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Elizabeth C Halvorsen

Liz Halvorsen

Training

  • BSc Hons. Microbiology, University of British Columbia (2012)

Program

  •  Ph.D. Candidate, Interdisciplinary Oncology Program, Faculty of Medicine, University of British Columbia (2012 - present)

Research Interests

  • Regulatory T cells
  • CCR5
  • Breast cancer
  • Immunotherapy
  • Metastasis

Publications

Journal Articles

  • Halvorsen E.C., Hamilton M.J., Young A., Wadsworth B.J., LePard N.E., Lee H.N., Firmino N., Collier J.C., and Bennewith K.L. Maraviroc decreases CCL8-mediated migration of CCR5+ regulatory T cells and reduces metastatic tumour growth in the lungs. OncoImmunology. (In press).

  • Hamilton, M.J., Halvorsen, E.C., LePard, N.E, Bosiljcic, M., Ho, V.W., Lam, V., Banáth, J.P.,  Bennewith, K.L, Krystal, G. (2015) SHIP represses lung inflammation and inhibits mammary tumor metastasis in BALB/c mice. Oncotarget. 7(4): 3677-91.
  • Hamilton, M.J., Bosiljcic, M., LePard, N.E, Halvorsen, E.C., Ho, V.W., Banáth, J.P., Krystal, G.,  Bennewith, K.L. (2014) Macrophages Are More Potent Immune Suppressors Ex Vivo Than Immature Myeloid-Derived Suppressor Cells Induced by Metastatic Murine Mammary Carcinomas. J Immunol. 192:512-522.
  • Halvorsen, E.C., Mahmoud, S., Bennewith, K.L. (2014) Emerging roles of regulatory T cells in tumour progression and metastasis. Cancer Metastasis Rev. 33(4):1025-41.
  •  Lange, J.N., Faasse, E., Tantikachornkiat, M., Gustafsson, F.S., Halvorsen, E.C, Kluftinger, A., Ledderhof, D., Durall, D.M. (2014) Implantation and persistence of yeast inoculum in Pinot noir fermentations at three Canadian wineries. Int J Food Microbiol. 180: 56-61.

Book Chapters

  • Cochrane, D.R., Lin, D., Dellaire, G., HalvorsenE.C, Berman, J.N, Wang, Y., Huntsman, D.G., Bennewith, K.L. (2014) Chapter 4: Animal models of metastasis. Genomic instability and DNA repair in cancer progression and metastasis. Ed. Chris A Maxwell, Calvin D Roskelley. Springer Science + Business Media. 20: 95-123.

 Published Abstracts

  • Halvorsen, E.C., Hamilton, M.J., LePard, N.E., Young, A., Wadsworth B.J., and Bennewith, K.L. (2015) CCR5+ regulatory T cells induced by metastatic breast carcinomas migrate toward a gradient of CCL8 and accumulate in metastatic lung tissue (TUM9P.1016). J Immunol. 194: 210.18.
  • Hamilton, M.J., Bosiljcic, M., Harbourne, B.T., LePard, N.E., Halvorsen, E.C., Kim, A.Y., Banath, J.P., Krystal, G., and Bennewith, K.L. (2013) Abstract A9: Immune suppressive myeloid cells induced by hypoxic mammary tumor cells persist after primary tumour resection and promote metastatic growth. Cancer Res.73; A9. 

Select Poster Presentations

  • CCR5+ Regulatory T cells induced by metastatic breast carcinomas migrate toward CCL8 and accumulate in metastatic lung tissue. The American Association of Immunologists Annual Meeting - New Orleans, Louisiana, United States. (2015)
  • CCR5+ Regulatory T cells migrate toward CCL8 and accumulate in metastatic lung tissue. Canadian Cancer Immunotherapy Consortium - Vancouver, BC, Canada. (2015)
  • The Role of Regulatory T Cells in Breast Cancer Metastasis. Bioinformatics, Genomics and Oncology Retreat. Child and Family Research Institute - Vancouver, BC, Canada. (2014)
  •  Regulatory T cell Accumulation in Pre-Metastatic Tissues in Response to Primary Tumour Hypoxia. Interdisciplinary Oncology and Bioinformatics 3rd Annual Research Day. Child and Family Research Institute - poster award recipient*, Vancouver, BC, Canada. (2013)
  • Regulatory T cell accumulation in response to primary tumour hypoxia. BC Cancer Agency Annual Cancer Conference. Vancouver - poster award recipient*, Vancouver, BC.  (2012)

Invited Talks

  • CCR5 antagonists as immune-modulating agents for the treatment of breast cancer metastasis. Poster "teaser" talk. Keystone: Cancer Pathophysiology, Integrating the Host and Tumor Environment  (2016)
  • CCR5 inhibition reduces breast cancer metastasis; potential therapeutic utility of Maraviroc. Knowledge Translation Seminar Series (2016)
  • Modulating immune-suppressive networks to inhibit breast cancer metastasis. Workshop on Tumor Hypoxia in the Genomics Era (2015)
  • The Role of CCR5+ Regulatory T cells in Breast Cancer Metastasis. Knowledge Translation Seminar Series (2015)
  • CCR5+ regulatory T cells infiltrate primary and metastatic breast tumours: examining their role in tumour metastasis. Knowledge Translation Seminar Series (2014)

 Awards

  • Keystone Symposia Future of Science Fund scholarship. Cancer Pathophysiology: Integrating the Host and Tumor Environments (2016)
  • Junior Investigator Award.14th International Tumour Microenvironment Workshop (2015)
  • Outstanding Presentation Award. Workshop on Tumour Hypoxia in the Genomics Era (2015)
  • Faculty of Medicine Award #6442, University of British Columbia (2015)
  • Four Year Doctoral Fellowship, University of British Columbia (2014)
  • Frederick Banting and Charles Best Canada Graduate Scholarship (CGS-M), Canadian Institutes of Health Research (2013)
  • Interdisciplinary Oncology and Bioinformatics Poster Award, 3rd Annual Research Day (2013)
  • College for Interdisciplinary Studies Graduate Award, University of British Columbia (2012)
  • Biology and Bioinformatics Poster Award, BC Cancer Agency Annual Cancer Conference (2012)
  • President’s Entrance Scholarship, University of British Columbia (2007)
  • British Columbia Government Scholarship, University of British Columbia (2007)

Links

| BCCA | BCCRC | Integrative Oncology