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Katey Enfield

PhD candidate

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kenfield@bccrc.ca   10th floor - 675 W.10th Avenue, Vancouver, BC, V5Z1L3, Canada


Training

  • BSc, Biochemistry and Microbiology, University of Victoria, 2009
  • PhD, Interdisciplinary Oncology Program, Faculty of Medicine, University of British Columbia, 2017
             Thesis: A multidimensional approach to understanding lung tumour aggressiveness

Program

PhD, Interdisciplinary Oncology, Faculty of Medicine, University of British Columbia (2010-2017)


Research Interests

Cancer Genomics

  • Both coding and non-coding RNA

The evolution of aggressive tumours

  • Genomic alterations incurred throughout tumourigenesis
  • Clonal evolution within the tumour microenvironment
  • Site-specific metastasis

Impact of tumour genomics on the immune-microenvironment

  • Immune cell infiltration
  • Response to immune therapies

Invited Talks

  • "Hyperspectral imaging tools capture the spatial organization of cell subsets within the tumour microenvironment." 5th AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic. San Diego, CA, USA. (January 2018)
  • “The developmental transcription factor ELF3 is critical for lung tumourigenesis.” NCRI Cancer Conference. Liverpool, UK. (November 2017)
  • “Inhibition of the novel oncogene ELF3 abolishes lung adenocarcinoma growth.” IASLC 18th World Conference on Lung Cancer. Yokohama, Japan. (October 2017)
  • “Linking genomics to immune phenotypes in lung adenocarcinoma.” Cancer Imaging Department Seminar Series, BCCRC. (April 2016)
  • “ELF3 is a novel oncogene frequently activated by genetic and epigenetic mechanisms in lung adenocarcinoma.” 15th World Conference of Lung Cancer. Sydney, Australia. (October 2013)
  • “Non-coding RNA in non-small cell lung cancer biology.” Respirology seminar. Vancouver General Hospital. (October 2013)
  • “MicroRNAs in lung cancer and their clinical applications.” Inter American Network of Academies of Sciences, North and South America research partnership workshop. BCCRC. (February 2012).
  • “Deregulation of specific miRNAs correlates with systemic therapy response in non-small cell lung cancer.” 14th World Conference on Lung Cancer. Amsterdam, The Netherlands. (July 2011)
  • “Predicting Drug Response Using MicroRNA”. Canadian Lung Cancer Conference. Vancouver, BC. (January 2011)

Publications

Journal Articles

  • Martinez VD, Anderson C, Marshall EA, Ng KW, Minatel BC, Enfield KSS, Sage AP, Xu Z, Lam WL (2017) Unique expression pattern of undescribed miRNAs in malignant pleural mesothelioma reveals potential as tissue of origin markers. Submitted.
  • Leung A, Veinotte C, Melong N, Oh MH, Chen K, Enfield KSS, Backstrom I, Warburton C, Yapp D, Berman J, Bally M, Lockwood WW (2017) In vivo validation of PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) as a cisplatin-sensitizing therapeutic target. Clinical Cancer Research. In press.
  • Enterina JR*, Enfield KSS*, Anderson C, Marshall EA, Ng KW, Lam WL (2017) DLK1-DIO3 locus deregulation in development, respiratory disease, and cancer. Expert Review of Respiratory Medicine. 11:9, 1-13. (* co-first authorship)
  • Enfield KSS, Martinez VD, Marshall EA, Stewart GL, Kung SHY, Enterina JR, Lam WL (2016) Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung cancer patient outcome. Oncotarget. 7:49, 80957-80966.
  • Marshall EA, KW Ng, Kung SHY, Conway EM, Martinez VD, Halvorsen EC, Rowbotham DA, Vucic EA,Plumb AW, Becker-Santos DD, Enfield KSS, Bennewith KL, Lockwood WW, Lam S, English JC, Abraham N, Lam WL (2016) Emerging roles of T Helper 17 and Regulatory T cells in lung cancer progression and metastasis. Molecular Cancer. 15:67, 1-15.
  • Ng KW, Anderson C, Marshall EA, Minatel BC, Enfield KSS, Saprunoff HL, Lam WL, Martinez VD (2016) Piwi-interacting RNAs in cancer: emerging functions and clinical utility. Molecular Cancer. Jan 15;15:5, 1-13.
  • Firmino N, Martinez VD, Rowbotham DA, Enfield KSS, Bennewith KL, Lam WL (2015) HPV status alters PIWI-interacing RNA expression pattern in head and neck cancer. Oral Oncology. Apr;55:43-8.
  • Martinez VD, Vucic EA, Thu KL, Hubaux R, Enfield KSS, Pikor LA, Becker-Santos DD, Brown CJ, Lam S, Lam WL (2015) Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology. Scientific Reports. 5:10423, 1-17.
  • Martinez VD*, Enfield KSS*, Rowbotham DA, Lam WL (2015) An atlas of gastric PIWI-Interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence. Gastric Cancer. 19:660-5. (* co-first authorship)
  • Vucic EA, Thu KL, Pikor LA, Enfield KSS, Yee J, English JC, MacAulay CE, Lam S, Jurisica I, Lam WL (2014) Smoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology. BMC Cancer. 2014, 14:778, 1-14.
  • Rowbotham D, Enfield KSS, Martinez VD, Thu KL, Vucic EA, Stewart GL, Bennewith K, Lam WL (2014) Multiple components of the VHL tumor suppressor complex are frequently affected by DNA copy number loss in pheochromocytoma. International Journal of Endocrinology. 2014:546347, 1-9.
  • Wilson IM, Vucic EA, Enfield KSS, Thu KL, Zhang YA, Chari R, Lockwood WW, Radulovich N, Starczynowski DT, Banath JP, Zhang M, Pusic A, Fuller M, Lonergan KM, Rowbotham D, Yee J, English JC, Buys TPH, Selama SA, Laird-Offringa IA, Liu P, Anderson M, You M, Tsao MS, Brown CJ, Bennewith KL, MacAulay CA, Karsan A, Gazdar AF, Lam S, Lam WL (2014) EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene. 33: 4464-7.
  • Hubaux R, Becker-Santos DD, Enfield KSS, Rowbotham D, Lam S, Lam WL, Martinez VC (2013) Molecular features in arsenic-induced lung tumors. Molecular Cancer. 12:20, 1-11.
  • Hubaux R, Becker-Santos DD, Enfield KSS, Lam S, Lam WL, Martinez VC (2012) Impact of Arsenic, Asbestos and Radon Exposure on the Lung Cancer Genome. Environmental Health. 11:89, 1-12.
  • Hubaux R, Becker-Santos DD, Enfield KSS, Lam S, Lam WL, Martinez VD (2012) MicroRNAs as biomarkers for clinical features of lung cancer. Metabolomics. 2:108, 1-11.
  • Gibb EA, Becker-Santos DD, Enfield KSS, Guillaud M, van Niekerk D, Matisic JP, MacAulay CE, Lam WL (2012) Aberrant expression of long non-coding RNAs in cervical intaepithelial neoplasia. International Journal of Gynecological Cancer. 22:(9):1557-63.
  • Enfield KSS, Pikor LA, Martinez VD, Lam WL (2012) Mechanistic roles of non-coding RNAs in lung cancer biology and their clinical implications. Genetic Research International.  vol. 2012, Article ID 737416, 16 pages, 2012.
  • Gibb EA, Enfield KSS, Stewart GL, Lonergan KM, Ng RT, Zhang L, MacAulay CE, Rosin MP, Lam WL (2011)  Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions. Oral Oncology. 47(11): 1055-61. 

  • Gibb EA, Vucic, EA, Enfield KSS, Stewart GL, Lonergan KM, Kennett JY, Becker-Santos DD, MacAulay CE, Lam S, Brown CJ, Lam WL (2011) Human cancer long non-coding RNA transcriptomes.  PLoS ONE 6: e25915, 1-10.

  • Enfield KSS*, Stewart GL*, Pikor LA*, Carlos E. Alvarez, Stephen Lam, Wan L. Lam, Raj Chari (2011) MicroRNA gene dosage alterations and drug response in lung cancer. Journal of Biomedicine and Biotechnology 2011: 474632, 1-15. (* co-first authorship)

  • Pikor LA*, Enfield KSS*, Cameron Heryet, Wan L. Lam (2011) DNA extraction from paraffin embedded material for genetic and epigenetic analyses.  Journal of Visualized Experiments 49: 2763. (* co-first authorship)
    [http://www.jove.com/details.stp?id=2763 doi: 10.3791/2763]

  • Gibb EA, Enfield KSS, Tsui IFL, Chari R, Lam, S, Alvarez CE, Lam WL (2011) Deciphering squamous cell carcinoma using multi-dimensional genomic approaches. Journal of Skin Cancer 2011: 1-16.

Abstracts

  • Enfield KSS, Marshall EA, Rahmati S, Fuller M, Anderson C, Ng K, Rowbotham DA, Chari R, Becker-Santos DD, MacAulay CE, Lam S, Lockwood WW, Karsan A, Jurisica I, Lam LW (2017) Genetic selection of ELF3 leads to oncogenic reprogramming in lung adenocarcinoma. Canary Foundation Symposium. Stanford University, CA.
  • Enfield KSS, Kung SHY, Gallagher P, Milne K, Chen ZY, Lam S, English JC, Guillaud M, MacAulay CE, Lam WL (2016) Single cell profiling and cell sociology of the lung tumour microenvironment. Cell Symposia: Hallmarks of Cancer. Ghent, Belgium.
  • Enfield KSS, Rahmati S, Rowbotham DA, Fuller M, Anderson C, Kennett JY, Marshall EA, Chari R, Becker-Santos DD, Ng K, MacAulay CE, Lam S, Politi K, Lockwood WW, Karsan A, Jurisica I, Lam WL (2016) ELF3 overexpression leads to oncogenic reprogramming of protein interactions exposing therapeutically actionable targets. 17th World Conference of Lung Cancer. Vienna, Austria.
  • Enfield KSS, Kung SHY, Gallagher P, Milne K, Chen ZY, Piga D, Lam S, English JC, Guillaud M, MacAulay CE, Lam WL (2016) Quantification of tumour-immune cell spatial relationships in the lung tumour microenvironment using single cell profiling. 17th World Conference of Lung Cancer. Vienna, Austria.
  • Kung SHY, Enfield KSS, Rowbotham DA, Marshall EA, Suzuki M, Holly A, Pastrello C, Minatel BC, Dellaire G, Jurisica I, MacAulay CE, Lam S, Lam WL (2016) Expression of miR-106 paralogs improves prognostic value of mesenchymal signatures but only miR-106b promotes invasiveness. 17th World Conference of Lung Cancer. Vienna, Austria.
  • Enfield KSS, Anderson C, Marshall E, Ng K, Minatel BC, Rowbotham DA, Chari R, Fuller M, Milne K, Becker-Santos DD, MacAulay CE, Karsan A, Lam S, Lam WL (2016) ELF3 amplification at 1q32.1 promotes SMAD4-independent tumourigenesis. Fourth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic. San Diego, CA.
  • Enfield KSS, Rowbotham DA, Holly A, Anderson C, Ng KW, Minatel BdC, Dellaire G, Pastrello C, Jurisica I, MacAulay C, Lam S, Lam WL (2015) miR-106a and miR-106b affect growth and metastasis of lung adenocarcinoma. AACR Non-coding RNAs and Cancer. Boston, MA.
  • Stewart GL, Enfield KSS, Rowbotham DA, Hubaux R, Martinez VD, Lam S, Lam WL (2015) OIP5-Antisense 1, a long non-coding RNA deregulated in non-small cell lung cancer. AACR Non-coding RNAs and Cancer. Boston, MA.
  • Enfield KSS, Anderson C, Ng KW, Minatel BdC, Rowbotham DA, Becker-Santos DD, Chari R, Fuller M, MacAulay C, Karsan A, Lam S, Lam WL (2015) ELF3 is a novel lung adenocarcinoma oncogene. BCCA Research Day. Vancouver, BC.
  • Enfield KSS, Ng KW, Anderson C, Minatel BdC, Rowbotham DA, Holly A, Dellaire G, Pastrello C, Jurisica I, MacAulay C, Lam S, Lam WL (2015) miR-106a and miR-106b are overexpressed in metastatic lung adenocarcinoma. BCCA Research Day. Vancouver, BC.
  • Enfield KSS, Rowbotham DA, Holly A, Dellaire G, Pastrello C, Jurisica I, MacAulay C, Lam S, Lam WL (2015) miR-106a and miR-106b affect metastasis of lung adenocarcinoma via EMT-dependent and EMT-independent pathways. TFRI Annual Meeting. St. John's, NL.
  • Enfield KSS, Rowbotham DA, Holly A, Dellaire G, Pastrello C, Jurisica I, MacAulay C, Lam S, Lam WL (2015) miR-106a and miR-106b affect metastasis of lung adenocarcinoma via EMT-dependent and EMT-independent pathways. GSAT/BTB/IOP Retreat. Vancouver, BC.
  • Stewart GL, Enfield KSS, Rowbotham DA, Hubaux R, Martinez VD, Lam S, Lam WL (2015) Deregulation of a natural antisense RNA, OIP5-Antisense 1, in non-small cell lung cancer. GSAT/BTB/IOP Retreat. Vancouver, BC.
  • Stewart GL, Enfield KSS, Hubaux R, Martinez V, Lam S, Lam WL (2014) Deregulation of natural antisense RNAs in non-small cell lung cancer. GSAT/BTB/IOP Retreat. Vancouver, BC.
  • Enfield KSS, Hubaux R, Vucic EA, Jurisica I, Lam S, Lam WL (2014) MicroRNA deregulation associated with node positive lung adenocarcinoma. GSAT/BTB/IOP Retreat. Vancouver, BC.
  • Enfield KSS, Ramnarine VR, Rowbotham DA, Lam S, Lam WL (2013) MicroRNA deregulation associated with node positive lung adenocarcinoma. World Conference of Lung Cancer. Sydney, Australia.
  • Stewart GL, Enfield KSS, Lam S, Lam WL (2013) Pseudogenes as miRNA sponges in non-small cell lung cancer. World Conference of Lung Cancer. Sydney, Australia.
  • Enfield KSS, Rowbotham DA, Becker-Santos DD, Chari R, Fuller M, Zhang M, Suzuki M, MacAulay CE, Karsan A, Lam S, Lam WL (2013) ELF3 is a novel oncogene frequently activated by genetic and epigenetic mechanisms in lung adenocarcinoma. World Conference of Lung Cancer. Sydney, Australia.
  • Enfield KSS, Ramnarine VR, Rowbotham DA, Lam S, Lam WL (2013) Deregulation of microRNAs associated with node positive lung adenocarcinoma. BC Cancer Agency Research Day. Vancouver, BC.
  • Enfield KSS, Ramnarine VR, Rowbotham DA, Lam S, Lam WL (2013) Deregulation of microRNAs associated with node positive lung adenocarcinoma. Bioinformatics and Oncology Research Day. Vancouver, BC.
  • Stewart GL, Enfield KSS, Lam S, Lam WL (2013) Pseudogenes as miRNA sponges in NSCLC. Bioinformatics and Oncology Research Day. Vancouver, BC.
  • Enfield KSS, Ramnarine VR, Rowbotham DA, Lam S, Lam WL (2013) MicroRNA deregulation associated metastasis and recurrence of non-small cell lung cancer. AACR-JCA Breakthroughs in Translational Research. Maui, HI.
  • Rowbotham D, Enfield KSS, Chari R, Becker-Santos D, Lam S, Lam WL (2012) ELF3, a fetal lung transcription factor, is frequently re-activated in lung adenocarcinoma. BCCA Annual Conference. Vancouver, BC.
  • Enfield KSS, Ramnarine VR, Lam S, Lam WL (2012) MicroRNA deregulation associated with non-small cell lung cancer metastasis. BCCA Annual Conference. Vancouver, BC.
  • Enfield KSS, Lam S, Lam WL (2012) MicroRNA deregulation associated with non-small cell lung cancer metastasis.Cold Spring Harbor: Mechanisms and Models of Cancer. Cold Spring Harbor Labs, NY.
  • Becker-Santos DD, Gibb EA, Vucic EA, Enfield KSS, Stewart GL, MacAulay CE, Lam S, Lam WL (2012) An expression map of long non-coding RNAs in human lung and non small cell lung cancer. AACR-IASLC: The Molecular Origins of Lung Cancer, San Diego, CA.
  • Stewart GL, Enfield KSS, Lam S, Lam WL (2012) DNA copy number alterations deregulate expression of miRNAs in lung adenocarcinoma. AACR Special Conference: Noncoding RNAs and Cancer, Miami, FL.
  • Enfield KSS, Lam S, Lam WL (2012) The paralogous microRNA clusters, miR-17-92 and miR-106-25, are specifically overexpressed in metastatic non-small cell lung carcinomas. AACR Special Conference: Non-Coding RNAs and Cancer, Miami, FL.
  • Gibb EA, Vucic, EA, Enfield KSS, Stewart GL, Kennet JY, Becker-Santos DD, Lonergan KM, MacAulay CE, Lam S, Brown CJ, Lam WL (2011) Human cancer long non-coding RNA transcriptomes. BC Annual Cancer Conference, Vancouver BC.
  • Enfield KS, Chari R, Becker-Santos DD, Lam S, Lam WL (2011) ELF3, a fetal lung transcription factor, is frequently re-activated in lung adenocarcinoma. BC Annual Cancer Conference, Vancouver, BC.
  • Enfield KSS, Stewart GL, Pikor LA, Alvarez CE, Lam S, Chari R, Lam WL (2011) MicroRNA deregulation is associated with inherent lung cancer cell line drug response. BC Annual Cancer Conference, Vancouver, BC.
  • Enfield KS, Chari R, Becker-Santos DD, Lam S, Lam WL (2011) ELF3 is a putative oncogene frequently gained and hypomethylated in the adenocarcinoma subtype of non-small cell lung cancer. In American Society of Human Genetics Annual Meeting, Montreal, QC.
  • Wilson I, Vucic EA, Enfield KSS, Chari R, Zhang YA, Radulovich N, Starczynowski D, Banath J, Zhang M, Pusic A, Fuller M, Lonergan K, Buys T, Yee J, Laird-Offringa IA, Liu P, Tsao MS, Anderson M, You M, Bennewith K, Karsan A, MacAulay CE, Lam S, Gazdar AF, Lam W (2010) EYA4 is a frequently inactivated tumour suppressor gene within the 6q lung cancer susceptibility locus. 14th World Conference on Lung Cancer, Amsterdam, The Netherlands.
  • Enfield KSS, Stewart GL, Pikor LA, Alvarez CE, Lam S, Chari R, Lam WL (2011) Deregulation of specific miRNAs correlates with systemic therapy response in non-small cell lung cancer. 14th World Conference on Lung Cancer, Amsterdam, The Netherlands. Oral presentation.
  • Enfield KSS, Stewart GL, Pikor LA, Alvarez CE, Lam S, Chari R, Lam WL (2011) Deregulation of specific microRNAs correlates with drug resistance in lung cancer cell lines. Bioinformatics & Oncology Retreat, Vancouver, BC.
  • Enfield KSS, Wilson IM, Vucic EA, Chari R, Zhang YA, You M, MacAulay CA, Lam SL, Gazdar AF, Lam WL (2010) EYA4 is a putative lung tumor suppressor on 6q23-25 with a role in DNA repair and apoptosis. BC Annual Cancer Conference, Vancouver, BC
  • Enfield KSS, Wilson IM, Vucic EA, Chari R, Zhang YA, You M, MacAulay C, Lam S, Gazdar AF, Lam WL (2010) Deletion and hypermethylation of a tumor suppressor gene EYA4 in 6q23-25 is associated with lung cancer risk and poor survival. AACR Frontiers in Cancer Prevention Conference, Philidelphia.
  • Wilson IM, Enfield KSS, Vucic EA, Chari R, Zhang YA, You M, MacAulay C, Lam S, Gazdar AF, Lam WL (2010) A novel lung tumor suppressor implicated in somatic and familial cancers. AACR Annual Meeting, Washington, D.C. Abstract #10-LB-8683-AACR

Scholarships and Awards

National and International
  • Company of Biologists Travel Award, NCRI Cancer Conference (November 2017)
  • Young Investigator Award, IASLC 18th World Conference on Lung Cancer (October 2017)
  • Lectureship Award, IASLC 18th World Conference on Lung Cancer (October 2017)
  • Canadian Cancer Society Research Institute Travel Award, IASLC 17th World Conference on Lung Cancer (December 2016)
  • Terry Fox Research Institute Trainee Travel Award, 6th Annual Scientific Meeting (May 2015)
  • Frederick Banting and Charles Best Canada Graduate Scholarship Doctoral Award, CIHR (May 2012 - April 2015)
  • American Association for Cancer Research-AstraZeneca Scholar-in-Training Award, AACR Special Conference: Noncoding RNAs and Cancer (January 2012)
  • Young Investigator Award, IASLC 14th World Conference on Lung Cancer (July 2011)
  • Betty Rice Award for Research Excellence in Lung Cancer (January 2011)
Provincial
  • Poster Award, Bioinformatics/Interdisciplinary Oncology/Genome Science (B.I.G.) Graduate Program Research Day (2017)
  • Faculty of Medicine Graduate Award (2016)
  • 4 Year Fellowship, University of British Columbia (May 2012 - April 2016)
  • Poster Award, Terry Fox Research Institute BC Node Research Day (November 2015)
  • Outstanding Student Lecture Prize, Lung Cancer Origins and Genetic Mechanisms Workshop (August 2014)
  • Interdisciplinary Oncology Program Travel Award (August 2014)
  • Interdisciplinary Oncology Program Tuition Award (April 2014)
  • Poster Award, B.I.G. Graduate Program Research Day (March 2014)
  • Interdisciplinary Oncology Program Travel Award (September 2013)
  • College for Interdisciplinary Studies Graduate Award (March 2013)
  • Best Speaker Award, BC Cancer Research Centre Seminar Series (June 2012)
  • Poster Award: Biology and Informatics, BC Cancer Annual Conference (November 2010)
  • Cancer Genetics Scholar in Training Award (October 2010)
  • Interdisciplinary Oncology Program Travel Award (April 2010)
  • Interdisciplinary Oncology Program Entrance Scholarship (January 2010)
  • University of Victoria Undergraduate Entrance Scholarship (2005)

Workshops

  • "Highlighting the impacts of North-South research collaboration in lung cancer among Canadian and South America partners" with Dr. Jorge Allende, University of Chile, Inter American Network of Academies of Sciences (February 2012) Organized by Dr. Victor Martinez, BCCRC.
  • "Lung Cancer Origins and Genetic Mechanisms Workshop" with Dr. Graham Dellaire, Dalhousie University (August 2014). BCCRC, Vancouver, BC.

Links

| BCCA | BCCRC | Integrative Oncology | Cancer Genetics | Wan Lam Lab |