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Brennan Wadsworth

Brennan Wadsworth


Training

  • BSc. (Kinesiology) University of Waterloo, 2010

Program

  • PhD Candidate - Pathology and Laboratory Medicine Program, University of British Columbia


Research Interests

  • Tumour Microenvironment
  • Vascular Physiology
  • Tumour Hypoxia
  • Radiation Biology

Publications

Journal Articles

  • Halvorsen EC, Franks SE, Wadsworth BJ, Harbourne BT, Cederberg RA, Steer CA, Martinez-Gonzalez I, Calder J, Lockwood WW, Takei F, Bennewith KL. IL-33 increases ST2+ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner. Oncoimmunology. (In Press).

  • Martinez VD, Firmino NS, Marshall EA, Ng KW, Wadsworth BJ, Anderson C, Lam WL, Bennewith KL. Non-coding RNAs predict recurrence-free survival of patients with hypoxic tumours. Sci Rep. 2018. 8(1):152. https://www.ncbi.nlm.nih.gov/pubmed/29317756

  • Wadsworth BJ, Pan J, Dude I, Colpo N, Bosiljcic M, Lin* KS, Benard* F, Bennewith*+ KL. 2-18F-Fluoroethanol is a PET reporter of solid tumour perfusion. J Nucl Med 2017. 58(5):815-820.  https://www.ncbi.nlm.nih.gov/pubmed/28126891

  • Halvorsen EC, Hamilton MJ, Young A, Wadsworth BJ, LePard NE, Lee HN, Firmino N, Collier JL and Bennewith KL.  Maraviroc decreases CCL8-mediated migration of CCR5+ regulatory T cells and reduces metastatic tumour growth in the lungs.  Oncoimmunology 2016. 5(6):e1150398. https://www.ncbi.nlm.nih.gov/pubmed/27471618
  • Fajardo VA, Bombardier E, McMillan EM, Tran K, Wadsworth BJ, Smith IC, Gamu D, Hopf A, Vigna C, Bellissimo C, Michel RN, Tarnopolsky MA, Quadrilatero J, Tupling AR (2015) Phospholamban overexpression in mice causes centronuclear myopathy-like phenotype. Dis Model Mech. 8(8), 999-1009 https://www.ncbi.nlm.nih.gov/pubmed/26035394

Oral Presentations

  • Wadsworth BJ, Pan J, Colpo N, Lin KS, Benard F, Bennewith KL.(2017) 2-18F-Fluoroethanol is a novel positron emission tomography (PET) reporter of solid tumour perfusion. UBC Faculty of Medicine Research Day, Vancouver, BC, Canada.
  • Wadsworth BJ, Pan J, Colpo N, Lin KS, Benard F, Bennewith KL.(2017) 2-18F-Fluoroethanol is a novel positron emission tomography (PET) reporter of solid tumour perfusion. 15th International Tumor Microenvironment Workshop, Miami Beach, Florida, USA.
  • Wadsworth BJ, Pan J, Colpo N, Lin KS, Benard F, Bennewith KL.(2016) 2-[18F]-Fluoro-ethanol is a novel positron emission tomography (PET) reporter of tumour perfusion. UBC Pathology Day Conference, Vancouver, Canada
  • Wadsworth BJ, Halvorsen EC, Bennewith KL. (2015) Oxygen sensitive fluorescent proteins: Making tumour cells report their oxygenation history. 14th International Tumour Microenvironment Workshop. Vancouver, BC.

Poster Presentations

  • Wadsworth BJ, Lin KS, Benard F, Bennewith KL. (2018) Losartan sensitizes hypoxic tumours to pentoxifylline induced radiosensitization. Radiation Research Society Annual Meeting, Chicago, IL, USA.
  • Wadsworth BJ, Villamil C, Yapp D, Wilson D, Benard F, McKenzie M, Bennewith KL. (2018) Evaluation of 18F-EF5 suitability for detection of hypoxia in localized adenocarcinoma of the prostate. Canadian Association of Radiation Oncology, Joint Scientific Meeting, Montreal, QC, Canada.
  • Wadsworth BJ, Cederberg RA, Franks SE, Halvorsen EC, Firmino NS, Pan J, Colpo N, Lin KS, Benard F, Bennewith KL. (2018) Applications of 2-18F-Fluoroethanol PET: Imaging solid tumour perfusion and testing perfusion modifying drugs. Canadian Association of Nuclear Medicine Annual Meeting, Vancouver, BC, Canada.
  • Wadsworth BJ, Pan J, Dude I, Colpo N, Lin KS, Benard F, Bennewith KL. (2017) 2-18F-Fluoroethanol is a novel positron emission tomography (PET) reporter of solid tumour perfusion. UBC Pathology Day Conference, Vancouver, BC, Canada.
  • Wadsworth BJ, Pan J, Dude I, Colpo N, Lin KS, Benard F, Bennewith KL. (2016) 2-[18F]-Fluoro-ethanol is a novel positron emission tomography (PET) reporter of tumour perfusion. Radiation Research Society Annual Meeting, Hawaii, USA.
  • Wadsworth BJ, Pan J, Dude I, Colpo N, Lin KS, Benard F, Bennewith KL. (2016) 2-[18F]-Fluoro-ethanol is a novel positron emission tomography (PET) reporter of tumour perfusion. Excellence in Radiation Research for the 21st Century Research Day, Toronto, ON.
  • Wadsworth BJ, Halvorsen EC, Young A, Firmino N, Bennewith KL (2016) A timecourse strategy to identify transiently hypoxic tumour cells in solid tumours. Terry Fox Research Institute Annual Scientific Meeting, Vancouver, BC.
  • Wadsworth BJ, Halvorsen EC, Young A, Firmino N, Collier J, Hamilton MJ, LePard N, Bennewith KL. (2015) Time course detection of tumour hypoxia and perfusion status for validation of clinically relevant perfusion modifying agents. Terry Fox Research Institute BC Node Research Day. Vancouver, BC.
  • Wadsworth BJ, Halvorsen EC, Bennewith KL. (2015) Improving the detection of transient hypoxia to provide insight into tumour physiology. International Workshop on Tumor Hypoxia in the Genomics Era. Vancouver, BC.
  • Wadsworth BJ, Halvorsen EC, Bennewith KL (2015) Oxygen sensitive fluorescent proteins report changes in tumour cell hypoxia. BC Cancer Agency Research Day. Vancouver, BC.
  • Wadsworth BJ, Halvorsen EC, Bennewith KL (2015) Detection of transient tumour hypoxia with a novel combination of oxygen-sensitive fluorescent proteins. UBC Pathology Day. Vancouver, BC.
  • Wadsworth BJ, Smith IC, Mitchell AS, Ng D, Quadrilatero J, Tupling AR. (2013) Apoptosis repressor with caspase recruitment domain (ARC) ablation facilitates a slow twitch contractile phenotype in skeletal muscle. CSEP Extreme Human Physiology: Pathology to Performance, Toronto, ON.

Awards

  • Alavi-Mandell Award Society of Nuclear Medicine and Molecular Imaging (2018)
  • BC Cancer Foundation Innovation Support Fund BC Cancer (2018)
  • Pathology Day Graduate Student Oral Presentation Award University of British Columbia (2018)
  • Canadian Institutes of Health Research Doctoral Scholarship Canadian Institutes of Health Research (2017)
  • Canadian Institutes of Health Research Travel Award - Institute Community Support Canadian Institutes of Health Research (2017)
  • Pathology Day Graduate Student Poster Presentation Award University of British Columbia (2017)
  • UBC Four Year Doctoral Fellowship University of British Columbia (2016)
  • Terry Fox Foundation Initiative for Strategic Training in Transdisciplinary Radiation Science for the 21st Century (STARS21) Alumni Award. (2016)
  • Terry Fox Foundation Initiative for Strategic Training in Transdisciplinary Radiation Science for the 21st Century (STARS21) Travel Award. (2016)
  • Radiation Research Society Scholar in Training Travel Award (2016)
  • Pathology Day Graduate Student Oral Presentation Award University of British Columbia (2016)
  • Terry Fox Foundation Strategic Initiative for Excellence in Radiation Research in the 21st Century (EIRR21) Doctoral Scholarship  (2015)
  • Northern Telecom Graduate Fellowship University of British Columbia (2015)
  • Jean MacDonald Graduate Fellowship University of British Columbia (2015)
  • Pathology Day Graduate Student Poster Presentation Award University of British Columbia (2015)
  • Natural Sciences and Engineering Research Council of Canada – Canada Graduate Scholarship Master’s Award University of British Columbia (2014)
  • Natural Sciences and Engineering Research Council of Canada – Undergraduate Summer Research Award, University of Waterloo (2013)
  • Natural Sciences and Engineering Research Council of Canada – Undergraduate Summer Research Award, University of Waterloo (2012)
  • William and Nona Heaslip Scholarship University of Waterloo (2012) 
  • President’s Research Award University of Waterloo (2012)

Links

BCCA | BCCRC | Integrative Oncology |