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Mateus de Camargo Barros Filho, Ph.D.


 

mbarros@bccrc.ca  675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab | Mateus de Camargo Barros Filho |


Program

  • Post-Doctoral international internship trainee (Integrative Oncology), British Columbia Cancer Research Centre, Vancouver Canada (2018-present)
  • Post-Doctoral Fellow (Oncology), AC Camargo Cancer Center, Sao Paulo, Brazil, (2015-2018)

Training

  • PhD (Oncology), AC Camargo Cancer Center, Sao Paulo, Brazil, 2014

  • M.Sc. (Oncology), Universidade de Sao Paulo, Sao Paulo, Brazil, 2009 

  • B.Sc. (Biology), Universidade Presbiteriana Mackenzie, Sao Paulo, Brazil, 2005


Research Interests

  • Lung cancer
  • Head and neck cancer 
  • Transcriptomics
  • Small non-coding RNA
  • DNA methylation
  • Biomarker discovery

Scholarships and Awards

2018: FAPESP - São Paulo Research Foundation Research Internships Abroad Fellowship.
2015: FAPESP - São Paulo Research Foundation Fellowship.
2015: Honor to the contribution and dedication to the Head and Neck oncology area in the department of Head and Neck Surgery in AC Camargo Cancer Center, Sao Paulo.
2015: Award for oral presentation at Simpósio de Mutagênese e Oncologia Genética (co-author): Ribeirão Preto, Brazil.
2011: FAPESP - São Paulo Research Foundation Fellowship.
2010: CAPES - Coordination for the Improvement of Higher Education Personnel Fellowship. 
2009: Avon Foundation-AACR International Scholar-in-Training Grants for paper presentation at the CTRC-AACR San Antonio Breast Cancer Symposium, San Antonio, USA.
2006: CAPES - Coordination for the Improvement of Higher Education Personnel Fellowship. 

Patents

WO 2016205911 A1. Title: In vitro method for detecting thyroid cancer in a patient, in vitro method for differentiating between thyroid cancer and normal thyroid tissue or benign thyroid lesions, use of a series of genes, method for obtaining data determining the treatment of thyroid cancer, laboratory kit and device for classifying a biological sample from the thyroid gland as malignant or benign. Register number: 102015015096-2. Inventors: Silvia ROGATTO SR, KOWALSKI LP, BARROS FILHO MC. Deposit: 06/23/2015; Concession: 07/28/2015; Publication: 12/29/2016.

Publications

First and co-first authorships are denoted by an underline

Journal Articles

  • Camargo Barros-Filho M, Barreto Menezes de Lima L, Bisarro Dos Reis M, Bette Homem de Mello J, Moraes Beltrami C, Lopes Pinto CA, Kowalski LP, Rogatto SR. PFKFB2 Promoter Hypomethylation as Recurrence Predictive Marker in Well-Differentiated Thyroid Carcinomas. Int J Mol Sci. 2019 Mar 16;20(6).

  • Barros-Filho MC, Pewarchuk M, Minatel BM, Sage AP, Marshall EA, Martinez VD, Rock LD, MacAulay G, Kowalski LP, Rogatto SR, Garnis C, Lam WL. Previously undescribed thyroid-specific miRNA sequences in papillary thyroid carcinoma. J Hum Genet. 2019 Mar 6.

  • Ortiz IMDP, Barros-Filho MC, Dos Reis MB, Beltrami CM, Marchi FA, Kuasne H, do Canto LM, de Mello JBH, Abildgaard C, Pinto CAL, Kowalski LP, Rogatto SR. Loss of DNA methylation is related to increased expression of miR-21 and miR-146b in papillary thyroid carcinoma. Clin Epigenetics. 2018 Nov 20;10:144.

  • Mello JBH, Barros-Filho MC, Abreu FB, Cirilo PDR, Domingues MAC, Pontes A, Rogatto SR. MicroRNAs involved in the HMGA2 deregulation and its co-occurrence with MED12 mutation in uterine leiomyomas. Mol Hum Reprod. 2018 Nov 1;24:556-63.

  • Kuasne H, Barros-Filho MC, Marchi FA, Drigo SA, Scapulatempo-Neto C, Faria EF, Rogatto SR. Nuclear loss and cytoplasmic expression of androgen receptor in penile carcinomas: role as a driver event and as a prognosis factor. Virchows Arch. 2018 Aug 11.

  • Barros-Filho MC, Reis-Rosa LA, Hatakeyama M, Marchi FA, Chulam T, Scapulatempo-Neto C, Nicolau UR, Carvalho AL, Pinto CAL, Drigo SA, Kowalski LP, Rogatto SR. Oncogenic drivers in 11q13 associated with prognosis and response to therapy in advanced oropharyngeal carcinomas. Oral Oncol. 2018 Aug;83:81-90.

  • Alves MR, E Melo NC, Barros-Filho MC, do Amaral NS, Silva FIB, Baiocchi Neto G, Soares FA, de Brot Andrade L, Rocha RM. Downregulation of AGR2, p21, and cyclin D and alterations in p53 function were associated with tumor progression and chemotherapy resistance in epithelial ovarian carcinoma. Cancer Med. 2018 May 29.

  • Stevanato Filho PR, Aguiar Júnior S, Begnami MD, Kuasne H, Spencer RM, Nakagawa WT, Bezerra TS, Kupper BC, Takahashi RM, Barros Filho M, Rogatto SR, Lopes S. Oestrogen receptor beta isoform expression in sporadic colorectal cancer, familial adenomatous polyposis and progressive stages of colorectal cancer. BMC Cancer. 17:754; 2017.
  • Melo DH, Mamede RCM, Neder L, Silva WA, Barros-Filho MC, Kowalski LP, Pinto CAL, Zago MA, Figueiredo DLA, Jungbluth AA. Expression of cancer/testis antigens MAGE-A, MAGE-C1, GAGE and CTAG1B in benign and malignant thyroid diseases. Oncology Letters. 2017 Sep 26.
  • Dos Reis MB, Barros-Filho MC, Marchi FA, Beltrami CM, Kuasne H, Pinto CAL, Ambatipudi S, Herceg Z, Kowalski LP, Rogatto SR. Prognostic classifier based on genome-wide DNA methylation profiling in well-differentiated thyroid tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.
  • Souza MF, Kuasne H, Barros-Filho MC, Cilião HL, Marchi FA, Fuganti PE, Paschoal AR, Rogatto SR, Cólus IMS. Circulating mRNAs and miRNAs as candidate markers for the diagnosis and prognosis of prostate cancer. PLoS One. 2017 Sep 14;12(9):e0184094.
  • Marchi FA, Martins DC, Barros-Filho MC, Kuasne H, Busso Lopes AF, Brentani H, Trindade Filho JCS, Guimarães GC, Faria EF, Scapulatempo-Neto C, Lopes A, Rogatto SR. Multidimensional integrative analysis uncovers driver candidates and biomarkers in penile carcinoma. Sci Rep. 2017 Jul 27;7(1):6707.
  • Beltrami CM, Dos Reis MB, Barros-Filho MC, Marchi FA, Kuasne H, Pinto CAL, Ambatipudi S, Herceg Z, Kowalski LP, Rogatto SR. Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid  carcinomas. Clin Epigenetics. 2017 May 2;9:45. 
  • Kuasne H, Barros-Filho MC, Busso-Lopes A, Marchi FA, Pinheiro M, Muñoz JJ, Scapulatempo-Neto C, Faria EF, Guimarães GC, Lopes A, Trindade-Filho JC, Domingues MA, Drigo SA, Rogatto SR.Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact. Oncotarget. 2017 Feb 28;8(9):15294-15306.
  • Barros-Filho MC, Marchi FA, Pinto CA, Rogatto SR, Kowalski LP. High Diagnostic Accuracy Based on CLDN10, HMGA2, and LAMB3 Transcripts in Papillary Thyroid Carcinoma. J Clin Endocrinol Metab. 2015 Jun;100(6):E890-9.
  • Kuasne H, Cólus IM, Busso AF, Hernandez-Vargas H, Barros-Filho MC, Marchi FA, Scapulatempo-Neto C, Faria EF, Lopes A, Guimarães GC, Herceg Z, Rogatto SR. Genome-wide methylation and transcriptome analysis in penile carcinoma: uncovering new molecular markers. Clin Epigenetics. 2015 Apr 18;7(1):46
  • Muñoz JJ, Drigo SA, Barros-Filho MC, Marchi FA, Scapulatempo-Neto C, Pessoa GS, Guimarães GC, Trindade Filho JC, Lopes A, Arruda MA, Rogatto SR. Down-regulation of SLC8A1 as a putative apoptosis-evasion mechanism by modulation of calcium levels in penile carcinoma. J Urol. 2014 Dec 3. pii: S0022-5347(14)05038-1.
  • Santoro AB, Vargens DD, Barros Filho MD, Bulzico DA, Kowalski LP, Meirelles RM, Paula DP, Neves RR, Pessoa CN, Struchine CJ, Suarez-Kurtz G. Effect of UGT1A1, UGT1A3, DIO1 and DIO2 polymorphisms on L-thyroxine doses required for TSH suppression in patients with differentiated thyroid cancer. Br J Clin Pharmacol. 2014 Nov;78(5):1067-75.
  • Villacis RA, Silveira SM, Barros-Filho MC, Marchi FA, Domingues MA, Scapulatempo-Neto C, Aguiar S Jr, Lopes A, Cunha IW, Rogatto SR. Gene expression profiling in leiomyosarcomas and undifferentiated pleomorphic sarcomas: SRC as a new diagnostic marker. PLoS One. 2014 Jul 16;9(7):e102281.
  • Bertonha FB, Barros Filho MD, Kuasne H, Dos Reis PP, da Costa Prando E, Muñoz JJ, Roffé M, Hajj GN, Kowalski LP, Rainho CA, Rogatto SR. PHF21B as a candidate tumor suppressor gene in head and neck squamous cell carcinomas. Mol Oncol. 2014 Oct 13. pii: S1574-7891(14)00233-6. 
  • Cirilo PD; Marchi FA; Barros Filho Mde C; Rocha RM; Domingues MAC; Jurisica I; Pontes A; Rogatto SR. An integrative genomic and transcriptomic analysis reveals potential targets associated with cell proliferation in uterine leiomyomas. Plos One, v. 8, p. e57901, 2013.
  • Silveira SM; Villacis RAR; Marchi FA; Barros Filho Mde C; Drigo SA; Scapulatempo C; Lopes A; Da Cunha IW; Rogatto SR. Genomic signatures predict poor outcome in undifferentiated pleomorphic sarcomas and leiomyosarcomas. Plos One, v. 8, p. e67643, 2013.
  • Barros Filho MC, Katayama ML, Brentani H, Abreu AP, Barbosa EM, Oliveira CT, Góes JC, Brentani MM, Folgueira MA. Gene trio signatures as molecular markers to predict response to doxorubicin cyclophosphamide neoadjuvant chemotherapy in breast cancer patients. Braz J Med Biol Res. 2010 Dec;43(12):1225-31.
  • Folgueira MA; Brentani H; Carraro DM; de Camargo Barros Filho M; Katayama ML; Abreu, AP; Barbosa EM; Oliveira CT; Patrão DF; Mota LD; Netto MM; Caldeira JR; Brentani MM. Gene expression profile of residual breast cancer after doxorubicin and cyclophosphamide neoadjuvant chemotherapy. Oncology Reports, v. 22, p. 805/19724859-813, 2009. 
 
Published Book Chapters
  • Barros-Filho MC, Guisier F, Rock LD, Becker-Santos DD, Sage AP, Marshall EA, Lam WL (Accepted February 2019). Tumour suppressor genes with oncogenic roles in lung cancer. Book Chapter in Tumour Suppressor Genes.

  • Guisier F, Barros-Filho MC, Rock LD, Constantino FB, Minatel BC, Sage AP, Marshall EA, Martinez VD, Lam WL (Accepted January 2019). Small non-coding RNA expression in cancer. Book Chapter in Gene Expression Profiling in Cancer.


Selected Abstracts and Presentations

  • Barros-Filho MC, Pewarchuk M, Minatel BM, Sage AP, Marshall EA, Rock L, Martinez, VD, MacAulay G, Kowalski LP, Rogatto SRR, Garnis C, Lam WL. Previously-undescribed thyroid-specific miRNAs disrupted in papillary thyroid carcinoma. BIG Research Day, Vancouver, Canada (2019). Poster presentation.
  • Barros-Filho MC, Pewarchuk M, Minatel BM, Sage AP, Marshall EA, Rock L, Martinez, VD, MacAulay G, Kowalski LP, Rogatto SRR, Garnis C, Lam WL. Thyroid-specific novel miRNA discovery in non-neoplastic and neoplastic thyroid tissues. Miami Thyroid Oncology Symposium, Miami, USA (2019). Oral presentation.
  • Barros-Filho MC, Pewarchuk M, Minatel BM, Sage AP, Marshall EA, Rock L, Martinez, VD, MacAulay G, Kowalski LP, Rogatto SRR, Garnis C, Lam WL. Putative novel microRNAs discovery in non-neoplastic and neoplastic thyroid tissues. BC Cancer Summit, Vancouver, Canada (2018). Oral presentation.
  • Barros-Filho MC; Dos Reis MB; Marchi FA; Beltrami CM; Kuasne H; Melo JB; Ambatipudi S; Herceg Z; Pinto CA; Kowalski LP, Rogatto SR. DNA methylation profile as a diagnostic tool in thyroid nodules. BC Cancer Summit, Vancouver, Canada (2018). Poster presentation.
  • Barros-Filho MC; De Lima LBM; Melo JB; Dos Reis MB; Beltrami CM; Pinto CA; Kowalski LP, Rogatto SR. DNA methylation as a prognostic marker in well-differentiated thyroid cancer. Frontiers in Molecular Oncology, Sao Paulo, Brazil (2018). Poster presentation.
  • Barros-Filho MC; Dos Reis MB; Marchi FA; Beltrami CM; Kuasne H; Melo JB; Ambatipudi S; Herceg Z; Pinto CA; Kowalski LP, Rogatto SR. DNA methylation profile as a diagnostic tool in thyroid nodules Next Frontiers to Cure Cancer, Sao Paulo, Brazil (2018). Poster presentation.
  • Barros-Filho MC, dos Reis MB, Beltrami C, Marchi FA, Kuasne H, Pinto AC, Ambatipudi S, Herceg Z, Kowalski LP, Rogatto SR. High accuracy to distinguish malignant from non-malignant thyroid tissues using DNA methylation profiling. American Head and Neck Society (AHNS) Annual Meeting. San Diego, USA (2017). Poster presentation.
  • Barros-Filho MC; Marchi FA; Pinto CA; Kowalski LP, Rogatto SR. Expression profile of papillary thyroid carcinomas according to cervical lymph node metastasis status. European Society for Medical Oncology (ESMO) Congress. Copenhagen, Denmark, (2016). Poster presentation.
  • Barros-Filho MC, Hatakeyama M, Drigo SA, Reis-Rosa LA, Marchi FA, Scapulatempo-Neto C, Nicolau UR, Carvalho AL, Rogatto SR, Kowalski LP. DNA copy number and gene expression analysis identify putative drivers in 11q13 related to prognosis in oropharyngeal squamous cell carcinomas. 5th World Congress of the International Academy of Oral Oncology (IAOO). Sao Paulo, Brazil, 2015. Oral presentation.
  • Barros-Filho MC; Marchi FA; Pinto CAL; Rogatto SR; Kowalski LP. Gene expression profiling in combination with meta-analysis reveals deregulated pathways and potential targets for therapy in papillary thyroid cancer. European Congress on Head and Neck Oncology. Liverpool, England (2014). Poster presentation.
  • Barros-Filho MC; Marchi FA; Pinto CAL; Rogatto SR; Kowalski LP. Putative diagnostic markers to discriminate papillary thyroid carcinomas from normal and benign thyroid tissues. International Federation of Head and Neck Oncologic Societies 5th World Congress. New York City, USA (2014).  Oral presentation.
  • Barros-Filho MC; Marchi FA; Pinto CAL; Rogatto SR; Kowalski LP. Differential expression profile of papillary thyroid carcinoma harboring BRAFV600E mutation. Next Frontiers to Cure Cancer - Integrating Science and Patient Care. Sao Paulo, Brazil, (2013). Oral presentation.
  • Barros-Filho MC; Marchi FA; Pinto CAL; Rogatto SR; Kowalski LP. Prognostic signature in papillary thyroid carcinoma patients that undergone total thyroid ablation. The American Society of Human Genetics Annual Meeting. Boston, USA (2013). Poster presentation.
  • Barros-Filho MC; Marchi FA; Pinto CAL; Rogatto SR; Kowalski LP. Distinct transcriptional signature of papillary thyroid carcinoma according to the frequency of BRAFV600E alleles. 83rd Annual Meeting of the American Thyroid Association. San Juan, Porto Rico (2013). Poster presentation.
  • Barros-Filho MC; Marchi FA; Pinto CAL; Rogatto SR; Kowalski LP. Large-scale gene expression analysis and confirmation by meta-analysis highlights key transcripts as candidates for the diagnosis of papillary thyroid carcinoma. X Congresso Paulista de Endocrinologia e Metabologia (COPEM). Sao Paulo, Brazil, (2013). Oral presentation.
  • Barros-Filho MC; Marchi FA; Pinto CAL; Rogatto SR; Kowalski LP. Sao Paulo Advanced School of Comparative Oncology. Transcription profiling in papillary thyroid carcinoma reveals potential diagnostic markers and drug targets. Águas de São Pedro, Brazil (2012). Poster presentation.
  • Barros-Filho MC; Marchi FA; Pinto CAL; Rogatto SR; Kowalski LP. Transcription profiling in papillary thyroid carcinoma. 8th International Conference on Head and Neck Cancer. Toronto, Canada (2012). Oral presentation.
  • Barros-Filho MC; Katayama ML; Brentani H; Abreu AP; Barbosa EM; Brentani MM; Folgueira MAK. Expression of gene trios as predictive markers of response to doxorubicin based primary chemotherapy in breast cancer patients. 32nd Annual CTRC-AACR San Antonio Breast Cancer Symposium. San Antonio, USA (2009). Poster presentation.
  • Barros-Filho MC; Katayama ML; Brentani H; Abreu AP; Barbosa EM; Brentani MM; Folgueira MAK. Expression of gene groups as predictive markers of response to neoadjuvant chemotherapy based in doxorubicin and cyclophosphamide in breast cancer patients. II Jornada de Oncologia do Instituto do Câncer do Estado de Sao Paulo (ICESP). Sao Paulo, Brazil (2009). Poster presentation.
  • Barros-Filho MC; Katayama ML; Brentani H; Abreu AP; Barbosa EM; Brentani MM; Folgueira MAK. Expression of gene trios as predictive markers of response to neoadjuvant chemotherapy based in doxorubicin and cyclophosphamide in breast cancer patients. I Jornada de Oncologia do Instituto do Câncer do Estado de Sao Paulo (ICESP). Sao Paulo, Brazil (2008). Poster presentation.
  • Barros-Filho MC; Katayama ML; Brentani H; Abreu AP; Barbosa EM; Brentani MM; Folgueira MAK. Gene expression of residual breast cancer after primary chemotherapy based on doxorubicin and cyclophosphamide. XI Sao Paulo Research Conference: Molecular Medicine and Pharmacogenetics. Sao Paulo, Brazil (2008). Poster presentation.
  • Barros-Filho MC; Folgueira MAK; Katayama ML; Brentani H; Carraro DM; Netto MM; Barbosa EM; Brentani MM. Gene expression of residual breast cancer after primary chemotherapy based on doxorubicin. 3º Simpósio Avanços em Pesquisas Médicas. Sao Paulo, Brazil (2007). Poster presentation.

 Invited Talks

  • Molecular methods useful for differential diagnosis of thyroid nodules. Integrated Seminars in Science - Fundação Antônio Prudente. Sao Paulo, Brazil (2018).
  • Carcinogenesis and Molecular Biology in Head and Neck Cancer. Post-Graduation Course Discipline Head and Neck Oncology at A.C.Camargo Cancer Center. Sao Paulo, Brazil (2017). 
  • Transcriptome alterations and applications in oncology. III Course of Cellular and Molecular Biology of Cancer at A.C.Camargo Cancer Center. Sao Paulo, Brazil (2017).
  • Somatic mutations and cancer. II Course on Cellular and Molecular Biology of Cancer at A.C.Camargo Cancer Center. Sao Paulo, Brazil (2016).
  • Carcinogenesis of head and neck. Post-Graduation Course Discipline Head and Neck Oncology at A.C.Camargo Cancer Center. Sao Paulo, Brazil (2016).
  • Genetic predisposition of head and neck cancer. Post-Graduation Course Discipline Head and Neck Oncology at A.C.Camargo Cancer Center. Sao Paulo, Brazil (2016).
  • Diagnostic and prognostic molecular markers in differentiated thyroid carcinoma. Basic Research Seminars at A.C.Camargo Cancer Center. Sao Paulo, Brazil (2016).
  • Gene expression, diagnostic, prognostic markers and therapeutic targets in thyroid cancer. Symposium on Innovation in Head and Neck Oncology at A.C.Camargo Cancer Center. Sao Paulo, Brazil (2015).
  • Carcinogenesis of head and neck. Post-Graduation Course Discipline Head and Neck Oncology at A.C.Camargo Cancer Center. Sao Paulo, Brazil (2015).
  • Genetic predisposition of head and neck cancer. Post-Graduation Course Discipline Head and Neck Oncology at A.C.Camargo Cancer Center. Sao Paulo, Brazil (2015).
  • Transcriptome alterations of human cancers. Post-Graduation Course Discipline Molecular Biology and Genetics: Module I Translational Science, UNESP-Botucatu. Botucatu, Brazil (2015).
  • Global gene expression in papillary thyroid carcinomas: search for diagnostic markers, prognoses and therapeutic targets. Integrated Seminars in Science - Fundação Antônio Prudente. Sao Paulo, Brazil (2014).
  • High-throughput gene expression analysis of the extrathyroidal extension process and search for recurrence prediction algorithms in patients with papillary thyroid carcinoma treated with surgery and radioiodine therapy. Basic Research Seminars at A.C.Camargo Cancer Center. Sao Paulo, Brazil (2012).
  • Global gene expression analysis of the extrathyroidal extension process and search for recurrence prediction algorithms in patients with papillary thyroid carcinoma treated with surgery and radioiodine therapy. Integrated Seminars in Science at A.C.Camargo Cancer Center. Sao Paulo, Brazil (2011).
  • Principles in quantitative PCR for relative expression analysis (RT-qPCR). Minicourses- How we can interact using our infrastructure at A.C.Camargo Cancer Center. Sao Paulo, Brazil (2013).
  • Analysis of specific transcripts by RT-qPCR. Post-Graduation Course Discipline Genomic Profile of Cancer, at UNESP-Botucatu. Botucatu, Brazil (2011).

Links

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab | Mateus de Camargo Barros Filho |