Born and raised in Kamloops, BC, Dr. Lockwood obtained his Ph.D. from the University of British Columbia and trained with the lung cancer research group at BC Cancer Research Centre where he worked on characterizing the genetic mechanisms underlying the development of different lung cancer subtypes. He pursued postdoctoral studies as a CIHR Jean-Francois St. Dennis Fellow in Cancer Research in the laboratory of Nobel laureate Dr. Harold Varmus, first at Memorial Sloan-Kettering Cancer Center, New York, and later at the National Human Genome Research Institute in Bethesda. There, he focused on utilizing mouse models of lung cancer to study mechanism of lung cancer initiation, progression and response to therapy and identifying novel therapeutics for lung cancer treatment. Dr. Lockwood returned to the BC Cancer to begin his own research group in 2014 with a focus on understanding lung cancer biology using integrative genomics approaches and is currently a Michael Smith Foundation for Health Research Scholar and Senior Scientist in the Integrative Oncology Department.

Affiliations

University of British Columbia

Credentials

Current Appointment

Associate Professor, Pathology and Laboratory Medicine, University of British Columbia 

Training

BSc (Microbiology and Immunology), University of British Columbia, 2004

PhD (Pathology and Laboratory Medicine), University of British Columbia, 2009

Post-Doctoral Fellow (Cancer Biology and Genetics), with Harold Varmus, Memorial Sloan-Kettering Cancer Center, 2009-2010

Post-Doctoral Fellow (Cancer Genetics), with Harold Varmus, National Human Genome Research Institute, 2010-2014

Selected Awards

  • Postgraduate Scholarship. National Sciences and Engineering Research Council of Canada. 2004-2006 
  • Research Trainee Award (Junior). Michael Smith Foundation for Health Research. 2006-2008
  • Canadian Graduate Scholarship (Doctoral). National Sciences and Engineering Research Council of Canada. 2006-2008
  • Research Trainee Award (Senior). Michael Smith Foundation for Health Research. 2008-2010
  • Postdoctoral Fellowship. Canadian Institutes of Health Research. 2010-2013 
  • Scholar Award. Michael Smith Foundation for Health Research. 2014-2019
  • New Investigator Award. Canadian Institutes of Health Research. 2016-2021

Selected Publications

Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells.

Cell reports, 2022
Johnson, Fraser D, Ferrarone, John, Liu, Alvin, Brandstädter, Christina, Munuganti, Ravi, Farnsworth, Dylan A, Lu, Daniel, Luu, Jennifer, Sihota, Tianna, Jansen, Sophie, Nagelberg, Amy, Shi, Rocky, Forcina, Giovanni C, Zhang, Xu, Cheng, Grace S W, Spencer Miko, Sandra E, de Rappard-Yuswack, Georgia, Sorensen, Poul H, Dixon, Scott J, Guha, Udayan, Becker, Katja, Djaballah, Hakim, Somwar, Romel, Varmus, Harold, Morin, Gregg B, Lockwood, William W
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An ErbB2 splice variant lacking exon 16 drives lung carcinoma.

Proceedings of the National Academy of Sciences of the United States of America, 2020
Smith, Harvey W, Yang, Lei, Ling, Chen, Walsh, Arlan, Martinez, Victor D, Boucher, Jonathan, Zuo, Dongmei, Sokol, Ethan S, Pavlick, Dean C, Frampton, Garrett M, Chmielecki, Juliann, Jones, Laura M, Roux, Philippe P, Lockwood, William W, Muller, William J
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