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Larissa Pikor, PhD

Postdoctoral research associate

Larissa Pikor


lpikor@bccrc.ca  675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada 

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab |


Training

  • PhD (Integrative Oncology), University of British Columbia, September 2014
  • BScH (Life Sciences [Major]), Queen's University, 2009
  • BPHE (Bachelor of Physical and Health Education), Queen's University, 2009

Research Interests

Genetic alterations that drive the differentiation of non-small cell lung cancer subtypes


Publications

Papers

  • Thu KL, Becker-Santos DD, Radulovich N, Pikor LA, Lam WL, Tsao MS (2014) SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types. Oncoscience 1 :326-35.

  • Martinez VD, Vucic EA, Thu KL, Pikor LA, Hubaux R, Lam WL (2014) Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer. BioMed Research International. In press.

  • Thu KL, Radulovich N, Becker-Santos DD, Pikor LA, Pusic A, Lockwood WW, Lam WL*, Tsao MS* (2014) SOX15 is a candidate tumor suppressor in pancreatic cancer with a role in Wnt/β-catenin signaling. Oncogene. 33(3):279-88. [PMID: 23318427]
  • Martinez VD*, Vucic EA*, Thu KL, Pikor LA, Lam S, Lam WL (2014) Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms is associated with poor prognosis in head and neck cancer. Head and Neck. In press. [PMID: 24596130]
  • Crea F, Watahiki A, Quagliata L, Xue H, Pikor L, Parolia A, Wang Y, Lin D, Lam WL, Farrar WL, Isogai T, Morant R, Castori-Eppenberger S, Chi KN, Wang Y, Helgason CD (2014) Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer. Oncotarget. In press. [PMID: 24519926]
  • Pikor LA, Lockwood WW, Thu KL, Vucic EA, Chari R, Gazdar AF, Lam S, Lam WL (2013) Integrative analysis identifies YEATS4, a novel oncogene in NSCLC that regulates the p53 pathway. Cancer Research 73:7301-12. [PMID: 24170126]
  • Martinez VD*, Vucic EA*, Pikor LA, Thu KL, Hubaux R, Lam WL (2013) Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer. Molecular Cancer 12:124, 1-6. [PMID: 24138990]
  • Pikor L, Thu K, Vucic E, Lam W (2013) The detection and implication of genome instability in cancer. Cancer Metastasis Review 32:341-52. [PMID:23510327]
  • Crea F, Sun L, Pikor L, Lam W, Helgason CD (2013) Mutational analysis of Polycomb genes in solid tumors identifies PHC3 amplification as a possible cancer-driving genetic alteration. British Journal of Cancer 109(6):1699-702 [PMID: 23942079]
  • Pikor LA*, Ramnarine VR*, Lam S, Lam WL (2013) Genetic alterations defining NSCLC subtypes and their therapeutic implications. Lung Cancer 82:179-89. [PMID: 24011633] (*co-first authorship)
  • Lockwood WW*, Thu KL*, Lin L, Pikor LA, Chari R., Lam WL*, Beer DG* (2012) Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma. Clinical Cancer Research 18: 1936-46. [PMID: 22328562]
  • Ho WC, Pikor, LA, Gao Y, Elliott BE, Greer PA (2012).  Calpain 2 regulates the Akt-FoxO-p27Kip1 signaling pathway in mammary carcinoma.  Journal of Biological Chemistry. 287:15458-65.

  • Lockwood WW, Wilson IM, Coe BP, Chari R, Pikor LA, Thu KL, Yee J, English J, Murray N, Tsao MS, Minna JD, Gazdar AF, MacAulay CE., Lam S, Lam WL (2012) Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.  PLoS ONE 7(5): e37775, 1-18. [PMID: 22629454]

  • Enfield KSS*, Pikor LA*, Martinez VD, Lam WL (2012) Mechanistic roles of non-coding RNAs in lung cancer biology and their clinical implications. Genetic Research International 2012: 737416, 1-16. (*co-first authorship)

  • Thu KL*, Pikor LA*, Chari R, Wilson IM, MacAulay CE, Tsao-MS, Gazdar AF, Lam S, Lam WL, Lockwood WW (2011) Disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism for NFkB pathway activation in lung cancer. Journal of Thoracic Oncology 6:1521-1529. (*co-first authorship)

  • Pikor LA*, Enfield KSS*, Cameron Heryet, Wan L. Lam (2011) DNA extraction from paraffin embedded material for genetic and epigenetic analyses.  Journal of Visualized Experiments 49: 2763. (* co-first authorship)
    [http://www.jove.com/details.stp?id=2763 doi: 10.3791/2763]

  • Enfield KSS*, Stewart GL*, Pikor LA*, Alvarez CE, Lam S, Lam WL, Chari R (2011). MicroRNA alterations and chemotherapeutic response in lung cancer. Journal of Biomedicine and Biotechnology 2011: 474632, 1-15. (*co-first authorship)

  • Chari R, Lonergan KM, Pikor LA, Coe BP, Zhu CQ, Chan THW, MacAulay C, Tsao MS, Lam S, Ng RT, Lam WL (2010) A sequence-based approach to identify reference genes for gene expression analysis.  BMC Medical Genomics 3:32, 1-11. 
  • Thu KL, Pikor LA, Kennett JY, Alvarez CE, Lam WL (2010) Methylation analysis by DNA immunoprecipitation, Journal of Cellular Physiology, 222:522-31. (link)

Abstracts

Published Abstract and Poster Presentations in Refereed International Conferences

  • Pikor L, Lockwood WW, Vucic EA, Chari R, Lam S, Lam WL (2010). Amplification status of GAS41 and MDM2 in lung adenocarcinomas.  AACR 101st Annual Meeting, Washington DC. Abstract # 240

  • Larissa Pikor, Kelsie L. Thu, Raj Chari, Ian M. Wilson, Calum E. MacAulay, John C. English, Ming-Sound Tsao, Adi F. Gazdar, Stephen Lam, and Wan L. Lam, William W. Lockwood (2010)  DNA alteration to the Cullin-3/Ring box protein-1 E3 ubiquitin ligase complex represents a novel mechanism of NF-kB activation in lung cancer AACR Frontiers in Cancer prevention, Philadelphia PA. Abstract # A14

  • Stewart GL, Pikor LA, Wilson IM, Coe BP, Chari R, Thu KL, Yee J, English J, Murray N, Tsao MS, Minna J, Gazdar AF, MacAulay CE, Lam S, Lam WL, Lockwood WW (2011).  Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways.  World Conference on Lung Cancer (WCLC), oral presentation, Amsterdam, Netherlands.

  • Larissa Pikor, Kelsie L. Thu,  Raj Chari, Ian M. Wilson, Calum E. MacAulay, John C. English, Ming-Sound Tsao, Adi F. Gazdar, Stephen Lam, William W. Lockwood and Wan L. Lam (2011) KEAP1/CUL3/Ring box protein-1 E3 ubiquitin ligase complex disruption is a novel genetic mechanism of NF-kB activation in lung cancer. World Conference on Lung Cancer, oral presentation.

  • Enfield KSS, Stewart GL, Pikor LA, Alvarez CE, Lam S, Chari R, Lam WL (2011) Deregulation of specific miRNAs correlates with systemic therapy response in NSCLC.  World Conference on Lung Cancer, chosen for oral presentation.

  • Stewart G, Thu KL, Vucic EA, Kennett JY, Pikor LA, Chari R, Lam S, Lam WL (2011). Gender related genomic differences in lung adenocarcinoma. World Conference on Lung Cancer.

  • Lockwood WW, Wilson IM, Coe BP, Chari R, Pikor LA, Thu KL, Yee J, English J, Murray N, Tsao MS, Minna J, Gazdar AF, MacAulay CE, Lam S, Lam WL (2011).  Genetic alteration in lung adenocarcinoma and squamous cell carcinoma develop through distinct genomic pathways.  ASHG annual meeting 2011, Montreal, QC

  • Pikor LA, Lockwood WW, Vucic EA, Chari R, Lam S, Lam WL (2012) Integrative Analysis identifies GAS41 as a novel oncogene in NSCLC, localizing to the 12q15 amplicon.  AACR-IASLC Joint conference on molecular origins of lung cancer, San Diego, USA

  • Pikor LA, Thu KL, Vucic EA, Lam S, Lam WL (2012). miRNAs display subtype specific patterns of aberrant expression in lung adenocarcinoma and squamous cell carcinoma. Mechanisms and Models of Cancer Conference, Cold Spring Harbour, NY, USA

  • Thu KL, Mosslemi M, Pikor LA, Vucic EA, Zhang W, Selemat SA, Laird-Offringa IA, Gazdar AF, Lam S, MacAulay CE, Lam WL (2012). Pathway profiles of lung adenocarcinoma in smokers and never smokers. Mechanisms and Models of Cancer Conference, Cold Spring Harbour, NY, USA

  • Vucic EA, Pikor LA, Thu KL, Ramnarine VR, Enfield KSS, MacAulay CE, Lam S, Lam WL (2012). Contribution of smoking to miRNA deregulation in lung tumors. Mechanisms and Models of Cancer Conference, Cold Spring Harbour, NY, USA

  • Pikor LA, Thu KL, Vucic EA, Ramnarine VR, Lam S, Lam WL (2013). miRNA sequencing identifies miRNAs that differentiate histology and distinguish tumor from non-malignant tissue in NSCLC. AACR/JCA Joint Conference, Maui, USA. Abstract A062

  • Vucic EA, Thu KL, Pikor LA, Enfield KSS, Ramnarine VR, Lam S, Lam WL (2013). Patterns of miRNA disruption specific to smoking and cancer in non-malignant and malignant lung tissues. AACR/JCA Joint Conference, Maui, USA. Abstract A063

  • Thu KL, Mosslemi M, Pikor LA, Vucic EA, Zhang W, Selamat SA, Laird-Offringa IA, Gazdar AF, Lam S, MacAulay CA, Lam WL (2012). Development of an integrative genomics algorithm to investigate differences in the molecular mechanisms contributing to lung adenocarcinoma of smokers and never smokers. American Thoracic Society Annual Meeting, Philadelphia, USA. Abstract A28

  • Thu KL, Mosslemi M, Vucic EA, Pikor LA, Zhang W, Selamat S, Laird-Offringa I, Gazdar AF, Ng Rt, English JC, MacAulay CE, Lam S, Lam WL (2013) Differential pathway disruption in lung adenocarcinomas from current and never smokers- A multi-omics data integration analysis. World Conference on Lung Cancer. Sydney, Australia. Abstract #1072

  • Pikor LA, Lockwood WW, Thu KL, Vucic EA, Chari R, Gazdar AF, MacAulay CE, Lam S, Lam WL (2013). Amplification of YEATS4, a novel oncogene in NSCLC inhibits the p53 pathway and increases cisplatin resistance. World Conference on Lung Cancer. Sydney, Australia. Abstract # 1073

  •  Pikor LA, Chari R, Kennett JY, Solis LM, Valencia I, Wistuba I, Gazdar AF, Lam S, Lam WL (2013). Downregulation of SIRPA induces senescence mediated by Rb and is associated with EGFR mutations. World Conference on Lung Cancer. Sydney, Australia. Abstract #1074

Published Abstract and Poster Presentations in Refereed Local Conferences

  • Pikor L, Ho WC, Greer PA (2009) The role of m-calpain in reducing breast tumor growth and metastasis. Life Science Poster Day, Queen's University, Kingston, ON. Abstract P4
  • Pikor L, Lockwood WW, Vucic EA, Chari R, Lam S, Lam WL (2010). Amplification of GAS41 and MDM2 in lung adenocarcinomas.  Pathology Day, University of British Columbia, Vancouver, BC. Abstract # 36

  • Larissa Pikor, Kelsie L. Thu, William W. Lockwood,  Raj Chari, Ian M. Wilson, Calum E. MacAulay, John C. English, Ming-Sound Tsao, Adi F. Gazdar, Stephen Lam, and Wan L. Lam (2010)  Disruption of the KEAP1/CULLIN-3 E3 Ubiquitin ligase complex represents a novel mechanism of NF-kB activation in lung cancer. BC Cancer Agency Annual Conference, Vancouver, BC.  Abstract # 28-D

  • Enfield KSS, Stewart GL, Pikor LA, Alvarez CE, Lam S, Chari R, Lam WL (2011) Deregulation of specific miRNAs correlates with systemic therapy response in NSCLC.  Bioinformatics and Interdisciplinary oncology Retreat, Vancouver BC

  • Stewart G, Thu KL, Vucic EA, Kennett JY, Pikor LA, Chari R, Lam S, Lam WL (2011). Gender related genomic differences in lung adenocarcinoma. Bioinformatics and Interdisciplinary oncology Retreat, Vancouver BC

  • Larissa Pikor, Kelsie L. Thu,  Raj Chari, Ian M. Wilson, Calum E. MacAulay, John C. English, Ming-Sound Tsao, Adi F. Gazdar, Stephen Lam, William W. Lockwood and Wan L. Lam (2011) KEAP1/CUL3/Ring box protein-1 E3 ubiquitin ligase complex disruption is a novel genetic mechanism of NF-kB activation in lung cancer.  Bioinformatics and Interdisciplinary Oncology Retreat, Vancouver BC

  • Lockwood WW, Wilson IM, Coe BP, Chari R, Pikor LA, Thu KL, Yee J, English J, Murray N, Tsao MS, Minna J, Gazdar AF, MacAulay CE, Lam S, Lam WL (2011).  Genetic alteration in lung adenocarcinoma and squamous cell carcinoma develop through distinct genomic pathways.  BC Cancer Agency Annual Conference, Vancouver, BC

  • Pikor LA, Lockwood WW, Vucic EA, Chari R, Lam S, Lam WL (2012) Integrative Analysis identifies GAS41 as a novel oncogene in NSCLC, localizing to the 12q15 amplicon.  Interdisciplinary Oncology Program/Bioinformatics Program Research Day

  • Mosslemi M, Vucic EA, Thu KL, Pikor LA, Lam WL (2012) Multi-omics integrated tumor-genome ranking analysis. Pathology Day, University of British Columbia, Vancouver, BC. Abstract 49.

  • Mosslemi M, Vucic EA, Thu KL, Pikor LA, MacAulay CE, Lam WL (2012). Identification of cancer driver genes using novel gene ranking algorithm. British Columbia Cancer Agency Annual Conference. Vancouver, BC.

  • Mosslemi M, Thu KL, Pikor LA, Vucic EA, Ramnarine VR, Lam S, MacAulay CA Lam WL (2012). Comparison of driver pathway of lung adenocarcinomas between smokers and never smokers. British Columbia Cancer Agency Annual Conference. Vancouver, BC.

  • Pikor LA, Thu KL, Vucic EA, Lam S, Lam WL (2012). Lung adenocarcinoma and squamous cell carcinoma display subtype specific patterns of miRNA expression. British Columbia Cancer Agency Annual Conference. Vancouver, BC. 

  • Becker-Santos DD, Thu KL, Vucic EA, Pikor LA, Martinez VD, Robinson WP, Lam S, Lam WL (2012). Similarities of miRNA expression patterns in cancerous and developing lung tissues. British Columbia Cancer Agency Annual Conference. Vancouver, BC.

  • Pikor LA, Thu KL, Vucic EA, Lam S, Lam WL (2013). miRNA sequencing identifies miRNA that differentiate histology and distinguish tumor from non-malignant tissue in non-small cell lung cancer. UBC Bioinformatics and Oncology Research Day, Vancouver, BC


 Invited Oral presentations

  • Amplification of YEATS4, a novel oncogene in NSCLC inhibits the p53 pathway and increases cisplatin resistance. IASLC World Conference on Lung Cancer. 2013. Sydney, Australia
  • A multi-platform approach to biomarker discovery in lung cancers in never smokers -- BC Cancer Agency Update.  Canary Foundation Lung Team Meeting 2012. MD Anderson, University of Texas. Houston, Texas.
  • A multi-platform approach to biomarker discovery in lung cancers in never smokers -- BC Cancer Agency Year 3 Progress. Canary Foundation Meeting 2012. Canary Center, Stanford University. Palo Alto.
  • Genetic differences between lung adenocarcinoma and squamous cell carcinoma. Invited presentation at UBC Respiratory Seminar Series, 2012. Vancouver, BC

  •  A multi-platform approach to biomarker discovery in lung cancers in never smokers-BC Cancer Agency Year 2 update.  Canary Lung Cancer Team Meeting 2011.  Canary Center, Stanford University, Palo Alto, CA

  • KEAP1/Cullin-3/Ring box protein-1 E3 ubiquitin ligase complex disruption is a novel genetic mechanism of NFkB activation in lung cancer.  Oral presentation at the 14th IASLC World Conference on Lung Cancer. 2011. Amsterdam, NL.
  • Genetic alterations in lung adenocarcinoma and squamous cell carcinoma.  Invited presentation BC Lung Tumor Group Research Day, Vancouver, BC
  • Amplification of GAS41, a candidate oncogene in lung cancer. Invited trainee presentation at  BC Cancer Agency Research Day. 2009. Vancouver, BC.
  • Amplification status of GAS41 and MDM2 in lung cancer.  Mini Symposium (for Genetics students) on Molecular Dysregulation in Epithelial Cancers. 2009. BC Cancer Agency. 

Awards

  • Canadian Cancer Society Travel Award (2013)
  • Outstanding Research Poster, 2012 BTP/IOP Research Day (March 2012)
  • Betty Rice Award, Lung Cancer Research (2012)
  • Young Investigator Award, International Association for the Study of Lung Cancer, World Congress of Lung Cancer (2011)

  • Vanier Canada Graduate Scholarship (2011-2014)
  • CIHR Frederick Banting and Charles Best Canada Graduate Scholarship, Doctoral Research Award (2011-2014)

  • College for Interdisciplinary Studies Graduate Award (2011)

  • Scholar in Training Award for the Ninth Annual International Conference on Frontiers in Cancer Prevention Research (2010)

  • Frederick Banting and Charles Best Canada Graduate Scholarship (2010)

  • UBC Four Year Doctoral Fellowship (2010 - 2014)
  • UBC Graduate Entrance Scholarship (January 2010)
  • Interdisciplinary Oncology Program Travel Award (October 2009)
  • College for Interdisciplinary Studies Graduate Award  (September 2009)
  • BC Cancer Agency Incentive Training Award (September 2009)
  • Natural Sciences and Engineering Research Council of Canada Undergraduate Student Research Award (June-August 2005, 2006, 2007) 

Links

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab |