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Victor Martinez, PhD

World Cancer Congress (Montreal, 2012)

(Epi)genomic mechanisms in environmentally-induced cancer and other diseases


Research interests

Environmental exposure induces molecular damage that will accumulate, leading to adverse health outcomes. An individual's exposome (the combined exposure to multiple agents during one's lifespan) imposes changes in the individual's genome. My research explores the causal relationship between (epi)genomic changes and diseases associated with environmental exposures for the purpose of estimating the risk of developing cancer and identifying treatment targets tailored to individual exposomes.

My research interests are:

  • To derive molecular signatures reflective of accumulated damage as a consequence of arsenic and asbestos exposure.
  • To understand the molecular mechanisms driving arsenic-induce cancer and other diseases.
  • To define actionable treatment targets personalized to (epi)genomic changes resulted from environmental exposures


Training

  • Research Associate. British Columbia Cancer Agency (2016-Current)
  • Post-Doctoral Fellow (Integrative Oncology), with Wan Lam, British Columbia Cancer Research Centre (2011-2016)
  • PhD (Biomedical Sciences) with Lionel Gil, Faculty of Medicine, University of Chile (2003-2010)
  • BSc (Biotechnology Engineering). University of Chile (2002)
  • Silicon Valley Immersion Program. University of San Francisco, California (2011)
  • Diploma in Market-oriented innovation Management. University of Santiago – University of Leipzig (2007)


Selected publications (per research area)

The full list of publication here

Environmental genomics
  • Minatel BC, Sage AP, Anderson C, Hubaux R, Marshall EA, Lam WL, Martinez VD. Environmental arsenic exposure: From genetic susceptibility to pathogenesis. Environment International 2018; 112: 183-197.
  • Martinez VD, Thu KL, Vucic EA, Hubaux R, Adonis M, Gil L, MacAulay C, Lam S, Lam WL. Whole-genome sequencing analysis identifies a distinctive mutational spectrum in an arsenic-related lung tumor. Journal of Thoracic Oncology 2013; 8: 1451-1455.
  • Martinez VD, Vucic EA, Lam S, Lam WL. Emerging arsenic threat in Canada. Science 2013; 342: 559.
  • Martinez VD, Vucic EA, Lam S, Lam WL. Arsenic and lung cancer in never-smokers: lessons from Chile. Am J Respiratory and Critical Care Medicine 2012; 185: 1131.
  • Martinez VD, Vucic EA, Becker-Santos DD, Gil L, Lam WL. Arsenic exposure and the induction of human cancers. Journal of Toxicology 2011; 2011: 431287.

Cancer genetics and clinical applications

  • Martinez VD, Firmino NS, Marshall EA, Ng KW, Wadsworth BJ, Anderson C, Lam WL, Bennewith KL. Non-coding RNAs predict recurrence-free survival of patients with hypoxic tumours. Scientific Reports 2018; 8: 152
  • Minatel BC*, Martinez VD*, Ng KW, Sage AP, Tokar T, Marshall EA, Anderson C, Enfield KSS, Stewart GL, Reis PP, Jurisica I, Lam WL. Large-scale discovery of previously undetected microRNAs specific to human liver. Human Genomics 2018; 12: 16 (*Co-1st authors)
  • Martinez VD, Enfield KS, Rowbotham DA, Lam WL. An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence. Gastric Cancer 2016; 19: 660.
  • Martinez VD, Vucic EA, Thu KL, Hubaux R, Enfield KS, Pikor LA, Becker-Santos DD, Brown CJ, Lam S, Lam WL. Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology. Scientific Reports 2015; 5: 10423

 Genetics and Environmental Toxicology

  • Martinez VD, Buys TP, Adonis M, Benitez H, Gallegos I, Lam S, Lam WL, Gil L. Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas. Br J Cancer 2010; 103: 1277-1283.
  • Adonis M, Martinez VD, Marin P, Berrios D, Gil L. Smoking habit and genetic factors associated with lung cancer in a population highly exposed to arsenic. Toxicol Lett 2005; 159: 32.
  • Adonis M, Martinez VD, Riquelme R, Ancic P, Gonzalez G, Tapia R, Castro M, Lucas D, Berthou F, Gil L. Susceptibility and exposure biomarkers in people exposed to PAHs from diesel exhaust. Toxicol Lett 2003; 144: 3.

Selected invited national and international talks

  • Malignant pleural mesothelioma tissue-of-origin classifiers developed from novel miRNAs sequences. 14th Meeting of the International Mesothelioma Interest Group (iMig 2018). May 2-5, 2018. Ottawa, Canada
  • Analysis of piwi-interacting RNA transcriptomes reveal cancer type-specificity and signatures predicting lung tumor behavior. HUGO-Human Genome Meeting. February 5-7, 2017. Barcelona, Spain
  • Piwi-interacting RNA transcriptome analyses identify cancer type-specific expression and signatures predicting lung tumor behavior. 4th AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic, January 4-7, 2016. San Diego, USA *AACR Scholar-in-training Award
  • Piwi-interacting RNA transcriptome analyses identify cancer type-specific expression patterns and signatures predicting lung cancer patient outcome. Terry Fox Research Institute 6th Annual Scientific Meeting. May 7-9, 2015. St. John’s, Newfoundland, Canada  * Trainee Travel Award
  • Multi-‘omic analysis of an arsenic-associated lung squamous cell carcinoma reveals specific DNA level signatures. 15th World Conference on Lung Cancer. October 27-30, 2013. Sydney, Australia.  *Young Investigator Award
  • Molecular events in lung squamous cell carcinomas associated with arsenic exposure (2012). 5th Latin-American Conference on Lung Cancer (LALCA2012). July 25-27, 2012. Rio de Janeiro, Brazil
  • Arsenic related lung cancer: A growing problem for the world. BC Cancer Annual Conference. December 1st, 2011. Vancouver, BC, Canada 
  • Alterations in arsenic-related lung squamous cell carcinomas using microarray-based high-resolution comparative genome hybridization. World Microarray Congress. March 19-20, 2008. Vancouver, BC, Canada  

Teaching experience

Post-graduate level 

  • 2005-2011 : Instructor at Biotechnology Management Master Program. Faculty of Engineering, University Of Santiago
  • 2007          :  Instructor  at Workshop “DNA microarray: from image analysis to interaction network discovery” Faculty of Medicine, University of Chile

Graduate level

  • 2012          : Speaker at "Occupational & Environmental Health Seminars". Faculty of Medicine, School of Population and Public Health. University of British Columbia
  • 2009-2010 :  Instructor  of Chemistry Chapter “Scientific Basis of Medicine). Faculty of Medicine, University of Chile
  • 2004          :  Instructor  in the course: “Environmental Toxicology and Toxicogenomic: Skills for Risk Assessment of Toxic Compounds”
  • 2004          : Assistant Instructor  for “Cell Biology”. Faculty of Medicine, University of Chile

Undergraduate Level

  • 2007          : Assistant Instructor  of “Genetics” . Faculty of Medicine, University of Chile
  • 2002-2003  : Assistant Instructor of Chemistry Chapter “Scientific Basis of Medicine). Course for medicine students (1st year). Faculty of Medicine, University of Chile

Editorial duties and society fellowships

  • Editorial Board Member: Biomed Research International, Scientific Reports
  • Postdoc member: AAAS (2012-present) 
  • Member: Canadian Society for Molecular Biosciences (2011-present)
  • Associate member, AACR (2004-present) 
  • Member: IASLC (2013-present)  


Awards and recognitions

  • 2018: University of British Columbia. Faculty of Medicine Graduate Award
  • 2017: University of British Columbia. Faculty of Medicine Graduate Award
  • 2017: University of British Columbia. International Tuition Award
  • 2016: Canadian Institutes of Health Research (CIHR). Travel Award
  • 2015: AACR-IASLC Scholar in Training Award (Fourth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic)
  • 2015: Terry Fox Research Institute (TFRI). Travel Award
  • 2013: 15th World Conference in Lung Cancer. Young Investigator Award. 
  • 2013: Canadian Cancer Society. Travel Award
  • 2011: BC Cancer Agency. Presentation Award - Research Translation/Population Health  
  • 2010: Chilean Society of Cancer Research. Annual prize for best presentations
  • 2008: Canada-Chile Leadership Exchange Program Scholarship. Government of Canada Awards Program

  • 2007: British Columbia Cancer Foundation. Visitant researchers supporting program

  • 2005: Chilean Biotechnologist Association. President (During 2 years)

  • 2006: MECESUP Program (Chile). Short-term research stay

  • 2005: Graduate Student Exchange Program Scholarship. Government of Canada Awards Program

  • 2004: Organization of American States. Scholarship for training programs

  • 2004: National Commission for Science and Technology. Scholarship for PhD studies

  • 2003: Institute for Biomedical Sciences (Faculty of Medicine, University of Chile). Scholarship for PhD studies

  • 2001: French Government (ÉGIDE). Research stay scholarship

  • 1999: Santander group (Spain). Scholarship for University studies  


Full list of publications 

Citation metrics in google scholar

Refereed Journal Publications

  1. Sage AP, Minatel BC, Marshall EA, Martinez VD, Stewart GL, Enfield KSS, Lam WL. Expanding the miRNA transcriptome of human kidney and renal cell carcinoma. Int J Genomics 2018; In press.
  2. Minatel BC, Sage AP, Anderson C, Hubaux R, Marshall EA, Lam WL, Martinez VD. Environmental arsenic exposure: From genetic susceptibility to pathogenesis. Environ Int 2018; 112: 183.
  3. Minatel BC, Martinez VD, Ng KW, Sage AP, Tokar T, Marshall EA, Anderson C, Enfield KSS, Stewart GL, Reis PP, Jurisica I, Lam WL. Large-scale discovery of previously undetected microRNAs specific to human liver. Hum Genomics 2018; 12: 16.
  4. Martinez VD, Firmino NS, Marshall EA, Ng KW, Wadsworth BJ, Anderson C, Lam WL, Bennewith KL. Non-coding RNAs predict recurrence-free survival of patients with hypoxic tumours. Sci Rep 2018; 8: 152.
  5. Drilon A, Somwar R, Mangatt BP, Edgren H, Desmeules P, Ruusulehto A, Smith RS, Delasos L, Vojnic M, Plodkowski AJ, Sabari J, Ng K, Montecalvo J, Chang J, Tai H, Lockwood WW, Martinez VD, Riely GJ, Rudin CM, Kris MG, Arcila ME, Matheny C, Benayed R, Rekhtman N, Ladanyi M, Ganji G. Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers. Cancer Discov 2018; 8: 686.
  6. Thu KL, Papari-Zareei M, Stastny V, Song K, Peyton M, Martinez VD, Zhang YA, Castro IB, Varella-Garcia M, Liang H, Xing C, Kittler R, Milchgrub S, Castrillon DH, Davidson HL, Reynolds CP, Lam WL, Lea J, Gazdar AF. A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas. Oncotarget 2017; 8: 50489.
  7. Sage AP, Minatel BC, Ng KW, Stewart GL, Dummer TJB, Lam WL, Martinez VD. Oncogenomic disruptions in arsenic-induced carcinogenesis. Oncotarget 2017; 8: 25736.
  8. Marshall EA, Sage AP, Ng KW, Martinez VD, Firmino NS, Bennewith KL, Lam WL. Small non-coding RNA transcriptome of the NCI-60 cell line panel. Sci Data 2017; 4: 170157.
  9. Ng KW, Anderson C, Marshall EA, Minatel BC, Enfield KS, Saprunoff HL, Lam WL, Martinez VD. Piwi-interacting RNAs in cancer: emerging functions and clinical utility. Mol Cancer 2016; 15: 5.
  10. Martinez VD, Enfield KS, Rowbotham DA, Lam WL. An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence. Gastric Cancer 2016; 19: 660.
  11. Marshall EA, Ng KW, Kung SH, Conway EM, Martinez VD, Halvorsen EC, Rowbotham DA, Vucic EA, Plumb AW, Becker-Santos DD, Enfield KS, Kennett JY, Bennewith KL, Lockwood WW, Lam S, English JC, Abraham N, Lam WL. Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis. Mol Cancer 2016; 15: 67.
  12. Firmino N*, Martinez VD*, Rowbotham DA, Enfield KSS, Bennewith KL, Lam WL. HPV status is associated with altered PIWI-interacting RNA expression pattern in head and neck cancer. Oral Oncol 2016; 55: 43. (*Co-1st authors)
  13. Enfield KS, Martinez VD, Marshall EA, Stewart GL, Kung SH, Enterina JR, Lam WL. Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung cancer patient outcome. Oncotarget 2016; 7: 80957.
  14. Becker-Santos DD, Thu KL, English JC, Pikor LA, Martinez VD, Zhang M, Vucic EA, Luk MT, Carraro A, Korbelik J, Piga D, Lhomme NM, Tsay MJ, Yee J, MacAulay CE, Lam S, Lockwood WW, Robinson WP, Jurisica I, Lam WL. Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma. J Pathol 2016; 240: 161.
  15. Kang SYC, Kannan N, Zhang L, Martinez VD, Rosin MP, Eaves CJ. Characterization of Epithelial Progenitors in Normal Human Palatine Tonsils and Their HPV16 E6/E7-Induced Perturbation. Stem Cell Reports 2015; 5: 1210.
  16. Martinez VD, Vucic EA, Thu KL, Pikor LA, Lam S, Lam WL. Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms: Association with poor prognosis in head and neck cancer. Head Neck 2015; 37: 727.
  17. Martinez VD, Vucic EA, Thu KL, Hubaux R, Enfield KS, Pikor LA, Becker-Santos DD, Brown CJ, Lam S, Lam WL. Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology. Sci Rep 2015; 5: 10423.
  18. Marshall EA, Ng KW, Anderson C, Hubaux R, Thu KL, Lam WL, Martinez VD. Gene expression analysis of microtubule affinity-regulating kinase 2 in non-small cell lung cancer. Genom Data 2015; 6: 145.
  19. Hubaux R, Thu KL, Vucic EA, Pikor LA, Kung SH, Martinez VD, Mosslemi M, Becker-Santos DD, Gazdar AF, Lam S, Lam WL. Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer. Int J Cancer 2015; 137: 2072.
  20. Rowbotham DA, Marshall EA, Vucic EA, Y. KJ, Lam WL, Martinez VD. Epigenetic Changes in Aging and Age-related Disease. J Aging Sci 2015; 3(1):130.
  21. Rowbotham DA, Enfield KS, Martinez VD, Thu KL, Vucic EA, Stewart GL, Bennewith KL, Lam WL. Multiple Components of the VHL Tumor Suppressor Complex Are Frequently Affected by DNA Copy Number Loss in Pheochromocytoma. Int J Endocrinol 2014; 2014: 546347.
  22. Martinez VD, Vucic EA, Thu KL, Pikor LA, Hubaux R, Lam WL. Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer. Biomed Res Int 2014; 2014: 159459.
  23. Martinez VD, MacAulay CE, Guillaud M, Lam WL, Zhang L, Corbett KK, Rosin MP. Targeting of chemoprevention to high-risk potentially malignant oral lesions: challenges and opportunities. Oral Oncol 2014; 50: 1123.
  24. Martinez VD, Vucic EA, Pikor LA, Thu KL, Hubaux R, Lam WL. Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer. Mol Cancer 2013; 12: 124.
  25. Martinez VD, Vucic EA, Lam S, Lam WL. Emerging arsenic threat in Canada. Science 2013; 342: 559.
  26. Martinez VD, Thu KL, Vucic EA, Hubaux R, Adonis M, Gil L, MacAulay C, Lam S, Lam WL. Whole-genome sequencing analysis identifies a distinctive mutational spectrum in an arsenic-related lung tumor. J Thorac Oncol 2013; 8: 1451.
  27. Hubaux R, Becker-Santos DD, Enfield KS, Rowbotham D, Lam S, Lam WL, Martinez VD. Molecular features in arsenic-induced lung tumors. Mol Cancer 2013; 12: 20.
  28. Martinez VD, Vucic EA, Lam S, Lam WL. Arsenic and lung cancer in never-smokers: lessons from Chile. Am J Respir Crit Care Med 2012; 185: 1131.
  29. Hubaux R, Becker-Santos DD, Enfield KS, Lam S, Lam WL, Martinez VD. MicroRNAs As Biomarkers For Clinical Features Of Lung Cancer. Metabolomics (Los Angel) 2012; 2: 1000108.
  30. Hubaux R, Becker-Santos DD, Enfield KS, Lam S, Lam WL, Martinez VD. Arsenic, asbestos, and radon: emerging players in lung tumorigenesis. Environ Health 2012; 11: 89.
  31. Enfield KS, Pikor LA, Martinez VD, Lam WL. Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications. Genet Res Int 2012; 2012: 737416.
  32. Martinez VD, Vucic EA, Becker-Santos DD, Gil L, Lam WL. Arsenic exposure and the induction of human cancers. J Toxicol 2011; 2011: 431287.
  33. Martinez VD, Vucic EA, Adonis M, Gil L, Lam WL. Arsenic biotransformation as a cancer promoting factor by inducing DNA damage and disruption of repair mechanisms. Mol Biol Int 2011; 2011: 718974.
  34. Martinez VD, Becker-Santos DD, Vucic EA, Lam S, Lam WL. Induction of human squamous cell-type carcinomas by arsenic. J Skin Cancer 2011; 2011: 454157.
  35. Martinez VD, Buys TP, Adonis M, Benitez H, Gallegos I, Lam S, Lam WL, Gil L. Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas. Br J Cancer 2010; 103: 1277.
  36. Adonis M, Martinez VD, Marin P, Gil L. CYP1A1 and GSTM1 genetic polymorphisms in lung cancer populations exposed to arsenic in drinking water. Xenobiotica 2005; 35: 519.
  37. Adonis M, Martinez VD, Marin P, Berrios D, Gil L. Smoking habit and genetic factors associated with lung cancer in a population highly exposed to arsenic. Toxicol Lett 2005; 159: 32.
  38. Adonis M, Martinez VD, Riquelme R, Ancic P, Gonzalez G, Tapia R, Castro M, Lucas D, Berthou F, Gil L. Susceptibility and exposure biomarkers in people exposed to PAHs from diesel exhaust. Toxicol Lett 2003; 144: 3.
  39. Jara L, Ampuero S, Santibanez E, Seccia L, Rodriguez J, Bustamante M, Martinez VD, Catenaccio A, Lay-Son G, Blanco R, Reyes JM. BRCA1 and BRCA2 mutations in a South American population. Cancer Genet Cytogenet 2006; 166: 36.
  40. Gil L, Martinez VD, Riquelme R, Ancic P, Gonzalez G, Rodriguez L, Adonis M. Occupational and environmental levels of mutagenic PAHs and respirable particulate matter associated with diesel exhaust in Santiago, Chile. J Occup Environ Med 2003; 45: 984.

  41. Adonis M, Riquelme R, Martinez VD, Gil L, Rios C, Rodriguez L, Rodriguez E. PAHs and Mutagenicity of Inhalable and Respirable Diesel Particulate Matter in Santiago, Chile. Polycyclic Aromatic Compounds 2003; 23: 495.

 Invited Editorials

  • Martinez VD, Becker-Santos DD, Lam S, Lam WL. Emerging Challenges for Management of Arsenic-Induced Lung Cancer. Editorial for Lung Cancer Management 2012; 1(4): 243. 
  • Verastegui J, Martinez VD, Roca W, Gil L (2004) The multinational biosafety project of the Organization of American States. Electron J Biotechnol 7:61-71

Published Books and Book Chapters

  • Hubaux R, Martinez VD, Rowbotham D, Lam WL. (2014) Comparative genomic hybridization and spectral karyotyping methods in cancer. In Molecular Testing in Cancer. George M. Yousef (ed.) Springer.
  • Martínez VD., Gil L. Bioseguridad y Comercio Internacional de Alimentos Transgénicos en las Américas: Decisiones y Desafíos. Santiago: Andros, 2005, p. 473. ISBN 956-291-992-7
  • Adonis M., Martínez VD., Gil L. Avances Recientes en Genómica y Proteómica Pronostican Mejoras en la Prevención y el Tratamiento personalizado del Cáncer Pulmonar. En: Adonis M., Gil L. (eds) Gestión-Innovación y Comercialización en Biotecnología. Santiago: Editorial Universitaria, 2007, p. 279-287. ISBN 956-11-1956-0
  • Verástegui J., Martínez VD., Roca W., de Peña M., Gil L. . El Proyecto Multinacional de Bioseguridad de la OEA: Fase 1 En: Martínez V., Gil, L. Bioseguridad y Comercio Internacional de Alimentos Transgénicos en las Américas: Decisiones y Desafíos. Santiago: Andros, 2005, p. 21-33. ISBN 956-291-992-7
  • Gil L., Martínez VD. Capacidades de Formación de Recursos Humanos en Biotecnología en Chile En: Martínez V., Gil, L. Bioseguridad y Comercio Internacional de Alimentos Transgénicos en las Américas: Decisiones y Desafíos. Santiago: Andros, 2005, p. 371-389. ISBN 956-291-992-7
  • Martínez VD., Dornberger U., Gil L. Estado Actual de la Industria Biotecnológica Chilena. En: Martínez V., Gil, L. Bioseguridad y Comercio Internacional de Alimentos Transgénicos en las Américas: Decisiones y Desafíos. Santiago: Andros, 2005, p. 415-433. ISBN 956-291-992-7
  • de Souza L., Oda L., Martínez VD., Gil L. Estudio Comparativo sobre la Percepción Pública de la Biotecnología Moderna en Brasil y Chile En: Martínez V., Gil, L. Bioseguridad y Comercio Internacional de Alimentos Transgénicos en las Américas: Decisiones y Desafíos. Santiago: Andros, 2005, p. 333-347. ISBN 956-291-992-7
  • Gil L., Martínez VD. Regulaciones de Bioseguridad en Chile en el Marco del Protocolo de Cartagena En: Solleiro JL, Castañon R. El protocolo de Cartagena y las necesidades para su Implementación en los Países de América Latina. Mexico, DF: CamBioTec, 2004, p. 117-143
  • Martínez VD., Gil L. Perfil de la Industria Biotecnológica a Nivel Nacional: Chile. En: Verástegui, J. La Biotecnología en América Latina: Panorama al año 2002. Ottawa: IDRC-Canadá, 2003, p. 80-94. ISBN 987-20494-3-2
  • Gil L., Martínez VD. Políticas Públicas y Cooperación Internacional en el Sector Biotecnológico Chileno, En: Biotecnología: Políticas públicas y Aceptación Social en Argentina, Brasil, Chile, Colombia, Cuba, Ecuador, España y México. Buenos Aires: Punthau, 2003, p. 50-59. ISBN 987-20494-4-0

Articles in Magazines

  • Gil L., Martínez VD., Irarrázabal C., Martínez C. Aceptación Pública de la Biotecnología y de los Alimentos Transgénicos. Ambiente y Desarrollo 2002; 17 (4): 52-58
  • Martinez VD., De Souza L., e Gil L. Implementacao do Protocolo Internacional de Biosseguranca. Pontos fortes e fracos de alguns países da área Andina. Journal Da ANBIO, Edicao N° 10, maio-junho de 2003, p.5

Invited talks

  • Analysis of piwi-interacting RNA transcriptomes reveal cancer type-specificity and signatures predicting lung tumor behavior. HUGO-Human Genome Meeting. February 5-7, 2017. Barcelona, Spain.
  • Piwi-interacting RNA transcriptome analyses identify cancer type-specific expression and signatures predicting lung tumor behavior. Fourth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic, San Diego, CA.* AACR Scholar-in-training Award
  • Piwi-interacting RNAs: small RNAs with a big (epigenetic) memory. Keynote at the International Workshop “Tumor Hypoxia in the Genomics Era”, Vancouver, August 2015
  • Piwi-interacting rna transcriptome analyses identify cancer type-specific expression patterns and signatures predicting lung cancer patient outcome. Terry Fox Research Institute 6th Annual Scientific Meeting. St. John’s Newfoundland, May 7-9th, 2015 * Trainee Travel Award
  • Multi-‘omic analysis of an arsenic-associated lung squamous cell carcinoma reveals specific DNA level signatures. 15th World Conference on Lung Cancer. Sidney, Australia, October 2013 *Young Investigator Award
  • The impact of environment on cancer: A focus on radon and arsenic. University of British Columbia: Occupational & Environmental Health Seminars. Vancouver, Canada (October 2012) *Together with Dr. Roland Hubaux
  • Arsenic in drinking water: an emerging risk factor for lung squamous cell carcinomas in never smokers. UBC Respiratory Seminars. Vancouver, Canada (January 2012)
  • Arsenic and cancer: A problem for the world. BC Annual Cancer Care Conference, 'Research Translation- Conversations in Cancer' session. Vancouver, Canada (December 2011)
** 2011 Oral Poster Award Winners- Population Health and Health Services**
  • Analysis of Whole Genome DNA Copy-Number Alterations in Arsenic-Related Lung Squamous Cell Carcinomas using Microarraybased High- Resolution Comparative Genome Hybridization. World Microarray Congress. Vancouver, Canada (2008)

Abstracts and Presentations

  • Martinez VD, Vucic EA, Thu KL, Marshall EA, Enfield KSS, Minatel BC, Rahmati S, Tokar T, Abovsky M, Pastrello C, Jurisica I, MacAulay CE, Lam S, Lam WL. Molecular biology underlying COPD and lung cancer converge on FOXM1 network. 17th World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC). December 4 to 7, 2016, Vienna, Austria.
  • de Silva T, Martinez VD, Thu K, Lu D, Oh MH, Lam S, Lam W, Varmus H, Lockwood W. Characterizing the genomes of lung adenocarcinoma from never smokers reveals a novel candidate tumour suppressor gene SHPRH. 17th World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC). December 4 to 7, 2016, Vienna, Austria.
  • Minatel BC, Martinez VD, Marshall EA, Ng K, Enfield KSS, Lam S, Lam W. A Piwi-interacting RNAs display cancer-specific expression patterns that hold prognostic value in lung cancer. 17th World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC). December 4 to 7, 2016, Vienna, Austria.
  • Enterina JR, Enfield KSS, Martinez VD, Marshall EA, Stewart GL, Lam WL. Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung adenocarcinoma patient outcome. 17th World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC). December 4 to 7, 2016, Vienna, Austria.
  • Stewart GL, Enfield KSS, Martinez VD, Marshall EA, Lam S, Lam WL. Long non-coding RNA expression from pseudogene loci are deregulated in lung adenocarcinoma, highlighting alternative regulatory mechanisms. 17th World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC). December 4 to 7, 2016, Vienna, Austria.
  • Becker-Santos DD, Minatel BC, Lonergan K, Thu KL, English JC, Martinez VD, MacAulay CE, Lockwood WW, Robinson WP, Jurisica I, Lam S, Lam WL. Expression of oncofetal miRNAs inactivates NFIB, a developmental transcription factor linked to tumour aggressiveness in lung adenocarcinoma. 17th World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC). December 4 to 7, 2016, Vienna, Austria.
  • Vucic EA, Thu KL, Martinez VD, Pastrello C, Yee J, Jurisica I, Lam S, Lam WL. (2014) Lung tumors and non-malignant airways from patients with chronic lung inflammatory disease bear distinct genetic and epigenetic disruptions corresponding to metabolic processes involved in senescence and methylation. Metabolism, Diet and Disease 2014: Cancer and Metabolism. Washington, DC
  • Vucic EA, Martinez VD, Thu KL, Pikor LA, Lam S, Lam WL. (2014) Genetic and Epigenetic Contribution to Chronic Obstructive Pulmonary Disease Related Lung Cancer. Keystone Symposia on Molecular and Cellular Biology: Cancer Epigenetics. Santa Fe, NM
  • Vucic EA, Martinez VD, Thu KL, Pikor LA, Enfield KSS, Yee J, Lam S, Lam WL. (2014) Distinct genetic and epigenetic disruptions in lung tumours and small airways of patients with chronic obstructive pulmonary disease and lung cancer. The Terry Fox Research Institute 5th Annual Scientific Meeting. Montreal, QC
  • Ramnarine VR, Martinez VD, Pikor LA, Mosslemi M, Lam S, Lam WL. Fusion gene identification in non-small cell lung cancer. 2012 Annual Cancer Conference: Evolving Dynamics in Research and Patient Care. December 2012
  • Becker-Santos DD*, Lam WL, V. D. Martinez VD (2012)  Establishment of a Cancer Biobank Network in Chile. World Cancer Congress. Montreal, Canada, August 2012
  • Becker-Santos DD*, Hubaux R, Vucic EA, Lam S, Lam WL, Martinez VD (2012) Molecular events in arsenic-realted lung cancer. World Cancer Congress. Montreal, Canada, August 2012
  • Becker-Santos DD, Hubaux R, Vucic EA, Lam S, Lam WL, Martinez VD (2012) Molecular events in lung squamous cell carcinomas associated with arsenic exposure. 5th Latin-American Conference on Lung Cancer (LALCA2012). Rio de Janeiro, Brazil, July 2012
  • Martinez VD, Vucic EA, Hubaux R, Becker DD, Lam S, Lam WL (2012) Genomic alterations in arsenic-related lung carcinogenesis. 55th Annual Conference of the Canadian Society Molecular Biology: Epigenetics and Genomic Stability. Whistler, BC. March 14 – 18, 2012
  • Becker-Santos DD, Vucic EA, Lam S, Lam WL, Martinez VD (2012) Genomic and epigenomic events in arsenic-related lung squamous cell carcinomas from smokers and never smokers. AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Biology, Therapy, and Personalized Medicine. San Diego, CA
  • Becker-Santos DD, Vucic EA,  Lam S, Lam WL, Martinez VD (2011) Genomic and epigenomic alterations in arsenic-related lung squamous cell carcinomas. In American Association for Cancer Research: Frontiers in Cancer Prevention Research Meeting, Boston, MA, USA, October, 2011.
  • Becker-Santos DD, Martinez VD, Vucic EA,  Lam S, Lam WL (2011) Arsenic-related genomic and epigenomic alterations in lung squamous cell carcinomas. In American Society of Human Genetics Annual Meeting, Montreal, QC, Canada, October, 2011.
  • Martinez VD, Becker-Santos DD, Vucic EA,  Lam S, Lam WL (2011) Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas. In Annual Conference, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, May 2011.
  • Martinez VD, Buys TPH, Adonis M, Benítez H, Gallegos I, Lam S, Lam WL and y Gil L (2010) XVIII Meeting of the Chilean Cancer Society. La Serena,  Chile. October 2011
  • Adonis M, Martinez VD, and Gil L. PRRI Chilean focal point activities 2007-2009 and an overview of genetic modified organisms in Latin America and Chile. Final Science 4 BioReg consortium meeting and  STOA  Panel of the European Parliament. Seminar on the impact of European Union  GMO regulations on public research in Biotechnology for the public good. European Parliament February, 24 and 25   2010, Brusells, Belgium 
  • Martínez VD, Adonis M, Lam WL and Gil L. . Copy-number Variations on Chilean Individuals. Annual Meeting of the Chilean Biology Society. Pucón, Chile; November 24, 2008.
  • Martínez VD, Gil L, Lam S, Adonis M, Benitez H and Lam WL.“Characterization of Whole Genome DNA Copy-Number Alterations in Arsenic Related Lung Squamous Cel Carcinomas”. 3rd Latin American Conference on Lung Cancer (IASLC-LALCA), Viña del Mar, Chile, 9 -10, Octubre, 2008.
  • Martínez VD, Lam WL, Lam S, Adonis M, Benítez H, and Gil L. DNA copy-number alterations on squamous cell lung cancer among individuals from Northern Chile. Annual Meeting of the Chilean Biology Society. Pucón, Chile; November 21, 2008
  • Martinez VD, Gil L, Lam S, Adonis M, Benitez H, Lam WL. Analysis of Whole Genome DNA Copy-Number Alterations in Arsenic-Related Lung Squamous Cell Carcinomas using Microarray-based High-Resolution Comparative Genome Hybridization. World Microarray Congress, Vancouver, Canada, June 28th-29th, 2008
  • Martinez VD, Lam S; MacAulay C; Gil L; Lam WL. Specific DNA copy number alterations in arsenic-related lung squamous cell carcinomas. 12th World Conference on Lung Cancer, Korea, Seoul, September 2-6, 2007. Journal of Thoracic Oncology, 2(8) Supplement 4:S437-S438, August 2007.
  • Martínez VD, Buys TPH, Galac L, Saprunoff H, Lam WL and Gil L. Signature genomic alterations identify arsenic exposed lung tumor. BC Cancer Agency Annual Cancer Conference Abstracts. Vancouver, Canada. p. 34, 2006.
  • Adonis M., Martínez VD, Marín P and Gil L. CYP1A1 and GSTM1 genetic polymorphisms in lung Cancer populations exposed to Arsenic in drinking water. 9th International Conference on Environmental Mutagens. San Francisco, USA September, 3-8, 2005
  • Gil L., Martínez VD., Ancic P. and Adonis M. Urinary mutagenicity, urinary 1-OH-Hydroxypyrene levels and genetic polymorphisms in Workers Exposed to Diesel Exhaust. 9th International Conference on Environmental Mutagens. San Francisco, USA September, 3-8, 2005.
  • Gil L, Martínez VD and Adonis M. Single and Combined Genotypes on Lung Cancer Susceptibility in Chilean People. 42st Annual Meeting. USA Society of Toxicology, Baltimore, Maryland, USA. March 21 -25, 2004.
  • Gil L., Martínez VD, Ancic P and Adonis M. Susceptibility and Exposure Biomarkers in Workers Exposed to Diesel Exhaust. Annual meeting, USA Society of Toxicology. Nashville, USA, Marzo, 17 –21, 2002.
  • Martínez VD, Adonis M, Aldunate CG, Berríos D, Rodríguez L y Gil L. Exposure and Risk Biomarkers in Chilean Population with Occupational and Urban Expousure”. MARTÍNEZ, V.; Adonis M; Aldunate CG; Berrios D; Rodríguez L and Gil L Biological Research, vol. 34 (3-4) R-91, 2001. XLIV Annual Meeting of the Chilean Biology Society. Pucón, Chile; November 6-10, 2001.

Events Organized

  • 2012: Workshop: Highlighting the impacts of North–South research collaboration in cancer research
**Dr. Jorge Allende (Chile), member of the National Academy of Sciences, was the keynote speaker of this workshop**
  • 2005: Playing with Biotechnology
**Event held at the National Congress in Chile to familiarize decision makers with science. Deputies and Senators participated performing simple scientific experiments**
  • 2005: Biotechnology Innovation and Commercialization
**Supported by The Organization of American States and the Chilean Economic Development Agency**
    • 2005: III Bio-entrepreneur Conference in South America
    **Supported by the Organization of American States, the Pasteur Institute (France) and the Chilean Economic Development Agency. Dr. Victor Ling and Dr. Samuel Abraham participated in this conference**