sjones@bcgsc.ca
 http://www.bcgsc.ca/faculty/l?p=sjones

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Department:	Genome Sciences Centre (@ the BCCRC since 1999)
Research Role:	Senior Scientist
Education:	PhD. (Bioinformatics), Sanger Centre, 1999 MSc. (Genetics), Simon Fraser University, 1994 BSc. (Biochemistry), Bristol University, 1990
Birthplace:	Wales, United Kingdom
Phone:	604-877-6084
Fax:	604-877-6085

Research Interests:

We are using expression profiling techniques to understand expression changes in early stage cancers. We are generating bioinformatic approaches to rapidly analyse and derive biological inference from such data. We also intend to integrate data from Comparative Genomic Hybridization and Proteomic data. This work is part forms part of the GenomeBC Cancer Genomics Program.

We are also embarking on a bioinformatic research program entitled the Bioinformatics of Mammalian Gene Expression. This program will develop computational approaches to combine both gene expression profiling technology and comparative genomic analysis to elucidate genetic regulatory control elements.

The bioinformatics group at the Genome Sciences is also involved in development of software to support high-throughput DNA sequencing activities. Current projects include the Mammalian Gene Collection (funded by the National Cancer Institute, NIH) and the whole genomic sequencing of the bactera Rhodococcus strain RHA1 (funded by GenomeBC). We are also involved in the generation BAC fingerprint physical maps of mammalian genomes. Genomes completed or in progress include mouse, rat and the bovine. In particular, implementing bioinformatic tools to improve the efficiency of this process such as automated band calling, a laboratory tracking database, improved fingerprint assembly generation and rapid dissemination of the data. Other physical maps being generated include those of the Salmon and Popular genomes. As part of an award from the Peter Wall institute of advanced studies to study Pathogenomics I am also investigating the use of bioinformatic tools in order to determine mechanisms by which pathogens invade and exploit their hosts. This work is being furthered through the Genome Canada Functional Pathogenomics of Mucosal Immunity. I am also working on bioinformatic approach to automate and support the C. elegans Gene Knockout consortium.

Previously, I was a researcher at the Sanger Institute, Cambridge, UK, where I worked on bioinformatic analysis of the Caenorhabditis elegans genome as part the C. elegans genome sequencing project.

Further contributions include my involvment as the founding director of the CIHR/MSFHR Bioinformatics Training Program as well as being a core faculty member of the Canadian Bioinformatics Workshop.

See Also:

• Marco Marra