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Dr. Peter Watson
- Chief Physician, Vancouver Island Center
- Director, Tumour Tissue Repository
- Senior Research Scientist
- BCCA Staff Pathologist
- Professor,
 Pathology & Laboratory Medicine, UBC - Adjunct Professor, Biochemistry and Molecular Biology, UVIC
 View Publications
| Department: |
Deeley Research Centre
(@ the BCCRC since 2005) |
| Research Role: |
Senior Scientist |
| Postdoctoral Fellows: |
Josh Wang
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| Graduate Students: |
Nathan West
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| Other lab members: |
Rebecca Barnes
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| Education: |
B.A. (Natural Sciences), University of Cambridge, 1978
M.Sc., University of Cambridge, 1982
MB B.Chir, University of Cambridge, 1983
FRCPC (Anatomic Pathology), University of Manitoba, 1988
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| Birthplace: |
New Zealand  |
| Phone: |
250-519-5700 |
| Fax: |
250-519-2009 |
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Research Interests:
Our laboratory studies breast tumor progression with the medium term goal of improving our understanding of the important events that occur in breast tissues that promote the development and progression from pre-neoplastic lesions to pre-invasive and invasive tumors. Our overall approach is to identify cellular and molecular changes that occur in human tissues and then to correlate, connect, and understand the functional and clinical significance of these factors through exploration of factors within laboratory models and repeated cross referencing of findings to human tissues. The overall goals are to identify indicators of diagnosis, markers of risk, and functional targets that will improve our ability to diagnose, predict, and treat breast cancer at its early stages.
Specific projects include the following
Early breast tumor progression One specific focus has been on the molecular pathology of carcinoma in-situ (DCIS). This work has involved identification of several novel gene alterations relating to the transition from DCIS to invasive cancer. Amongst these we first identified S100A7 as an important gene in DCIS and progression of early breast cancer, and have subsequently defined some of its functions and mechanism of action through the S100A7-Jab1 pathway [Cancer Research 1996, Clinical Cancer Research 2002, Cancer Research 2003, Cancer Research 2005,Breast Cancer Research 2008]
Estrogen signalling and breast cancer We have a long standing interest in elucidating components and alterations in the mechanism of estrogen action. This work has led to the characterization of many alterations potentially relevant to the progression from hormone therapy responsive to hormone resistant disease. Most recently we have identified chronic hypoxia as a potential cause of alterations in estrogen signalling during breast cancer progression. [Cancer Research 1991, Am. J. Pathology 1997, Clinical Cancer Research 2004]
Tissue resources, microdissection and tumor analysis Our laboratory has pioneered and contributed to cumulative technical and tumor bank tissue resource developments. These have facilitated direct approaches to study human breast cancer through analysis of histologically defined breast tumor tissue. This effort has previously included the development of the Manitoba Breast Tumour Bank, and now the development of the BCCA Tumour Tissue Repository program, BC BioLibrary, and the CTRNet network in Canada. [JNCI 1993, Biotechniques 1996, CMAJ 1996, Cancer Epidemiol Biomarkers Prev 2008.]
Other areas of interest
Research and the Vancouver Island Center, BC Cancer Agency
BC Cancer Agency Tumor Tissue Repository
BC BioLibrary
Canadian Tumor Tissue Repository Network (CTRNet)
Manitoba Breast Tumor Bank
URL: http://www.bccrc.ca/drc/people_pwatson1.html
The BC Cancer Agency Research Centre is the research arm of the BC Cancer Agency (BCCA),
and is supported by the BC Cancer Foundation.
This page was last modified at 5:13pm on June 16, 2009
© 1999-2008.
BC Cancer Agency. All rights reserved.
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675 West 10th Avenue
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pwatson@bccancer.bc.ca
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