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Victor Martinez, PhD


vmartinez@bccrc.ca  675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada 

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam LabVictor Martinez |

 World Cancer Congress (Montreal, 2012)


Lung cancer is the deadliest type of cancer worldwide. Cigarette smoking is the leading cause, although up to 25% of cases arise in never smokers. Since lung cancer is primarily viewed as a smoker's disease, the risk of never smokers developing lung cancer is often overlooked, leading to delays in diagnosis and poor survival rates.

With anticipated success in smoking prevention and cessation worldwide campaigns, lung cancer will increasingly become a disease of never (and former) smokers. The biological mechanisms underlying lung tumorigenesis in never smokers are largely unknown; however, major pathological and molecular differences in lung cancers arising in smokers and never smokers have been recognized, suggesting that never smokers develops lung tumors through mechanisms different from those induced by tobacco carcinogens. Therefore, understanding these differences between tumors from smokers and in never smokers is urgently needed to improve patient prognosis.


Research Interests

An integrative analysis of different aspects of lung tumor genomes and epigenomes in conjunction with gene expression (e.g. DNA copy number, DNA methylation, heterozygosity, mutation with mRNA and miRNA expression) allow the identification of causal events in tumorigenesis. By using this approach, my research is focused on improvement of the understanding of molecular mechanisms driving lung cancer biology in never smokers and development of molecular biomarkers that can be used in novel therapeutic strategies. Current and future research projects includes:

  • Discovery of coding and non-coding genes disrupted in lung carcinogenesis in never smokers
  • Identification of known and novel gene interactions (networks/complexes) associated with lung cancer phenotypes, where identified disrupted genes are involved
  • Assessment of clinical applications of candidates genes/complexes

Together with contribution to elucidation of scientific questions in lung cancer biology and advance in development of new therapeutic alternatives, the motivation of this research is also to provide relief (in the broader sense) to cancer patients and their families.


Training

My training has combined biomedical research and entrepreneurial activities, both in Chile and North America. This combination have significantly marked and complemented my scientific development 

  • 2011: Silicon Valley Immersion Program. University of San Francisco, California
  • 2010: PhD in Biomedical Sciences, Faculty of Medicine, University of Chile
  • 2007: Diploma in Market-oriented innovation Management. University of Santiago – Small Enterprise Promotion and Training Centre (SEPT), University of Leipzig (Germany)
  • 2003: Biotechnology Engineer, University of Chile
  • 2002: Licensed in Molecular Biotechnology Engineering, University of Chile  


Research and Work Experiences

  • Current    : Postdoctoral fellow. Wan Lam Lab, Integrative Oncology, British Columbia Cancer Research Centre
  • 2010-2011: Co-founding and development of the Science&Business Unit. Plataforma 360 Ltda.
  • 2005-2010: PhD. Thesist. Center for Cancer Technologies. Faculty of Medicine University of Chile. Supervisor: Lionel Gil, PhD
  • 2005-2006: Executive for the Science & Business Unit. Octantis (business incubator). Business School, University Adolfo Ibanez (Santiago, Chile)
  • 2004-2005: Chilean Coordinator for Innoways GMBH (Consulting firm from Leipzig, Germany)
  • 2000-2003: Sub-coordinator. CamBioTec - Chile
  • 2000-2001: Undergraduate Thesis. Biochemistry and Environmental Toxicology Laboratory. Faculty of Medicine, University of Chile 

Teaching Experience

Post-graduate level 

  • 2005-2011 : Instructor at Biotechnology Management Master Program. Faculty of Engineering, University Of Santiago
  • 2007          :  Instructor  at Workshop “DNA microarray: from image analysis to interaction network discovery” Faculty of Medicine,                        University of Chile

Graduate level

  • 2012          : Speaker at "Occupational & Environmental Health Seminars". Faculty of Medicine, School of Population and Public Health. University of British Columbia
  • 2009-2010 :  Instructor  of Chemistry Chapter “Scientific Basis of Medicine). Faculty of Medicine, University of Chile
  • 2004          :  Instructor  in the course: “Environmental Toxicology and Toxicogenomic: Skills for Risk Assessment of Toxic Compounds”
  • 2004          : Assistant Instructor  for “Cell Biology”. Faculty of Medicine, University of Chile

Undergraduate Level

  • 2007          : Assistant Instructor  of “Genetics” . Faculty of Medicine, University of Chile
  • 2002-2003  : Assistant Instructor of Chemistry Chapter “Scientific Basis of Medicine). Course for medicine students (1st year). Faculty of Medicine, University of Chile

Editorial Duties and Society Fellows

  • Editorial Board Member: Biomed Research International, Scientific Reports
  • Postdoc member: AAAS (2012-present) 
  • Member: Canadian Society for Molecular Biosciences (2011-present)
  • Associate member, AACR (2004-present) 
  • Member: IASLC (2013-present)  
  • Reviewer for: Cancer Research UK, Genome Research,  Molecular Cancer Research, BMC Cancer, Cancer Prevention Research, Chemical Research in Toxicology, Critical Reviews in Environmental Science and Technology,  Environmental Geochemistry and Health, Toxicological Sciences, Lung Cancer, Revista Medica de Chile 



Awards and Recognitions

  • 2016: Canadian Institutes of Health Research (CIHR). Travel Award
  • 2015: AACR-IASLC Scholar in Training Award (Fourth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic)
  • 2015: Terry Fox Research Institute (TFRI). Travel Award
  • 2013: 15th World Conference in Lung Cancer. Young Investigator Award. 
  • 2013: Canadian Cancer Society. Travel Award
  • 2011: BC Cancer Agency. Presentation Award - Research Translation/Population Health  
  • 2010: Chilean Society of Cancer Research. Annual prize for best presentations
  • 2008: Canada-Chile Leadership Exchange Program Scholarship. Government of Canada Awards Program

  • 2007: British Columbia Cancer Foundation. Visitant researchers supporting program

  • 2005: Chilean Biotechnologist Association. President (During 2 years)

  • 2006: MECESUP Program (Chile). Short-term research stay

  • 2005: Graduate Student Exchange Program Scholarship. Government of Canada Awards Program

  • 2004: Organization of American States. Scholarship for training programs

  • 2004: National Commission for Science and Technology. Scholarship for PhD studies

  • 2003: Institute for Biomedical Sciences (Faculty of Medicine, University of Chile). Scholarship for PhD studies

  • 2001: French Government (ÉGIDE). Research stay scholarship

  • 1999: Santander group (Spain). Scholarship for University studies  


Publications

Journal publications
    * Corresponding Author
    • Sage AP, Minatel BC, Ng KW, Stewart GL, Dummer TJ, Lam WL, Martinez VD (2017). Oncogenomic disruptions in arsenic-induced carcinogenesis. Oncotarget. Accepted (PMID: 28179585) [Epub ahead of print]
    • Enfield KSS, Martinez VD, Marshall EA, Stewart GL, Kung SHY, Enterina J, Lam WL (2016) Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung cancer patient outcome. Oncotarget – Accepted
    • Marshall EA, Ng KW, Kung SHY, Conway EM, Martinez VD, Halvorsen EC, Rowbotham DA, Vucic EA, Plumb AW, Becker-Santos DD, Enfield KSS, Kennett JY, Bennewith KL, Lockwood WW, Lam S, English JC, Abraham N, Lam WL (2016) Emerging Roles of T Helper 17 and Regulatory T Cells in Lung Cancer Progression and Metastasis” Molecular Cancer - Accepted
    • Thu KL, Papari-Zareei M, Stastny V, Song K, Peyton M, Martinez VD, Zhang YA, Castro IB, Varella-Garcia M, Liang H, Xing C, Kittler R, Milchgrub S, Castrillon DH, Davidson HL, Reynolds CP, Lam WL, Lea J, Gazdar AF (2016) A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas. Oncotarget – Accepted
    • Becker-Santos DD, Thu KL, English JC, Pikor LA, Martinez VD, Zhang M, Vucic EA, Luk MT, Carraro A, Korbelik J, Piga D, Lhomme NM, Tsay MJ, Yee J, MacAulay CE, Lam S, Lockwood WW, Robinson WP, Jurisica I, Lam WL (2016) Developmental transcription factor NFIB is a putative target of oncofetal miRNAs and is associated with tumour aggressiveness in lung adenocarcinoma. The Journal of pathology – Accepted.
    • Firmino N, Martinez VD*, Rowbotham DA, Enfield KS, Bennewith KL, Lam WL (2016)HPV status is associated with altered PIWI-interacting RNA expression pattern in head and neck cancer. Oral Oncology, Accepted for publication. [co-first authorship] 
    • Ng KW, Anderson C, Marshall EA, Minatel BC, Enfield KSS, Saprunoff HL, Lam WL, Martinez VD* (2016) Piwi-interacting RNAs in cancer: emerging functions and clinical utility. Molecular Cancer. Accepted for publication.
    • Kang C, Kannan N, Zhang L, Martinez VD, Rosin M, Eaves C (2015) Characterization of Epithelial Progenitors in Normal Human Palatine Tonsils and Their HPV16 E6/E7-induced Perturbation. Stem Cells Reports - Accepted
    • Marshall EA, Ng KW, Anderson C, Hubaux R, Thu KL, Lam WL Martinez VD (2015) Gene expression analysis of microtubule affinity-regulating kinase 2 in non-small cell lung cancer. Genomics Data 6:145–148

    • Martinez VD*, Vucic EA, Thu KL, Hubaux R, Enfield KS, Pikor LA, Becker-Santos DD, Brown CJ, Lam S, Lam WL. (2015) Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology. Sci Rep. 5:10423. doi: 10.1038/srep10423.

    • Hubaux R, Thu KL, Vucic EA, Pikor LA, Kung SH, Martinez VD, Mosslemi M, Becker-Santos DD, Gazdar AF, Lam S, Lam WL. (2015) Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer. Int J Cancer. Apr 22. doi: 10.1002/ijc.29577.

    • Martinez VD*, Enfield KS, Rowbotham DA, Lam WL. (2015) An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence. Gastric Cancer. 2015 Mar 17. [Epub ahead of print]

    • Rowbotham DA, Marshall EA, Vucic EA, Kennett JY, LamWL, Martinez VD. (2014) Epigenetic Changes and Aging. Journal of Aging Science, 3(1) doi: 10.4172/2329-8847.1000130.

    • Martinez VD, MacAulay CE, Guillaud M, Lam WL, Zhang L, Corbett KK, Rosin MP (2014) Targeting of chemoprevention to high-risk potentially malignant oral lesions: Challenges and opportunities.Oral Oncology 50(12):1123-30

    • Rowbotham D, Enfield KSS, Martinez VD*, Thu KL, Vucic EA, Stewart GL,  Bennewith KL, Lam WL (2014) Multiple components of the VHL tumor suppressor complex are frequently affected by DNA copy number losses in pheochromocytoma. International Journal of Endocrinology. In press. co-first / corresponding author

    • Martinez VD*, Vucic EA, Thu KL, Pikor LA, Lam S, Lam WL. (2014). Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms is associated with poor prognosis in head and neck cancer. Head and Neck. In press.

    • Martinez VD*, Vucic EA, Thu KL, Pikor LA, Hubaux R, Lam WL (2014) Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer. BioMed Research International. In press.

    • Martinez VD*, Vucic EA, Lam S, Lam WL. (2013). Emerging arsenic threat in Canada. Science 342(6158):559. 

    • Martinez VD*, Vucic EA, Pikor LA, Thu KL, Hubaux R, Lam WL. (2013). Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer. Molecular Cancer 12(1):124.

    • Martinez VD*, Thu KL, Vucic EA, Hubaux R, Adonis M, Gil L, Macaulay C, Lam S, Lam WL (2013) Whole-genome sequencing analysis identifies a distinctive mutational spectrum in an arsenic-related lung tumor. Journal of Thoracic Oncology 8(11):1451-5.

    • Hubaux R, Becker-Santos DD, Enfield KS, Rowbotham D, Lam S, Lam WL, Martinez VD* (2013). Molecular features in arsenic induced lung tumors. Molecular Cancer 12(1):20, 1-11 [Highly Accesed].

    • Hubaux R, Becker-Santos DD, Enfield KS, Lam S, Lam WL and Martinez VD (2012) Arsenic, asbestos and radon: emerging players in lung tumorigenesis. Environmental Health 2012, 11:89 [Highly Accessed].

    • Martinez VD, Becker-Santos DD, Lam S, Lam WL (2012) Emerging Challenges for Management of Arsenic-Induced Lung Cancer. Invited Editorial for Lung Cancer Management. December 2012, Vol. 1, No. 4, Pages 243-246 [Open Access].

    • Martinez VDVucic EA , Lam S , Lam WL (2012) Arsenic and lung cancer in never smokers: lessons from Chile. American Journal of Respiratory Critical Care Medicine. 2012 May 15;185(10):1131-2.

    • Enfield KS, Pikor LA, Martinez VD, Lam WL (2012) Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications. Genetics Research International. 2012;2012:737416. Epub 2012 Jul 18. [Open Access]

    • Hubaux R, Becker-Santos DD, Enfield KS, Lam S, Lam WL, Martinez VD (2012) MicroRNAs as Biomarkers for Clinical Features of Lung Cancer. Metabolomics: Open Access. 2012, 2:3 [Open Access]

    • Martinez VD*, Becker-Santos DD, Vucic EA, Lam S, Lam WL (2011) Induction of human squamous cell-type carcinomas by arsenic. Journal of Skin Cancer. 2011; 2011: 454157. [Open Access]

    • Martinez VD*, Vucic E, Becker-Santos D, Gil L and Lam WL (2011). Arsenic Toxicity Induction of Human Cancers. Journal of Toxicology. 2011: 431287. [Open Access]

    •  Martinez VD*, Vucic E, Adonis M, Gil L and Lam WL (2011). Arsenic biotransformation as a cancer promoting factor by inducing DNA damage and disruption of repair mechanisms. Molecular Biology International 2011: 718974, 1-11. [Open Access]

    • Martinez VD*, Buys TPH, Adonis M, Benitez H, Gallegos I Lam S, Lam WL, Gil L (2010) Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas. British J Cancer.;103(8):1277-83.

    • Jara L, Ampuero S, Santibáñez E, Seccia L, Rodríguez J, Bustamante M, Martínez VD, Catenaccio A, Lay-Son G, Blanco R, Reyes J (2006) BRCA1 and BRCA2 mutations in a South American population. Cancer Genetics Cytogenetics 166:36-45

    • Adonis M, Martínez VD, Marín P, Berrios D, Gil L (2005) Smoking habit and genetic factors associated with lung cancer in a population highly exposed to arsenic. Toxicol Lett 159:32-37

    •  Adonis M, Martínez VD, Marín P, Gil L (2005) CYP1A1 and GSTM1 genetic polymorphisms in lung cancer populations exposed to arsenic in drinking water. Xenobiotica 35:519-530

    • Verastegui J, Martinez VD, Roca W, Gil L (2004) The multinational biosafety project of the Organization of American States. Electron J Biotechnol 7:61-71

    • Adonis MI, Riquelme RM, Martinez VD, Gil L, Rios C, Rodriguez L, Rodriguez EM (2003) PAHs and Mutagenicity of Inhalable and Respirable Diesel Particulate Matter in Santiago, Chile. Polycycl Aromat Comp 23:495 – 514

    • Adonis M, Martínez VD, Riquelme R, Ancic P, González G, Tapia R, Castro M, Lucas D, Berthou F, Gil L (2003) Susceptibility and exposure biomarkers in people exposed to PAHs from diesel exhaust. Toxicol Lett 144:3-15

    • Gil L, Martínez VD, Riquelme R, Ancic P, González G, Rodríguez L, Adonis M (2003) Occupational and environmental levels of mutagenic PAHs and respirable particulate matter associated with diesel exhaust in Santiago, Chile. J Occup Environ Med 45:984-992

     Books and Chapters
    • Hubaux R, Martinez VD, Rowbotham D, Lam WL. (2014) Comparative genomic hybridization and spectral karyotyping methods in cancer. In Molecular Testing in Cancer. George M. Yousef (ed.) Springer.
    • Martínez VD., Gil L. Bioseguridad y Comercio Internacional de Alimentos Transgénicos en las Américas: Decisiones y Desafíos. Santiago: Andros, 2005, p. 473. ISBN 956-291-992-7
    • Adonis M., Martínez VD., Gil L. Avances Recientes en Genómica y Proteómica Pronostican Mejoras en la Prevención y el Tratamiento personalizado del Cáncer Pulmonar. En: Adonis M., Gil L. (eds) Gestión-Innovación y Comercialización en Biotecnología. Santiago: Editorial Universitaria, 2007, p. 279-287. ISBN 956-11-1956-0
    • Verástegui J., Martínez VD., Roca W., de Peña M., Gil L. . El Proyecto Multinacional de Bioseguridad de la OEA: Fase 1 En: Martínez V., Gil, L. Bioseguridad y Comercio Internacional de Alimentos Transgénicos en las Américas: Decisiones y Desafíos. Santiago: Andros, 2005, p. 21-33. ISBN 956-291-992-7
    • Gil L., Martínez VD. Capacidades de Formación de Recursos Humanos en Biotecnología en Chile En: Martínez V., Gil, L. Bioseguridad y Comercio Internacional de Alimentos Transgénicos en las Américas: Decisiones y Desafíos. Santiago: Andros, 2005, p. 371-389. ISBN 956-291-992-7
    • Martínez VD., Dornberger U., Gil L. Estado Actual de la Industria Biotecnológica Chilena. En: Martínez V., Gil, L. Bioseguridad y Comercio Internacional de Alimentos Transgénicos en las Américas: Decisiones y Desafíos. Santiago: Andros, 2005, p. 415-433. ISBN 956-291-992-7
    • de Souza L., Oda L., Martínez VD., Gil L. Estudio Comparativo sobre la Percepción Pública de la Biotecnología Moderna en Brasil y Chile En: Martínez V., Gil, L. Bioseguridad y Comercio Internacional de Alimentos Transgénicos en las Américas: Decisiones y Desafíos. Santiago: Andros, 2005, p. 333-347. ISBN 956-291-992-7
    • Gil L., Martínez VD. Regulaciones de Bioseguridad en Chile en el Marco del Protocolo de Cartagena En: Solleiro JL, Castañon R. El protocolo de Cartagena y las necesidades para su Implementación en los Países de América Latina. Mexico, DF: CamBioTec, 2004, p. 117-143
    • Martínez VD., Gil L. Perfil de la Industria Biotecnológica a Nivel Nacional: Chile. En: Verástegui, J. La Biotecnología en América Latina: Panorama al año 2002. Ottawa: IDRC-Canadá, 2003, p. 80-94. ISBN 987-20494-3-2
    • Gil L., Martínez VD. Políticas Públicas y Cooperación Internacional en el Sector Biotecnológico Chileno, En: Biotecnología: Políticas públicas y Aceptación Social en Argentina, Brasil, Chile, Colombia, Cuba, Ecuador, España y México. Buenos Aires: Punthau, 2003, p. 50-59. ISBN 987-20494-4-0
     Articles in Magazines
    • Gil L., Martínez VD., Irarrázabal C., Martínez C. Aceptación Pública de la Biotecnología y de los Alimentos Transgénicos. Ambiente y Desarrollo 2002; 17 (4): 52-58
    • Martinez VD., De Souza L., e Gil L. Implementacao do Protocolo Internacional de Biosseguranca. Pontos fortes e fracos de alguns países da área Andina. Journal Da ANBIO, Edicao N° 10, maio-junho de 2003, p.5

    Invited talks

    • Analysis of piwi-interacting RNA transcriptomes reveal cancer type-specificity and signatures predicting lung tumor behavior. HUGO-Human Genome Meeting. February 5-7, 2017. Barcelona, Spain.
    • Piwi-interacting RNA transcriptome analyses identify cancer type-specific expression and signatures predicting lung tumor behavior. Fourth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic, San Diego, CA.* AACR Scholar-in-training Award
    • Piwi-interacting RNAs: small RNAs with a big (epigenetic) memory. Keynote at the International Workshop “Tumor Hypoxia in the Genomics Era”, Vancouver, August 2015
    • Piwi-interacting rna transcriptome analyses identify cancer type-specific expression patterns and signatures predicting lung cancer patient outcome. Terry Fox Research Institute 6th Annual Scientific Meeting. St. John’s Newfoundland, May 7-9th, 2015 * Trainee Travel Award
    • Multi-‘omic analysis of an arsenic-associated lung squamous cell carcinoma reveals specific DNA level signatures. 15th World Conference on Lung Cancer. Sidney, Australia, October 2013 *Young Investigator Award
    • The impact of environment on cancer: A focus on radon and arsenic. University of British Columbia: Occupational & Environmental Health Seminars. Vancouver, Canada (October 2012) *Together with Dr. Roland Hubaux
    • Arsenic in drinking water: an emerging risk factor for lung squamous cell carcinomas in never smokers. UBC Respiratory Seminars. Vancouver, Canada (January 2012)
    • Arsenic and cancer: A problem for the world. BC Annual Cancer Care Conference, 'Research Translation- Conversations in Cancer' session. Vancouver, Canada (December 2011)
    ** 2011 Oral Poster Award Winners- Population Health and Health Services**
    • Analysis of Whole Genome DNA Copy-Number Alterations in Arsenic-Related Lung Squamous Cell Carcinomas using Microarraybased High- Resolution Comparative Genome Hybridization. World Microarray Congress. Vancouver, Canada (2008)

    Abstracts and Presentations

    • Martinez VD, Vucic EA, Thu KL, Marshall EA, Enfield KSS, Minatel BC, Rahmati S, Tokar T, Abovsky M, Pastrello C, Jurisica I, MacAulay CE, Lam S, Lam WL. Molecular biology underlying COPD and lung cancer converge on FOXM1 network. 17th World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC). December 4 to 7, 2016, Vienna, Austria.
    • de Silva T, Martinez VD, Thu K, Lu D, Oh MH, Lam S, Lam W, Varmus H, Lockwood W. Characterizing the genomes of lung adenocarcinoma from never smokers reveals a novel candidate tumour suppressor gene SHPRH. 17th World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC). December 4 to 7, 2016, Vienna, Austria.
    • Minatel BC, Martinez VD, Marshall EA, Ng K, Enfield KSS, Lam S, Lam W. A Piwi-interacting RNAs display cancer-specific expression patterns that hold prognostic value in lung cancer. 17th World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC). December 4 to 7, 2016, Vienna, Austria.
    • Enterina JR, Enfield KSS, Martinez VD, Marshall EA, Stewart GL, Lam WL. Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung adenocarcinoma patient outcome. 17th World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC). December 4 to 7, 2016, Vienna, Austria.
    • Stewart GL, Enfield KSS, Martinez VD, Marshall EA, Lam S, Lam WL. Long non-coding RNA expression from pseudogene loci are deregulated in lung adenocarcinoma, highlighting alternative regulatory mechanisms. 17th World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC). December 4 to 7, 2016, Vienna, Austria.
    • Becker-Santos DD, Minatel BC, Lonergan K, Thu KL, English JC, Martinez VD, MacAulay CE, Lockwood WW, Robinson WP, Jurisica I, Lam S, Lam WL. Expression of oncofetal miRNAs inactivates NFIB, a developmental transcription factor linked to tumour aggressiveness in lung adenocarcinoma. 17th World Conference on Lung Cancer of the International Association for the Study of Lung Cancer (IASLC). December 4 to 7, 2016, Vienna, Austria.
    • Vucic EA, Thu KL, Martinez VD, Pastrello C, Yee J, Jurisica I, Lam S, Lam WL. (2014) Lung tumors and non-malignant airways from patients with chronic lung inflammatory disease bear distinct genetic and epigenetic disruptions corresponding to metabolic processes involved in senescence and methylation. Metabolism, Diet and Disease 2014: Cancer and Metabolism. Washington, DC
    • Vucic EA, Martinez VD, Thu KL, Pikor LA, Lam S, Lam WL. (2014) Genetic and Epigenetic Contribution to Chronic Obstructive Pulmonary Disease Related Lung Cancer. Keystone Symposia on Molecular and Cellular Biology: Cancer Epigenetics. Santa Fe, NM
    • Vucic EA, Martinez VD, Thu KL, Pikor LA, Enfield KSS, Yee J, Lam S, Lam WL. (2014) Distinct genetic and epigenetic disruptions in lung tumours and small airways of patients with chronic obstructive pulmonary disease and lung cancer. The Terry Fox Research Institute 5th Annual Scientific Meeting. Montreal, QC
    • Ramnarine VR, Martinez VD, Pikor LA, Mosslemi M, Lam S, Lam WL. Fusion gene identification in non-small cell lung cancer. 2012 Annual Cancer Conference: Evolving Dynamics in Research and Patient Care. December 2012
    • Becker-Santos DD*, Lam WL, V. D. Martinez VD (2012)  Establishment of a Cancer Biobank Network in Chile. World Cancer Congress. Montreal, Canada, August 2012
    • Becker-Santos DD*, Hubaux R, Vucic EA, Lam S, Lam WL, Martinez VD (2012) Molecular events in arsenic-realted lung cancer. World Cancer Congress. Montreal, Canada, August 2012
    • Becker-Santos DD, Hubaux R, Vucic EA, Lam S, Lam WL, Martinez VD (2012) Molecular events in lung squamous cell carcinomas associated with arsenic exposure. 5th Latin-American Conference on Lung Cancer (LALCA2012). Rio de Janeiro, Brazil, July 2012
    **Selected for oral presentation**
    • Martinez VD, Vucic EA, Hubaux R, Becker DD, Lam S, Lam WL (2012) Genomic alterations in arsenic-related lung carcinogenesis. 55th Annual Conference of the Canadian Society Molecular Biology: Epigenetics and Genomic Stability. Whistler, BC. March 14 – 18, 2012
    • Becker-Santos DD, Vucic EA, Lam S, Lam WL, Martinez VD (2012) Genomic and epigenomic events in arsenic-related lung squamous cell carcinomas from smokers and never smokers. AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Biology, Therapy, and Personalized Medicine. San Diego, CA
    • Becker-Santos DD, Vucic EA,  Lam S, Lam WL, Martinez VD (2011) Genomic and epigenomic alterations in arsenic-related lung squamous cell carcinomas. In American Association for Cancer Research: Frontiers in Cancer Prevention Research Meeting, Boston, MA, USA, October, 2011.
    • Becker-Santos DD, Martinez VD, Vucic EA,  Lam S, Lam WL (2011) Arsenic-related genomic and epigenomic alterations in lung squamous cell carcinomas. In American Society of Human Genetics Annual Meeting, Montreal, QC, Canada, October, 2011.
    • Martinez VD, Becker-Santos DD, Vucic EA,  Lam S, Lam WL (2011) Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas. In Annual Conference, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, May 2011.
    • Martinez VD, Buys TPH, Adonis M, Benítez H, Gallegos I, Lam S, Lam WL and y Gil L (2010) XVIII Meeting of the Chilean Cancer Society. La Serena,  Chile. October 2011
    **Selected for oral presentation / Best presentation award**
    • Adonis M, Martinez VD, and Gil L. PRRI Chilean focal point activities 2007-2009 and an overview of genetic modified organisms in Latin America and Chile. Final Science 4 BioReg consortium meeting and  STOA  Panel of the European Parliament. Seminar on the impact of European Union  GMO regulations on public research in Biotechnology for the public good. European Parliament February, 24 and 25   2010, Brusells, Belgium 
    • Martínez VD, Adonis M, Lam WL and Gil L. . Copy-number Variations on Chilean Individuals. Annual Meeting of the Chilean Biology Society. Pucón, Chile; November 24, 2008.
    **Selected for oral presentation**
    • Martínez VD, Gil L, Lam S, Adonis M, Benitez H and Lam WL.“Characterization of Whole Genome DNA Copy-Number Alterations in Arsenic Related Lung Squamous Cel Carcinomas”. 3rd Latin American Conference on Lung Cancer (IASLC-LALCA), Viña del Mar, Chile, 9 -10, Octubre, 2008.
    • Martínez VD, Lam WL, Lam S, Adonis M, Benítez H, and Gil L. DNA copy-number alterations on squamous cell lung cancer among individuals from Northern Chile. Annual Meeting of the Chilean Biology Society. Pucón, Chile; November 21, 2008
    **Selected for oral presentation**
    • Martinez VD, Gil L, Lam S, Adonis M, Benitez H, Lam WL. Analysis of Whole Genome DNA Copy-Number Alterations in Arsenic-Related Lung Squamous Cell Carcinomas using Microarray-based High-Resolution Comparative Genome Hybridization. World Microarray Congress, Vancouver, Canada, June 28th-29th, 2008
    **Invited for oral presentation**
    • Martinez VD, Lam S; MacAulay C; Gil L; Lam WL. Specific DNA copy number alterations in arsenic-related lung squamous cell carcinomas. 12th World Conference on Lung Cancer, Korea, Seoul, September 2-6, 2007. Journal of Thoracic Oncology, 2(8) Supplement 4:S437-S438, August 2007.
    • Martínez VD, Buys TPH, Galac L, Saprunoff H, Lam WL and Gil L. Signature genomic alterations identify arsenic exposed lung tumor. BC Cancer Agency Annual Cancer Conference Abstracts. Vancouver, Canada. p. 34, 2006.
    • Adonis M., Martínez VD, Marín P and Gil L. CYP1A1 and GSTM1 genetic polymorphisms in lung Cancer populations exposed to Arsenic in drinking water. 9th International Conference on Environmental Mutagens. San Francisco, USA September, 3-8, 2005
    • Gil L., Martínez VD., Ancic P. and Adonis M. Urinary mutagenicity, urinary 1-OH-Hydroxypyrene levels and genetic polymorphisms in Workers Exposed to Diesel Exhaust. 9th International Conference on Environmental Mutagens. San Francisco, USA September, 3-8, 2005.
    • Gil L, Martínez VD and Adonis M. Single and Combined Genotypes on Lung Cancer Susceptibility in Chilean People. 42st Annual Meeting. USA Society of Toxicology, Baltimore, Maryland, USA. March 21 -25, 2004.
    • Gil L., Martínez VD, Ancic P and Adonis M. Susceptibility and Exposure Biomarkers in Workers Exposed to Diesel Exhaust. Annual meeting, USA Society of Toxicology. Nashville, USA, Marzo, 17 –21, 2002.
    • Martínez VD, Adonis M, Aldunate CG, Berríos D, Rodríguez L y Gil L. Exposure and Risk Biomarkers in Chilean Population with Occupational and Urban Expousure”. MARTÍNEZ, V.; Adonis M; Aldunate CG; Berrios D; Rodríguez L and Gil L Biological Research, vol. 34 (3-4) R-91, 2001. XLIV Annual Meeting of the Chilean Biology Society. Pucón, Chile; November 6-10, 2001.

    Events Organized

    • 2012: Workshop: Highlighting the impacts of North–South research collaboration in cancer research
    **Dr. Jorge Allende (Chile), member of the National Academy of Sciences, was the keynote speaker of this workshop**
    • 2005: Playing with Biotechnology
    **Event held at the National Congress in Chile to familiarize decision makers with science. Deputies and Senators participated performing simple scientific experiments**
    • 2005: Biotechnology Innovation and Commercialization
    **Supported by The Organization of American States and the Chilean Economic Development Agency**
      • 2005: III Bio-entrepreneur Conference in South America
      **Supported by the Organization of American States, the Pasteur Institute (France) and the Chilean Economic Development Agency. Dr. Victor Ling and Dr. Samuel Abraham participated in this conference**