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Kim M. Lonergan, PhD

Postdoctoral Research Associate / Staff Scientist  675 West 10th Avenue, Vancouver, B.C., V5Z 1L3, Canada.  Ph: 604-675-8000 ext. 7708

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab | Kim Lonergan |



Ph.D., Biochemistry, Dalhouisie University

PDF, Dana Farber Cancer Inst., Harvard Medical School

Research Interests

  • Expression changes during cancer progression
  • Lung cancer


  • Vucic EA, Chari R, Wilson IM, Cotton AM, Thu KL, Kennett JY, Zhang M, Lonergan KM, Steiling K, Brown CJ, McWilliams A, Ohtani K, Lenburg ME, Sin DD, Spira A, MacAulay CE, Lam S, Lam WL (2014) Aberrant DNA methylation patterns are widespread in small airways of former smokers with COPD.  American Journal of Respiratory Cell Molecular Biology. In press. [PMID: 24298892]
  • Wilson IM*, Vucic EA*, Enfield KSS, Thu KL, Zhang Y-A, Chari R, Lockwood WW, Radulovich N, Starczynowski DT, Banáth JP, Zhang M, Pusic A, Fuller M, Lonergan KM, Rowbotham D, Yee J, English JC, Buys TPH, Selamat SA, Laird-Offinga I, Liu P, Anderson M, You M, Tsao-MS, Brown CJ, Bennewith KL, MacAulay CE, Karsan A, Gazdar AF, Lam S, Lam WL (2014) EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene.  In press. [PMID: 24096489]

  • Gibb EA, Vucic, EA, Enfield KSS, Stewart GL, Lonergan KM, Kennett JY, Becker-Santos DD, MacAulay CE, Lam S, Brown CJ, Lam WL (2011) Human cancer long non-coding RNA transcriptomes.  PLoS ONE 6: e25915, 1-10. [PMID: 21991387]

  • Gibb EA, Enfield KSS, Stewart GL, Lonergan KM, Ng RT, Zhang L, MacAulay CE, Rosin MP, Lam WL (2011)  Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions. Oral Oncology 47:1055-61. [PMID: 21835683]

  • Chari R, Lonergan KM, Pikor LA, Coe BP, Zhu CQ, Chan THW, MacAulay C, Tsao MS, Lam S, Ng RT, Lam WL (2010) A sequence-based approach to identify reference genes for gene expression analysis.  BMC Medical Genomics 3:32, 1-11. [PMID: 20682026]
  • Chari R, Thu KL, Wilson IM, Lockwood WW, Lonergan KM, Coe BP, Malloff CA, Gazdar AF, Lam S, Garnis C, MacAulay CE, Alvarez CE, Lam WL (2010) Integrating the multiple dimensions of genomic and epigenomic lanscapes of cancer. Cancer and Metastasis Reviews 29: 73-93. [PMID: 20108112]
  • Lonergan, KM, Chari R, Coe BP, Wilson IM, Tsao MS, Ng RT, MacAulay C, Lam S, Lam WL (2010) Transcriptome profiles of carcinoma-in-situ and invasive non-small cell lung cancer as revealed by SAGE. PLoS ONE 5: e9162, 1-22. [PMID: 20161782]
  • Shadeo A, Chari R, Lonergan KM, Pusic A, Miller D, Ehlen T, Van Niekerk D, Matisic J, Richards-Kortum R, Follen M, Guillaud M, Lam WL, MacAulay C. (2008) Up regulation in gene expression of chromatin remodelling factors in cervical intraepithelial neoplasia. BMC Genomics 9:64, 1-14. [PMID: 18248679] 
  • Chari R, Lonergan KM, Ng RT, MacAulay C, Lam WL, Lam S. (2007) Effect of active smoking on the human bronchial epithelium transcriptome. BMC Genomics 8:297, 1-13. [PMID: 17727719] 
  • Shadeo A, Chari R, Vatcher G, Campbell J, Lonergan KM, Matisic J, van Niekerk D, Ehlen T, Miller D, Follen M, Lam WL, MacAulay C. Comprehensive serial analysis of gene expression of the cervical transcriptome. (2007) BMC Genomics. 8:142, 1-11. [PMID: 17543121] 
  • Lonergan KM, Chari R, Deleeuw RJ, Shadeo A, Chi B, Tsao MS, Jones S, Marra M, Ling V, Ng R, Macaulay C, Lam S, Lam WL. (2006) Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression. Am J Respir Cell Mol Biol. 35: 651-61. [PMID: 16809635] 
  • Kaelin WG, Iliopoulos O, Lonergan KM, Ohh M. Functions of the von Hippel-Lindau tumour suppressor protein. (1998) J Intern Med. 243: 535-9. [PMID: 9681855] 
  • Ohh M, Yauch RL, Lonergan KM, Whaley JM, Stemmer-Rachamimov AO, Louis DN, Gavin BJ, Kley N, Kaelin WG Jr, Iliopoulos O. (1998) The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell. 1: 959-68. [PMID: 9651579] 
  • Pause A, Lee S, Lonergan KM, Klausner RD. (1998) The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal. Proc Natl Acad Sci U S A. 95: 993-8. [PMID: 9448273] 
  • Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, Kaelin WG Jr. (1998) Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. Mol Cell Biol. 18: 732-41. [PMID: 9447969] 
  • Lonergan KM, Gray MW. (1996) Expression of a continuous open reading frame encoding subunits 1 and 2 of cytochrome c oxidase in the mitochondrial DNA of Acanthamoeba castellanii. J Mol Biol. 257: 1019-30. [PMID: 8632465] 
  • Turmel M, Cote V, Otis C, Mercier JP, Gray MW, Lonergan KM, Lemieux C. (1995) Evolutionary transfer of ORF-containing group I introns between different subcellular compartments (chloroplast and mitochondrion). Mol Biol Evol. 12: 533-45. [PMID: 7659010] 
  • Burger G, Plante I, Lonergan KM, Gray MW. (1995) The mitochondrial DNA of the amoeboid protozoon, Acanthamoeba castellanii: complete sequence, gene content and genome organization. J Mol Biol. 245: 522-37. [PMID: 7844823] 
  • Lonergan KM, Gray MW. (1994) The ribosomal RNA gene region in Acanthamoeba castellanii mitochondrial DNA. A case of evolutionary transfer of introns between mitochondria and plastids? J Mol Biol. 239: 476-99. [PMID: 8006963] 
  • Lonergan KM, Gray MW. (1993) Predicted editing of additional transfer RNAs in Acanthamoeba castellanii mitochondria. Nucleic Acids Res. 21: 4402. [PMID: 8415006] 
  • Lonergan KM, Gray MW. (1993) Editing of transfer RNAs in Acanthamoeba castellanii mitochondria. Science. 259: 812-6. [PMID: 8430334] 
  • Rajaraman R, Lonergan K. (1982) Fibronectin distribution pattern and the three-dimensional growth behavior of mammalian cells under anchorage-independent conditions. Exp Cell Biol. 50: 2-12. [PMID: 7037497] 
  • Lazier CB, Richman J, Lonergan K. (1984) The effect of molybdate on the intracellular distribution of estrogen receptor in mammary tumors. Breast Cancer Res Treat. 4: 19-26. [PMID: 6697008] 
  • Lazier CB, Lonergan K, Mommsen TP. (1985) Hepatic estrogen receptors and plasma estrogen-binding activity in the Atlantic salmon. Gen Comp Endocrinol. 57:234-45. [PMID: 3979805]


| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab | Kim Lonergan |