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Victor Ling, PhD

Distinguished Scientist - Genetics Unit, Integrative Oncology

VictorLing

vling@bccrc.ca   675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada

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Current Appointments

Professor, Pathology & Laboratory Medicine, UBC

Professor, Biochemistry and Molecular Biology, UBC

Director, Interdisciplinary Oncology Program, UBC (http://www.iop.ca/)

Founding Scientific Director of the Terry Fox Research Institute (http://www.tfri.ca/

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Training 

B.Sc (Biochemistry), University of Toronto

Ph.D (Biochemistry), University of British Columbia

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Research Interests

Our laboratory works to understand the mechanism of resistance to anticancer drugs observed in many human cancers. Among other things, we have identified one mechanism of multi-drug resistance (MDR) involving P-glycoprotein (Pgp) which functions as a drug efflux pump of broad specificity. In some cancers the correlation between the presence of Pgp function and non-response to chemotherapy has been established and the use of agents that block Pgp functiton has begun to yield promising results in combination with conventional chemotherapy. Our research in understanding the structure and function of Pgp will provide the fundamental basis for the pharmaceutical industry to design better blockers of Pgp. We and others have also discovered that PgP is a member of a superfamily of related proteins called ABC transporters which may be represented by more than 50 members in the human genome. These transporters are found in all kingdoms of life and appear to be involved in many fundamental biological processes. An inventory of ABC Transporters is currently being generated and we are profiling their expression patterns in different drug-resistant cell lines and some cancers. We are also studying a related liver-specific gene discovered in our lab, the sister of P-glycoprotein (sPgp), and its function in bile formation and cholesterol homeostasis. The mutation of Spgp in humans can cause Progressive Familiar Intrahepatic Cholaestasis -a liver disease, which is often fatal , especially in children. Technologies/expertise in our laboratory include: quantitative RT-PCR, expression profiling, generation of knockout mice, phylogenetic analysis, serial analysis of gene expression (SAGE), Protein biochemistry, Fluorescence labelling, and Transport kinetics.

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Personnel

Ruth Graham (Administration)

Jonathan Sheps  (Postdoctoral Fellow)

Renxue Wang (Postdoctoral Fellow)

Tania Kastelic (Associate Member)

Lin Liu (Research Staff) 

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Recent Publications

  1. Liu T, Wang RX, Han J, Hao CZ, Qiu YL, Yan YY, Li LT, Wang NL, Gong JY, Lu Y, Zhang MH, Xie XB, Yang JC, You YJ, Li JQ, Knisely AS, Borchers CH, Ling V, Wang JS. Comprehensive bile acid profiling in hereditary intrahepatic cholestasis: Genetic and clinical correlations.  Liver Int. 2018 Sep;38(9):1676-1685.
  2. Qiu YL, Gong JY, Feng JY, Wang RX, Han J, Liu T, Lu Y, Li LT, Zhang MH, Sheps JA, Wang NL, Yan YY, Li JQ, Chen L, Borchers CH, Sipos B, Knisely AS, Ling V, Xing QH, Wang JS. Defects in myosin VB are associated with a spectrum of previously undiagnosed low γ-glutamyltransferase cholestasis.  Hepatology. 2017 May;65(5):1655-1669. 
  3. Gooijert KE, Havinga R, Wolters H, Wang R, Ling V, Tazuma S, Verkade HJ. The mechanism of increased biliary lipid secretion in mice with genetic inactivation of bile salt export pump.  Am J Physiol Gastrointest Liver Physiol. 2015 Mar 1;308(5):G450-7.              
  4. Han J, Liu Y, Wang R, Yang J, Ling V, Borchers CH. Metabolic profiling of bile acids in human and mouse blood by LC-MS/MS in combination with phospholipid-depletion solid-phase extraction.  Anal Chem. 2015 Jan 20;87(2):1127-36. 
  5. Hrycay E, Forrest D, Liu L, Wang R, Tai J, Deo A, Ling V, Bandiera S.  Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep (-/-) mice.  Mol Cell Biochem. 2014 Apr;389(1-2):119-32.