mediated endothelial survival signal. Blood . (2004).
     [View Abstract - PubMed 14996708]  Request Paper

2003

34. Harfouche R, Gratton JP, Yancopoulos GD, Noseda M, Karsan A, Hussain SN. Angiopoietin-1 activates both anti- and proapoptotic mitogen-activated protein kinases. FASEB J 17(11):1523-5. (2003).
     [View Abstract - PubMed 12824293]  Request Paper

35. Larrivee B, Lane DR, Pollet I, Olive PL, Humphries RK, Karsan A. Vascular endothelial growth factor receptor-2 induces survival of hematopoietic progenitor cells. J Biol Chem 278(24):22006-13. (2003).
     [View Abstract - PubMed 12668684]  Request Paper

36. Pollet I, Opina CJ, Zimmerman C, Leong KG, Wong F, Karsan A. Bacterial lipopolysaccharide directly induces angiogenesis through TRAF6-mediated activation of NF-{kappa}B and c-Jun N-terminal kinase. Blood 102(5):1740-1742. (2003).
     [View Abstract - PubMed 12714497]  Request Paper

2002

37. Hull C, McLean G, Wong F, Duriez PJ, Karsan A. Lipopolysaccharide signals an endothelial apoptosis pathway through TNF receptor-associated factor 6-mediated activation of c-Jun NH2-terminal kinase. J Immunol 169(5):2611-8. (2002).
     [View Abstract - PubMed 12193732]  Request Paper

38. Leong KG, Hu X, Li L, Noseda M, Larrivee B, Hull C, Hood L, Wong F, Karsan A. Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation. Mol Cell Biol 22(8):2830-41. (2002).
     [View Abstract - PubMed 11909975]  Request Paper

39. Levkau B, Kenagy RD, Karsan A, Weitkamp B, Clowes AW, Ross R, Raines EW. Activation of metalloproteinases and their association with integrins: an auxiliary apoptotic pathway in human endothelial cells. Cell Death Differ 9(12):1360-7. (2002).
     [View Abstract - PubMed 12478473]  Request Paper

40. Litwin C, Leong KG, Zapf R, Sutherland H, Naiman SC, Karsan A. Role of the microenvironment in promoting angiogenesis in acute myeloid leukemia. Am J Hematol 70(1):22-30. (2002).
     [View Abstract - PubMed 11994978]  Request Paper

41. Zheng X, Karsan A, Duronio V, Chu F, Walker DC, Bai TR, Schellenberg RR. Interleukin-3, but not granulocyte-macrophage colony-stimulating factor and interleukin-5, inhibits apoptosis of human basophils through phosphatidylinositol 3-kinase: requirement of NF-kappaB-dependent and -independent pathways. Immunology 107(3):306-15. (2002).
     [View Abstract - PubMed 12423306]  Request Paper

2001

42. Churg A, Dai J, Zay K, Karsan A, Hendricks R, Yee C, Martin R, MacKenzie R, Xie C, Zhang L, Shapiro S, Wright JL. Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects. Lab Invest 81(8):1119-31. (2001).
     [View Abstract - PubMed 11502863]  Request Paper

43. Imanishi T, Hano T, Nishio I, Han DK, Schwartz SM, Karsan A. Apoptosis of vascular smooth muscle cells is induced by Fas ligand derived from endothelial cells. Jpn Circ J. 65(6):556-60. (2001).
     [View Abstract - PubMed 11407740]  Request Paper

44. Roskelley CD, Williams DE, McHardy LM, Leong KG, Troussard A, Karsan A, Andersen RJ, Dedhar S, Roberge M. Inhibition of tumor cell invasion and angiogenesis by motuporamines. Cancer Res 61(18):6788-94. (2001).
     [View Abstract - PubMed 11559552]  Request Paper

2000

45. Duriez PJ, Wong F, Dorovini-Zis K, Shahidi R, Karsan A. A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor. J Biol Chem 275(24):18099-107. (2000).
     [View Abstract - PubMed 10849436]  Request Paper

46. Larrivee B, Karsan A. Signaling pathways induced by vascular endothelial growth factor (review). Int J Mol Med 5(5):447-56. (2000).
     [View Abstract - PubMed 10762646]  Request Paper

47. Leong KG, Karsan A. Signaling pathways mediated by tumor necrosis factor alpha. Histol Histopathol 15(4):1303-25. (2000).
     [View Abstract - PubMed 11005254]  Request Paper

1999

48. Schwartz BR, Karsan A, Bombeli T, Harlan JM. A novel beta 1 integrin-dependent mechanism of leukocyte adherence to apoptotic cells. J Immunol 162(8):4842-8. (1999).
     [View Abstract - PubMed 10202028]  Request Paper

49. Stempien-Otero A, Karsan A, Cornejo CJ, Xiang H, Eunson T, Morrison RS, Kay M, Winn R, Harlan J. Mechanisms of hypoxia-induced endothelial cell death. Role of p53 in apoptosis. J Biol Chem 274(12):8039-45. (1999).
     [View Abstract - PubMed 10075703]  Request Paper

50. Zen K, Karsan A, Stempien-Otero A, Yee E, Tupper J, Li X, Eunson T, Kay MA, Wilson CB, Winn RK, Harlan JM. NF-kappaB activation is required for human endothelial survival during exposure to tumor necrosis factor-alpha but not to interleukin-1beta or lipopolysaccharide. J Biol Chem 274(40):28808-15. (1999).
     [View Abstract - PubMed 10497254]  Request Paper

1998

51. Choi KB, Wong F, Harlan JM, Chaudhary PM, Hood L, Karsan A. Lipopolysaccharide mediates endothelial apoptosis by a FADD-dependent pathway. J Biol Chem 273(32):20185-8. (1998).
     [View Abstract - PubMed 9685365]  Request Paper

52. Hu X, Yee E, Harlan JM, Wong F, Karsan A. Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells. Blood 92(8):2759-65. (1998).
     [View Abstract - PubMed 9763560]  Request Paper

53. Karsan A, Cornejo CJ, Winn RK, Schwartz BR, Way W, Lannir N, Gershoni-Baruch R, Etzioni A, Ochs HD, Harlan JM. Leukocyte Adhesion Deficiency Type II is a generalized defect of de novo GDP-fucose biosynthesis. Endothelial cell fucosylation is not required for neutrophil rolling on human nonlymphoid endothelium. J Clin Invest 101(11):2438-45. (1998).
     [View Abstract - PubMed 9616215]  Request Paper