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Alastair Kyle

Radiation Biology Unit - Department of Integrative Oncology

Alastair Kyle pic

Research Associate     Rm. 9-223 • 675 West 10th Ave, Vancouver       Tel. +1 604 675 8000 ext 7033


Accepted book chapter in collective work:
Kyle A.H., Minchinton A.I. “Drug penetration and therapeutic resistance” in Tumor Microenvironment (ed D. W. Siemann), John Wiley & Sons, Ltd, Chichester, UK. Ch15, pp 329-347.

Published refereed articles in past 5 years (last update 2011):
1. Kyle, A.H., J.H.E. Baker, and A.I. Minchinton, Transient stimulation of quiescent tumor cells via the IGF-1 receptor increases response to chemotherapy in xenograft systems. Cancer Res. 2011 Dec 12.[Epub ahead of print] PMID: 22158947

2. Chang, A. C., Fu, Y., et al, A. Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase. Dev Cell, 21: 288-300, 2011.
3. Lou, Y., McDonald, P. C., et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res, 71: 3364-3376, 2011.

4. Farinha, P., Kyle, A., Minchinton, A., Connors, J., Karsan, A., and Gascoyne, R. Vascularization predicts overall survival and risk of transformation in follicular lymphoma. Haematologica, 95: 2157-2160, 2010.

5. Bains .LJ., Baker J.H.E., Kyle A.H., Minchinton A.I. and Reinsberg S.A. (2009). “Detecting Vascular-Targeting Effects of the Hypoxic Cytotoxin Tirapazamine in Tumor Xenografts Using Magnetic Resonance Imaging”  International Journal of Radiation Oncology, Biology & Physics 73(4) 957-65.

6. Lenz, G., Wright, G., Dave, S. S., Xiao, W., Powell, J., Zhao, H., Xu, W., Tan, B., Goldschmidt, N., Iqbal, J., Vose, J., Bast, M., Fu, K., Weisenburger, D. D., Greiner, T. C., Armitage, J. O., Kyle, A., May, L., Gascoyne, R. D., Connors, J. M., Troen, G., Holte, H., Kvaloy, S., Dierickx, D., Verhoef, G., Delabie, J., Smeland, E. B., Jares, P., Martinez, A., Lopez-Guillermo, A., Montserrat, E., Campo, E., Braziel, R. M., Miller, T. P., Rimsza, L. M., Cook, J. R., Pohlman, B., Sweetenham, J., Tubbs, R. R., Fisher, R. I., Hartmann, E., Rosenwald, A., Ott, G., Muller-Hermelink, H. K., Wrench, D., Lister, T. A., Jaffe, E. S., Wilson, W. H., Chan, W. C. and Staudt, L. M. (2008). "Stromal gene signatures in large-B-cell lymphomas." N Engl J Med 359(22): 2313-23.

7. Baker, J. H., Lam, J., Kyle, A. H., Sy, J., Oliver, T., Co, S. J., Dragowska, W. H., Ramsay, E., Anantha, M., Ruth, T. J., Adam, M. J., Yung, A., Kozlowski, P., Minchinton, A. I., Ng, S. S., Bally, M. B. and Yapp, D. T. (2008). "Irinophore C, a novel nanoformulation of irinotecan, alters tumor vascular function and enhances the distribution of 5-fluorouracil and doxorubicin." Clin Cancer Res 14(22): 7260-71.

8. Baker, J. H., Lindquist, K. E., Huxham, L. A., Kyle, A. H., Sy, J. T. and Minchinton, A. I. (2008). "Direct visualization of heterogeneous extravascular distribution of trastuzumab in human epidermal growth factor receptor type 2 overexpressing xenografts." Clin Cancer Res 14(7): 2171-9.

9. Edwards, L. A., Woo, J., Huxham, L. A., Verreault, M., Dragowska, W. H., Chiu, G., Rajput, A., Kyle, A. H., Kalra, J., Yapp, D., Yan, H., Minchinton, A. I., Huntsman, D., Daynard, T., Waterhouse, D. N., Thiessen, B., Dedhar, S. and Bally, M. B. (2008). "Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of integrin-linked kinase (ILK)." Mol Cancer Ther 7(1): 59-70.

10. Huxham, L. A., Kyle, A. H., Baker, J. H., McNicol, K. L. and Minchinton, A. I. (2008). "Exploring vascular dysfunction caused by tirapazamine." Microvasc Res 75(2): 247-55.

11. Tucker, C. A., Kapanen, A. I., Chikh, G., Hoffman, B. G., Kyle, A. H., Wilson, I. M., Masin, D., Gascoyne, R. D., Bally, M. and Klasa, R. J. (2008). "Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor-kappaB, p53, bax, and p27 levels." Mol Cancer Ther 7(4): 749-58.

12. Kyle, A. H., Huxham, L. A., Yeoman, D. M. and Minchinton, A. I. (2007). "Limited tissue penetration of taxanes: a mechanism for resistance in solid tumors." Clin Cancer Res 13(9): 2804-10.

13. Huxham LA, Kyle AH, Baker JH, McNicol KL, Minchinton AI.  Tirapazamine causes vascular dysfunction in HCT-116 tumour xenografts. Radiother Oncol. 2006 Feb;78(2):138-45. Epub 2006 Feb 7. PMID: 16455148

14. Baker JH, Huxham LA, Kyle AH, Lam KK, Minchinton AI.  Vascular-specific quantification in an in vivo Matrigel chamber angiogenesis assay. Microvasc Res. 2006 Mar;71(2):69-75. Epub 2006 Mar 20.

15. Kyle AH, Huxham LA, Chiam AS, Sim DH, Minchinton AI.  Direct assessment of drug penetration into tissue using a novel application of three-dimensional cell culture. Cancer Res. 2004 Sep 1;64(17):6304-9.

16. Huxham LA, Kyle AH, Baker JH, Nykilchuk LK, Minchinton AI.  Microregional effects of gemcitabine in HCT-116 xenografts. Cancer Res. 2004 Sep 15;64(18):6537-41.

17. Dragowska WH, Warburton C, Yapp DT, Minchinton AI, Hu Y, Waterhouse DN, Gelmon K, Skov K, Woo J, Masin D, Huxham LA, Kyle AH, Bally MB.  HER-2/neu overexpression increases the viable hypoxic cell population within solid tumors without causing changes in tumor vascularization. Mol Cancer Res. 2004 Nov;2(11):606-19.

18. Kyle AH, Huxham LA, Baker JH, Burston HE, Minchinton AI.  Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent. Cancer Res. 2003 Sep 15;63(18):5707-11.

19. Minchinton AI, Tonn DA, Sutherland DP, Kyle AH.  Carbogen breathing after irradiation enhances the effectiveness of tirapazamine in SiHa tumors but not SCCVII tumors in mice. Radiat Res. 2002 Jul;158(1):94-100.

20. Kyle AH, Chan CT, Minchinton AI.  Characterization of three-dimensional tissue cultures using electrical impedance spectroscopy. Biophys J. 1999 May;76(5):2640-8.

21. Kyle AH, Minchinton AI.  Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model. Cancer Chemother Pharmacol. 1999;43(3):213-20. Kyle AH, Chan CT, Minchinton AI.  Characterization of three-dimensional tissue cultures using electrical impedance spectroscopy. Biophys J. 1999 May;76(5):2640-8.

22. Buchinger F., Kyle A.H., Lee J.K.P., Webb C. (1995). “Identification of individual bistable defects in avalanche photodiodes.” Applied Physics Letters 66(18), 2367-9.